Bellahcene, A., Waltregny, D., & Castronovo, V. (1999). The role of bone sialoprotein in the process of bone metastases development. Amsterdam, Netherlands: IOS Press. |
![]() ![]() | Ruscitti, C., Abinet, J., Maréchal, P., Meunier, M., de Meeûs, C., Vanneste, D., Janssen, P., Dourcy, M., Thiry, M., Bureau, F., Schneider, C., Machiels, B., Hidalgo, A., Ginhoux, F., Dewals, B. G., Guiot, J., Schleich, F., Garigliany, M.-M., Bellahcene, A., ... Marichal, T.*. (02 August 2024). Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. Science Immunology, 9 (98), 1227. doi:10.1126/sciimmunol.ado1227 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Anania, S., Farnir, M., Peiffer, R., Boumahd, Y., Thiry, M., Agirman, F., Maloujahmoum, N., Bellahcene, A., & Peulen, O. (17 February 2024). Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines. Cell Communication and Signaling, 22 (1), 133. doi:10.1186/s12964-024-01514-z ![]() |
![]() ![]() | Crake, R., Gasmi, I., Dehaye, J., Lardinois, F., Peiffer, R., Maloujahmoum, N., Agirman, F., KOOPMANSCH, B., D’Haene, N., Azurmendi Senar, O., Arsenijevic, T., Lambert, F., Peulen, O., Van Laethem, J.-L., & Bellahcene, A. (17 May 2023). Resistance to Gemcitabine in Pancreatic Cancer Is Connected to Methylglyoxal Stress and Heat Shock Response. Cells, 12 (10), 1414. doi:10.3390/cells12101414 ![]() |
![]() ![]() | Dube, G., Tiamiou, A., Bizet, M., Boumahd, Y., Gasmi, I., Crake, R., Bellier, J., Nokin, M.-J., Calonne, E., Deplus, R., Wissocq, T., Peulen, O., Castronovo, V., Fuks, F., & Bellahcene, A. (31 March 2023). Methylglyoxal: a novel upstream regulator of DNA methylation. Journal of Experimental and Clinical Cancer Research, 42 (1), 78. doi:10.1186/s13046-023-02637-w ![]() |
![]() ![]() | Peiffer, R., Boumahd, Y., Gullo, C., Crake, R., Letellier, E., Bellahcene, A., & Peulen, O. (22 December 2022). Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer. Cancers, 15 (1), 61. doi:10.3390/cancers15010061 ![]() |
![]() ![]() | Rademaker, G.* , Boumahd, Y.* , Peiffer, R., Anania, S., Wissocq, T., Liégeois, M., Luis, G., Sounni, N. E., Agirman, F., Maloujahmoum, N., De Tullio, P., Thiry, M., Bellahcene, A., Castronovo, V., & Peulen, O. (July 2022). Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells. Redox Biology, 53, 102324. doi:10.1016/j.redox.2022.102324 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Chiavarina, B., Ronca, R., Otaka, Y., Sutton, R. B., Rezzola, S., Yokobori, T., Chiodelli, P., Souche, R., Pourquier, D., Maraver, A., Faa, G., Khellaf, L., Turtoi, E., Oyama, T., Gofflot, S., Bellahcene, A., Detry, O., Delvenne, P., Castronovo, V., ... Turtoi, A. (March 2022). Fibroblast-derived prolargin is a tumor suppressor in hepatocellular carcinoma. Oncogene, 41 (10), 1410-1420. doi:10.1038/s41388-021-02171-z ![]() |
![]() ![]() | Rademaker, G., Costanza, B., Pyr Dit Ruys, S., Peiffer, R., Agirman, F., Maloujahmoum, N., Vertommen, D., Turtoi, A., Bellahcene, A., Castronovo, V.* , & Peulen, O.*. (2022). Paladin, overexpressed in colon cancer, is required for actin polymerisation and liver metastasis dissemination. Oncogenesis, 11, 42. doi:10.1038/s41389-022-00416-4 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Chiavarina, B., Costanza, B., Ronca, R., Blomme, A., Rezzola, S., Chiodelli, P., Giguelay, A., Belthier, G., Doumont, G., Van Simaeys, G., Lacroix, S., Yokobori, T., Erkhem-Ochir, B., Balaguer, P., Cavailles, V., Fabbrizio, E., Di Valentin, E., Gofflot, S., Detry, O., ... Turtoi, A. (January 2021). Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis. Theranostics, 11 (4), 1626-1640. doi:10.7150/thno.51507 ![]() |
![]() ![]() | Luis, G.* , Godfroid, A.* , Nishiumi, S., Cimino, J., Blacher, S., Maquoi, E., Wery, C., Collignon, A., Longuespée, R., MONTERORUIZ, L., Dassoul, I., Maloujahmoum, N., Pottier, C., Mazzucchelli, G., De Pauw, E., Bellahcene, A., Yoshida, M., Noël, A., & Sounni, N. E. (2021). Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence. Redox Biology, 43, 102006. doi:10.1016/j.redox.2021.102006 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Anania, S., Peiffer, R., Rademaker, G., Hego, A., Thiry, M., Deldicque, L., Francaux, M., Maloujahmoum, N., Agirman, F., Bellahcene, A., Castronovo, V., & Peulen, O. (21 June 2020). Myoferlin is a yet unknown interactor of the mitochondrial dynamics’ machinery in pancreas cancer cells. Cancers, 12 (6), 1643. doi:10.3390/cancers12061643 ![]() |
![]() ![]() | Bellier, J., Nokin, M.-J., Caprasse, M., Tiamiou, A., Blomme, A., Scheijen, J. L., KOOPMANSCH, B., MacKay, G. M., Chiavarina, B., Costanza, B., Rademaker, G., Durieux, F., Agirman, F., Maloujahmoum, N., Cusumano, P. G., LOVINFOSSE, P., Leung, H. Y., LAMBERT, F., Bours, V., ... Bellahcene, A. (04 February 2020). Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab. Cell Reports, 30 (5), 1400-1416.e6. doi:10.1016/j.celrep.2020.01.012 ![]() |
![]() ![]() | Peulen, O., Rademaker, G., Anania, S., Turtoi, A., Bellahcene, A., & Castronovo, V. (August 2019). Ferlin overview: from membrane to cancer biology. Cells, 8, 954. doi:10.3390/cells8090954 ![]() |
![]() ![]() | Rademaker, G., Costanza, B., Anania, S., Agirman, F., Maloujahmoum, N., Di Valentin, E., Goval, J.-J., Bellahcene, A., Castronovo, V., & Peulen, O. (June 2019). Myoferlin contributes to the metastatic phenotype of pancreatic cancer cells by enhancing their migratory capacity through the control of oxidative phosphorylation. Cancers, 11 (6). doi:10.3390/cancers11060853 ![]() |
![]() ![]() | Costanza, B., Rademaker, G., Tiamiou, A., De Tullio, P., Leenders, J., Blomme, A., Bellier, J., Bianchi, E., Turtoi, A., Delvenne, P., Bellahcene, A., Peulen, O.* , & Castronovo, V.*. (2019). TGFBI, an ECM interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration. International Journal of Cancer. doi:10.1002/ijc.32247 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Bellier, J., Nokin, M.-J., Lardé, E., Karoyan, P., Peulen, O., Castronovo, V., & Bellahcene, A. (2019). Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer. Diabetes Research and Clinical Practice. doi:10.1016/j.diabres.2019.01.002 ![]() |
![]() ![]() | Nokin, M.-J., Bellier, J., Durieux, F., Peulen, O., Rademaker, G., Gabriel, M., Monseur, C., CHARLOTEAUX, B., Verbeke, L., van Laere, S., RONCARATI, P., Herfs, M., Lambert, C., Scheijen, J., Schalkwijk, C., Colige, A., Caers, J., Delvenne, P., Turtoi, A., ... Bellahcene, A. (2019). Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer. Breast Cancer Research, 21(1, 11. doi:10.1186/s13058-018-1095-7 ![]() |
![]() ![]() | Rademaker, G., Costanza, B., Bellier, J., Herfs, M., Peiffer, R., Agirman, F., Maloujahmoum, N., Habraken, Y., Delvenne, P., Bellahcene, A., Castronovo, V.* , & Peulen, O.*. (2019). Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis. Oncogenesis. doi:10.1038/s41389-019-0130-6 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Rademaker, G., Hennequière, V., Nokin, M.-J., LOVINFOSSE, P., Durieux, F., GOFFLOT, S., Bellier, J., Costanza, B., Herfs, M., Peiffer, R., Bettendorff, L., Deroanne, C., Thiry, M., Delvenne, P., Hustinx, R., Bellahcene, A., Castronovo, V., & Peulen, O. (April 2018). Myoferlin controls mitochondrial structure and activity in pancreatic ductal adenocarcinoma, and affects tumor aggressiveness. Oncogene, 37 ((32)), 4398-4412. doi:10.1038/s41388-018-0287-z ![]() |
![]() ![]() | Blomme, A., van Simaeys, G., Doumont, G., Costanza, B., Bellier, J., Otaka, Y., Sherer, F., LOVINFOSSE, P., Boutry, S., Palacios, A. P., De Pauw, E., Hirano, T., Yokobori, T., Hustinx, R., Bellahcene, A., Delvenne, P., DETRY, O., Goldman, S., Nishiyama, M., ... Turtoi, A. (March 2018). Murine stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases. Oncogene, 37 (9), 1237-1250. doi:10.1038/s41388-017-0018-x ![]() |
![]() ![]() | Costanza, B., Turtoi, A., Bellahcene, A., Hirano, T., Peulen, O., Blomme, A., Hennequiere, J., MUTIJIMA NZARAMBA, E., Boniver, J., Meuwis, M.-A., JOSSE, C., KOOPMANSCH, B., SEGERS, K., Yokobori, T., Fahmy, K., Thiry, M., COIMBRA MARQUES, C., Garbacki, N., Colige, A., ... Castronovo, V. (2018). Innovative methodology for the identification of soluble biomarkers in fresh tissues. Oncotarget, 9 (12), 10665-10680. doi:10.18632/oncotarget.24366 ![]() |
![]() ![]() | Bellahcene, A., Nokin, M.-J., Castronovo, V., & Schalkwijk, C. (2018). Methylglyoxal-derived stress: an emerging biological factor involved in the onset and progression of cancer. Seminars in Cancer Biology. doi:10.1016/j.semcancer.2017.05.010 ![]() |
![]() ![]() | Chiavarina, B., Nokin, M.-J., Bellier, J., Durieux, F., BLETARD, N., Sherer, F., LOVINFOSSE, P., Peulen, O., Verset, L., Dehon, R., Demetter, P., Turtoi, A., Uchida, K., Goldman, S., Hustinx, R., Delvenne, P., Castronovo, V., & Bellahcene, A. (2017). Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer. International Journal of Molecular Sciences, 18 (1). doi:10.3390/ijms18010213 ![]() |
![]() ![]() | Nokin, M.-J., Durieux, F., Bellier, J., Peulen, O., Uchida, K., Spiegel, D. A., Cochrane, J. R., Hutton, C. A., Castronovo, V., & Bellahcene, A. (2017). Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death. Scientific Reports, 7 (1), 11722. doi:10.1038/s41598-017-12119-7 ![]() |
![]() ![]() | Ebralidze, L., Mskhiladze, L., Ledoux, A., Frederich, M., Bellahcene, A., Bero, J., Quetin-Leclercq, J., & Bakuridze, A. (2017). ANTICANCER, ANTIPLASMODIAL AND ANTITRYPANOSOMAL ACTIVITIES OF CRUDE EXTRACTS OF PLATANUS ORIENTALIS. World Journal of Pharmaceutical Research, 6 (3), 170-175. doi:10.20959/wjpr20173-7985 ![]() |
![]() ![]() | Blomme, A., Fahmy, K., Peulen, O., Costanza, B., Fontaine, M., Struman, I., Baiwir, D., De Pauw, E., Thiry, M., Bellahcene, A., Castronovo, V.* , & Turtoi, A.*. (2016). Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes. Oncotarget. doi:10.18632/oncotarget.13276 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Blomme, A., Costanza, B., De Tullio, P., Thiry, M., Van Simaeys, G., Boutry, S., Doumont, G., Di Valentin, E., Hirano, T., Yokobori, T., GOFFLOT, S., Peulen, O., Bellahcene, A., Sherer, F., Le Goff, C., Cavalier, E., Mouithys-Mickalad, A., Jouret, F., CUSUMANO, G., ... Turtoi, A. (2016). Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer. Oncogene. doi:10.1038/onc.2016.369 ![]() |
![]() ![]() | Nokin, M.-J., Durieux, F., Peixoto, P., Chiavarina, B., Peulen, O., Blomme, A., Turtoi, A., Costanza, B., Smargiasso, N., Baiwir, D., Scheijen, J., Schalkwijk, C., Leenders, J., De Tullio, P., BIANCHI, E., Thiry, M., Uchida, K., Spiegel, D., Cochrane, J., ... Bellahcene, A. (2016). Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP- mediated tumor growth and metastasis. eLife. doi:10.7554/eLife.19375 ![]() |
![]() ![]() | Henry, A., Nokin, M.-J., Leroi, N., Lallemand, F., Lambert, J., Goffart, N., RONCARATI, P., BIANCHI, E., Peixoto, P., Blomme, A., Turtoi, A., Peulen, O., Habraken, Y., Scholtes, F., Martinive, P., Delvenne, P., Rogister, B., Castronovo, V., & Bellahcene, A. (2016). New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity. Oncotarget. doi:10.18632/oncotarget.11483 ![]() |
![]() ![]() | Fradet, A., Bouchet, M., Delliaux, C., Gervais, M., Kan, C., Benetollo, C., Pantano, F., Vargas, G., Bouazza, L., Croset, M., Bala, Y., Leroy, X., Rosol, T. J., Rieusset, J., Bellahcene, A., Castronovo, V., Aubin, J. E., Clezardin, P., Duterque-Coquillaud, M., & Bonnelye, E. (2016). Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone. Oncotarget, 7 (47), 77071-77086. doi:10.18632/oncotarget.12787 ![]() |
![]() ![]() | Blomme, A., Cusumano, P., Peulen, O., Bellahcene, A., Castronovo, V., & Turtoi, A. (2016). L'asporine : une nouvelle defense naturelle contre le cancer du sein. MS. Medecine Sciences, 32 (11), 1019-1022. doi:10.1051/medsci/20163211020 ![]() |
![]() ![]() | Binsfeld, M., Muller, J., Lamour, V., De Veirman, K., De Raeve, H., Bellahcene, A., Van Valckenborgh, E., BARON, F., BEGUIN, Y., CAERS, J., & Heusschen, R. (2016). Granulocytic myeloid-derived suppressor cells promote angiogenesis in the context of multiple myeloma. Oncotarget, 7, 37931-37943. doi:10.18632/oncotarget.9270 ![]() |
![]() ![]() | Fahmy, K., Gonzalez, A., Arafa, M., Peixoto, P., Bellahcene, A., Turtoi, A., Delvenne, P., Thiry, M., Castronovo, V., & Peulen, O. (2016). Myoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer. International Journal of Cancer, 138, 652-663. doi:10.1002/ijc.29820 ![]() |
![]() ![]() | Peixoto, P.* , Blomme, A.* , Costanza, B.* , Ronca, R., Rezzola, S., Palacios, A., SCHOYSMAN, L., Boutry, S., Goffart, N., Peulen, O., Maris, P., Di Valentin, E., Hennequière, V., BIANCHI, E., Henry, A., Meunier, P., Rogister, B., MULLER, R., Delvenne, P., ... Turtoi, A. (2016). HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies. Oncogene. doi:10.1038/onc.2015.506 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Lamour, V., Henry, A., Kroonen, J., Nokin, M.-J., von Marschall, Z., Fisher, L., Chau, T.-L., Chariot, A., Sanson, M., Delattre, J.-Y., Turtoi, A., Peulen, O., Rogister, B., Castronovo, V., & Bellahcene, A. (2015). Targeting osteopontin suppresses glioblastoma stem-like cell character and tumorigenicity in vivo. International Journal of Cancer. doi:10.1002/ijc.29454 ![]() |
![]() ![]() | Mskhiladze, L., Chincharadze, D., Tits, M., Wauters, J.-N., Bellahcene, A., Castronovo, V., Mouithys-Mickalad, A., Franck, T., & Frederich, M. (2015). Identification of Cytotoxic and Antioxidant Compounds from Allium gramineum Flowers. International Journal of Pharmaceutical Sciences and Drug Research, 7, 78-82. ![]() |
![]() ![]() | Maris, P., Blomme, A., Palacios, A. P., Costanza, B., Bellahcene, A., BIANCHI, E., GOFFLOT, S., Drion, P., Trombino, G. E., Di Valentin, E., CUSUMANO, G., MAWEJA, S., JERUSALEM, G., Delvenne, P., LIFRANGE, E., Castronovo, V., & Turtoi, A. (2015). Asporin Is a Fibroblast-Derived TGF-beta1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer. PLoS Medicine, 12 (9), 1001871. doi:10.1371/journal.pmed.1001871 ![]() |
![]() ![]() | Turtoi, A., Peixoto, P., Castronovo, V., & Bellahcene, A. (2015). Histone deacetylases and cancer-associated angiogenesis: current understanding of the biology and clinical perspectives. Critical Reviews in Oncogenesis, 20 (1-2), 119-37. doi:10.1615/CritRevOncog.2014012423 ![]() |
![]() ![]() | Chiavarina, B.* , Nokin, M.-J.* , Durieux, F., BIANCHI, E., Turtoi, A., Peulen, O., Peixoto, P., Irigaray, P., Uchida, K., Belpomme, D., Delvenne, P., Castronovo, V., & Bellahcene, A. (2014). Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes. Oncotarget. doi:10.18632/oncotarget.2121 ![]() * These authors have contributed equally to this work. |
![]() ![]() | Tilli, T. M., Bellahcene, A., Castronovo, V., & Gimba, E. R. P. (2014). Changes in the transcriptional profile in response to overexpression of the osteopontin-c splice isoform in ovarian (OvCar-3) and prostate (PC-3) cancer cell lines. BMC Cancer, 14, 433. doi:10.1186/1471-2407-14-433 ![]() |
![]() ![]() | Lamour, V., Nokin, M.-J., Henry, A., Castronovo, V., & Bellahcene, A. (2013). Les proteines SIBLING - Outils moleculaires de la progression tumorale et de l'angiogenese. MS. Medecine Sciences, 29 (11), 1018-25. doi:10.1051/medsci/20132911019 ![]() |
![]() ![]() | Pesesse, L., Sanchez, C., Delcour, J.-P., Bellahcene, A., Baudouin, C., Msika, P., & Henrotin, Y. (2013). Consequences of chondrocyte hypertrophy on osteoarthritic cartilage: potential effect on angiogenesis. Osteoarthritis and Cartilage, 21 (12), 1913-23. doi:10.1016/j.joca.2013.08.018 ![]() |
![]() ![]() | Turtoi, A.* , Blomme, A.* , Bellahcene, A., Gilles, C., Hennequière, V., Peixoto, P., BIANCHI, E., Noël, A., De Pauw, E., LIFRANGE, E., Delvenne, P., & Castronovo, V. (2013). Myoferlin is a key regulator of EGFR activity in breast cancer. Cancer Research, 73, 5438-5448. doi:10.1158/0008-5472.CAN-13-1142 ![]() * These authors have contributed equally to this work. |
![]() ![]() | bournine, L., Bensalem, S., Wauters, J.-N., Iguer-Ouada, M., Maiza-Benabdesselam, F., Bedjou, F., Castronovo, V., Bellahcene, A., Tits, M., & Frederich, M. (2013). Identification and Quantification of the Main Active Anticancer Alkaloids from the Root of Glaucium flavum. International Journal of Molecular Sciences, 14, 23533-23544. doi:10.3390/ijms141223533 ![]() |
![]() ![]() | Bournine, L., Bensalem, S., Peixoto, P., Gonzalez, A., Maiza-Benabdesselam, F., Bedjou, F., Wauters, J.-N., Tits, M., Frederich, M., Castronovo, V., & Bellahcene, A. (2013). Revealing the anti-tumoral effect of Algerian Glaucium flavum roots against human cancer cells. Phytomedicine, 20 (13), 1211-1218. doi:10.1016/j.phymed.2013.06.007 ![]() |
![]() ![]() | Fradet, A., Sorel, H., Depalle, B., Serre, C. M., Farlay, D., Turtoi, A., Bellahcene, A., Follet, H., Castronovo, V., Clezardin, P., & Bonnelye, E. (2013). A new murine model of osteoblastic/osteolytic lesions from human androgen-resistant prostate cancer. PLoS ONE, 8 (9), 75092. doi:10.1371/journal.pone.0075092 ![]() |
![]() ![]() | Dumont, B., Castronovo, V., Peulen, O., BLETARD, N., Clézardin, P., Delvenne, P., De Pauw, E., Turtoi, A., & Bellahcene, A. (2012). Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis. Journal of Proteome Research. doi:10.1021/pr201022n ![]() |
![]() ![]() | Tilli, T. M., Mello, K. D., Ferreira, L. B., Matos, A. R., Accioly, M. T., Faria, P. A., Bellahcene, A., Castronovo, V., & Gimba, E. R. (2012). Both osteopontin-c and osteopontin-b splicing isoforms exert pro-tumorigenic roles in prostate cancer cells. Prostate. doi:10.1002/pros.22523 ![]() |
![]() ![]() | Mathieu, V., de Lassalle, E. M., Toelen, J., Mohr, T., Bellahcene, A., Van, G., Verschuere, T., Bouzin, C., Debyser, Z., De Vleesschouwer, S., Van Gool, S., Poirier, F., Castronovo, V., Kiss, R., & Feron, O. (2012). Galectin-1 in Melanoma Biology and Related Neo-Angiogenesis Processes. Journal of Investigative Dermatology. doi:10.1038/jid.2012.142 ![]() |
![]() ![]() | Turtoi, A., Mottet, D., Matheus, N., Dumont, B., Peixoto, P., Hennequière, V., Deroanne, C., Colige, A., De Pauw, E., Bellahcene, A., & Castronovo, V. (2012). The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells. Angiogenesis. doi:10.1007/s10456-012-9279-8 ![]() |
![]() ![]() | Kischel, P., Bellahcene, A., Deux, B., Lamour, V., Dobson, R., De Pauw, E., Clezardin, P., & Castronovo, V. (2012). Overexpression of CD9 in human breast cancer cells promotes the development of bone metastases. Anticancer Research, 32 (12), 5211-20. ![]() |
![]() ![]() | Fradet, A., Sorel, H., Bouazza, L., Goehrig, D., Depalle, B., Bellahcene, A., Castronovo, V., Follet, H., Descotes, F., Aubin, J. E., Clezardin, P., & Bonnelye, E. (2011). Dual function of ERR alpha in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin. Cancer Research, 71 (17), 5728-38. doi:10.1158/0008-5472.CAN-11-1431 ![]() |
![]() ![]() | Sin, S., Bonin, F., Petit, V., Meseure, D., Lallemand, F., Bieche, I., Bellahcene, A., Castronovo, V., de Wever, O., Gespach, C., Lidereau, R., & Driouch, K. (2011). Role of the Focal Adhesion Protein Kindlin-1 in Breast Cancer Growth and Lung Metastasis. Journal of the National Cancer Institute, 103, 1-15. doi:10.1093/jnci/djr290 ![]() |
![]() ![]() | Stresing, V., Fournier, P. G., Bellahcene, A., Benzaid, I., Monkkonen, H., Colombel, M., Ebetino, F. H., Castronovo, V., & Clezardin. (2011). Nitrogen-containing bisphosphonates can inhibit angiogenesis in vivo without the involvement of farnesyl pyrophosphate synthase. BONE, 48 (2), 259-66. doi:10.1016/j.bone.2010.09.035 ![]() |
![]() ![]() | Pirotte, S., Lamour, V., Lambert, V., Alvarez Gonzalez, M.-L., Ormenese, S., Noël, A., Mottet, D., Castronovo, V., & Bellahcene, A. (2011). Dentin Matrix Protein 1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation. Blood, 117 (8), 2515-26. doi:10.1182/blood-2010-08-298810 ![]() |
![]() ![]() | Lamour, V., Le Mercier, M., Lefranc, F., Hagedorn, M., Javerzat, S., Bikfalvi, A., Kiss, R., Castronovo, V., & Bellahcene, A. (2010). Selective osteopontin knockdown exerts anti-tumoral activity in a human glioblastoma model. International Journal of Cancer, 126, 1797-1805. doi:10.1002/ijc.24751 ![]() |
![]() ![]() | Mottet, D., Pirotte, S., Lamour, V., Hagedorn, M., Javerzat, S., Bikfalvi, A., Bellahcene, A., Castronovo, V., & Verdin, E. (2009). HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene, 28 (2), 243-56. doi:10.1038/onc.2008.371 ![]() |
![]() ![]() | Bellahcene, A., Castronovo, V., Ogbureke, K. U., Fisher, L. W., & Fedarko, N. S. (March 2008). Small Integrin-Binding Ligand N-Linked Glycoproteins (Siblings): Multifunctional Proteins in Cancer. Nature Reviews. Cancer, 8 (3), 212-26. doi:10.1038/nrc2345 ![]() |
![]() ![]() | Detry, C., Lamour, V., Castronovo, V., & Bellahcene, A. (February 2008). Creb-1 and Ap-1 Transcription Factors Jund and Fra-2 Regulate Bone Sialoprotein Gene Expression in Human Breast Cancer Cells. BONE, 42 (2), 422-31. doi:10.1016/j.bone.2007.10.016 ![]() |
![]() ![]() | Sanchez, C., Deberg, M., Bellahcene, A., Castronovo, V., Msika, P., Delcour, J.-P., Crielaard, J.-M., & Henrotin, Y. (February 2008). Phenotypic Characterization of Osteoblasts from the Sclerotic Zones of Osteoarthritic Subchondral Bone. Arthritis and Rheumatism, 58 (2), 442-55. doi:10.1002/art.23159 ![]() |
![]() ![]() | Landemaine, T., Jackson, A., Bellahcene, A., Rucci, N., Sin, S., Abad, B. M., Sierra, A., Boudinet, A., Guinebretiere, J.-M., Ricevuto, E., Nogues, C., Briffod, M., Bieche, I., Cherel, P., Garcia, T., Castronovo, V., Teti, A., Lidereau, R., & Driouch, K. (2008). A six-gene signature predicting breast cancer lung metastasis. Cancer Research, 68 (15), 6092-9. doi:10.1158/0008-5472.CAN-08-0436 ![]() |
![]() ![]() | Kischel, P., Guillonneau, F., Dumont, B., Bellahcene, A., Stresing, V., Clezardin, P., De Pauw, E., & Castronovo, V. (2008). Cell membrane proteomic analysis identifies proteins differentially expressed in osteotropic human breast cancer cells. Neoplasia, 10 (9), 1014-20. doi:10.1593/neo.08570 ![]() |
![]() ![]() | Saidi, A., Javerzat, S., Bellahcene, A., De Vos, J., Bello, L., Castronovo, V., Deprez, M., Loiseau, H., Bikfalvi, A., & Hagedorn, M. (2008). Experimental anti-angiogenesis causes upregulation of genes associated with poor survival in glioblastoma. International Journal of Cancer, 122 (10), 2187-98. doi:10.1002/ijc.23313 ![]() |
![]() ![]() | Lamour, V., Detry, C., Sanchez, C., Henrotin, Y., Castronovo, V., & Bellahcene, A. (14 December 2007). Runx2-and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. Journal of Biological Chemistry, 282 (50), 36240-36249. doi:10.1074/jbc.M705833200 ![]() |
![]() ![]() | Mottet, D., Bellahcene, A., Pirotte, S., Waltregny, D., Deroanne, C., Lamour, V., Lidereau, R., & Castronovo, V. (07 December 2007). Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis. Circulation Research, 101 (12), 1237-1246. doi:10.1161/CIRCRESAHA.107.149377 ![]() |
![]() ![]() | Le Gall, C., Bellahcene, A., Bonnelye, E., Gasser, J. A., Castronovo, V., Green, J., Zimmermann, J., & Clezardin, P. (15 October 2007). A cathepsin K inhibitor reduces breast cancer-induced osteolysis and skeletal tumor burden. Cancer Research, 67 (20), 9894-9902. doi:10.1158/0008-5472.CAN-06-3940 ![]() |
![]() ![]() | Bucciarelli, E., Sidoni, A., Bellezza, G., Cavaliere, A., Brachelente, G., Costa, G., Chaplet, M., Castronovo, V., & Bellahcene, A. (September 2007). Low dentin matrix protein 1 expression correlates with skeletal metastases development in breast cancer patients and enhances cell migratory capacity in vitro. Breast Cancer Research and Treatment, 105 (1), 95-104. doi:10.1007/s10549-006-9436-0 ![]() |
![]() ![]() | Bellahcene, A., Chaplet, M., Bonjean, K., & Castronovo, V. (2007). Zoledronate inhibits alpha v beta 3 and alpha v beta 5 integrin cell surface expression in endothelial cells. Endothelium: Journal of Endothelial Cell Research, 14 (2), 123-130. doi:10.1080/10623320701347187 ![]() |
![]() ![]() | Bellahcene, A., Bachelier, R., Detry, C., Lidereau, R., Clezardin, P., & Castronovo, V. (January 2007). Transcriptome analysis reveals an osteoblast-like phenotype for human osteotropic breast cancer cells. Breast Cancer Research and Treatment, 101 (2), 135-148. doi:10.1007/s10549-006-9279-8 ![]() |
![]() ![]() | Delmulle, L., Bellahcene, A., Dhooge, W., Comhaire, F., Roelens, F., Huvaere, K., Heyerick, A., Castronovo, V., & De Keukeleire, D. (November 2006). Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines. Phytomedicine, 13 (9-10), 732-734. doi:10.1016/j.phymed.2006.01.001 ![]() |
![]() ![]() | de Leval, X., Dassesse, T., Dogné, J.-M., Waltregny, D., Bellahcene, A., Benoit, V., Pirotte, B., & Castronovo, V. (September 2006). Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents. Journal of Pharmacology and Experimental Therapeutics, 318 (3), 1057-1067. doi:10.1124/jpet.106.101188 ![]() |
![]() ![]() | Chaplet, M., Waltregny, D., Detry, C., Fisher, L., Castronovo, V., & Bellahcene, A. (February 2006). Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressiveness. International Journal of Cancer, 118 (4), 850-856. doi:10.1002/ijc.21442 ![]() |
![]() ![]() | Chaplet, M., Deroanne, C., Fisher, L. W., Castronovo, V., Bellahcene, A., & Detry, C. (15 December 2004). Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition. Biochemical Journal, 384 (Pt 3), 591-598. doi:10.1042/BJ20040380 ![]() |
![]() ![]() | Waltregny, D., de Leval, L., Glenisson, W., Ly Tran, S., North, B., Bellahcene, A., Weidle, U., & Castronovo, V. (August 2004). Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. American Journal of Pathology, 165 (2), 553-564. doi:10.1016/S0002-9440(10)63320-2 ![]() |
![]() ![]() | Chaplet, M., de Leval, L., Waltregny, D., Detry, C., Fornaciari, G., Bevilacqua, G., Fisher, L., Castronovo, V., & Bellahcene, A. (August 2003). Dentin matrix protein 1 is expressed in human lung cancer. Journal of Bone and Mineral Research, 18 (8), 1506-1512. doi:10.1359/jbmr.2003.18.8.1506 ![]() |
![]() ![]() | Detry, C., Waltregny, D., Quatresooz, P., Chaplet, M., Kedzia, W., Castronovo, V., Delvenne, P., & Bellahcene, A. (July 2003). Detection of bone sialoprotein in human (pre)neoplastic lesions of the uterine cervix. Calcified Tissue International, 73 (1), 9-14. doi:10.1007/s00223-002-2108-0 ![]() |
![]() ![]() | Barnes, G. L., Javed, A., Waller, S. M., Kamal, M. H., Hebert, K. E., Hassan, M. Q., Bellahcene, A., van Wijnen, A. J., Young, M. F., Lian, J. B., Stein, G. S., & Gerstenfeld, L. C. (15 May 2003). Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. Cancer Research, 63 (10), 2631-2637. ![]() |
![]() ![]() | Wood, J., Bonjean, K., Ruetz, S., Bellahcene, A., Devy, L., Foidart, J.-M., Castronovo, V., & Green, J. R. (September 2002). Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. Journal of Pharmacology and Experimental Therapeutics, 302 (3), 1055-1061. doi:10.1124/jpet.102.035295 ![]() |
![]() ![]() | De Pinieux, G., Flam, T., Zerbib, M., Taupin, P., Bellahcene, A., Waltregny, D., Vieillefond, A., & Poupon, M.-F. (2001). Bone sialoprotein, bone morphogenetic protein 6 and thymidine phosphorylase expression in localized human prostatic adenocarcinoma as predictors of clinical outcome: a clinicopathological and immunohistochemical study of 43 cases. Journal of Urology, 166 (5), 1924-30. doi:10.1016/S0022-5347(05)65722-9 ![]() |
![]() ![]() | Bellahcene, A., Van Riet, I., de Greef, C., Antoine, N., Young, M. F., Van Camp, B., & Castronovo, V. (December 2000). Bone Sialoprotein Mrna and Protein Expression in Human Multiple Myeloma Cell Lines and Patients. British Journal of Haematology, 111 (4), 1118-21. doi:10.1046/j.1365-2141.2000.02506.x ![]() |
Waltregny, D., Bellahcene, A., de Leval, X., Florkin, B., Weidle, U., & Castronovo, V. (May 2000). Increased Expression of Bone Sialoprotein in Bone Metastases Compared with Visceral Metastases in Human Breast and Prostate Cancers. Journal of Bone and Mineral Research, 15 (5), 834-43. doi:10.1359/jbmr.2000.15.5.834 ![]() |
![]() ![]() | Bellahcene, A., Bonjean, K., Fohr, B., Fedarko, N. S., Robey, F. A., Young, M. F., Fisher, L. W., & Castronovo, V. (28 April 2000). Bone Sialoprotein Mediates Human Endothelial Cell Attachment and Migration and Promotes Angiogenesis. Circulation Research, 86 (8), 885-91. doi:10.1161/01.RES.86.8.885 ![]() |
![]() ![]() | Bellahcene, A., Albert, V., Pollina, L., Basolo, F., Fisher, L. W., & Castronovo, V. (August 1998). Ectopic Expression of Bone Sialoprotein in Human Thyroid Cancer. Thyroid, 8 (8), 637-41. doi:10.1089/thy.1998.8.637 ![]() |
![]() ![]() | Waltregny, D., Bellahcene, A., Van Riet, I., Fisher, L. W., Young, M., Fernandez, P., Dewé, W., de Leval, J., & Castronovo, V. (01 July 1998). Prognostic Value of Bone Sialoprotein Expression in Clinically Localized Human Prostate Cancer. Journal of the National Cancer Institute, 90 (13), 1000-8. doi:10.1093/jnci/90.13.1000 ![]() |
Castronovo, V., & Bellahcene, A. (February 1998). Evidence That Breast Cancer Associated Microcalcifications Are Mineralized Malignant Cells. International Journal of Oncology, 12 (2), 305-8. doi:10.3892/ijo.12.2.305 ![]() |
![]() ![]() | Bellahcene, A., Maloujahmoum, N., Fisher, L. W., Pastorino, H., Tagliabue, E., Menard, S., & Castronovo, V. (September 1997). Expression of Bone Sialoprotein in Human Lung Cancer. Calcified Tissue International, 61 (3), 183-8. doi:10.1007/s002239900320 ![]() |
![]() ![]() | van den Brûle, F., Bellahcene, A., Jackers, P., Liu, F.-T., Sobel, M. E., & Castronovo, V. (1997). Antisense galectin-3 alters thymidine incorporation in human MDA-MB435 breast cancer cells. International Journal of Oncology, 11 (2), 261-264. doi:10.3892/ijo.11.2.261 ![]() |
![]() ![]() | Bellahcene, A., & Castronovo, V. (January 1997). Expression of Bone Matrix Proteins in Human Breast Cancer: Potential Roles in Microcalcification Formation and in the Genesis of Bone Metastases. Bulletin du Cancer, 84 (1), 17-24. ![]() |
![]() ![]() | Bellahcene, A., Menard, S., Bufalino, R., Moreau, L., & Castronovo, V. (22 August 1996). Expression of Bone Sialoprotein in Primary Human Breast Cancer Is Associated with Poor Survival. International Journal of Cancer, 69 (4), 350-3. doi:10.1002/(SICI)1097-0215(19960822)69:4<350::AID-IJC19>3.0.CO;2-9 ![]() |
Bellahcene, A., Antoine, N., Clausse, N., Tagliabue, E., Fisher, L. W., Kerr, J. M., Jares, P., & Castronovo, V. (August 1996). Detection of Bone Sialoprotein in Human Breast Cancer Tissue and Cell Lines at Both Protein and Messenger Ribonucleic Acid Levels. Laboratory Investigation, 75 (2), 203-10. ![]() |
![]() ![]() | Bellahcene, A., Kroll, M., Liebens, F., & Castronovo, V. (May 1996). Bone Sialoprotein Expression in Primary Human Breast Cancer Is Associated with Bone Metastases Development. Journal of Bone and Mineral Research, 11 (5), 665-70. doi:10.1002/jbmr.5650110514 ![]() |
Dejardin, E., Bonizzi, G., Bellahcene, A., Castronovo, V., Merville, M.-P., & Bours, V. (02 November 1995). Highly-Expressed P100/P52 (Nfkb2) Sequesters Other Nf-Kappa B-Related Proteins in the Cytoplasm of Human Breast Cancer Cells. Oncogene, 11 (9), 1835-41. ![]() |
![]() ![]() | Bellahcene, A., & Castronovo, V. (January 1995). Increased Expression of Osteonectin and Osteopontin, Two Bone Matrix Proteins, in Human Breast Cancer. American Journal of Pathology, 146 (1), 95-100. ![]() |
![]() ![]() | Bellahcene, A., Merville, M.-P., & Castronovo, V. (01 June 1994). Expression of Bone Sialoprotein, a Bone Matrix Protein, in Human Breast Cancer. Cancer Research, 54 (11), 2823-6. ![]() |
![]() ![]() | Bellahcene, A., Merville, M.-P., Gielen Jacques, Lambotte, R., Simar, L., & Castronovo, V. (01 May 1994). La protéine P53, protectrice de l'intégrité du génome: rôle dans la genèse des cancers. Revue Médicale de Liège, 49 (5), 274-84. ![]() |
![]() ![]() | Costanza, B., Blomme, A., Bellahcene, A., Peulen, O., MUTIJIMA NZARAMBA, E., DELVENNE, P., De Pauw, E., DETRY, O., COIMBRA MARQUES, C., Castronovo, V., & Turtoi, A. (2016). EXPEL: A Novel Non-Destructive Method for Mining Soluble Tumor Biomarkers. Acta Gastro-Enterologica Belgica, 79 (1), 11. ![]() |
![]() ![]() | Binsfeld, M., Heusschen, R., Lamour, V., Van Valckenborgh, E., Bellahcene, A., Baron, F., BEGUIN, Y., & CAERS, J. (2014). Multiple myeloma cells instruct myeloid-derived suppressor cells to release pro-angiogenic cytokines. Belgian Journal of Hematology. |
![]() ![]() | Sanchez, C., Deberg, M., Bellahcene, A., Castronovo, V., Msika, P., & Henrotin, Y. (2006). Phenotypic characterisation of osteoblasts from the sclerotic zone of human osteoarthritic subchondral bone. Osteoarthritis and Cartilage, 14 (Suppl B), 75. ![]() |
![]() ![]() | Sanchez, C., Deberg, M., Bellahcene, A., Castronovo, V., Msika, P., & Henrotin, Y. (2006). Caractérisation du phénotype des ostéoblastes issus des zones sclérosées de l’os sous-chondral arthrosique humain. Revue du Rhumatisme, 73 (10-11), 1058. ![]() |
![]() ![]() | Chaplet, M., Waltregny, D., Detry, C., Fisher, L., Castronovo, V., & Bellahcene, A. (2005). Dentin sialophosphoprotein expression correlates with progression markers in human prostate cancer. Journal of Bone and Mineral Research, 20 (Suppl. 2), 45. ![]() |
Castronovo, V., Waltregny, D., Fisher, L., & Bellahcene, A. (2002). The role of bone sialoprotein and other members of the SIBLING family in bone metastases formation. In 3rd International Conference on Osteopontin and SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) Proteins (pp. 195-197). The Scientific World eBook. doi:10.1100/tsw.2002.323 |
Bellahcene, A., Waltregny, D., & Castronovo, V. (1999). The role of bone sialoprotein in bone metastasis. In G. G. Skouteris & G. L. Nicolson (Eds.), Intermolecular Cross-Talk in Tumor Metastasis. Amsterdam, Netherlands: IOS Press. |
Waltregny, D., Bellahcene, A., de Leval, X., & Castronovo, V. (1998). Detection of bone sialoprotein in primary and metastatic lesions of human breast and prostate carcinomas, the two major osteotropic cancers. Revue du Rhumatisme, 7-9, 527. ![]() |
Waltregny, D., Bellahcene, A., Van Riet, I., Fisher, L., Fernandez, P., Dewé, W., de Leval, J., & Castronovo, V. (1998). Expression of bone sialoprotein in human prostate cancer is associated with progression. Proceedings of the American Association for Cancer Research, 39, 322. ![]() |
Bellahcene, A., Albert, V., Nyabi, O., Cheung, N. K. V., Kramer, K., Waltregny, D., Fisher, L., & Castronovo, V. (1998). Bone sialoprotein is expressed in both human neuroblastoma tissues and cell lines. Proceedings of the American Association for Cancer Research, 39, 209. ![]() |
Waltregny, D., Bellahcene, A., Van Riet, I., Fisher, L., Fernandez, P., Dewé, W., de Leval, J., & Castronovo, V. (January 1998). Expression of bone sialoprotein in human prostate cancer is associated with progression. Acta Clinica Belgica, 53 (3), 221-240. ![]() |
Castronovo, V., Bellahcene, A., & Pirotte, S. (02 February 2012). Dentin Matrix Protein 1 (DMP1) for use in pharmaceutical compositions. |