Article (Scientific journals)
Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients.
Kautbally, Shakeel; Lepropre, Sophie; Onselaer, Marie-Blanche et al.
2019In JACC: Basic to Translational Science, 4 (5), p. 596-610
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Keywords :
ACC, acetyl-CoA carboxylase; AMPK; AMPK, adenosine monophosphate-activated protein kinase; AU, arbitrary units; AoC, extra-coronary calcification score; CAC, coronary artery calcification; CAD, coronary artery disease; S-CAD, stable coronary artery disease; TG, triglyceride; acetyl-CoA carboxylase; coronary artery disease; lipidomics; oxLDL, oxidized low-density lipoprotein; phosphoACC, acetyl-CoA carboxylase phosphorylation on serine 79; platelet
Abstract :
[en] Adenosine monophosphate-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK-induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK-induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Kautbally, Shakeel
Lepropre, Sophie
Onselaer, Marie-Blanche
Le Rigoleur, Astrid
Ginion, Audrey
De Meester de Ravenstein, Christophe
Ambroise, Jerome
Boudjeltia, Karim Z.
Octave, Marie
WERA, Odile 
Cheramy-Bien, Jean-Paul
Huby, Thierry
Giera, Martin
Gerber, Bernhard
Pouleur, Anne-Catherine
Guigas, Bruno
Vanoverschelde, Jean-Louis
Kefer, Joelle
Bertrand, Luc
Oury, Cécile  ;  Université de Liège - ULiège > Cardiovascular Sciences-Cardiology
Horman, Sandrine
Beauloye, Christophe
More authors (14 more) Less
Language :
English
Title :
Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients.
Publication date :
September 2019
Journal title :
JACC: Basic to Translational Science
eISSN :
2452-302X
Publisher :
Elsevier, New-York, United States - New York
Volume :
4
Issue :
5
Pages :
596-610
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2019 The Authors.
Available on ORBi :
since 03 February 2020

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