Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients.

Kautbally, Shakeel; Lepropre, Sophie; Onselaer, Marie-Blanche; Le Rigoleur, Astrid; Ginion, Audrey; De Meester de Ravenstein, Christophe; Ambroise, Jerome; Boudjeltia, Karim Z.; Octave, Marie; WERA, Odile; Hego, Alexandre; PINCEMAIL, Joël; Cheramy-Bien, Jean-Paul; Huby, Thierry; Giera, Martin; Gerber, Bernhard; Pouleur, Anne-Catherine; Guigas, Bruno; Vanoverschelde, Jean-Louis; Kefer, Joelle; Bertrand, Luc; Oury, Cécile; Horman, Sandrine; Beauloye, Christophe

doi:10.1016/j.jacbts.2019.04.005

Article (Scientific journals)

Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients.

Kautbally, Shakeel; Lepropre, Sophie; Onselaer, Marie-Blanche et al.

2019 • In JACC: Basic to Translational Science, 4 (5), p. 596-610

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/244396

DOI
10.1016/j.jacbts.2019.04.005

PubMed
31768476

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Keywords :

ACC, acetyl-CoA carboxylase; AMPK; AMPK, adenosine monophosphate-activated protein kinase; AU, arbitrary units; AoC, extra-coronary calcification score; CAC, coronary artery calcification; CAD, coronary artery disease; S-CAD, stable coronary artery disease; TG, triglyceride; acetyl-CoA carboxylase; coronary artery disease; lipidomics; oxLDL, oxidized low-density lipoprotein; phosphoACC, acetyl-CoA carboxylase phosphorylation on serine 79; platelet

Abstract :

[en] Adenosine monophosphate-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK-induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK-induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Kautbally, Shakeel

Lepropre, Sophie

Onselaer, Marie-Blanche

Le Rigoleur, Astrid

Ginion, Audrey

De Meester de Ravenstein, Christophe

Ambroise, Jerome

Boudjeltia, Karim Z.

Octave, Marie

WERA, Odile

More authors (14 more)

Language :

English

Title :

Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients.

Publication date :

September 2019

Journal title :

JACC: Basic to Translational Science

eISSN :

2452-302X

Publisher :

Elsevier, New-York, United States - New York

Volume :

Issue :

Pages :

596-610

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 03 February 2020

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