Reference : A quality by design approach for liposomes production by innovative method using supe...
Scientific conferences in universities or research centers : Scientific conference in universities or research centers
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/242943
A quality by design approach for liposomes production by innovative method using supercritical fluids: which parameters use to obtain good physicochemical characteristics?
English
Penoy, Noémie mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Avohou, Tonakpon Hermane mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Lebrun, Pierre mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Evrard, Brigitte mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Piel, Géraldine mailto [Université de Liège - ULiège > Département de pharmacie > Développement de nanomédicaments >]
11-Dec-2019
National
Second CIRM Scientific Day
11 Décembre 2019
CIRM - Center for Interdisciplinary Research on Medicines
Liège
Belgique
[en] Liposomes ; QbD ; Supercritical fluids
[en] Liposomes are nanoparticles made of phospholipids, able to encapsulate many active molecules, protecting and transporting them in a targeted way. Liposomes are thus widely studied as vectors of numerous active molecules, improving their therapeutic window. However, the usual production methods at the laboratory scale have many disadvantages and are generally difficult to transfer to the industrial scale under GMP conditions [1], [2].
Supercritical fluids are increasingly used in the pharmaceutical industry. One of the pharmaceutical applications of supercritical fluids is the production of particles. For the liposomes production, the use of supercritical CO2 as a dispersing agent has been preferred because of the total absence of organic solvent. Since this process involves many parameters such as pressure, temperature, stirring speed, lipid concentration, volume and contact time, a quality by design approach was used in order to determine the influence of each parameters on the physicochemical properties of liposomes such as the size and the polydispersity.
These experimental analyses helped us to find two production areas. These conditions were validated with five different liposome formulations regarding the size and polydispersity expectations. We will now focus on the impact of each parameter on the physicochemical properties of liposomes but also their impact on the integrity of the phospholipids used.



References
[1] C. Tikshdeep, A. Sonia, P. Bharat, and C. Abhishek, “Liposome Drug Delivery,” Int. J. Pharm. Chem. Sci., vol. 1, no. 3, pp. 1103–1113, 2012.
[2] L. A. Meure, N. R. Foster, and F. Dehghani, “Conventional and Dense Gas Techniques for the Production of Liposomes: A Review,” AAPS PharmSciTech, vol. 9, no. 3, pp. 798–809, 2008.
[3] B. S. Sekhon, “Supercritical fluid technology: An overview of pharmaceutical applications,” Int. J. PharmTech Res., vol. 2, no. 1, pp. 810–826, 2010
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
FEDER - Fonds Européen de Développement Régional
NANOPHARE
Researchers
http://hdl.handle.net/2268/242943

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