  | Avohou, T. H., Sacre, P.-Y., Hamla, S., Lebrun, P., Hubert, P., & Ziemons, E. (05 September 2022). Optimizing the soft independent modeling of class analogy (SIMCA) using statistical prediction regions. Analytica Chimica Acta, 1229, 340339. doi:10.1016/j.aca.2022.340339  Peer Reviewed verified by ORBi |
 | Avohou, T. H., Sacre, P.-Y., Lebrun, P., Hubert, P., & Ziemons, E. (01 February 2021). A probabilistic class-modelling method based on prediction bands for functional spectral data: Methodological approach and application to near-infrared spectroscopy. Analytica Chimica Acta, 1144, 130-149. doi:10.1016/j.aca.2020.11.039 Peer Reviewed verified by ORBi |
 | Hubert, C., Deidda, R., Dispas, A., Van Laethem, T., Zhao, X., Lebrun, P., & Hubert, P. (28 January 2020). Implementing principles of Analytical Quality by Design (AQbD) for method development in quality control environment [Paper presentation]. 16th International Symposium on Hyphenated Techniques in Chromatography and Separation technology, Ghent, Belgium. |
Avohou, T. H., Lebrun, P., Rozet, E., & Boulanger, B. (2020). Bayesian methods in design and analysis of stability studies. In E. Lesaffre, G. Baio, ... B. Boulanger, Bayesian methods in pharmaceutical research (pp. 391-405). Boca Raton, United States: CRC Press. Peer reviewed |
 | Penoy, N., Avohou, T. H., Lebrun, P., Evrard, B., & Piel, G. (11 December 2019). A quality by design approach for liposomes production by innovative method using supercritical fluids: which parameters use to obtain good physicochemical characteristics? [Paper presentation]. Second CIRM Scientific Day, Liège, Belgium. |
  | Penoy, N., Avohou, T. H., Lebrun, P., Evrard, B., & Piel, G. (11 December 2019). A quality by design approach for liposomes production by innovative method using supercritical fluids: which parameters use to obtain good physicochemical characteristics? [Paper presentation]. Second CIRM Scientific Day, Liège, Belgium. |
 | Avohou, T. H., Sacre, P.-Y., Lebrun, P., Hubert, P., & Ziemons, E. (15 November 2019). Class-modelling methods based on 𝜷-expectation tolerance regions for functional spectral (NIR and Raman) data [Paper presentation]. Scientific Workshops, Pharmalex, Mont Sain-Guilbert, Belgium. |
| Penoy, N., Bigazzi, W., Avohou, T. H., Lebrun, P., Evrard, B., & Piel, G. (20 May 2019). LIPOSOME PRODUCTION BY INNOVATIVE METHOD USING SUPERCRITICAL FLUIDS [Paper presentation]. 20th Forum of Pharmaceutical Sciences, Bruxelles, Belgium. |
 | Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (19 October 2018). SFC-MS as a preventive tool for the quality control of potentially adulterated cannabis with synthetic cannabinoids [Paper presentation]. SFC 2018, Strasbourg, France. |
 | Dispas, A., Lebrun, P., Marini Djang'Eing'A, R., Desfontaine, V., Kotoni, D., Clarke, A., Veuthey, J.-L., Guillarme, D., & Hubert, P. (October 2018). Evaluation of measurement uncertainty: from SFC method development to inter-laboratory study [Poster presentation]. SFC 2018, Strasbourg, France. |
 | Avohou, T. H., Sacre, P.-Y., Lebrun, P., Hubert, P., & Ziemons, E. (12 September 2018). A novel probabilistic spectral matching strategy based on wavelets regression and Bayesian modeling for product identification and quality verification [Paper presentation]. 11th International Symposium on Drug Analysis and 29th International Symposium on Pharmaceutical and Biomedical Analysis, DA-PB, Leuven, Belgium. |
| Sacre, P.-Y., Avohou, T. H., Lebrun, P., Coic, L., Marini Djang'Eing'A, R., Hubert, P., & Ziemons, E. (September 2018). Bayesian securing of the pharmaceutical supply chain [Paper presentation]. Medicine Quality and Public Health 2018, Oxford, United Kingdom. |
 | Dispas, A., Avohou, T. H., Lebrun, P., Hubert, P., & Hubert, C. (April 2018). ‘Quality by Design’ approach for the analysis of impurities in pharmaceutical drug products and drug substances. TrAC: Trends in Analytical Chemistry, 101, 24-33. doi:10.1016/j.trac.2017.10.028 Peer Reviewed verified by ORBi |
 | Salvé, M., Avohou, T. H., Monbaliu, J.-C., Lebrun, P., Lemaire, C., Damblon, C., De Tullio, P., Hubert, P., Hustinx, R., & Luxen, A. (12 February 2018). NOTA‐PRGD2 and NODAGA‐PRGD2: Bioconjugation, characterization, radiolabelling, and design space. Journal of Labelled Compounds and Radiopharmaceuticals, 61, 487-500. doi:10.1002/jlcr.3613 Peer Reviewed verified by ORBi |
 | Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (2018). Quality control of medicinal cannabis: implementation of a generic sfc-ms method to address counterfeiting with synthetic cannabinoids [Poster presentation]. International Symposium DA-PBA 2018, Leuven, Belgium. |
Avohou, T. H., Hubert, C., Debrus, B., Lebrun, P., Rudaz, S., Boulanger, B., & Hubert, P. (2018). Statistical methods in Quality by Design approach to Liquid Chromatography method development. In S. Fekete & I. Molnar, Software-Assisted Method Development for Modeling High Performance Liquid Chromatography (pp. 109-150). London, United Kingdom: World Scientific Publishing. doi:10.1142/q0161 Peer reviewed |
 | Jambo, H., Dispas, A., Avohou, T. H., André, S., Hubert, C., Lebrun, P., Ziemons, E., & Hubert, P. (2018). Implementation of a generic SFC-MS method for the quality control of potentially counterfeited medicinal cannabis with synthetic cannabinoids. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 1092, 332-342. doi:10.1016/j.jchromb.2018.05.049 Peer Reviewed verified by ORBi |
 | Hubert, C., Lebrun, P., Boulanger, B., & Hubert, P. (23 November 2017). Intégration de la validation dans le concept AQbD [Paper presentation]. AFSEP - "La validation dans l'incertitude, l'incertitude dans la validation : comment garder le sourire?", Paris, France. |
Dispas, A., Andri, B., Lebrun, P., & Hubert, P. (18 May 2017). La SFC, une réelle alternative pour le contrôle de qualité des médicaments? [Paper presentation]. Journée thématique de l'AFSEP, Paris, France. |
| Dispas, A., Andri, B., Lebrun, P., Desfontaine, V., Koroni, D., Clarke, A., Guillarme, D., & Hubert, P. (17 May 2017). Implementation of SFC for the quality control of pharmaceuticals [Paper presentation]. ChromSoc’s spring symposium 2017 : Supercritical and ultra-high performance chromatography, Sandwich, Kent, United Kingdom. |
 | Hubert, C., Lebrun, P., Boulanger, B., & Hubert, P. (11 May 2017). Cycle de vie des méthodes, vers une maîtrise intégrée des performances quantitatives [Paper presentation]. AFSEP - Comment garantir un résultat quantitatif ?, Lyon, France. |
 | Avohou, T. H., Lambert, P., Govaerts, B., & Lebrun, P. (24 April 2017). Bayesian predictions of probabilities of out-of-specification drug products during a stability analysis [Poster presentation]. 6th International Biometric Society Channel Network Conference, Hasselt, Belgium. |
 | Dispas, A., Desfontaine, V., Andri, B., Lebrun, P., Kotoni, D., Clarke, A., Guillarme, D., & Hubert, P. (30 March 2017). La chromatographie en phase supercritique : une alternative aux méthodes de référence de la Pharmacopée Européenne ? [Paper presentation]. 12e congrès francophone de l’AFSep sur les sciences séparatives et les couplages, Paris, France. |
 | Hubert, C., Houari, S., Lebrun, P., Rozet, E., & Hubert, P. (28 March 2017). Validation de l'espace opérationnel : de l'optimisation à la validation en une seule étape [Poster presentation]. 12ème Congrès de l'Association Francophone des Sciences Séparatives, Paris, France. |
 | Habyalimana, V., Mbinze Kindenge, J., Yemoa, L., Waffo Tchounga, C., Diallo, T., Kalenda Tshilombo, N., Kadima Ntokamunda, J.-L., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (February 2017). Application of design space optimization strategy to the developmentof LC methods for simultaneous analysis of 18 antiretroviral medicinesand 4 major excipients used in various pharmaceutical formulations. Journal of Pharmaceutical and Biomedical Analysis, 139, 8-21. doi:10.1016/j.jpba.2017.02.040 Peer Reviewed verified by ORBi |
 | Dispas, A., Desfontaine, V., Andri, B., Lebrun, P., Kotoni, D., Clarke, A., Guillarme, D., & Hubert, P. (February 2017). Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 134, 170-180. doi:10.1016/j.jpba.2016.11.039 Peer Reviewed verified by ORBi |
 | Dispas, A., Lebrun, P., & Hubert, P. (2017). Chapter 11 - Validation of Supercritical Fluid Chromatography Methods. In Poole, Colin (Ed.), Supercritical Fluid Chromatography - Handbook in Separation Science. Elsevier. doi:10.1016/B978-0-12-809207-1.00011-2 Peer reviewed |
 | Andri, B., Lebrun, P., Dispas, A., Klinkenberg, R., Streel, B., Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (2017). Optimization and validation of a fast Supercritical Fluid Chromatography method for the quantitative determination of vitamin D3 and its related impurities. Journal of Chromatography. A. doi:10.1016/j.chroma.2017.01.090 Peer Reviewed verified by ORBi |
 | Habyalimana, V., Mbinze Kindenge, J., Yemoa, L., Waffo Tchounga, C., Diallo, T., Kalenda Tshilombo, N., Kadima Ntokamunda, J.-L., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (18 October 2016). APPLICATION OF DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS FOR SIMULTANEOUS ANALYSIS OF 18 ANTIRETROVIRAL MEDICINES AND 4 MAJOR EXCIPIENTS USED IN VARIOUS PHARMACEUTICAL FORMULATIONS [Paper presentation]. 19th Forum of Pharmaceutical Sciences / BELGIAN SOCIETY OF PHARMACEUTICAL SCIENCES, Brussels, Belgium. |
 | Dispas, A., Lebrun, P., Ziemons, E., & Hubert, P. (07 October 2016). SFC: A green alternative for quantitative analysis in the pharmaceutical field? [Paper presentation]. SFC 2016, Vienna, Austria. |
 | Andri, B., Lebrun, P., Dispas, A., Klinkenberg, R., Streel, B., Ziemons, E., Marini Djang'Eing'A, R., & Hubert, P. (October 2016). A fully validated UHPSFC method for the quality control of vitamin D3 as an alternative to pharmacopeias NPLC methods [Poster presentation]. 10th International Conference on Packed-column SFC - SFC2016, Vienna, Austria. |
 | Dispas, A., Lebrun, P., Sacre, P.-Y., & Hubert, P. (29 August 2016). Preliminary study of SFC critical method parameters for the determination of pharmaceutical compounds [Paper presentation]. International Symposium on Chromatography, Cork, Ireland. |
 | Andri, B., Lebrun, P., Dispas, A., klinkenberg, R., Streel, B., Marini Djang'Eing'A, R., & Hubert, P. (August 2016). Quality control of vitamin D3 by means of a fully validated UHPSFC method [Poster presentation]. International Symposium on Chromatography - ISC 2016, Cork, Ireland. |
 | Dispas, A., Lebrun, P., Sacre, P.-Y., & Hubert, P. (05 June 2016). Screening study of SFC critical method parameters for the determination of pharmaceutical compounds. Journal of Pharmaceutical and Biomedical Analysis, 125, 339-354. doi:10.1016/j.jpba.2016.04.005 Peer Reviewed verified by ORBi |
Hubert, C., Lebrun, P., Rozet, E., & Hubert, P. (10 May 2016). Implementing principles of Quality by Design (QbD) in validation context [Paper presentation]. Eurachem International Workshop - Method Validation in Analytical Science - Current Practices and Future Challenges, Ghent, Belgium. |
 | Andri, B., Lebrun, P., Dispas, A., Klinkenberg, R., Streel, B., Marini Djang'Eing'A, R., & Hubert, P. (May 2016). Optimization and validation of an UHPSFC method for the quality control of vitamin D3 raw material [Poster presentation]. Eurachem Workshop 2016 - Method Validation - Current Practices and Future Challenges, Ghent, Belgium. |
 | Thiry, J., Lebrun, P., Netchacovitch, L., Pestieau, A., Ziemons, E., Hubert, P., Krier, F., & Evrard, B. (October 2015). Production of Itraconazole/Soluplus® Extrudates: Optimization of Both Formulation and Hot-Melt Extrusion Process Through a Single Design of Experiment [Poster presentation]. AAPS Orlando 2015. |
 | Chavez, P.-F., Lebrun, P., Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Cuypers, S., Mantanus, J., Motte, H., Schubert, M., Evrard, B., Hubert, P., & Ziemons, E. (30 May 2015). Optimization of a Pharmaceutical Tablet Formulation based on a Design Space Approach and using Vibrational Spectroscopy as PAT Tool. International Journal of Pharmaceutics, 486 (1-2), 13-20. doi:10.1016/j.ijpharm.2015.03.025 Peer Reviewed verified by ORBi |
Pestieau, A., Krier, F., Lebrun, P., & Evrard, B. (29 May 2015). Optimization of a PGSS process for a fenofibrate lipid-based solid dispersion formulation [Paper presentation]. 18th Forum of Pharmaceutical Sciences, Blankenberge, Belgium. |
Ziemons, E., Hubert, C., Marini Djang'Eing'A, R., Rozet, E., Lebrun, P., Boulanger, B., & Hubert, P. (12 May 2015). Validation des méthodes analytiques: Approche basée sur l'erreur totale [Paper presentation]. Chimie Analytique et chimie des eaux, Mons, Belgium. |
 | Pestieau, A., Krier, F., Lebrun, P., Brouwers, A., Streel, B., & Evrard, B. (18 March 2015). Optimization of a PGSS (particles from gas saturated solutions) process for a fenofibrate lipid-based solid dispersion formulation. International Journal of Pharmaceutics, 485, 295-305. doi:10.1016/j.ijpharm.2015.03.027 Peer Reviewed verified by ORBi |
 | Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., Hubert, C., & Hubert, P. (22 January 2015). Design Space for Analytical Methods: Why ? What ? How ? [Paper presentation]. AFSEP - Innovation en développements de méthodes, Lyon, France. |
 | Sacre, P.-Y., Lebrun, P., Chavez, P.-F., De Bleye, C., Netchacovitch, L., Hubert, P., & Ziemons, E. (20 January 2015). Distributional homogeneity index (DHI), a valuable tool during pharmaceutical development [Paper presentation]. Chimiométrie XVI, Genève, Switzerland. |
 | Mbinze Kindenge, J., Yemoa, A., Lebrun, P., Sacre, P.-Y., Habyalimana, V., Kalenda Tshilombo, N., Bigot, A., Atindehou, E., Hubert, P., & Marini Djang'Eing'A, R. (19 January 2015). Fighting Poor Quality Medicines: Develop-ment, Transfer and Validation of Generic HPLC Methods for Analyzing two WHO Recommended Antimalarial Tablets. American Journal of Analytical Chemistry, 6, 127-144. doi:10.4236/ajac.2015.62012 Peer reviewed |
 | Hubert, C., Houari, S., Rozet, E., Lebrun, P., & Hubert, P. (2015). Towards a full integration of optimization and validation phases: An Analytical-Quality-by-Design approach. Journal of Chromatography. A. doi:10.1016/j.chroma.2015.03.059 Peer Reviewed verified by ORBi |
 | Rozet, E., Lebrun, P., Michiels, J.-F., Sondag, P., Scherder, T., & Boulanger, B. (2015). Analytical Procedure Validation and the Quality by Design Paradigm. Journal of Biopharmaceutical Statistics, 25, 1-9. doi:10.1080/10543406.2014.971176 Peer Reviewed verified by ORBi |
 | Lebrun, P., Giacoletti, K., Scherder, T., Rozet, E., & Boulanger, B. (2015). A quality by design approach for longitudinal quality attributes. Journal of Biopharmaceutical Statistics, 25, 1-13. doi:10.1080/10543406.2014.979197 Peer Reviewed verified by ORBi |
Chavez, P.-F., Lebrun, P., Sacre, P.-Y., De Bleye, C., Netchacovitch, L., Mantanus, J., Motte, H., Schubert, M., Hubert, P., & Ziemons, E. (13 November 2014). Optimization of a Pharmaceutical Tablet Formulation using a Design Space Approach and Vibrational Spectroscopy as PAT Tool [Paper presentation]. Séminaire du CIRM, Liège, Belgium. |
 | Pestieau, A., Krier, F., Lebrun, P., & Evrard, B. (November 2014). Optimization of a PGSS manufacturing process of a lipid based solid dispersion of a BCS II API [Poster presentation]. 2014 AAPS Annual Meeting and Exposition, San Diego, United States. |
 | Dispas, A., Lebrun, P., Ziemons, E., Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (August 2014). Evaluation of the quantitative performances of Supercritical Fluid Chromatography : from method development to validation. Journal of Chromatography. A, 1353 (Method Validation), 78-88. doi:10.1016/j.chroma.2014.01.046 Peer Reviewed verified by ORBi |
 | Chavez, P.-F., Netchacovitch, L., Sacre, P.-Y., De Bleye, C., Lebrun, P., Motte, H., Schubert, M., Evrard, B., Hubert, P., & Ziemons, E. (June 2014). Optimization of a Pharmaceutical Tablet Formulation using a Design Space Approach and Vibrational Spectroscopy as PAT Tool [Poster presentation]. Drug Analysis 2014, Liège, Belgium. |
 | Habyalimana, V., Kalenda Tshilombo, N., Dispas, A., Andri, B., Loconon Yemoa, A., Kindenge Mbinze, J., Kadima Ntokamunda, J., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (June 2014). MULTI-TRANSFER OF GENERIC ANALYTICAL METHODS TO COMBAT POOR QUALITY ANTIMALARIAL MEDICINES: A LABORATORY BASED APPROACH TO SUPPORT DRUG QA/QC SYSTEMS [Poster presentation]. DRUG ANALYSIS 2014: 10th International Symposium on Drug Analysis & 25th International Symposium on Pharmaceutical and Biomedical Analysis. |
 | Dispas, A., Lebrun, P., & Hubert, P. (June 2014). Quantitative performances of UHPSFC and UHPLC : a comparative study [Paper presentation]. Drug Analysis 2014, Liège, Belgium. |
 | Habyalimana, V., Kalenda Tshilombo, N., Dispas, A., Mbinze Kindenge, J., Kadima Ntokamunda, J.-L., Lebrun, P., Hubert, P., & Marini Djang'Eing'A, R. (May 2014). Méthodes chromatographiques génériques de criblage pour lutter contre les médicaments de qualité inférieure. Spectra Analyse, 43, 30. Peer reviewed |
 | Hubert, C., Lebrun, P., Houari, S., Ziemons, E., Rozet, E., & Hubert, P. (25 January 2014). Improvement of a stability-indicating method by Quality-by-Design versus Quality-by-Testing: A case of a learning process. Journal of Pharmaceutical and Biomedical Analysis, 88, 401-409. doi:10.1016/j.jpba.2013.09.026 Peer Reviewed verified by ORBi |
 | De Bleye, C., Sacre, P.-Y., Dumont, E., Chavez, P.-F., Netchacovitch, L., Piel, G., Rozet, E., Lebrun, P., Hubert, P., & Ziemons, E. (20 January 2014). Quantitative approaches based on Surface-Enhanced Raman Scattering (SERS) and Surface-Enhanced Raman Chemical Imaging (SER-CI) [Paper presentation]. Forum des jeunes chercheurs, Liège, Belgium. |
 | Dispas, A., Lebrun, P., Andri, B., Rozet, E., & Hubert, P. (January 2014). Robust method optimization strategy – a useful tool for method transfer: the case of SFC. Journal of Pharmaceutical and Biomedical Analysis, 88, 519-524. doi:10.1016/j.jpba.2013.09.030 Peer Reviewed verified by ORBi |
 | Sacre, P.-Y., Lebrun, P., Chavez, P.-F., De Bleye, C., Netchacovitch, L., Rozet, E., Klinkenberg, R., Streel, B., Hubert, P., & Ziemons, E. (2014). A new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms. Analytica Chimica Acta, 818, 7-14. doi:10.1016/j.aca.2014.02.014 Peer Reviewed verified by ORBi |
 | Mbinze Kindenge, J., Dispas, A., Lebrun, P., Mavar Tayey Mbay, J., Habyalimana, V., Kalenda Tshilombo, N., Rozet, E., Hubert, P., & Marini Djang'Eing'A, R. (November 2013). Application of an innovative design space optimization strategy to thedevelopment of LC methods for the simultaneous screening of antibiotics to combat poor quality medicines. Journal of Pharmaceutical and Biomedical Analysis, 85, 83– 92. doi:10.1016/j.jpba.2013.06.036 Peer Reviewed verified by ORBi |
 | Mputu Malolo, C.-L., Ndelo di Phanzu, J., Marini Djang'Eing'A, R., Rozet, E., Lebrun, P., Lusakibanza Manzo, M., DUBOIS, N., & CHARLIER, C. (18 October 2013). Niveaux du plomb sanguin, du plomb urinaire, de l’acide δ-aminolévulinique et des porphyrines urinaires chez les personnes vivant à Kinshasa, R.D. Congo : une étude pilote de biosurveillance [Paper presentation]. 5èmes Journées Internationales de Toxicologie, Liège, Belgium. |
 | Dispas, A., Lebrun, P., & Hubert, P. (October 2013). Robust SFC method optimization using design space strategy [Paper presentation]. 17e Forum des Sciences Pharmaceutiques, Spa, Belgium. |
Ziemons, E., De Bleye, C., Chavez, P.-F., Netchacovitch, L., Sacre, P.-Y., Rozet, E., Lebrun, P., & Hubert, P. (10 September 2013). Vibrational spectroscopy as PAT compliant tools [Paper presentation]. Chemical Manufacturing and Control (CMC) Seminar, Diepenbeek, Belgium. |
 | Sacre, P.-Y., Lebrun, P., Chavez, P.-F., De Bleye, C., Netchacovitch, L., Rozet, E., Hubert, P., & Ziemons, E. (September 2013). A new criterion to assess distributional homogeneity in hyperspectral images of solid pharmaceutical dosage forms [Paper presentation]. EuPAT 6 (Sixth pan-European QbD & PAT Science Conference), Porto, Portugal. |
 | Chavez, P.-F., Netchacovitch, L., Sacre, P.-Y., De Bleye, C., Lebrun, P., Motte, H., Evrard, B., Hubert, P., & Ziemons, E. (September 2013). Application of a Design Space Approach for a Pharmaceutical Tablet Formulation Optimization based on a Mixture Design of Experiments and using Vibrational Spectroscopy as PAT Tool [Poster presentation]. EuPAT 6 - Sixth pan-European QbD & PAT Science Conference, Porto, Portugal. |
 | Dispas, A., Mbinze Kindenge, J., Lebrun, P., Kalenda, N., Habyalimana, V., Rozet, E., Marini Djang'Eing'A, R., & Hubert, P. (July 2013). ANALYTICAL DESIGN SPACE STRATEGY FOR THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT ANTIBIOTIC DRUGS [Paper presentation]. 24th International Symposium on Pharmaceutical and Biomedical Analysis, Bologne, Italy. |
 | Hubert, C., Lebrun, P., Houari, S., Dispas, A., Rozet, E., Ziemons, E., & Hubert, P. (July 2013). Innovative strategy based on the quality by design concept for the development of a LC/MS method [Poster presentation]. 24th Symposium on Pharmaceutical and Biomedical Analysis, Bologna, Italy. |
| Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (06 June 2013). Innovative Methodology for the Definition of Design Spaces of Chromatographic Methods [Paper presentation]. 10ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages, Paris, France. |
 | Hubert, C., Lebrun, P., Houari, S., Dispas, A., Rozet, E., Ziemons, E., & Hubert, P. (June 2013). Innovative strategy based on the quality by design concept for the development of a LC/MS method [Poster presentation]. 10ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages, Paris, France. |
 | Dispas, A., Lebrun, P., Rozet, E., Ziemons, E., Vial, J., Thiébaut, D., & Hubert, P. (June 2013). Optimisation robuste de méthodes SFC par une approche de type design space [Paper presentation]. 10e congrès francophone de l'Afsep sur les sciences séparatives et les couplages, Paris, France. |
 | Rozet, E., Lebrun, P., Boulanger, B., & Hubert, P. (21 May 2013). A BAYESIAN PROBABILITY CRITERION TO ASSESS ANALYTICAL RESULTS RELIABILITY [Paper presentation]. BAYES 2013, Rotterdam, Netherlands. |
 | Lebrun, P., Boulanger, B., Debrus, B., Lambert, P., & Hubert, P. (2013). A Bayesian Design Space for analytical methods based on multivariate models and predictions. Journal of Biopharmaceutical Statistics, 23, 1330–1351. doi:10.1080/10543406.2013.834922 Peer Reviewed verified by ORBi |
 | Rozet, E., Lebrun, P., Debrus, B., Boulanger, B., & Hubert, P. (2013). Design Spaces for Analytical Methods. TrAC: Trends in Analytical Chemistry, 42, 157-167. doi:10.1016/j.trac.2012.09.007 Peer Reviewed verified by ORBi |
 | Mputu Malolo, C.-L., Ndelo di Phanzu, J., Marini Djang'Eing'A, R., Rozet, E., Lebrun, P., Lusakibanza Manzo, M., DUBOIS, N., & Charlier, C. (2013). Blood lead, urinary lead, urinary δ-aminolevulinic acid and urinary porphyrins levels among people living in kinshasa, D.R. Congo : a pilot biomonitoring study. Acta Clinica Belgica, 68 (6), 475. |
 | Nistor, I., Lebrun, P., Ceccato, A., Lecomte, F., Slama, I., Oprean, R., Badarau, E., Dufour, F., Dossou, K. S. S., Fillet, M., Liégeois, J.-F., Hubert, P., & Rozet, E. (2013). Implementation of a Design Space Approach for Enantiomeric Separations in Polar Organic Solvent Chromatography. Journal of Pharmaceutical and Biomedical Analysis, 74, 273-283. doi:10.1016/j.jpba.2012.10.015 Peer Reviewed verified by ORBi |
 | Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2012). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport d'activité de 36 mois, -). Liège, Belgium: ULg. |
 | Dispas, A., Lebrun, P., Sassiat, P., Thiébaut, D., Vial, J., & Hubert, P. (October 2012). Innovative green supercritical fluid chromatography development for the separation of neurotransmitters using design space strategy [Paper presentation]. SFC2012, Bruxelles, Belgium. |
 | Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Kalenda Tshilombo, N., Mavar Tayey Mbay, J., Schofield, T., Boulanger, B., Rozet, E., Hubert, P., & Marini Djang'Eing'A, R. (12 September 2012). APPLICATION OF AN INNOVATIVE DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT NONSTEROIDAL ANTIINFLAMMATORY DRUGS. Journal of Chromatography. A, 1263, 113-124. doi:10.1016/j.chroma.2012.09.038 Peer Reviewed verified by ORBi |
 | Dispas, A., Lebrun, P., Sassiat, P., Ziemons, E., Thiébaut, D., Vial, J., & Hubert, P. (September 2012). Innovative green supercritical fluid chromatography development for the determination of polar compounds. Journal of Chromatography. A, 1256, 253-260. doi:10.1016/j.chroma.2012.07.043 Peer Reviewed verified by ORBi |
 | Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Crommen, J., Hubert, P., Servais, A.-C., & Fillet, M. (07 August 2012). Development of a generic micellar electrokinetic chromatography method for the separation of 15 antimalarial drugs as a tool to detect medicine counterfeiting. Electrophoresis, 33, 1669-1678. doi:10.1002/elps.201100621 Peer Reviewed verified by ORBi |
 | Lebrun, P. (2012). Bayesian Design Space applied to Pharmaceutical Development [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/126503 |
 | Hubert, C., Lebrun, P., Houari, S., Bakima, P., Rozet, E., Ziemons, E., & Hubert, P. (20 June 2012). First Application of an Innovative Design Space Optimization Strategy for the Development of a LC/MS Method [Poster presentation]. 38th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Anaheim, United States - California. |
Dispas, A., Lebrun, P., Hubert, C., Thiébaut, D., Vial, J., & Hubert, P. (June 2012). INNOVATIVE GREEN SUPERCRITICAL FLUID CHROMATOGRAPHY DEVELOPMENT FOR THE SEPARATION OF NEUROTRANSMITTERS USING DESIGN SPACE STRATEGY [Poster presentation]. HPLC 2012, Anaheim, California, United States. |
 | Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Hubert, C., Rozet, E., Marini Djang'Eing'A, R., & Hubert, P. (June 2012). APPLICATION OF AN INNOVATIVE DESIGN SPACE OPTIMIZATION STRATEGY TO THE DEVELOPMENT OF LC METHODS TO COMBAT POTENTIALLY COUNTERFEIT NSAIDS [Poster presentation]. HPLC 2012, Anaheim, California, United States. |
 | Ziemons, E., De Bleye, C., Chavez, P.-F., Rozet, E., Lebrun, P., & Hubert, P. (10 May 2012). Development of near infrared spectroscopic methods using desirability indexes: How to select the most appropriate calibration model [Paper presentation]. EuPAT 5 - Fith pan-European QbD & PAT Science Conference, Ghent, Belgium. |
 | Mbinze Kindenge, J., Lebrun, P., Debrus, B., Dispas, A., Hubert, P., & Marini Djang'Eing'A, R. (May 2012). THE DEVELOPMENT OF LC GENERIC ANALYTICAL METHODS TO FIGHT COUNTERFEIT NSAIDS USING DESIGN SPACE OPTIMISATION STRATEGY [Paper presentation]. 16ème FORUM DES SCIENCES PHARMACEUTIQUES, Blankenberge, Belgium. |
| Marini Djang'Eing'A, R., Lebrun, P., Rozet, E., & Hubert, P. (2012). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°5, -). Liège, Belgium: ULg. |
Rozet, E., Govaerts, B., Lebrun, P., Boulanger, B., Ziemons, E., & Hubert, P. (March 2012). RELIABILITY OF ANALYTICAL METHODS’ RESULTS: A BAYESIAN APPROACH TO ANALYTICAL METHOD VALIDATION [Paper presentation]. AGROSTAT 2012, Paris, France. |
 | Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkerberg, R., Streel, B., Evrard, B., & Hubert, P. (March 2012). AN INNOVATIVE APPROACH TO SELECT THE PREDICTION MODEL IN THE DEVELOPMENT OF NIR SPECTROSCOPIC METHODS [Poster presentation]. AGROSTAT 2012, Paris, France. |
| Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (February 2012). COMBINATION OF INDEPENDENT COMPONENT ANALYSIS, DESIGN OF EXPERIMENTS AND DESIGN SPACE FOR A NOVEL METHODOLOGY TO DEVELOP CHROMATOGRAPHIC METHODS [Poster presentation]. 12th International Symposium on Hyphenated Techniques for Chromatography (HTC-12), Bruges, Belgium. |
 | Rozet, E., Lebrun, P., Debrus, B., & Hubert, P. (2012). New Methodology for the development of chromatographic methods with bioanalytical application. Bioanalysis, 4 (7), 755-758. doi:10.4155/bio.12.47 Peer Reviewed verified by ORBi |
 | Lebrun, P., Krier, F., Mantanus, J., Grohganz, H., Yang, M., Rozet, E., Boulanger, B., Evrard, B., Rantanen, J., & Hubert, P. (2012). Design space approach in the optimization of the spray-drying process. European Journal of Pharmaceutics and Biopharmaceutics, 80 (1), 226-234. doi:10.1016/j.ejpb.2011.09.014 Peer Reviewed verified by ORBi |
 | Rafamantanana, M. H., Debrus, B., Raoelison, G., Rozet, E., Lebrun, P., Uverg-Ratsimamanga, S., Hubert, P., & Quetin-Leclercq, J. (2012). APPLICATION OF DESIGN OF EXPERIMENTS AND DESIGN SPACE METHODOLOGY FOR THE HPLC-UV SEPARATION OPTIMIZATION OF APORPHINE ALKALOIDS FROM LEAVES OF Spirospermum penduliflorum THOUARS. Journal of Pharmaceutical and Biomedical Analysis, 62, 23-32. doi:10.1016/j.jpba.2011.12.028 Peer Reviewed verified by ORBi |
 | Dispas, A., Lebrun, P., Mbinze Kindenge, J., Debrus, B., Mavar Tayer Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., & Hubert, P. (December 2011). Application d'une nouvelle méthode de développement de méthodes chromatographiques pour lutter contre la contrefaçon des médicaments anti-inflammatoires [Paper presentation]. Chimiométrie 2011, Marseille, France. |
 | Boulanger, B., Lebrun, P., Rozet, E., & Hubert, P. (29 November 2011). Design Space ou Espace de Conception [Paper presentation]. Liège Creative, Liege, Belgium. |
| Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2011). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°4, -). Liège, Belgium: ULg. |
 | Rozet, E., Debrus, B., Lebrun, P., Boulanger, B., & Hubert, P. (08 September 2011). New Methodology for the Development of Chromatographic Methods [Paper presentation]. 17th International Symposium on Separation Sciences – ISSS 2011, Cluj, Romania. |
 | Rozet, E., Marini Djang'Eing'A, R., Lebrun, P., Ziemons, E., Boulanger, B., & Hubert, P. (September 2011). A BAYESIAN PREDICTIVE PROBABILITY CRITERION TO ASSESS ANALYTICAL METHODS VALIDITY [Poster presentation]. Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy. |
 | Marini Djang'Eing'A, R., Mbinze Kindenge, J., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Lamalle, C., Fillet, M., Rudaz, S., & Hubert, P. (September 2011). IMPLEMENTATION OF GENERIC ANALYTICAL METHODS TO FIGHT AGAINST COUNTERFEIT MEDICINES [Paper presentation]. Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy. |
Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Crommen, J., Hubert, P., Servais, A.-C., & Fillet, M. (September 2011). GENERIC MEKC METHOD FOR THE SEPARATION OF 15 ANTIMALARIAL DRUGS [Poster presentation]. Recent Development in Pharmaceutical Analysis (RDPA), Pavia, Italy. |
Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Krier, F., Evrard, B., & Hubert, P. (June 2011). La spectroscopie vibrationnelle, outil indispensable pour l'industrie pharmaceutique ? |
Lamalle, C., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Servais, A.-C., Crommen, J., Hubert, P., & Fillet, M. (June 2011). Development of a Generic MEKC Method for the Separation of 15 Antimalarial Drugs by a Design Space Approach [Poster presentation]. 36th International symposium on HPLC and Related Techniques, Budapest, Hungary. |
 | Mantanus, J., Rozet, E., Lebrun, P., Evrard, B., Hubert, P., & Ziemons, E. (19 May 2011). Une solution analytique verte pour le PAT: la spectroscopie proche infrarouge [Paper presentation]. Chimie analytique verte: chromatographie en phase supercritique, liquides ioniques, haute température et miniaturisation, Paris, France. |
Lebrun, P., Boulanger, B., & Hubert, P. (29 April 2011). Validation and Routine of Ligand-Binding Assays, a Bayesian Perspective [Paper presentation]. Bayes 2011, Louvain-la-Neuve, Belgium. |
| Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2011). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°3, -). Liège, Belgium: ULg. |
Lebrun, P., Boulanger, B., & Jullion, A. (02 March 2011). Trial predictions vs. trial simulations in Model-based Drug Development: integrating uncertainties to evaluate the predictive probability of success [Paper presentation]. The Second International Symposium on Biopharmaceutical Statistics, Berlin, Germany. |
 | Lebrun, P., Boulanger, B., Hubert, P., Mbinze Kindenge, J., & Debrus, B. (02 March 2011). Design Space and desirability index. A Bayesian predictive risk-based approach to flexibly achieve multi-criteria decision methods [Paper presentation]. The Second International Symposium on Biopharmaceutical Statistics, Berlin, Germany. |
 | Debrus, B., Broséus, J., Guillarme, D., Lebrun, P., Hubert, P., Veuthey, J.-L., Esseiva, P., & Rudaz, S. (March 2011). Innovative methodology to transfer conventional GC-MS heroin profiling to UHPLC-MS/MS. Analytical and Bioanalytical Chemistry, 399 (8), 2719-2730. doi:10.1007/s00216-010-4282-7 Peer Reviewed verified by ORBi |
 | Nistor, I., Cao, M., Debrus, B., Lebrun, P., Lecomte, F., Rozet, E., Angenot, L., Frederich, M., Oprean, R., & Hubert, P. (2011). Application of a new optimization strategy for the separation of tertiary alkaloids extracted from Strychnos usambarensis leaves. Journal of Pharmaceutical and Biomedical Analysis, 56, 30-37. doi:10.1016/j.jpba.2011.04.027 Peer Reviewed verified by ORBi |
| Nistor, I., Lebrun, P., Ceccato, A., Lecomte, F., Slama, I., Rozet, E., Oprean, R., Badarau, E., Dufour, F., Liégeois, J.-F., & Hubert, P. (2011). Implementation of a design space approach for enatiomeric separations in polar organic solvent chromatography [Poster presentation]. 36th International Symposium on High-Performance Liquid Phase Separations and Related Techniques, Budapest, Hungary. |
 | Debrus, B., Lebrun, P., Mbinze Kindenge, J., Lecomte, F., Ceccato, A., Caliaro, G., Mavar Tayey Mbay, J., Boulanger, B., Marini Djang'Eing'A, R., Rozet, E., & Hubert, P. (2011). Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space. Journal of Chromatography. A, 1218, 5205-5215. doi:10.1016/j.chroma.2011.05.102 Peer Reviewed verified by ORBi |
 | Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (2011). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities. Journal of Pharmaceutical and Biomedical Analysis, 54, 694-700. doi:10.1016/j.jpba.2010.10.022 Peer Reviewed verified by ORBi |
 | Rozet, E., Govaerts, B., Lebrun, P., Michail, K., Ziemons, E., Wintersteiger, R., Rudaz, S., Boulanger, B., & Hubert, P. (2011). Evaluating the reliability of analytical results using a probability criterion: a Bayesian perspective. Analytica Chimica Acta, 705, 193-206. doi:10.1016/j.aca.2011.05.028 Peer Reviewed verified by ORBi |
 | Ziemons, E., Bourichi, H., Mantanus, J., Rozet, E., Lebrun, P., Essassi, E., Cherrah, Y., Bouklouze, A., & Hubert, P. (2011). Determination of binary polymorphic mixtures of fluconazole using near infrared spectroscopy and X-ray powder diffraction: A comparative study based on the pre-validation stage results. Journal of Pharmaceutical and Biomedical Analysis, 55, 1208-1212. doi:10.1016/j.jpba.2011.02.019 Peer Reviewed verified by ORBi |
 | Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Rozet, E., Nistor, I., Oprean, R., Rupérez, F. J., Barbas, C., Boulanger, B., & Hubert, P. (2011). Application of new methodologies based on design of experiments, independent component analysis and design space for robust optimization in liquid chromatography. Analytica Chimica Acta, 691, 33-42. doi:10.1016/j.aca.2011.02.035 Peer Reviewed verified by ORBi |
 | Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkenberg, R., Streel, B., Moonen, F., Evrard, B., & Hubert, P. (08 December 2010). Vibrational spectroscopy in pharmaceutical industry: From development of the most appropriate predictive model to routine implementation [Poster presentation]. BioWin Day 2010, Louvain-la-Neuve, Belgium. |
 | Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkenberg, R., Streel, B., Evrard, B., Moonen, F., & Hubert, P. (02 December 2010). Use of tolerance intervals in the development of near infrared spectroscopic methods: An innovative way to select the most appropriate calibration model [Poster presentation]. Chimiométrie 2010, Paris, France. |
 | Rozet, E., Lebrun, P., Boulanger, B., Ziemons, E., & Hubert, P. (02 December 2010). Evaluating analytical results reliability using a Bayesian probability criterion [Poster presentation]. Congrès Chimimétrie 2010, Paris, France. |
 | Lebrun, P., Lambert, P., Debrus, B., Hubert, P., Marini Djang'Eing'A, R., Moonen, F., & Boulanger, B. (December 2010). Developing and optimizing analytical chromatographic method in a Quality by Design environment. Bayesian multi-criteria risk-based Design Space to guarantee future quality [Poster presentation]. Chimiométrie 2010, Paris, France. |
 | Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Ziemons, E., Evrard, B., & Hubert, P. (15 November 2010). Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities [Poster presentation]. The FIP Pharmaceutical Sciences World Congress 2010 in association with the AAPS Annual Meeting & Exposition, new orléans, United States. |
 | Lebrun, P., Boulanger, B., & Hubert, P. (04 November 2010). How can QbD be used and implemented to optimize method development and validation? [Paper presentation]. Biological Assay Conference (Informa), London, United Kingdom. |
Boulanger, B., Govaerts, B., Le Boulengé, E., Lebrun, P., Marini Djang'Eing'A, R., Ziemons, E., & Hubert, P. (2010). Plans expérimentaux. (ULiège - Université de Liège). |
 | Mantanus, J., Lebrun, P., Rozet, E., Evrard, B., Hubert, P., & Ziemons, E. (14 October 2010). La spectroscopie proche infrarouge et Raman: Nouvelles armes vertes dans le contrôle de la qualité du médicament [Poster presentation]. Journée Scientifique Annuelle de la Société Royale de Chimie: Chimie Verte, Gembloux, Belgium. |
Rozet, E., Lebrun, P., Boulanger, B., Ziemons, E., & Hubert, P. (October 2010). Analytical results reliability using a probability criterion: a Bayesian perspective [Poster presentation]. Chemometrics in Analytical Chemistry, Antwerpen, Belgium. |
 | Hubert, P., Ziemons, E., Mantanus, J., Lebrun, P., Boulanger, B., & Rozet, E. (October 2010). RISK MANAGMENT IN THE VALIDATION OF ANALYTICAL METHODS [Paper presentation]. CNFR 2010 Congress, Targu-Mures, Romania. |
 | Lebrun, P., Boulanger, B., & Hubert, P. (28 September 2010). Optimization of ligand-binding assay in a QbD environment. Use of Bayesian non-linear regression to set up probability profile as quality response [Paper presentation]. Non clinical statistics conference, Lyon, France. |
 | Nistor, I., Debrus, B., Lebrun, P., Cao, M., Frederich, M., Angenot, L., Oprean, R., & Hubert, P. (September 2010). Application of experimental design and design space for the separation of compounds extracted from the leaves of Strychnos usambarensis [Paper presentation]. Drug Analysis 2010, Antwerpen, Belgium. |
Krier, F., Brion, M., Debrus, B., Lebrun, P., Driesen, A., Evrard, B., & Hubert, P. (September 2010). Optimisation and validation of a fast HPLC method for the quantitation of sulindac and its impurities [Poster presentation]. Drug Analysis 2010, Anvers (Antwerp), Belgium. |
 | Marini Djang'Eing'A, R., Mbinze Kindenge, J., Montes, M. L. A., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Rohrbasser, C., Rudaz, S., & Hubert, P. (September 2010). Analytical tools to fight against counterfeit medicines. Chimica Oggi, 28 (5), 10-14. Peer Reviewed verified by ORBi |
 | Ziemons, E., Mantanus, J., Rozet, E., Lebrun, P., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (September 2010). An innovative approach to select the prediction model in the development of NIR spectroscopy methods [Poster presentation]. Drug Analysis, Antwerpen, Belgium. |
Marini Djang'Eing'A, R., Mbinze Kindenge, J., Montes, M. L. A., Debrus, B., Lebrun, P., Mantanus, J., Ziemons, E., Rudaz, S., & Hubert, P. (September 2010). Contribution to fight against counterfeit medecines applying several analytical tools [Poster presentation]. International Symposium on Drug Analysis 2010, Anvers, Belgium. |
 | Nistor, I., Lecomte, F., Mbinze Kindenge, J., Debrus, B., Lebrun, P., Marini Djang'Eing'A, R., Oprean, R., & Hubert, P. (September 2010). Transfer of a conventional LC method for the screening of conterfeit antimalarial medicines to UHPLC [Poster presentation]. Drug analysis 2010, Antwerpen, Belgium. |
Debrus, B., Lebrun, P., Boulanger, B., Rozet, E., Caliaro, G., Ceccato, A., & Hubert, P. (September 2010). Implementation of design space concept for the development of robust analytical methods [Poster presentation]. Drug Analysis 2010, Anvers (Antwerp), Belgium. |
 | Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (September 2010). Application of experimental design and design for the separation of compounds extracted from the leaves of Strychnos Usambarensis [Poster presentation]. Drug analysis 2010, Antwerpen, Belgium. |
 | Marini Djang'Eing'A, R., Mbinze Kindende, J., Lecomte, F., Debrus, B., Lebrun, P., Rozet, E., Mantanus, J., Ziemons, E., & Hubert, P. (31 July 2010). La contrefaçon des médicaments : outils pour lutter contre ce fléau [Paper presentation]. Conférence Scientifique, Kisangani, Province Orientale, Congo - Kinshasa. |
Lebrun, P., Boulanger, B., Rozet, E., & Hubert, P. (May 2010). Bayesian hierarchical linear regression for the validation of analytical methods [Paper presentation]. PhD days 2010, Gembloux, Belgium. |
Lebrun, P., Boulanger, B., & Lambert, P. (May 2010). Use of Bayesian multivariate prediction models to optimize chromatographic methods [Paper presentation]. Bayes 2010, Braine l'Alleud, Belgium. |
| Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Martine, C., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (26 January 2010). Optimisation de la séparation des alcaloïdes extraits des feuilles de Strychnos usambarensis au moyen du design space [Paper presentation]. Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium. |
 | Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (2010). Active content determination of non-coated pharmaceutical pellets by near infrared spectroscopy: Method development, validation and reliability evaluation. Talanta, 80, 1750-1757. doi:10.1016/j.talanta.2009.10.019 Peer Reviewed verified by ORBi |
Debrus, B., Lebrun, P., Boulanger, B., Rozet, E., Caliaro, G., Ceccato, A., & Hubert, P. (2010). Development of robust analytical methods using design space methodology [Poster presentation]. Chimiométrie 2010, Paris, France. |
 | Gillotin, F., Chiap, P., Frederich, M., Van Heugen, J.-C., Francotte, P., Lebrun, P., Pirotte, B., & De Tullio, P. (2010). Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 (2), 232-240. doi:10.1124/dmd.109.028928 Peer Reviewed verified by ORBi |
 | Ziemons, E., Mantanus, J., Lebrun, P., Rozet, E., Evrard, B., & Hubert, P. (2010). Acetaminophen determination in low-dose pharmaceutical syrup by NIR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, 53, 510-516. doi:10.1016/j.jpba.2010.06.003 Peer Reviewed verified by ORBi |
 | De Backer, B., Debrus, B., Lebrun, P., Theunis, L., Dubois, N., Decock, L., Verstraete, A., Hubert, P., & Charlier, C. (08 December 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (32), 4115-4124. doi:10.1016/j.jchromb.2009.11.004 Peer Reviewed verified by ORBi |
 | Mbinze Kindenge, J., Marini Djang'Eing'A, R., Debrus, B., Lebrun, P., Lecomte, F., Boulanger, B., & Hubert, P. (December 2009). Développement d’une méthode pour la séparation de 19 antipaludéens par HPLC au moyen de la planification expérimentale et du Design Space [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France. |
 | Nistor, I., Debrus, B., Lebrun, P., Lecomte, F., Cao, M., Frederich, M., Angenot, L., Boulanger, B., Oprean, R., & Hubert, P. (December 2009). Application de la planification expérimentale et du design space pour la séparation des composés extraits des feuilles de Strychnos usambarensis [Poster presentation]. 7ème congrès francophone de l'AfSep sur les sciences séparatives et les couplages (SEP'09), Marseille, France. |
| Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2009). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°2, -). Liège, Belgium: ULg. |
 | Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., & Hubert, P. (November 2009). Active content determination of non-coated pharmaceutical pellets by near infrared spectroscopy: Method development, validation and reliability evaluation [Poster presentation]. Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, Los Angeles, United States. |
De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (October 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material [Paper presentation]. 4èmes journées internationales de Toxicologie, Liège, Belgium. |
De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (October 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material [Poster presentation]. 4èmes journées internationales de Toxicologie, Liège, Belgium. |
Boulanger, B., & Lebrun, P. (October 2009). Prediction-based Design Space as a general concept for drug development... and role for statisticians [Paper presentation]. Non-clinical biostatistics conference (NCB09), Boston, United States. |
Lebrun, P., & Boulanger, B. (October 2009). Expected Design Space: a Bayesian perspective based on modelling, prediction and multi-criteria decision method [Paper presentation]. Non-clinical biostatistics conference (NCB09), Boston, United States. |
| Marini Djang'Eing'A, R., Lebrun, P., & Hubert, P. (2009). Modèles statistiques Bayésiens et méthodologies pour calculer le Design Space (OPTIMAL-DS). (Rapport semestriel N°1, -). Liège, Belgium: ULg. |
 | Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Rudaz, S., Klinkenberg, R., Streel, B., & Hubert, P. (September 2009). Validation of a near infrared spectroscopy method for the quantitative determination of an active ingredient in non-coated pharmaceutical pellets [Poster presentation]. 13th International Meeting of Recent Developments in Pharmaceutical Analysis, Milan, Italy. |
 | De Backer, B., Debrus, B., Lebrun, P., Dubois, N., Hubert, P., & Charlier, C. (August 2009). Innovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoïds in cannabis plant material [Poster presentation]. 47ème meeting de l'International Association of Forensic Toxicologists (TIAFT), Genève, Switzerland. |
 | Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Govaerts, B., Olsen, B. A., Rozet, E., Boulanger, B., & Hubert, P. (30 June 2009). A new statistical method for the automated detection of peaks in UV-DAD chromatograms of a sample mixture. Talanta, 79, 77-85. doi:10.1016/j.talanta.2009.03.009 Peer Reviewed verified by ORBi |
 | Nistor, I., Debrus, B., Lebrun, P., Rozet, E., Ceccato, A., Caliaro, G., Oprean, R., Boulanger, B., & Hubert, P. (27 April 2009). Nouvelle méthodologie pour le développement automatisé de méthodes analytiques en chromatographie liquide pour l'analyse de mélanges de composés inconnus [Paper presentation]. Assemblée générale du CIRM et forum des jeunes chercheurs, Liège, Belgium. |
 | Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (2009). Moisture content determination of pharmaceutical pellets by near infrared spectroscopy: method development and validation. Analytica Chimica Acta, 642 (1-2), 186-92. doi:10.1016/j.aca.2008.12.031 Peer Reviewed verified by ORBi |
 | Debrus, B., Lebrun, P., Rozet, E., Nistor, I., Ceccato, A., Caliaro, G., Oprean, R., Boulanger, B., & Hubert, P. (2009). Nouvelle méthodologie pour le développement automatisé de méthodes analytiques en chromatographie liquide pour l’analyse de mélanges de composés inconnus. Spectra Analyse, 268, 28-33. Peer reviewed |
 | Ziemons, E., Bourichi, H., Mantanus, J., Lebrun, P., Bouklouze, A., Cherrah, Y., & Hubert, P. (October 2008). Analyse quantitative de mélanges binaires de deux formes cristallines du fluconazole par la spectroscopie proche infrarouge et par diffraction des rayons X: comparaison des deux méthodes [Paper presentation]. 2ème Congrès des Sciences Analytiques, Casablanca, Morocco. |
Lebrun, P., Boulanger, B., Jullion, A., Govaerts, B., Debrus, B., & Hubert, P. (September 2008). Design Space for analytical methods. A Bayesian perspective based on multivariate models and prediction [Paper presentation]. Non-clinical statistics 2008 (NCS2008), Leuven, Belgium. |
 | Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Rozet, E., Rupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (July 2008). Chromatographic separation of a pharmaceutical formulation using Design of Experiment and Design Space [Poster presentation]. 11th conference on Chemometrics in Analytical Chemistry (CAC'2008), Montpellier, France. |
Lebrun, P., Boulanger, B., Debrus, B., Govaerts, B., & Hubert, P. (June 2008). The Expected Design Space for analytical methods: a new perspective based on modeling and prediction [Paper presentation]. International symposium on biopharmaceutical statistics, Shanghai, China. |
 | Debrus, B., Lebrun, P., Ceccato, A., Caliaro, G., Jupérez, J., Barbas, C., Boulanger, B., & Hubert, P. (June 2008). Usefulness of design space for the optimization of chromatographic separations [Paper presentation]. 19th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2008), Gdansk, Poland. |
Lebrun, P., Debrus, B., Boulanger, B., Govaerts, B., & Hubert, P. (May 2008). Use of Independent Component Analysis and clustering methods to find and identify relevant components in a matrix of UV-spectral data. |
 | Ziemons, E., Mantanus, J., Lebrun, P., Rozet, E., & Hubert, P. (2008). Reflexions, La Chimie Analytique Verte. (Planet'ULg, ULiège - Université de Liège). Reflexions. |
 | Lebrun, P., Govaerts, B., Debrus, B., Ceccato, A., Caliaro, G., Hubert, P., & Boulanger, B. (2008). Development of a new predictive modelling technique to find with confidence equivalence zone and design space of chromatographic analytical methods. Chemometrics and Intelligent Laboratory Systems, 91, 4-16. doi:10.1016/j.chemolab.2007.05.010 Peer Reviewed verified by ORBi |
 | Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., & Hubert, P. (2008). Moisture content determination of pharmaceutical pellets by near infrared spectroscopy: model selection, evaluation and validation [Poster presentation]. 11th Conference on Chemometrics in Analytical Chemistry, Montpellier, France. |
 | Mantanus, J., Ziemons, E., Lebrun, P., Rozet, E., Klinkenberg, R., Streel, B., Evrard, B., & Hubert, P. (2008). Determination of moisture content in pharmaceutical pellets using near infrared spectroscopy: Method development and validation [Paper presentation]. PAT Workshop, Gent, Belgium. |
 | Lebrun, P., Debrus, B., Boulanger, B., Caliaro, G., Ceccato, A., & Hubert, P. (June 2007). Numerical separation in HPLC-UV-DAD with Independent Component Analysis (ICA) using high order statistics for the automated identification of peaks [Poster presentation]. HPLC 2007, Gent, Belgium. |
| Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Séparation numérique et quantification automatique de pics en CLHP-UV grâce à l’utilisation de l’analyse en composantes indépendantes (ICA) [Paper presentation]. SEP 2007, Grenoble, France. |
| Debrus, B., Lebrun, P., Boulanger, B., Dewé, W., Ceccato, A., & Hubert, P. (20 March 2007). Evaluation d'une nouvelle méthode pour le développement entièrement automatisé de méthodes analytiques en chromatographie liquide [Poster presentation]. SEP 2007, Grenoble, France. |
 | Lebrun, P., Boulanger, B., Hubert, P., Debrus, B., & Govaerts, B. (December 2006). Statistical Models and Multi-Criteria Optimization Techniques in Chromatography [Paper presentation]. Chimiométrie 2006, Paris, France. |
| Boulanger, B., Dewé, W., Ceccato, A., Debrus, B., Lebrun, P., & Hubert, P. (December 2006). Utilisation de l’Analyse en Composantes Indépendantes (ICA) pour la séparation numérique des pics et la quantification automatique en CLHP-UV [Paper presentation]. Chimiométrie 2006, Paris, France. |