[en] Penile cancer occurs predominantly in elderly men and is associated with a high morbidity and mortality rate. Invasive penile squamous cell cancer (pSCC) accounts for around 90% of all penile cancers. pSCC is associated in about40%of the cases with the presence of high-risk human papillomaviruses (HR-HPV), in particular, the oncogenic genotypes. In general, in less differentiated SCC, the incidence of HR-HPV is lower than in well differentiated SCC.
Disciplines :
Dermatology
Author, co-author :
LEBAS, Eve ; Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de dermatologie
DORMAL, Martin ; Centre Hospitalier Universitaire de Liège - CHU > Département de chirurgie > Service d'urologie
Herfs, Michael ; Université de Liège - ULiège > Cancer-Experimental Pathology
ARRESE ESTRADA, Jorge ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service dermatopathologie
NIKKELS, Arjen ; Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de dermatologie
Language :
English
Title :
Simultaneous condylomata acuminata and squamous cell carcinoma of the penis with different HPV genotypes
Alternative titles :
[en] Condylomata acuminata simultanée et carcinome épidermoïde du pénis avec différents génotypes de VPH
Hansen BT, Orumaa M, Lie AK, et al. Trends in incidence, mortality and survival of penile squamous cell carcinoma in Norway 1956–2015. Int J Cancer 2018; 142: 1586–93.
Gross G. Genitoanal human papillomavirus infection and associated neoplasias. Curr Probl Dermatol 2014; 45: 98–122.
Fernandez-Nestosa MJ, Guimera N, Sanchez DF, et al. Human papillomavirus (HPV) genotypes in condylomas, intraepithelial neoplasia, and invasive carcinoma of the penis using laser capture microdissection (LCM)-PCR: a study of 191 lesions in 43 patients. Am J Surg Pathol 2017; 41: 820–32.
Guimera N, Lloveras B, Lindeman J, et al. The occasional role of low-risk human papillomaviruses 6, 11, 42, 44, and 70 in anogenital carcinoma defined by laser capture microdissection/PCR methodology: results from a global study. Am J Surg Pathol 2013; 37: 1299–310.
Egawa K, Shibasaki Y, de Villiers EM. Double infection with human papillomavirus 1 and human papillomavirus 63 in single cells of a lesion displaying only a human papillomavirus 63-induced cytopathogenic effect. Lab Invest 1993; 69: 583–8.
Ciotti M, Paba P, Bonifacio D, Di Bonito L, Benedetto A, Favalli C. Single or multiple HPV types in cervical cancer and associated metastases. Oncol Rep 2006; 15: 143–8.
Parra-Herran C, Herfs M, Doria M, Crum CP, Nucci MR. Giant condyloma of the cervix: an uncommon entity associated with lowrisk human papilloma virus infection. Am J Surg Pathol 2013; 37: 300–4.
Miralles-Guri C, Bruni L, Cubilla AL, et al. Human papillomavirus prevalence and type distribution in penile carcinoma. J Clin Pathol 2009; 62: 870–8.
Pitisuttithum P, Velicer C, Luxembourg A. 9-Valent HPV vaccine for cancers, pre-cancers and genital warts related to HPV. Expert Rev Vaccines 2015; 14: 1405–19. doi:10.1684/ejd.2019.3578