Role of neutrophils in allergic asthma

[en] The contribution of neutrophils to asthma pathogenesis has been mainly studied in the context of non-allergic neutrophilic asthma. However, neutrophils can also be rapidly recruited and are largely present in the airways of allergic eosinophilic asthmatic patients. Under these circumstances, they possess specific phenotypic features distinguishing them from resting blood neutrophils and are endowed with particular functions. The exact contribution of neutrophils to allergic asthma pathogenesis is still unclear, but growing experimental evidence supports the ability of neutrophils or neutrophil-derived products to influence the underlying allergic type 2 immune response and cardinal features of allergic asthma, thus shedding new light on neutrophil biology and functions in an allergic context. © 2018 Elsevier Ltd

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Radermecker, Coraline ; Université de Liège - ULiège > GIGA-Research

Louis, Renaud ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie

Bureau, Fabrice ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire

Marichal, Thomas ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire

Language :

English

Title :

Role of neutrophils in allergic asthma

Publication date :

2018

Journal title :

Current Opinion in Immunology

ISSN :

0952-7915

eISSN :

1879-0372

Publisher :

Elsevier Ltd

Volume :

Pages :

28-34

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 November 2019

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