Comparison of hyperspectral imaging techniques for the elucidation of falsified medicines composition

[en] Hyperspectral imaging has shown a high potential to analyze falsifications of solid pharmaceutical products since the last decade. Thanks to the non-destructive, ecological and non-invasive properties, it is a preferred technique for these kinds of applications. Moreover, thanks to the spectroscopic properties, it is possible to detect as well organic compounds as inorganic compounds in a single analysis. Therefore, we recommend using it as second-line laboratory analysis technique. Raman microscopy and Fourier Transform Infrared (FT-IR) microscopy are two interesting techniques that are complementary. In this study, the potential of the two hyperspectral imaging techniques is evaluated to elucidate the composition of falsified antimalarial tablets. Hyperspectral data are analyzed by Multivariate Curve Resolution-Alternating Least Square (MCR-ALS). The results obtained from this study show that Raman hyperspectral imaging seems to be more suited to detect low dosed compounds possibly due to a smallest sampling volume. It has been also possible to link formulations of falsified samples of two different brands.

Research center :

CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Coic, Laureen ^✱; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Sacre, Pierre-Yves ^✱; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Dispas, Amandine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

sakira, Abdoul Karim

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Marini Djang'Eing'A, Roland ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Hubert, Philippe ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Ziemons, Eric ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Comparison of hyperspectral imaging techniques for the elucidation of falsified medicines composition

Publication date :

01 June 2019

Journal title :

Talanta

ISSN :

0039-9140

eISSN :

1873-3573

Publisher :

Elsevier, Netherlands

Volume :

198

Pages :

457-463

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

FEDER-PHARE

Funders :

FEDER - Fonds Européen de Développement Régional [BE]
DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie [BE]

Available on ORBi :

since 14 February 2019

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Bibliography

Hamilton, W.L., Doyle, C., Halliwell-Ewen, M., Lambert, G., Public health interventions to protect against falsified medicines: a systematic review of international, national and local policies. Health Policy Plan. 31 (2016), 1448–1466, 10.1093/heapol/czw062.
Council of Europe, The MEDICRIME Convention, 2011.
WHO | WHO Member State Mechanism, WHO. 〈 http://www.who.int/medicines/regulation/ssffc/mechanism/en/〉. (Accessed 19 September 2018).
J. Nwokike, M.P. Joshi, Assessment of Pharmacovigilance and Medicine Safety System in Rwanda. 〈 www.msh.org/sps〉. (Accessed 19 September 2018).
Heyman, M.L., Williams, R.L., Ensuring global access to quality medicines: role of the US pharmacopeia. J. Pharm. Sci. 100 (2011), 1280–1287, 10.1002/jps.22391.
D.A. ASIIMWE, Rwanda Pharmacovigilance Guidelines, 2010.
Newton, P.N., Caillet, C., Guerin, P.J., A link between poor quality antimalarials and malaria drug resistance. Expert Rev. Anti Infect. Ther. 14 (2016), 531–533, 10.1080/14787210.2016.1187560.
Circulation of Fake Anti-Malaria Drugs – NAFDAC, (n.d.). 〈 https://www.nafdac.gov.ng/circulation-of-fake-anti-malaria-drugs/〉. (Accessed 19 September 2018).
O. ILUNGA KALENGA, R.D.C. _Santé : ALERTE! COMMUNIQUE DU MINISTRE DE LA SANTE |, 2017. 〈 http://aicmonline.com/rdc-_sante-alerte-communique-ministre-de-sante/〉. (Accessed 19 September 2018).
E. ZIEMINE, Le Coartem en plaquette interdit, 2013. 〈 http://ct2015.cameroon-tribune.cm/index.php?option=com_content&view=article&id=77643:antipaludeens-le-coartem-en-plaquette-interdit&catid=4:societe&Itemid=3〉. (Accessed 19 September 2018).
Kaur, H., Allan, E.L., Mamadu, I., Hall, Z., Green, M.D., Swamidos, I., Dwivedi, P., Culzoni, M.J., Fernandez, F.M., Garcia, G., Hergott, D., Monti, F., Prevalence of substandard and falsified artemisinin-based combination antimalarial medicines on Bioko Island, Equatorial Guinea. BMJ Glob. Health, 2, 2017, e000409, 10.1136/bmjgh-2017-000409.
A. Basit, Fake Medicines For Malaria Uncovered, 2018. 〈 http://www.ghanalive.tv/2018/06/27/fake-medicines-malaria-uncovered/〉.
Hoellein, L., Holzgrabe, U., Development of simplified HPLC methods for the detection of counterfeit antimalarials in resource-restraint environments. J. Pharm. Biomed. Anal. 98 (2014), 434–445, 10.1016/j.jpba.2014.06.013.
Marini, R.D., Rozet, E., Montes, M.L.A., Rohrbasser, C., Roht, S., Rhème, D., Bonnabry, P., Schappler, J., Veuthey, J.L., Hubert, P., Rudaz, S., Reliable low-cost capillary electrophoresis device for drug quality control and counterfeit medicines. J. Pharm. Biomed. Anal. 53 (2010), 1278–1287, 10.1016/j.jpba.2010.07.026.
Debrus, B., Lebrun, P., Kindenge, J.M., Lecomte, F., Ceccato, A., Caliaro, G., Mbay, J.M.T., Boulanger, B., Marini, R.D., Rozet, E., Hubert, P., Innovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space. J. Chromatogr. A 1218 (2011), 5205–5215, 10.1016/j.chroma.2011.05.102.
Mbinze, J.K., Sacré P.-Y., Yemoa, A., Mavar Tayey Mbay, J., Habyalimana, V., Kalenda, N., Hubert, P., Marini, R.D., Ziemons, E., Development, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops. J. Pharm. Biomed. Anal. 111 (2015), 21–27, 10.1016/j.jpba.2015.02.049.
Coelho Neto, J., Lisboa, F.L.C., ATR-FTIR characterization of generic brand-named and counterfeit sildenafil- and tadalafil-based tablets found on the Brazilian market. Sci. Justice 57 (2017), 283–295, 10.1016/j.scijus.2017.04.009.
Sacré P.-Y., Deconinck, E., De Beer, T., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., Beer, J.O. De, Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines. J. Pharm. Biomed. Anal. 53 (2010), 445–453, 10.1016/j.jpba.2010.05.012.
Rebiere, H., Ghyselinck, C., Lempereur, L., Brenier, C., Investigation of the composition of anabolic tablets using near infrared spectroscopy and Raman chemical imaging. (n/a-n/a) Drug Test. Anal., 8, 2015, 10.1002/dta.1843.
Ellis, D.I., Eccles, R., Xu, Y., Griffen, J., Muhamadali, H., Matousek, P., Goodall, I., Goodacre, R., Through-container, extremely low concentration detection of multiple chemical markers of counterfeit alcohol using a handheld SORS device. Sci. Rep. 7 (2017), 1–8, 10.1038/s41598-017-12263-0.
Rebiere, H., Martin, M., Ghyselinck, C., Bonnet, P.-A., Brenier, C., Raman chemical imaging for spectroscopic screening and direct quantification of falsified drugs. J. Pharm. Biomed. Anal. 148 (2018), 316–323, 10.1016/j.jpba.2017.10.005.
Sacré P.-Y., Deconinck, E., Saerens, L., De Beer, T., Courselle, P., Vancauwenberghe, R., Chiap, P., Crommen, J., De Beer, J.O., Detection of counterfeit Viagra® by Raman microspectroscopy imaging and multivariate analysis. J. Pharm. Biomed. Anal. 56 (2011), 454–461, 10.1016/j.jpba.2011.05.042.
Barmpalexis, P., Karagianni, A., Nikolakakis, I., Kachrimanis, K., Artificial neural networks (ANNs) and partial least squares (PLS) regression in the quantitative analysis of cocrystal formulations by Raman and ATR-FTIR spectroscopy. J. Pharm. Biomed. Anal. 158 (2018), 214–224, 10.1016/j.jpba.2018.06.004.
Calvo, N.L., Balzaretti, N.M., Antonio, M., Kaufman, T.S., Maggio, R.M., Chemometrics-assisted study of the interconversion between the crystalline forms of nimodipine. J. Pharm. Biomed. Anal. 158 (2018), 461–470, 10.1016/j.jpba.2018.06.019.
Kahmann, A., Anzanello, M.J., Fogliatto, F.S., Chaovalitwongse, W.A., Marcelo, M.C.A., Ferrão, M.F., Ortiz, R.S., Mariotti, K.C., Interval importance index to select relevant ATR-FTIR wavenumber Intervals for falsified drug classification. J. Pharm. Biomed. Anal. 158 (2018), 494–503, 10.1016/j.jpba.2018.06.046.
Chan, K.L.A., Hammond, S.V., Kazarian, S.G., Applications of attenuated total reflection infrared spectroscopic imaging to pharmaceutical formulations. Anal. Chem. 75 (2003), 2140–2146, 10.1021/ac026456b.
Wray, P.S., Clarke, G.S., Kazarian, S.G., Dissolution of tablet-in-tablet formulations studied with ATR-FTIR spectroscopic imaging. Eur. J. Pharm. Sci. 48 (2013), 748–757, 10.1016/j.ejps.2012.12.022.
Yemoa, A., Habyalimana, V., Mbinze, J.K., Crickboom, V., Muhigirwa, B., Ngoya, A., Sacre, P.-Y., Gbaguidi, F., Quetin-Leclercq, J., Hubert, P., Marini, R.D., Detection of poor quality artemisinin-based combination therapy (ACT) medicines marketed in benin using simple and advanced analytical techniques. Curr. Drug Saf. 12 (2017), 178–186, 10.2174/1574886312666170616092457.
P.H.C. Eilers, H.F.M. Boelens, asymmetric least squares for baseline correction, 2005.
Kessler, W., Oelkrug, D., Kessler, R., Using scattering and absorption spectra as MCR-hard model constraints for diffuse reflectance measurements of tablets. Anal. Chim. Acta 642 (2009), 127–134, 10.1016/j.aca.2009.01.057.
Kumar, K., Random initialisation of the spectral variables: an alternate approach for initiating multivariate curve resolution alternating least square (MCR-ALS) analysis. J. Fluoresc. 27 (2017), 1957–1968, 10.1007/s10895-017-2132-0.
Gao, Q., Liu, Y., Li, H., Chen, H., Chai, Y., Lu, F., Comparison of several chemometric methods of libraries and classifiers for the analysis of expired drugs based on Raman spectra. J. Pharm. Biomed. Anal. 94 (2014), 58–64, 10.1016/j.jpba.2014.01.027.