Reference : An Integrative Memory model of recollection and familiarity to understand memory deficits
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/232843
An Integrative Memory model of recollection and familiarity to understand memory deficits
English
Bastin, Christine mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn. >]
Besson, Gabriel mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn. >]
Simon, Jessica mailto [Université de Liège - ULiège > Département de Psychologie > Psychologie quantitative >]
Delhaye, Emma mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Geurten, Marie mailto [Université de Liège - ULiège > Département de Psychologie > Neuroimagerie des troubles de la mémoire et revalid. cogn. >]
Willems, Sylvie mailto [Université de Liège - ULiège > > Clinique psychologique et logopédique universitaire (CPLU) >]
Salmon, Eric mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn. >]
2019
Behavioral and Brain Sciences
Cambridge University Press
Yes (verified by ORBi)
International
0140-525X
1469-1825
United Kingdom
[en] Humans can recollect past events in details (recollection) and/or know that an object, person or place has been encountered before (familiarity). During the last two decades, there has been intense debate about how recollection and familiarity are organized in the brain. Here, we propose an Integrative Memory model which describes the distributed and interactive neurocognitive architecture of representations and operations underlying recollection and familiarity. In this architecture, the subjective experience of recollection and familiarity arises from the interaction between core systems storing particular kinds of representations shaped by specific computational mechanisms and an attribution system. By integrating principles from current theoretical views about memory functioning, we provide a testable framework to refine the prediction of deficient versus preserved mechanisms in memory-impaired populations. The case of Alzheimer’s disease is considered as an example because it entails progressive lesions starting with limited damage to core systems before invading step-by-step most parts of the model-related network. We suggest a chronological scheme of cognitive impairments along the course of Alzheimer’s disease, where the inaugurating deficit would relate early neurodegeneration of the perirhinal/anterolateral entorhinal cortex to impaired familiarity for items that need to be discriminated as viewpoint-invariant conjunctive entities. The Integrative Memory model can guide future neuropsychological and neuroimaging studies aiming to understand how such a network allows humans to remember past events, to project into the future and possibly also to share experiences.
http://hdl.handle.net/2268/232843
10.1017/S0140525X19000621

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