Reference : Pharmacokinetic study of estetrol in murin model developing a whole blood microsampli...
Scientific congresses and symposiums : Unpublished conference/Abstract
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/213899
Pharmacokinetic study of estetrol in murin model developing a whole blood microsampling, extraction procedure and an UHPLC-MS/MS method
English
Nys, Gwenaël mailto [Université de Liège > Département de pharmacie > Analyse des médicaments >]
Servais, Anne-Catherine mailto [Université de Liège > Département de pharmacie > Analyse des médicaments >]
Pequeux, Christel mailto [Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Fillet, Marianne mailto [Université de Liège > Département de pharmacie > Analyse des médicaments >]
17-Oct-2016
1
No
No
National
Forum of pharmaceutical sciences
17-18 octobre 2016
Belgian society of pharmaceutical sciences
Brussels
Belgium
[en] UHPLC-MS/MS ; Microsampling ; Estetrol
[en] We developed a sensitive UHPLC-MS/MS method with a simple yet efficient sample collection and preparation protocol to accurately quantify E4 in whole blood. This method was then successfully applied for the pharmacokinetic study of E4 in a murin model providing the best administration route for E4. The innovative sampling allowed decreasing the number of animals used for the study as VAMS only draws few microliters of blood thus leaving the mice alive for the whole PK study reducing the inter-individual variability.
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
Researchers
http://hdl.handle.net/2268/213899

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