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Nys Gwenaël

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Main Referenced Co-authors
Fillet, Marianne  (62)
Cobraiville, Gaël  (34)
Servais, Anne-Catherine  (32)
Gou, Marie-Jia  (14)
Kok, Miranda  (13)
Main Referenced Keywords
Mass spectrometry (6); Estetrol (5); Capillary zone electrophoresis mass spectrometry (4); Proteomics (4); proteomics (4);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège (37)
Centre Interfacultaire de Recherche du Médicament - CIRM (2)
GIGA Neuroscience (1)
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège (1)
Giga Neurosciences - ULiège (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (54)
Neurosciences & behavior (7)
Rheumatology (2)

Publications (total 62)

The most downloaded
1941 downloads
Houbart, V., COBRAIVILLE, G., Nys, G., Servais, A.-C., & Fillet, M. (May 2016). Volumetric Absorptive Microsampling for Hepcidin Peptide Extraction from Whole Blood. LC GC North America, 34 (5). https://hdl.handle.net/2268/196988

The most cited

61 citations (OpenAlex)

Nys, G., Kok, M., Servais, A.-C., & Fillet, M. (December 2017). Beyond dried blood spot: Current microsampling techniques in the context of biomedical applications. TrAC: Trends in Analytical Chemistry, 97, 326-332. doi:10.1016/j.trac.2017.10.002 https://hdl.handle.net/2268/216200

Gou, M.-J., Nix, C., Nys, G., Cobraiville, G., Caers, J., & Fillet, M. (14 November 2022). Capillary electrophoresis and microfluidic-RPLC coupled to ion mobility mass spectrometry as complementary tools to discover surface antigens in multiple myeloma [Paper presentation]. Symposium Advanced analytical technologies for clinical and pharmaceutical applications, Uppsala, Sweden.
Peer reviewed

Nix, C., Nys, G., Cobraiville, G., de Seny, D., & Fillet, M. (11 September 2022). Quantification of serum amyloid A variants in plasma, synovial fluid and cell culture medium to better understand rheumatoid arthritis [Poster presentation]. 12th International Symposium on Drug Analysis and the 32nd International Symposium on Pharmaceutical and Biomedical Analysis (DA-PBA 2022, Mons, Belgium.
Peer reviewed

Gou, M.-J., Cobraiville, G., Nys, G., Caers, J., & Fillet, M. (06 July 2022). Interest of capillary zone electrophoresis coupled to mass spectrometry for clinical proteomics analysis : how to improve sensitivity? [Paper presentation]. 38th International Symposium on Microscale Separations and Bioanalysis, Liège, Belgium.

Nix, C., Gou, M.-J., Nys, G., Cobraiville, G., & Fillet, M. (31 August 2021). Contribution of proteomics to the development of new therapeutics [Paper presentation]. 31st International Symposium on Pharmaceutical and Biomedical Analysis, PBA2021, virtual edition, Belgium.
Peer reviewed

CIREGIA, F., Nys, G., Cobraiville, G., Badot, V., Di Romana, S., Sidiras, P., Sokolova, T., Durez, P., Fillet, M., Malaise, M., & de Seny, D. (2021). A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis. Frontiers in Immunology. doi:10.3389/fimmu.2021.638814
Peer Reviewed verified by ORBi

Delage, C., Nys, G., Fillet, M., & Cornil, C. (2021). Effect of cyclo-oxygenase inhibition on embryonic microglia and the sexual differentiation of the brain and behavior of Japanese quail (Coturnix japonica). Hormones and Behavior, 134, 105024. doi:10.1016/j.yhbeh.2021.105024
Peer Reviewed verified by ORBi

de Bournonville, M.-P., de Bournonville, C., Vandries, L., Nys, G., Fillet, M., Ball, G., Balthazart, J., & Cornil, C. (2021). Rapid changes in brain estrogen concentration during male sexual behavior are site and stimulus specific. Scientific Reports, 11 (1), 20130. doi:10.1038/s41598-021-99497-1
Peer Reviewed verified by ORBi

Gou, M.-J., Nys, G., COBRAIVILLE, G., Demelenne, A., Servais, A.-C., CAERS, J., & Fillet, M. (30 September 2020). CE-MS/MS: investigation of two hyphenating approaches for proteomics studies in the context of multiple myeloma [Paper presentation]. 36th International Symposium on Microscale Separations and Bioanalysis, Saint-Malo, France.

Gou, M.-J., Nys, G., COBRAIVILLE, G., Demelenne, A., Servais, A.-C., Caers, J., & Fillet, M. (September 2020). Capillary electrophoresis tandem mass spectrometry for proteomics in the context of multiple myeloma: investigation of two hyphenating approaches [Paper presentation]. 36th International Symposium on Microscale Separations and Bioanalysis.

Nix, C., COBRAIVILLE, G., Nys, G., & Fillet, M. (September 2020). Micro pillar array columns in the context of proteomics studies [Poster presentation]. 36th International Symposium on Microscale Separations and Bioanalysis.

Nix, C., Gou, M.-J., Nys, G., COBRAIVILLE, G., & Fillet, M. (February 2020). Microfluidic separation systems coupled to ion-mobility-Q-TOF for comprehensive proteomic analysis in the context of new therapeutic approaches [Paper presentation]. 6th International Ion Mobility Spectrometry (IMS) meeting, Duisburg-Essen, Germany.

Nys, G., Nix, C., COBRAIVILLE, G., Servais, A.-C., & Fillet, M. (2020). Enhancing protein discoverability by data independent acquisition assisted by ion mobility mass spectrometry. Talanta. doi:10.1016/j.talanta.2020.120812
Peer Reviewed verified by ORBi

Gou, M.-J., Nys, G., COBRAIVILLE, G., Demelenne, A., Servais, A.-C., & Fillet, M. (2020). Hyphenation of capillary zone electrophoresis with mass spectrometry for proteomic analysis: Optimization and comparison of two coupling interfaces. Journal of Chromatography. A. doi:10.1016/j.chroma.2020.460873
Peer Reviewed verified by ORBi

Nix, C., Nys, G., COBRAIVILLE, G., & Fillet, M. (January 2020). Multidimensional performance assessment of micro pillar array column chromatography combined to ion mobility-mass spectrometry for proteomics research [Paper presentation]. 16th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, Ghent, Belgium.

Demelenne, A., Gou, M.-J., Nys, G., Parulski, C., Crommen, J., Servais, A.-C., & Fillet, M. (2020). Evaluation of Hydrophilic Interaction Liquid Chromatography, Capillary Zone Electrophoresis and Drift Tube Ion-Mobility Quadrupole Time Of Flight mass spectrometry for the characterization of phosphodiester and phosphorothioate oligonucleotides. Journal of Chromatography. A. doi:10.1016/j.chroma.2019.460716
Peer Reviewed verified by ORBi

Gou, M.-J., Nys, G., COBRAIVILLE, G., Demelenne, A., Servais, A.-C., & Fillet, M. (11 December 2019). Proteomic analysis using capillary electrophoresis hyphenated with high resolution mass spectrometry: comparison of two coupling interfaces [Poster presentation]. 2nd Cirm Day, Liège, Belgium.

Demelenne, A., Gou, M.-J., Nys, G., Parulski, C., Servais, A.-C., & Fillet, M. (11 December 2019). Ion mobility high resolution mass spectrometry coupled to HILIC and CZE for the characterization of phosphodiester and phosphorothioate oligonucleotides [Paper presentation]. 2nd Cirm Day, Liège, Belgium.

Nys, G., COBRAIVILLE, G., Servais, A.-C., Malaise, M., DE SENY, D., & Fillet, M. (2019). Targeted proteomics reveals serum amyloid A variants and alarmins S100A8-S100A9 as key plasma biomarkers of rheumatoid arthritis. Talanta. doi:10.1016/j.talanta.2019.06.044
Peer reviewed

Nys, G., COBRAIVILLE, G., Servais, A.-C., & Fillet, M. (October 2019). Chromatographic and electrophoretic techniques coupled to ion-mobility mass spectrometry for the deciphering of molecular networks [Paper presentation]. 3rd International Symposium on Advances in Pharmaceutical Analysis (APA 2019), Xian, China.

Demelenne, A., Gou, M.-J., Nys, G., Parulski, C., Servais, A.-C., & Fillet, M. (17 September 2019). Quality control of therapeutic phosphorothioate oligonucleotides by hydrophilic interaction liquid chromatography coupled with ION-MOBILITY QTOF [Paper presentation]. 30 th INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL & BIOMEDICAL ANALYSIS, Tel Aviv, Israel.

Gou, M.-J., Nys, G., Demelenne, A., COBRAIVILLE, G., Servais, A.-C., & Fillet, M. (17 September 2019). Comparison of two capillary electrophoresis-mass spectrometry interfaces for proteomic analysis [Poster presentation]. 30th International Symposium on Pharmaceutical and Biomedical Analysis, Tel Aviv, Israel.

Nys, G., COBRAIVILLE, G., Servais, A.-C., & Fillet, M. (September 2019). Evaluation and comparison of different separation techniques coupled to ion-mobility mass spectrometry for the deciphering of molecular networks [Paper presentation]. 26th International Symposium on Electroseparation and liquid-phase separation techniques (ITP 2019), Toulouse, France.

Gou, M.-J., Nys, G., Demelenne, A., COBRAIVILLE, G., Servais, A.-C., & Fillet, M. (01 September 2019). Capillary electrophoresis tandem mass spectrometry for proteomic analysis: optimization and comparison of two coupling interfaces [Poster presentation]. 26th International Symposium on Electroseparation and Liquid Phase-Separation Techniques, Toulouse, France.

Gou, M.-J., Nys, G., COBRAIVILLE, G., Servais, A.-C., & Fillet, M. (20 May 2019). CE-MS/MS for bottom-up proteomics: comparaison of two coupling interfaces with ion mobility qTOF [Paper presentation]. 20th Forum of Pharmaceutical Sciences, Brussels, Belgium.

Delage, C., Nys, G., Fillet, M., & Cornil, C. (May 2019). Microglia and prostanoids, potential players in sexual differentiation of the brain and behavior of the Japanese quail [Paper presentation]. Sex differences, dimorphisms, divergences: impact on brain and behavior in health and disease.

Nys, G., COBRAIVILLE, G., & Fillet, M. (2019). Multidimensional performance assessment of micro pillar array column chromatography combined to ion mobility-mass spectrometry for proteome research. Analytica Chimica Acta, 1086, 1-13. doi:10.1016/j.aca.2019.08.068
Peer Reviewed verified by ORBi

Kok, M., Nix, C., Nys, G., & Fillet, M. (2019). Targeted metabolomics of whole blood using volumetric absorptive microsampling. Talanta, 197, 49-58. doi:10.1016/j.talanta.2019.01.014
Peer Reviewed verified by ORBi

Huang, Y., Jansen, O., Frederich, M., Mouithys-Mickalad, A., Nys, G., Servais, A.-C., Crommen, J., Jiang, Z., & Fillet, M. (2019). Capillary electrophoresis, high-performance liquid chromatography, and thin-layer chromatography analyses of phenolic compounds from rapeseed plants and evaluation of their antioxidant activity. Journal of Separation Science, 1-10. doi:10.1002/jssc.201800712
Peer Reviewed verified by ORBi

Ion, V., Nys, G., COBRAIVILLE, G., Cavalier, E., Crommen, J., Servais, A.-C., Muntean, D.-L., & Fillet, M. (2019). Ultra-high-performance liquid chromatography-mass spectrometry method for neutrophil gelatinase-associated lipocalin as a predictive biomarker in acute kidney injury. Talanta, 195, 668-675. doi:10.1016/j.talanta.2018.11.050
Peer Reviewed verified by ORBi

Palazzo, C., Laloy, J., Delvigne, A. S., Nys, G., Fillet, M., Dogne, J. M., Pequeux, C., Foidart, J.-M., Evrard, B., & Piel, G. (2019). Development of injectable liposomes and drug-in-cyclodextrin-in-liposome formulations encapsulating estetrol to prevent cerebral ischemia of premature babies. European Journal of Pharmaceutical Sciences, 9 (127), 52-59. doi:10.1016/j.ejps.2018.10.006
Peer Reviewed verified by ORBi

Kok, M., Nix, C., Nys, G., De Tullio, P., Lecomte, J., LAMBERT, V., & Fillet, M. (19 December 2018). Fluxomics of AMD using mass spectrometry from 10 µL of mice whole blood; investigation of DCA treatment [Poster presentation]. First CIRM Day.

Nys, G., COBRAIVILLE, G., Servais, A.-C., & Fillet, M. (19 December 2018). Data independent acquisition for proteomics studies using ion mobility mass spectrometry [Paper presentation]. CIRM Day, Liège, Belgium.

Ion, V., Nys, G., COBRAIVILLE, G., CAVALIER, E., Servais, A.-C., Muntean, D.-L., & Fillet, M. (19 December 2018). Targeted LC-MS/MS proteomics approach for the analysis of Neutrophyl Gelatinase Associated Lipocalin in AKI patients [Poster presentation]. 1st CIRM Day, Liège, Belgium.

Nys, G., COBRAIVILLE, G., Farcas, E., Demelenne, A., Kok, M., Servais, A.-C., & Fillet, M. (October 2018). Microfluidic analytical approaches to drive drug development [Paper presentation]. In the framework of High-end Foreign Experts program, Guangzhou, China.

Nys, G., COBRAIVILLE, G., Kok, M., Servais, A.-C., & Fillet, M. (September 2018). Microfluidics coupled to mass spectrometry to decipher molecular networks and monitor active molecules in body fluids [Paper presentation]. 11th International Symposium on Drug Analysis and 29th International Symposium on Pharmaceutical and Biomedical Analysis (DA-PBA 2018), Leuven, Belgium.

Nys, G., COBRAIVILLE, G., Servais, A.-C., & Fillet, M. (31 July 2018). (Nano)-LC coupled to Ion Mobility Q-TOF for an improved sensitivity and proteome coverage [Poster presentation]. HPLC 2018, United States - District of Columbia.

Nys, G., COBRAIVILLE, G., Demelenne, A., Servais, A.-C., & Fillet, M. (12 June 2018). ion mobility Q-TOF, an attractive tool for biomarker discovery and biopharmaceutical analysis [Paper presentation]. Agilent Day BELUX, Gent, Belgium.

Kok, M., Nys, G., & Fillet, M. (23 May 2018). Volumetric absorptive microsampling for targeted metabolomics of whole blood [Paper presentation]. 11ème Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique (RFMF), Liège, Belgium.

Nys, G., COBRAIVILLE, G., & Fillet, M. (18 January 2018). Strategies to improve sensitivity and proteome coverage using ion mobility Q-TOF [Paper presentation]. European Ion mobility meeting, Utrecht, Netherlands.

Nys, G., & Fillet, M. (2018). Microfluidics contribution to pharmaceutical sciences: From drug discovery to post marketing product management. Journal of Pharmaceutical and Biomedical Analysis, 159, 348-362. doi:10.1016/j.jpba.2018.07.011
Peer Reviewed verified by ORBi

Nys, G., Kok, M., Servais, A.-C., & Fillet, M. (December 2017). Beyond dried blood spot: Current microsampling techniques in the context of biomedical applications. TrAC: Trends in Analytical Chemistry, 97, 326-332. doi:10.1016/j.trac.2017.10.002
Peer Reviewed verified by ORBi

Nys, G., COBRAIVILLE, G., DE SENY, D., & Fillet, M. (14 November 2017). Targeted analysis of potential biomarkers of rheumatoid arthritis by LC-MS/MS [Paper presentation]. CIRM seminar, Liège, Belgium.

Nys, G., Kok, M., & Fillet, M. (14 November 2017). Metabolomic and proteomic biomarker quantification in the context of personalized medicin [Paper presentation]. Séminaires Scientifiques du CIRM.

Nys, G., COBRAIVILLE, G., Kok, M., Wéra, O., Servais, A.-C., & Fillet, M. (November 2017). Comparison of nanofluidic and ultra-high performance liquid chromatography-tandem mass spectrometry for high sensitive pharmacokinetic studies of estrogens starting from whole blood microsampling. Journal of Chromatography. A, 1524, 160-168. doi:10.1016/j.chroma.2017.10.006
Peer Reviewed verified by ORBi

Kok, M., Thiry, J., Evrard, B., Nys, G., & Fillet, M. (12 September 2017). Sampling only 10 μL of whole blood to study the bioavailability of itraconazole formulations in rats [Paper presentation]. International Symposium on Electro- and Liquid Phase- Separation Techniques (ITP), Sopot, Poland.

Fillet, M., Thiry, J., Evrard, B., Nys, G., Servais, A.-C., & Kok, M. (September 2017). Blood microsampling for itraconazole pharmacokinetic study on individual rodent in the context of drug formulation optimization [Paper presentation]. Recent Developments in Pharmaceutical Analysis (RDA 2017), Rimini, Italy.

Fillet, M., Nys, G., Servais, A.-C., & Kok, M. (July 2017). Evaluation of crude biofluid microsampling methods from living animal models for sensitive quantitation of pharmacologically active molecules [Paper presentation]. 28th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2017), Madrid, Spain.

Nys, G., Gallez, A., Kok, M., COBRAIVILLE, G., Servais, A.-C., Piel, G., Pequeux, C.* , & Fillet, M.*. (05 June 2017). Whole blood microsampling for the quantitation of estetrol without derivatization by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 140, 258-265. doi:10.1016/j.jpba.2017.02.060
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Delage, C., Nys, G., Fillet, M., & Cornil, C. (2017). Potential role of microglia and prostaglandins in the sexual differentiation of brain and behavior of Japanese quail. Frontiers in Neuroscience. doi:10.3389/conf.fnins.2017.94.00103

Delage, C., Nys, G., Fillet, M., & Cornil, C. (May 2017). Role of microglia and prostaglandins in estrogen-dependent sexual differentiation of brain and behavior [Poster presentation]. Euron PhD workshop & Symposium: Microglia in development and disease, Hasselt, Belgium.

Delage, C., Nys, G., Fillet, M., & Cornil, C. (May 2017). Potential role of microglia and prostaglandins in the sexual differentiation of brain and behavior of Japanese quail [Poster presentation]. 12ième congrès national de la société belge de neuroscience, Ghent, Belgium.

Nys, G., Servais, A.-C., Pequeux, C., & Fillet, M. (29 March 2017). Lc-chip versus UHPLC-tandem mass spectrometry for the quantitation of estetrol and estradiol without derivatization after whole blood microsampling [Paper presentation]. 12éme congrès francophone sur les sciences séparatives et les couplages, Paris, France.

Nys, G., Servais, A.-C., Pequeux, C., & Fillet, M. (March 2017). Microsampling and micropreparation of biological fluids for sensitive quantitation of estetrol by LC-(Chip)-MS/MS [Paper presentation]. 33th International Symposium on Microscale Bioseparations (MSB), Madrid, Spain.

Fillet, M., Nys, G., Servais, A.-C., & Pequeux, C. (March 2017). MICROSAMPLING AND MICROPREPARATION OF BIOLOGICAL FLUIDS FOR SENSITIVE QUANTITATION OF ESTETROL BY LC-(CHIP)-MS/MS [Paper presentation]. Microscale separation and bioanalysis (MSB).

Delage, C., Nys, G., Fillet, M., & Cornil, C. (01 February 2017). Investigating the role of microglia and prostaglandins in sexual differentiation of brain and behavior mediated by estrogens [Paper presentation]. GIGA Day, Liège, Belgium.

Thiry, J., Evrard, B., Nys, G., Fillet, M., & Kok, M. (2017). Sampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study. Journal of Chromatography. A, 1479, 161-168. doi:10.1016/j.chroma.2016.12.009
Peer Reviewed verified by ORBi

COBRAIVILLE, G., Fillet, M., Sharif, M., Ourradi, K., Nys, G., Malaise, M., & DE SENY, D. (2017). Validation of a new method by nano-liquid chromatography on chip tandem mass spectrometry for combined quantitation of C3f and the V65 vitronectin fragment as biomarkers of diagnosis and severity of osteoarthritis. Talanta, 169, 170-180. doi:10.1016/j.talanta.2017.03.078
Peer Reviewed verified by ORBi

Palazzo, C., Laloy, J., Delvigne, A.-S., Nys, G., Dogne, J.-M., Fillet, M., Foidart, J.-M., Evrard, B., & Piel, G. (December 2016). NEW INJECTABLE LIPOSOME AND DRUG-IN-CYCLODEXTRIN-IN LIPOSOME SYSTEMS ENCAPSULATING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES IN PREMATURE BABIES [Poster presentation]. Journées annuelles SFNano, Paris 2016, Paris, France.

Nys, G., Servais, A.-C., Pequeux, C., & Fillet, M. (17 October 2016). Pharmacokinetic study of estetrol in murin model developing a whole blood microsampling, extraction procedure and an UHPLC-MS/MS method [Paper presentation]. Forum of pharmaceutical sciences, Brussels, Belgium.

Palazzo, C., Laloy, J., Delvigne, A.-S., Nys, G., Dogne, J.-M., Karim, R., Fillet, M., Foidart, J.-M., Evrard, B., & Piel, G. (28 September 2016). INNOVATIVE INJECTABLE LIPOSOME AND DRUG-IN-CYCLODEXTRIN-IN LIPOSOME SYSTEMS ENCAPSULATING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES IN PREMATURE BABIES [Paper presentation]. 4th Congress on Innovation in Drug Delivery, Antibes-Juan-Les-Pins, France.

Houbart, V., COBRAIVILLE, G., Nys, G., Servais, A.-C., & Fillet, M. (May 2016). Volumetric Absorptive Microsampling for Hepcidin Peptide Extraction from Whole Blood. LC GC North America, 34 (5).
Peer reviewed

Houbart, V., COBRAIVILLE, G., Nys, G., Merville, M.-P., & Fillet, M. (2016). Impact of injection solvent composition on protein identification incolumn-switching chip-liquid chromatography/mass spectrometry. Journal of Chromatography. A, 1445, 27-35. doi:10.1016/j.chroma.2016.03.056
Peer Reviewed verified by ORBi

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