Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field

[en] Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is more sensitive allowing its use for the detection and the quantification of low-dose substances contained in pharmaceutical samples. However, the analytical performance of SERS is limited due to the difficulty to implement a quantitative methodology correctly validated. Nevertheless, some studies reported the development of SERS quantitative methods especially in pharmaceutical approaches. In this context, this review presents the main concepts of the SERS technique. The different steps that need to be applied to develop a SERS quantitative method are also deeply described. The last part of the present manuscript gives a critical overview of the different SERS pharmaceutical applications that were developed for a non-exhaustive list of pharmaceutical compounds with the aim to highlights the validation criteria for each application.

Research Center/Unit :

Centre Interfacultaire de Recherche du Médicament - CIRM

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Cailletaud, Johan ; Université de Liège > Département de pharmacie > Chimie analytique

De Bleye, Charlotte ; Université de Liège > Département de pharmacie > Département de pharmacie

Dumont, Elodie ; Université de Liège > Département de pharmacie > Chimie analytique

Sacre, Pierre-Yves ; Université de Liège > Département de pharmacie > Chimie analytique

Netchacovitch, Lauranne ; Université de Liège > Département de pharmacie > Chimie analytique

Gut, Yoann; Technologie Servier

Boiret, Mathieu; Horiba France

Ginot, Yves-Michel; Technologie Servier

Hubert, Philippe ; Université de Liège > Département de pharmacie > Chimie analytique

Ziemons, Eric ; Université de Liège > Département de pharmacie > Département de pharmacie

Language :

English

Title :

Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field

Publication date :

05 January 2018

Journal title :

Journal of Pharmaceutical and Biomedical Analysis

ISSN :

0731-7085

eISSN :

1873-264X

Publisher :

Elsevier

Volume :

147

Pages :

458-472

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 June 2017

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