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Article (Scientific journals)

tRNA modification: is cancer having a wobble?

Rapino, Francesca; Zhou, Zhaoli; Delaunay, Sylvain et al.

2017 • In Trends in Cancer, 3, p. 249-252

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/210919

DOI
10.1016/j.trecan.2017.02.004

PubMed
28718436

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Keywords :

Cancer; tRNA; Translation

Abstract :

[en] Translational control of protein synthesis supports tumor development and progression to metastasis. Wobble tRNA modifications are required during translation elongation and sustain proteome homeostasis. Recent work has highlighted the surprising upregulation of the wobble uridine 34 (U34) tRNA cascade in cancer, which underlies the specific requirement for this pathway in tumor development.

Research Center/Unit :

GIGA Molecular Biology of Diseases - ULiège

Disciplines :

Oncology

Author, co-author :

Rapino, Francesca ; Université de Liège > Département de pharmacie > Chimie médicale

Zhou, Zhaoli ; Université de Liège > Département de pharmacie > Chimie médicale

Delaunay, Sylvain ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

Chariot, Alain ; Université de Liège > Département de pharmacie > Chimie médicale

Close, Pierre ; Université de Liège > Département de pharmacie > Chimie médicale

Language :

English

Title :

tRNA modification: is cancer having a wobble?

Publication date :

2017

Journal title :

Trends in Cancer

ISSN :

2405-8033

eISSN :

2405-8025

Publisher :

Cell Press Elsevier, United States

Volume :

3

Pages :

249-252

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
WELBIO - Institut wallon virtuel de recherche d'excellence dans les domaines des sciences de la vie
Télévie

Available on ORBi :

since 22 May 2017

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182 (36 by ULiège)

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12 (11 by ULiège)

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Scopus citations^®

37

Scopus citations^®
without self-citations

32

OpenCitations

38

OpenAlex citations

46

Bibliography

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7 Deng, W., et al. Trm9-catalyzed tRNA modifications regulate global protein expression by codon-biased translation. PLoS Genet., 11, 2015, e1005706.
8 Nedialkova, D.D., Leidel, S.A., Optimization of codon translation rates via tRNA modifications maintains proteome integrity. Cell 161 (2015), 1–13.
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10 Laguesse, S., et al. A dynamic unfolded protein response contributes to the control of cortical neurogenesis. Dev. Cell 35 (2015), 553–567.
11 Chen, Y.-T., et al. Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP. Mol. Cell. Biol. 29 (2009), 736–744.
12 Songe-Møller, L., et al. Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. Mol. Cell. Biol. 30 (2010), 1814–1827.
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