Profil

Chariot Alain

GIGA Stem Cells - Medical Chemistry

Département de pharmacie

Chimie médicale

See author's contact details
Main Referenced Co-authors
Close, Pierre  (59)
Nguyen, Laurent  (51)
Malgrange, Brigitte  (36)
Bours, Vincent  (29)
Merville, Marie-Paule  (27)
Main Referenced Keywords
Elongator (19); NF-kappa B (12); inner ear (11); NF kappa B (10); Humans (8);
Main Referenced Unit & Research Centers
Giga-Signal Transduction - ULiège [BE] (50)
Giga Neurosciences - ULiège [BE] (12)
GIGA‐R - Giga‐Research - ULiège [BE] (6)
GIGA Molecular Biology of Diseases - ULiège [BE] (4)
Giga-Cancer - ULiège [BE] (3)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (87)
Oncology (23)
Neurology (17)
Otolaryngology (11)
Anatomy (cytology, histology, embryology...) & physiology (11)

Publications (total 158)

The most downloaded
5661 downloads
Viatour, P., Merville, M.-P., Bours, V., & Chariot, A. (January 2005). Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation [letter to the editor]. Trends in Biochemical Sciences, 30 (1), 43-52. doi:10.1016/j.tibs.2004.11.009 https://hdl.handle.net/2268/1280

The most cited

1260 citations (Scopus®)

Viatour, P., Merville, M.-P., Bours, V., & Chariot, A. (January 2005). Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation [letter to the editor]. Trends in Biochemical Sciences, 30 (1), 43-52. doi:10.1016/j.tibs.2004.11.009 https://hdl.handle.net/2268/1280

Tielens, S., Krusy, N., Stern, D., Van Hees, L., Reyskens, C., Laguesse, S., Chariot, A., & Nguyen, L. (28 September 2023). Unveiling the embryonic basis of neurodegeneration linked to impaired nucleocytoplasmic transport [Poster presentation]. Axon2023, Alicante, Spain.

Petrellis, G., Rolot, M., Preure, A., Wathieu, C., Dougal, A., Chetty, A., Chariot, A., Horsnell, W., & Dewals, B. G. (01 May 2023). IL-4 RECEPTOR SIGNALING REGULATES LUNG MACROPHAGES DURING HELMINTH COINFECTION RESULTING IN ENHANCED GAMMAHERPESVIRUS PERMISSIVENESS. Journal of Immunology, 210 (1_Supplement), 72.36-72.36. doi:10.4049/jimmunol.210.supp.72.36
Peer Reviewed verified by ORBi

Tielens, S., Krusy, N., Stern, D., Van Hees, L., Turchetto, S., Maurizy, C., Stoufflet, J., Laguesse, S., Chariot, A., & Nguyen, L. (06 September 2022). Unveilling the embryonic basis of neurodegeneration linked to impaired nucleocytoplasmic transport [Poster presentation]. GIGA day, Liège, Belgium.

Lion, Q., Wen, X., Shostak, K., Vanleyssem, R., Close, P., Dejardin, E., & Chariot, A. (06 September 2022). ROLE OF THE tRNA-MODIFYING ENZYME ELONGATOR IN LIVER [Poster presentation]. GIGA DAY 2022.

Chen, D., Nemazanyy, I., Peulen, O., Shostak, K., Xu, X., Tang, S. C., Wathieu, C., Turchetto, S., Tielens, S., Nguyen, L., Close, P., Desmet, C., Klein, S., Florin, A., Büttner, R., Petrellis, G., Dewals, B. G., & Chariot, A. (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO Journal, 109353. doi:10.15252/embj.2021109353
Peer Reviewed verified by ORBi

Wathieu, C., Tielens, S., Lavergne, A., Shostak, K., Rolot, M., El Hachem, N., Xu, X., Close, P., Nguyen, L., Desmet, C., Dewals, B. G., & CHARIOT, A. (10 May 2022). A role for the tRNA-modifying enzyme Elp3 in tuft cell differentiation and in the immune response in the intestine [Paper presentation]. Type 2 Immunity in Early Life Symposium, Liège, Belgium.

Petrellis, G., Rolot, M., Preure, A., Wathieu, C., Dougall, A., Chetty, A., CHARIOT, A., Hornsell, W., & Dewals, B. G. (09 May 2022). IL-4rα-dependent Lung Macrophage Responses To Helminths Increase Permissiveness To Gammaherpesvirus Infection [Paper presentation]. Type 2 Immunity in Early Life, Liège, Belgium.

Tang, S. C., Lion, Q., Peulen, O., Chariot, P., Lavergne, A., Mayer, A., Allepuz Fuster, P., Close, P., Klein, S., Florin, A., Büttner, R., Nemazanyy, I., Shostak, K., & Chariot, A. (29 January 2022). The E3 ligase COP1 promotes ERα signaling and suppresses EMT in breast cancer. Oncogene, 41, 173-190. doi:10.1038/s41388-021-02038-3
Peer Reviewed verified by ORBi

Petrellis, G., Rolot, M., Preure, A., Wathieu, C., Dougall, A., Chetty, A., Chariot, A., Hornsell, W., & Dewals, B. G. (30 November 2021). Il-4rα-dependent Lung Macrophage Response To Helminth Increases Permissiveness To Gammaherpesvirus Infection [Paper presentation]. Belgian Society of Parasitology & Protistology Annual scientific meeting, Antwerp, Belgium.

Petrellis, G., Rolot, M., Preure, A., Wathieu, C., Dougall, A., Chetty, A., Chariot, A., Horsnell, W., & Dewals, B. G. (November 2021). IL-4 receptor signaling regulates lung macrophages during helminth coinfection resulting in enhanced gammaherpesvirus permissiveness [Poster presentation]. Translational Immunology, Ghent, Belgium.

Jeschke, J., Collignon, E., Al Wardi, C., Krayem, M., Bizet, M., Jia, Y., Garaud, S., Wimana, Z., Calonne, E., Hassabi, B., Morandini, R., Deplus, R., Putmans, P., Dube, G., Singh, N. K., Koch, A., Shostak, K., Rizzotto, L., Ross, R. L., ... Fuks, F. (June 2021). Downregulation of the FTO m6A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors. Nature Cancer, 2 (6), 611-628. doi:10.1038/s43018-021-00223-7
Peer reviewed

Rapino, F.* , ZHOU, Z.* , RONCERO SANCHEZ, A. M.* , Joiret, M., Seca, C., El Hachem, N., Valenti, G., Latini, S., Shostak, K., Geris, L., Li, P., Huang, G., Mazzucchelli, G., Baiwir, D., Desmet, C., Chariot, A., Georges, M., & Close, P. (2021). Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate. Nature Communications, 12 (1), 2170. doi:10.1038/s41467-021-22254-5
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Rosu, A., El Hachem, N., Rapino, F., Rouault-Pierre, K., Jorssen, J., SOMJA, J., Ramery, E., Thiry, M., Nguyen, L., Jacquemyn, M., Daelemans, D., Adams, C. M., Bonnet, D., Chariot, A., Close, P., Bureau, F., & Desmet, C. (2021). Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis. Journal of Experimental Medicine, 218 (3). doi:10.1084/jem.20200662
Peer reviewed

Shostak, K., Wathieu, C., Tielens, S., & Chariot, A. (2021). NF-κB Signaling in Ex-Vivo Mouse Intestinal Organoids. Methods in Molecular Biology, 2366, 283-292. doi:10.1007/978-1-0716-1669-7_17
Peer reviewed

Even, A.* , Morelli, G.* , Turchetto, S.* , Shilian, M., Le Bail, R., Laguesse, S., Krusy, N., Brisker, A., Brandis, A., Inbar, S., Chariot, A., Saudou, F., Dietrich, P., Dragatsis, I., Brone, B., Broix, L., Rigo, J.-M., Weil, M., & Nguyen, L. (2021). ATP-citrate lyase promotes axonal transport across species. Nature Communications, 12 (1), 5878. doi:10.1038/s41467-021-25786-y
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Lemaitre, P., Bai, Q., Legrand, C., Chariot, A., Close, P., Bureau, F., & Desmet, C. (2021). Loss of the Transfer RNA Wobble Uridine-Modifying Enzyme Elp3 Delays T Cell Cycle Entry and Impairs T Follicular Helper Cell Responses through Deregulation of Atf4. Journal of immunology (Baltimore, Md. : 1950). doi:10.4049/jimmunol.2000521
Peer reviewed

Shostak, K., Jiang, Z., CHARLOTEAUX, B., Mayer, A., Habraken, Y., Tharun, L., Klein, S., Xu, X., Duong, H. Q., Vislovukh, A., Close, P., Florin, A., Rambow, F., Marine, J.-C., Büttner, R., & Chariot, A. (09 March 2020). The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage. Nature Communications, 11 (1). doi:10.1038/s41467-020-15003-7
Peer Reviewed verified by ORBi

Balthazart, J., Blanpain, C., Bureau, F., Cani, P., Chariot, A., Drion, P., Engel, V., Hanson, J., de Kerchove d'Exaerde, A., Malgrange, B., Muraille, E., Nguyen, L., Servais, O., Seutin, V., & Tissir, F. (2019). L’expérimentation animale : toujours une nécessité pour la santé animale et humaine. Le Soir.

DEROYER, C., CHARLIER, E., NEUVILLE, S., MALAISE, O., GILLET, P., KURTH, W., Chariot, A., MALAISE, M., & DE SENY, D. (2019). CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes. Cell Death and Disease. doi:10.1038/s41419-019-1377-8
Peer Reviewed verified by ORBi

Freeman, S.* , Mateo Sánchez, S.* , Pouyo, R., Van Lerberghe, P.-B., Hanon, K., Thelen, N., Thiry, M., Morelli, G., Van Hees, L., Laguesse, S., Chariot, A., Nguyen, L., Delacroix, L.* , & Malgrange, B.*. (2019). Proteostasis is essential during cochlear development for neuron survival and hair cell polarity. EMBO Reports, 20 (9). doi:10.15252/embr.201847097
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Wathieu, C., Tielens, S., Rolot, M., Shostak, K., Close, P., Dewals, B. G., & CHARIOT, A. (16 October 2018). A role for the tRNA-modifying enzyme Elp3 in tuft cell differentiation and in the immune response in the intestine [Poster presentation]. EMBO workshop From epigenomen towards epitranscriptome in cell fate choice, Capri, Italy.

Rapino, F., Delaunay, S., Rambow, F., Zhou, Z., Tharun, L., De Tullio, P., Sin, O., Shostak, K., Schmitz, S., Piepers, J., Guesquière, B., Karim, L., Charloteaux, B., Jamart, D., Florin, A., Lambert, C., RORIVE, A., JERUSALEM, G., Leucci, E., ... Close, P. (28 June 2018). Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature, 558, 605-609. doi:10.1038/s41586-018-0243-7
Peer Reviewed verified by ORBi

Duong, H. Q., Nemazanyy, I., Rambow, F., Tang, S. C., Delaunay, S., Tharun, L., Florin, A., Büttner, R., VAN DAELE, D., Close, P., Marine, J.-C., Shostak, K., & Chariot, A. (2018). The endosomal protein CEMIP links Wnt signaling to MEK1-ERK1/2 activation in Selumetinib-resistant intestinal organoids. Cancer Research, 10.1158/0008-5472.CAN-17-3149. doi:10.1158/0008-5472.CAN-17-3149
Peer Reviewed verified by ORBi

Laguesse, S., Huysseune, S., Boutin, C., Tielens, S., Franco, B., Mateo Sánchez, S., Delacroix, L., Boutin, P., Malgrange, B., CHARIOT, A., Goffinet, A., Tissir, F., Creppe, C., Seuntjens, E., & Nguyen, L. (13 June 2018). Loss of Elp3 induces postnatal hydrocephalus by inducing endoplasmic reticulum stress and dysregulation of Notch signaling [Poster presentation]. BSCDB spring meeting, Liege, Belgium.

Close, P., Debojit, B., Chariot, A., & Leidel, S. (2018). Dynamic regulation of tRNA modifications in Cancer. In Translational Epigenetics (édition revue et corrigée, pp. 163-186). Elsevier. doi:10.1016/B978-0-12-811022-5.00010-3
Peer reviewed

Bento-Abreu, A., Jager, G., Swinnen, B., Rué, L., Hendrickx, S., Jones, A., Staats, K. A., Taes, I., Eykens, C., Nonneman, A., Nuyts, R., Timmers, M., Silva, L., Chariot, A., Nguyen, L., Ravits, J., Lemmens, R., Cabooter, D., Van Den Bosch, L., ... Robberecht, W. (2018). Elongator subunit 3 (ELP3) modifies ALS through tRNA modification. Human Molecular Genetics, 27 (7), 1276-1289. doi:10.1093/hmg/ddy043
Peer Reviewed verified by ORBi

Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique.

Boerboom, A., Reusch, C., Pieltain, A., Chariot, A., & Franzen, R. (October 2017). KIAA1199: a novel regulator of MEK/ERK-induced Schwann cell dedifferentiation. Glia, 65 (10), 1682-1696. doi:10.1002/glia.23188
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Boerboom, A., Dion, V., CHARIOT, A., & Franzen, R. (2017). Molecular Mechanisms Involved in Schwann Cell Plasticity. Frontiers in Molecular Neuroscience. doi:10.3389/fnmol.2017.00038
Peer Reviewed verified by ORBi

Rapino, F., Zhou, Z., Delaunay, S., Chariot, A., & Close, P. (2017). tRNA modification: is cancer having a wobble? Trends in Cancer, 3, 249-252. doi:10.1016/j.trecan.2017.02.004
Peer Reviewed verified by ORBi

Laguesse, S., Close, P., Van Hees, L., Chariot, A., Malgrange, B., & Nguyen, L. (2017). Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex. Frontiers in Cellular Neuroscience, 11, 122. doi:10.3389/fncel.2017.00122
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Delaunay, S., Rapino, F., Tharun, L., Zhou, Z., Heukamp, L., Termathe, M., Shostak, K., Klevernic, I., Florin, A., Desmecht, H., Desmet, C., Nguyen, L., Leiden, S. A., Willis, A. E., Buettner, R., Chariot, A., & Close, P. (October 2016). ELP3 links tRNA modification to IRES-dependent translation of LEF-1 to promote metastasis in breast cancer. Journal of Experimental Medicine, 213, 2503-2523. doi:10.1084/jem.20160397
Peer Reviewed verified by ORBi

Tielens, S., Huysseune, S., Godin, J., CHARIOT, A., Malgrange, B., & Nguyen, L. (12 May 2016). Elongator controls cortical interneuron migration by regulating actomyosin dynamics [Poster presentation]. ISDN, France.

Delaunay, S., Rapino, F., Tharun, L., Zhou, Z., Heukamp, L., Termathe, M., Shostak, K., Klevernic, I., Florin, A., Desmecht, H., Nguyen, L., Leidel, S., Willis, A., Chariot, A., & Close, P. (May 2016). tRNA modification: Elogator sustains Breast cancer metastasis [Paper presentation]. Invitation pour une présentation au Stem Cell Institute - Cambridge University, Cambridge, United Kingdom.

Boerboom, A., Dion, V., Pieltain, A., Shostak, K., Chariot, A., & Franzen, R. (May 2016). KIAA1199 links ErbB signalling to Schwann cell development and plasticity [Poster presentation]. Gordon seminar + conference Myelin.

Mateo Sanchez, S., Delacroix, L., Freeman, S., Laguesse, S., Huysseune, S., Delrez, S., Chariot, A., Nguyen, L., & Malgrange, B. (25 January 2016). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-Day.

Delaunay, S., Rapino, F., Zhou, Z., Shostak, K., LADANG, A., Chariot, A., & Close, P. (25 January 2016). tRNA modification: Elogator promotes metastasis in breast cancer [Paper presentation]. GIGA-DAY 2016, Liège, Belgium.

Dion, V., Boerboom, A., Pieltain, A., Chariot, A., & Franzen, R. (2016). Remyelination in the adult central nervous system: A possible role for Elongator [Poster presentation]. Gordon Research Conferences - Myelin.

Göktuna, S., Shostak, K., Chau, T.-L., Heukamp, L., Hennuy, B., Duong, H. Q., LADANG, A., Close, P., Klevernic, I., Olivier, F., Florin, A., Ehx, G., Baron, F., Vandereyken, M., Rahmouni, S., Vereecke, L., van Loo, G., Büttner, R., Greten, F., & Chariot, A. (2016). The Prosurvival IKK-Related Kinase IKK« Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine. Cancer Research, 76, 2587-99. doi:10.1158/0008-5472.CAN-15-1473
Peer Reviewed verified by ORBi

Tielens, S.* , Huysseune, S.* , Godin, J. D., Chariot, A., Malgrange, B., & Nguyen, L. (2016). Elongator controls cortical interneuron migration by regulating actomyosin dynamics. Cell Research. doi:10.1038/cr.2016.112
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Mateo Sanchez, S., Delacroix, L., Freeman, S., Laguesse, S., Huysseune, S., Delrez, S., Chariot, A., Nguyen, L., & Malgrange, B. (23 November 2015). UNRAVELLING THE ROLES OF LYSINE ACETYLATION BY ELP3 DURING INNER EAR DEVELOPMENT [Poster presentation]. Belgian Society for Cell and Developmental Biology (BSCDB).

LADANG, A.* , Rapino, F.* , Heukamp, L., Tharun, L., Shostak, K., Hermand, D., Delaunay, S., Klevernic, I., Jiang, Z., Jacques, N., Jamart, D., Migeot, V., Florin, A., Göktuna, S., Malgrange, B., Samson, O., Nguyen, L., Buettner, R., Close, P., & Chariot, A. (16 November 2015). Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. Journal of Experimental Medicine, 212 (12), 2057-75. doi:10.1084/jem.20142288
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Czajkowski, A., Chariot, A., Delacroix, L., & Malgrange, B. (November 2015). Unravelling Cemip expression and functions in the auditory portion of the inner ear [Poster presentation]. BSCDB - BELGIAN SOCIETY FOR CELL AND DEVELOPMENTAL BIOLOGY.

Mateo Sanchez, S., Delacroix, L., Freeman, S., Laguesse, S., Huysseune, S., Delrez, S., Chariot, A., Nguyen, L., & Malgrange, B. (06 June 2015). UNRAVELLING THE ROLES OF LYSINE ACETYLATION BY ELP3 DURING INNER EAR DEVELOPMENT [Poster presentation]. Belgian Society for Cell and Developmental Biology (BSCDB).

Shostak, K., & Chariot, A. (June 2015). EGFR and NF-kB: partners in cancer. Trends in Molecular Medicine, 21, 385-393. doi:10.1016/j.molmed.2015.04.001
Peer Reviewed verified by ORBi

Czajkowski, A., Chariot, A. (Other coll.), Delacroix, L. (Other coll.), & Malgrange, B. (Other coll.). (29 May 2015). Unravelling Cemip expression and functions in the auditory portion of the inner ear [Poster presentation]. BSCDB - BELGIAN SOCIETY FOR CELL AND DEVELOPMENTAL BIOLOGY.

Czajkowski, A., Chariot, A., Delacroix, L., & Malgrange, B. (22 May 2015). Unravelling Cemip expression and functions in the auditory portion of the inner ear [Poster presentation]. 11th meeting of the Belgian Neuroscience Society, Mons, Belgium.

Boerboom, A., Dion, V., Pieltain, A., Chariot, A., & Franzen, R. (May 2015). KIAA1199 is involved in Schwann cell survival and differentiation [Poster presentation]. Belgian Society for Neuroscience 2015.

Delaunay, S., Rapino, F., Zhou, Z., LADANG, A., Shostak, K., Chariot, A., & Close, P. (09 March 2015). Elongator: mcm5s2 modification fosters breast cancer metastasis [Paper presentation]. MRC toxicology meeting, Leicester, United Kingdom.

Delaunay, S., Rapino, F., Heukamp, L., LADANG, A., Jiang, Z., Nguyen, L., Buettner, R., Chariot, A., & Close, P. (March 2015). Elongator promotes breast cancer metastasis [Poster presentation]. EMBO meeting, Frontiers in stem cells, Heidelberg, Germany.

Mateo Sanchez, S., Delacroix, L., Freeman, S., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (27 January 2015). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-Day.

Lamour, V., Henry, A., Kroonen, J., Nokin, M.-J., von Marschall, Z., Fisher, L., Chau, T.-L., Chariot, A., Sanson, M., Delattre, J.-Y., Turtoi, A., Peulen, O., Rogister, B., Castronovo, V., & Bellahcene, A. (2015). Targeting osteopontin suppresses glioblastoma stem-like cell character and tumorigenicity in vivo. International Journal of Cancer. doi:10.1002/ijc.29454
Peer Reviewed verified by ORBi

Creppe, C., Laguesse, S., Nedialkova, D., Prevot, P.-P., Borgs, L., Huysseune, S., Franco, B., Duysens, G., Kruzy, N., Lee, G., Thelen, N., Thiry, M., Close, P., Chariot, A., Leidel, S., Godin, J., & Nguyen, L. (2015). A dynamic Unfolded Protein Response controls cortical neurogenesis [Poster presentation]. FENS Featured Regional Meeting 2015, Thessaloniki, Greece.

Laguesse, S.* , Creppe, C.* , Nedialkova, D., Prevot, P.-P., Borgs, L., Huysseune, S., Franco, B., Duysens, G., Krusy, N., Lee, G., Thelen, N., Thiry, M., Close, P., Chariot, A., Malgrange, B., Leidel, S., Godin, J., & Nguyen, L. (2015). A dynamic unfolded protein response contributes to the control of cortical neurogenesis. Developmental Cell, 35, 553-567. doi:10.1016/j.devcel.2015.11.005
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Dion, V., Boerboom, A., Pieltain, A., Chariot, A., & Franzen, R. (2015). Role of Elongator in central nervous system remyelination [Poster presentation]. Belgian Society for Neuroscience 2015.

Chau, T.-L., Göktuna, S., Rammal, A., Casanova Bustos, T. R., Duong, H. Q., GATOT, J.-S., Close, P., Dejardin, E., Desmecht, D., Shostak, K., & Chariot, A. (2015). A role for APPL1 in tlr3/4-dependent TBK1 and IKKε activation in macrophages. Journal of Immunology. doi:10.4049/jimmunol.1401614
Peer Reviewed verified by ORBi

Creppe, C., Laguesse, S., Nedialkova, D., Prevot, P.-P., Borgs, L., Huysseune, S., Franco, B., Duysens, G., Krusy, N., Lee, G., Thelen, N., Thiry, M., Close, P., CHARIOT, A., Malgrange, B., Leidel, S., Godin, J., & Nguyen, L. (2015). A dynamic Unfolded Protein Response controls cortical neurogenesis [Poster presentation]. BSCDB meeting "Neural stem cells and cortical development", Liege, Belgium.

Tielens, S., Huysseune, S., Malgrange, B., CHARIOT, A., Godin, J., & Nguyen, L. (08 July 2014). Deciphering the role of Elp3 in interneuron migration in cortical development [Poster presentation]. FENS, Milano, Italy.

Delaunay, S., Heukamp, L., Zhou, Z., Shostak, K., LADANG, A., Jiang, Z., Nguyen, L., Chariot, A., & Close, P. (08 May 2014). Elongator drives breast cancer initiation and metastasis formation [Poster presentation]. ENBDC meeting 2014, Weggis, Switzerland.

Shostak, K.* , Patrascu, F.* , Göktuna, S., Close, P., Borgs, L., Nguyen, L., Olivier, F., Rammal, A., Brinkhaus, H., Bentires-Alj, M., Marine, J.-C., & Chariot, A. (May 2014). MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation. Cell Death and Differentiation, 5 (21), 811-24. doi:10.1038/cdd.2014.2
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Volvert, M.-L., Prevot, P.-P., Close, P., Laguesse, S., Pirotte, S., Hemphill, J., Rogister, F., Krusy, N., SACHELI, R., MOONEN, G., Deiters, A., Merkenschlager, M., CHARIOT, A., Malgrange, B., Godin, J., & Nguyen, L. (May 2014). MicroRNA Targeting of CoREST controls polarization of migrating cortical neurons. Cell Reports, 7 (4), 1168-83. doi:10.1016/j.celrep.2014.03.075
Peer Reviewed verified by ORBi

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (27 January 2014). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Paper presentation]. GIGA-Day.

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (2014). Unravelling the roles of lysine acetyl-transferase activity of Elongator complex during inner ear development [Paper presentation]. Inner Ear Biology meeting (IEB).

Shostak, K., Zhang, X., Hubert, P., Göktuna, S., Jiang, Z., Klevernic, I., Hildebrand, J., Roncarati, P., Hennuy, B., Ladang, A., SOMJA, J., Gothot, A., Close, P., Delvenne, P., & Chariot, A. (2014). NF-kappaB-induced KIAA1199 promotes survival through EGFR signalling. Nature Communications, 5, 5232. doi:10.1038/ncomms6232
Peer Reviewed verified by ORBi

Göktuna, S., Canli, O., Bollrath, J., Fingerle, A. A., Horst, D., Diamanti, M. A., Pallangyo, C., Bennecke, M., Nebelsiek, T., Mankan, A. K., Lang, R., Artis, D., Hu, Y., Patzelt, T., Ruland, J., Kirchner, T., Taketo, M. M., Chariot, A., Arkan, M. C., & Greten, F. R. (2014). IKKalpha promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells. Cell Reports, 7 (6), 1914-25. doi:10.1016/j.celrep.2014.05.006
Peer Reviewed verified by ORBi

Stellzig, J., Chariot, A., Shostak, K., Göktuna, S., Renner, F., Acker, T., Pagenstecher, A., & Schmitz, M. (11 November 2013). Deregulated expression of TANK in glioblastomas triggers pro-tumorigenic ERK1/2 and AKT signaling pathways. Observatoire (L'), e79. doi:10.1038/oncsis.2013.42
Peer reviewed

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (18 October 2013). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. Belgian Society for Cell and Developmental Biology (BSCDB).

Ladang, A., Heukamp, L., Buettner, R., Jiang, Z., Jamart, D., Close, P., & Chariot, A. (18 September 2013). Elp3 is required for initiation of colon cancer [Poster presentation]. Experimental models of human diseases.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (June 2013). p27(Kip1) as a master regulator of cortical neuron migration [Paper presentation]. EMBO fellow meeting.

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (31 May 2013). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. BSN Congress.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., MOONEN, G., Malgrange, B., Chariot, A., Métin, C., Besson, A., & Nguyen, L. (March 2013). p27(Kip1) as a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration [Paper presentation]. Microtubule cytoskeleton in development and disease conference.

Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (28 January 2013). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-DAY.

Delacroix, L., Mateo Sanchez, S., Nguyen, L., Chariot, A., & Malgrange, B. (2013). Unravelling the role of lysine acetylation by Elongator complex during inner ear development [Poster presentation]. Molecular Biology of Hearing and Deafness Conference, San Francisco, United States - California.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2013). p27(Kip1) as a master regulator of cortical neuron migration [Poster presentation]. annual meeting of the american society for cell biology.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2013). p27 Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration [Poster presentation]. annual meeting of the belgium society for neuroscience.

Boerboom, A., Chaballe, L., Close, P., Schoenen, J., Chariot, A., & Franzen, R. (October 2012). Acetylation and Wallerian degeneration [Poster presentation]. Belgian Brain Congress 2012.

Close, P., Gillard, M., Ladang, A., Jiang, Z., Papuga, J., Hawkes, N., Nguyen, L., CHAPELLE, J.-P., Bouillenne, F., Svejstrup, J., Fillet, M., & Chariot, A. (2012). DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. Journal of Biological Chemistry. doi:10.1074/jbc.M112.402727
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Mateo Sanchez, S., Delacroix, L., Laguesse, S., Huysseune, S., Chariot, A., Nguyen, L., & Malgrange, B. (04 May 2012). Unravelling the roles of lysine acetylation by Elp3 during inner ear development [Poster presentation]. GIGA-DAY.

Close, P., East, P., Svejstrup, B., Hartmann, H., Heron, M., Maslen, S., Chariot, A., Söding, J., Skehel, M., & Svejstrup, J. (2012). DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Nature. doi:10.1038/nature10925
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Ortis, F., Miani, M., Colli, M., Cunha, D., Gurzov, E., Allagnat, F., Chariot, A., & Eizirik, D. L. (05 April 2012). Differential usage of NF-kB activating signals by IL-1b and TNF-a in pancreatic beta cells. FEBS Letters, 586, 984-989.
Peer Reviewed verified by ORBi

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2012). p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration [Poster presentation]. Federation of European Neuroscience Societies (FENS).

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2012). p27(Kip1) as a master regulator of cortical neuron migration [Poster presentation]. EMBO Workshop on Cortical interneurons in health and disease.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2012). p27(Kip1) as a master regulator of cortical neuron migration [Poster presentation]. EMBO Conference Series Microtubules Structure, Regulation and Functions.

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (2012). Cortical interneurons tangential migration : p27(Kip1) as a novel master regulator [Poster presentation]. Cortical development conference.

Godin, J.* , Thomas, N.* , Laguesse, S.* , Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Chariot, A., Metin, C., Besson, A., & Nguyen, L. (2012). p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration. Developmental Cell, 23 (4), 729-44. doi:10.1016/j.devcel.2012.08.006
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* These authors have contributed equally to this work.

Ganeff, C., Remouchamps, C., Boutaffala, L., Benezech, C., Galopin, G., Vandepaer, S., Bouillenne, F., Ormenese, S., Chariot, A., Schneider, P., Caamano, J., Piette, J., & Dejardin, E. (30 November 2011). Induction of the Alternative NF-{kappa}B Pathway by Lymphotoxin {alpha}{beta} (LT{alpha}{beta}) Relies on Internalization of LT{beta} Receptor. Molecular and Cellular Biology, 21, 4319-4334. doi:10.1128/MCB.05033-11
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Shostak, K., & Chariot, A. (26 July 2011). NF-kB, stem cells and breast cancer: the links get stronger. Breast Cancer Research, 13 (4), 214. doi:10.1186/bcr2886
Peer Reviewed verified by ORBi

Godin, J., Thomas, N., Laguesse, S., Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Métin, C., Chariot, A., & Nguyen, L. (June 2011). p27(Kip1) as a master regulator of cortical neuron migration [Paper presentation]. cancéropole - Toulouse - France.

Close, P., Gillard, M., Ladang, A., Jiang, Z., Fillet, M., & Chariot, A. (12 March 2011). DERP6 and C3orf75 regulate the invasive potential of melanoma cells as subunits of the elongator complex [Poster presentation]. Stem Cells, Cancer and Metastasis, United States.

Chaballe, L., Close, P., SEMPELS, M., DELSTANCHE, S., FANIELLE, J., Moons, L., Carmeliet, P., Schoenen, J., Chariot, A., & Franzen, R. (March 2011). Involvement of placental growth factor in Wallerian degeneration. Glia, 59 (3), 379-396. doi:10.1002/glia.21108
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Chaballe, L., Close, P., Sempels, M., Delstanche, S., Fanielle, J., Moons, L., Carmeliet, P., Schoenen, J., Chariot, A., & Franzen, R. (September 2010). Involvement of Placental growth factor in Wallerian degeneration [Poster presentation]. Belgian Brain Congress, Bruxelles, Belgium.

Keutgens, A., Shostak, K., Close, P., Zhang-Shao, X., Hennuy, B., Aussems, M., Chapelle, J.-P., Viatour, P., Gothot, A., Fillet, M., & Chariot, A. (August 2010). The repressing function of the oncoprotein BCL-3 requires CtBP while its polyubiquitination and degradation involve the E3 ligase TBLR1. Molecular and Cellular Biology, 30, 4006-4021. doi:10.1128/MCB.01600-09
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Close, P., Creppe, C., Gillard, M., LADANG, A., Chapelle, J.-P., Nguyen, L., & Chariot, A. (April 2010). The emerging role of lysine acetylation of non-nuclear proteins. Cellular and Molecular Life Sciences, 67 (8), 1255-1264. doi:10.1007/s00018-009-0252-7
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creppe, C., malinouskaya, L., Volvert, M.-L., Close, P., Laguesse, S., Gillard, M., Chariot, A., & Nguyen, L. (2010). Elongator orchestrates cerebral cortical neurogenesis. MS. Medecine Sciences. doi:10.1051/medsci/2010262135

Heng, J., Chariot, A., & Nguyen, L. (2010). Molecular Layers underlying cytoskeletal remodelling during cortical development. Trends in Neurosciences, 33, 38-47. doi:10.1016/j.tins.2009.09.003
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Keutgens, A., Zhang-Shao, X., Shostak, K., Robert, I., Olivier, S., Vanderplasschen, A., Chapelle, J.-P., Viatour, P., Merville, M.-P., Bex, F., Gothot, A., & Chariot, A. (2010). BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1. Journal of Biological Chemistry, 285 (33), 25831–25840. doi:10.1074/jbc.M110.112128
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Ganeff, C., Galopin, G., Remouchamps, C., Benezech, C., Boutaffala, L., de trez, C., Bouillenne, F., Ormenese, S., CHARIOT, A., Norris, P., Ware, C., Schneider, P., Caamano, J., Piette, J., & Dejardin, E. (January 2010). TNFL–Induced p100 processing (TIPP) relies on the internalization of the cognate TNFR [Paper presentation]. Inflammation 2010, Luxembourg, Luxembourg.

Nguyen, L., Humbert, S., Saudou, F., & Chariot, A. (January 2010). Elongator - an emerging role in neurological disorders. Trends in Molecular Medicine, 16, 1-6. doi:10.1016/j.molmed.2009.11.002
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Charlier, E., Condé, C., Zhang, J., Deneubourg, L., Di Valentin, E., Rahmouni, S., Chariot, A., Agostinis, P., Pang, P.-C., Haslam, S., Dell, A., Penninger, J., Erneux, C., Piette, J., & Gloire, G. (2010). SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity. Leukemia. doi:10.1038/leu.2010.9
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Chariot, A. (August 2009). The NF-κ B-independent functions of IKK subunits in immunity and cancer. Trends in Cell Biology, 19, 404-413. doi:10.1016/j.tcb.2009.05.006
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Robert, I., Aussems, M., Keutgens, A., Zhang-Shao, X., Hennuy, B., Viatour, P., Vanstraelen, G., Merville, M.-P., Chapelle, J.-P., de Leval, L., LAMBERT, F., Dejardin, E., Gothot, A., & Chariot, A. (02 April 2009). Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-κB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes. Oncogene, 28 (13), 1626-1638. doi:10.1038/onc.2009.6
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Creppe, C., Malinouskaya, L., Volvert, M.-L., Gillard, M., Close, P., Malaise, O., Laguesse, S., Cornez, I., Rahmouni, S., Ormenese, S., Belachew, S., Malgrange, B., Chapelle, J.-P., Siebenlist, U., Moonen, G., Chariot, A., & Nguyen, L. (06 February 2009). Elongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin. Cell, 136, 551-564. doi:10.1016/j.cell.2008.11.043
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Claudio, E., Sonder, S. U., Saret, S., Carvalho, G., Ramalingam, T. R., Wynn, T. A., Chariot, A., Garcia-Perganeda, A., Leonardi, A., Paun, A., Chen, A., Ren, N. Y., Wang, H., & Siebenlist, U. (2009). The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. Journal of Immunology, 182, 1617-1639. doi:10.4049/jimmunol.182.3.1617
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Ortis, F., Pirot, P., Naamane, N., Kreins, A. Y., Rasschaert, J., Moore, F., Theatre, E., Verhaeghe, C., Magnusson, N. E., Chariot, A., Orntoft, T. F., & Eizirik, D. L. (July 2008). Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia, 51, 1213-1225. doi:10.1007/s00125-008-0999-7
Peer Reviewed verified by ORBi

Cornez, I., Creppe, C., Gillard, M., Hennuy, B., Chapelle, J.-P., Dejardin, E., Merville, M.-P., Close, P., & Chariot, A. (June 2008). Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells. Biochemical Pharmacology, 75, 2122-2134. doi:10.1016/j.bcp.2008.03.006
Peer Reviewed verified by ORBi

Verstrepen, L., Bekaert, T., Chau, T.-L., Tavernier, J., Chariot, A., & Beyaert, R. (2008). TLR-4, IL-1R and TNF-R signaling to NF-kB: variations on a common theme. Cellular and Molecular Life Sciences, 65, 2964-2978. doi:10.1007/s00018-008-8064-8
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Jonville, M., Kodja, H., Humeau, L., Fournel, J., Chariot, A., De Mol, P., Cao, M.-C., Angenot, L., & Frederich, M. (2008). Evaluation of medicinal plants from Reunion Island for antimalarial and cytotoxic activities. Planta Medica, 74 (9), 1002-1002.
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Chau, T.-L., Gioia, R., GATOT, J.-S., Patrascu, F. A., Carpentier, I., Chapelle, J.-P., O'Neill, L., Beyaert, R., Piette, J., & Chariot, A. (2008). Are the IKKs and IKK-related kinases TBK1 and IKK-ε similarly activated ? Trends in Biochemical Sciences, 33, 171-180. doi:10.1016/j.tibs.2008.01.002
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Gioia, R., GATOT, J.-S., Chau, T.-L., Warnier, M., Chapelle, J.-P., Piette, J., Dejardin, E., & Chariot, A. (December 2007). Insight into the TBK1/IKK-dependent signalling pathways required in innate immunity through identification of the TANK/I-TRAF interactome [Poster presentation]. Journée Télévie, ULB GOsselies, Belgium.

GATOT, J.-S., Gioia, R., Chau, T.-L., Patrascu, F. A., Warnier, M., Close, P., Chapelle, J.-P., Muraille, E., Brown, K., Siebenlist, U., Piette, J., Dejardin, E., & Chariot, A. (26 October 2007). Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKK epsilon-dependent lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. Journal of Biological Chemistry, 282 (43), 31131-31146. doi:10.1074/jbc.M701690200
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Lambert, C., Oury, C., Dejardin, E., Chariot, A., Piette, J., Malaise, M., Merville, M.-P., & Franchimont, N. (September 2007). Further insights in the mechanisms of interleukin-1beta stimulation of osteoprotegerin in osteoblast-like cells. Journal of Bone and Mineral Research, 22 (9), 1350-1361. doi:10.1359/jbmr.070508
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Gloire, G., Horion, J., El Mjiyad, N., Bex, F., Chariot, A., Dejardin, E., & Piette, J. (20 July 2007). Promoter-dependent effect of IKK alpha on NF-kappa B/p65 DNA binding. Journal of Biological Chemistry, 282 (29), 21308-21318. doi:10.1074/jbc.M610728200
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Lambert, F., Heimann, P., Herens, C., Chariot, A., & Bours, V. (July 2007). Consultations in molecular diagnostics - A case of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia with a rare FIP1L1 breakpoint. Journal of Molecular Diagnostics, 9 (3), 414-419. doi:10.2353/jmoldx.2007.060196
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Jokhadze, M., Eristavi, L., Kutchukhidze, J., Chariot, A., Angenot, L., Tits, M., Jansen, O., & Frederich, M. (July 2007). In vitro cytotoxicity of some medicinal plants from Georgian amaryllidaceae. Phytotherapy Research, 21 (7), 622-624. doi:10.1002/ptr.2130
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Verhaeghe, C., Remouchamps, C., Hennuy, B., Vanderplasschen, A., Chariot, A., Tabruyn, S. P., Oury, C., & Bours, V. (15 June 2007). Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways. Biochemical Pharmacology, 73 (12), 1982-1994. doi:10.1016/j.bcp.2007.03.019
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Creppe, C., Close, P., Cornez, I., Rahmouni, S., Merville, M.-P., Chapelle, J.-P., Nusgens, C., Deroanne, C., & Chariot, A. (March 2007). A role for the transcriptional complex elongator in cell migration and spreading [Poster presentation]. Colloque "Chromatin Dynamics and Epigenetics" Société belge de biologie cellulaire et du développement, Liège, Belgium.

GATOT, J.-S., Gioia, R., Chau, T.-L., Warnier, M., Chapelle, J.-P., Merville, M.-P., Brown, K., Siebenlist, U., Muraille, E., Dejardin, E., Piette, J., & Chariot, A. (March 2007). Polyubiquitination of the scaffold protein tank/I-traf: implications for the TLR-mediated signalling pathways [Poster presentation]. Colloque "Chromatin Dynamics and Epigenetics" Société belge de biologie cellulaire et du développement, Liège, Belgium.

Chariot, A. (30 October 2006). 20 years of NF-kappa B. Biochemical Pharmacology, 72 (9), 1051-1053. doi:10.1016/j.bcp.2006.08.023

Keutgens, A., Robert, I., Viatour, P., & Chariot, A. (30 October 2006). Deregulated NF-kappa B activity in haematological malignancies. Biochemical Pharmacology, 72 (9), 1069-1080. doi:10.1016/j.bcp.2006.06.011
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Benoit, V., de Moraes, E., Dar, N. A., Taranchon, E., Bours, V., Hautefeuille, A., Taniere, P., Chariot, A., Scoazec, J. Y., Gallo, C. V. D., Merville, M.-P., & Hainaut, P. (21 September 2006). Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. Oncogene, 25 (42), 5708-5718. doi:10.1038/sj.onc.1209579
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Close, P., Hawkes, N., Cornez, I., Creppe, C., Lambert, C. A., Rogister, B., Siebenlist, U., Merville, M.-P., Slaugenhaupt, S. A., Bours, V., Svejstrup, J. Q., & Chariot, A. (May 2006). Transcription impairment and cell migration defects in elongator-depleted cells: Implication for familial dysautonomia. Molecular Cell, 22 (4), 521-531. doi:10.1016/j.molcel.2006.04.017
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Olivier, S., Close, P., Castermans, E., de Leval, L., Tabruyn, S., Chariot, A., Malaise, M., Merville, M.-P., Bours, V., & Franchimont, N. (May 2006). Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature. Molecular Pharmacology, 69 (5), 1615-1623. doi:10.1124/mol.105.020479
Peer Reviewed verified by ORBi

Jansen, O., Akhmedjanova, V., Angenot, L., Balansard, G., Chariot, A., Ollivier, E., Tits, M., & Frederich, M. (21 April 2006). Screening of 14 alkaloids isolated from Haplophyllum A. Juss. for their cytotoxic properties. Journal of Ethnopharmacology, 105 (1-2), 241-245. doi:10.1016/j.jep.2005.11.001
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Chariot, A., Hawkes, N., Cornez, I., Creppe, C., Lambert, C., Rogister, B., Siebenlist, U., Merville, M., Slaugenhaupt, S., Bours, V., Svejstrup, J., & Close, P. (23 March 2006). News from a lost friend: IKAP depletion causes defective transcript elongation of genes involved in cell migration throught NFkB-independent meachanisms: implications for familial dysautonomia [Poster presentation]. Keystone Symposia, Banff, Alberta, Canada.

Gloire, G., Charlier, E., Rahmouni, S., Volanti, C., Chariot, A., Erneux, C., & Piette, J. (2006). Restoration of SHIP-1 activity in human leukemic cells modifies NF-kappaB activation pathway and cellular survival upon oxidative stress. Oncogene, 25 (40), 5485-94. doi:10.1038/sj.onc.1209542
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Lambert, F., Schioppa, A., Castermans, S., Lopez, M.-J., Chariot, A., & Bours, V. (2006). Accurate genotyping of the V617F janus kinase (JAK) 2 mutation combining ARMS PCR and capillary electrophoresis. Acta Clinica Belgica, 61 (2, MAR-APR), 108.
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Robe, P., Martin, D., Albert, A., Deprez, M., Chariot, A., & Bours, V. (2006). A phase 1-2, prospective, double blind, randomized study of the safety and efficacy of Sulfasalazine for the treatment of progressing malignant gliomas: study protocol of [ISRCTN45828668]. BMC Cancer, 6, 29. doi:10.1186/1471-2407-6-29
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Bonif, M., Meuwis, M.-A., Close, P., Benoit, V., Heyninck, K., Chapelle, J.-P., Bours, V., Merville, M.-P., Piette, J., Beyaert, R., & Chariot, A. (2006). TNFa and IKKb-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKg and NF-kB activation. Biochemical Journal, 394, 593-603. doi:10.1042/BJ20051659
Peer Reviewed verified by ORBi

Close, P., Hawkes, N., Cornez, I., Creppe, C., Lambert, C., Rogister, B., Siebenlist, U., Merville, M., Slaugnhaupt, S., Bours, V., Svejstrup, J., & Chariot, A. (15 November 2005). Elongator depletion causes defective transcript elongation of genes that regulate cell motility [Poster presentation]. Chromatin structure and function, Nassau, Bahamas.

Olivier, S., Close, P., Castermans, E., de Leval, L., Tabruyn, S., Chariot, A., Malaise, M., Merville, M.-P., Bours, V., & Franchimont, N. (September 2005). SERMs-induced myeloma cell apoptosis: A study of NF-kappa B inhibition and gene expression signature. Journal of Bone and Mineral Research, 20 (9, Suppl. 1), 213.

Lechanteur, C., Jacobs, N., Greimers, R., Benoit, V., Deregowski, V., Chariot, A., Merville, M.-P., & Bours, V. (03 March 2005). Low daunomycin concentrations protect colorectal cancer cells from hypoxia-induced apoptosis. Oncogene, 24 (10), 1788-1793. doi:10.1038/sj.onc.1208436
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Franchimont, N., Lambert, C., Huynen, P., Ribbens, C., Relic, B., Chariot, A., Bours, V., Piette, J., Merville, M.-P., & Malaise, M. (2005). Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells. Arthritis and Rheumatism, 52 (1), 84-93. doi:10.1002/art.20727
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Viatour, P., Merville, M.-P., Bours, V., & Chariot, A. (January 2005). Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation [letter to the editor]. Trends in Biochemical Sciences, 30 (1), 43-52. doi:10.1016/j.tibs.2004.11.009
Peer Reviewed verified by ORBi

Viatour, P., Merville, M.-P., Bours, V., & Chariot, A. (December 2004). Protein phosphorylation as a key mechanism for the regulation of BCL-3 activity. Cell Cycle, 3 (12), 1498-1501. doi:10.4161/cc.3.12.1328
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Viatour, P., Dejardin, E., Warnier, M., Lair, F., Claudio, E., Bureau, F., Marine, J. C., Merville, M.-P., Maurer, U., Green, D., Piette, J., Siebenlist, U., Bours, V., & Chariot, A. (08 October 2004). GSK3-Mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity. Molecular Cell, 16 (1), 35-45. doi:10.1016/j.molcel.2004.09.004
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Adam, E., Quivy, V., Bex, F., Chariot, A., Collette, Y., Vanhulle, C., Haterte, S., Goffin, V., Nguyen, T. L.-A., Gloire, G., Carrard, G., Friguet, B., de Launoit, Y., Burny, A., Bours, V., Piette, J., & Van Lint, C. (August 2004). Erratum: Potentiation of tumor necrosis factor-induced NF-κb activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of IκBα (Molecular and Cellular Biology (2003) 23, 17 (6200-6209)). Molecular and Cellular Biology, 24 (15), 6890. doi:10.1128/MCB.24.15.6890.2004

Benoit, V., Relic, B., de Leval, L., Chariot, A., Merville, M.-P., & Bours, V. (February 2004). Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2. Oncogene, 23 (8), 1631-1635. doi:10.1038/sj.onc.1207295
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Benoit, V., Chariot, A., Delacroix, L., Deregowski, V., Jacobs, N., Merville, M.-P., & Bours, V. (2004). Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappa B through c-FLIP-L expression. Cancer Research, 64 (8), 2684-2691. doi:10.1158/0008-5472.CAN-03-2914
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Viatour, P., Legrand-Poels, S., van Lint, C., Warnier, M., Merville, M.-P., Gielen, J.-L., Piette, J., Bours, V., & Chariot, A. (21 November 2003). Cytoplasmic I kappa B alpha increases NF-kappa B-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3. Journal of Biological Chemistry, 278 (47), 46541-46548. doi:10.1074/jbc.M306381200
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Mauro, C., Vito, P., Mellone, S., Pacifico, F., Chariot, A., Formisano, S., & Leonardi, A. (12 September 2003). Role of the adaptor protein CIKS in the activation of the IKK complex. Biochemical and Biophysical Research Communications, 309 (1), 84-90. doi:10.1016/S0006-291X(03)01532-8
Peer reviewed

Adam, E., Quivy, V., Bex, F., Chariot, A., Collette, Y., Vanhulle, C., Haterte, S., Goffin, V., Nguyen, T. L.-A., Gloire, G., Carrard, G., Friguet, B., de Launoit, Y., Burny, A., Bours, V., Piette, J., & Van Lint, C. (September 2003). Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. Molecular and Cellular Biology, 23 (17), 6200-6209. doi:10.1128/MCB.23.17.6200-6209.2003
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Viatour, P., Bentires-Alj, M., Chariot, A., Deregowski, V., de Leval, L., Merville, M.-P., & Bours, V. (July 2003). NF-kappa B2/p100 induces Bcl-2 expression. Leukemia, 17 (7), 1349-1356. doi:10.1038/sj.leu.2402982
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Chariot, A., Meuwis, M.-A., Bonif, M., Leonardi, A., Merville, M.-P., Gielen, J.-L., Piette, J., Siebenlist, U., & Bours, V. (April 2003). NF-kappa B activating scaffold proteins as signaling molecules and putative therapeutic targets. Current Medicinal Chemistry, 10 (7), 593-602. doi:10.2174/0929867033457926
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Viatour, P., Legrand-Poels, S., Van Lint, C., Warnier, M., Merville, M.-P., Gielen, J., Piette, J., BOURS, V., & Chariot, A. (2003). Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histones deacetylases (HDAC1 and HDAC3). Journal of Biological Chemistry.
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Bentires-Alj, M., Barbu, V., Fillet, M., Chariot, A., Relic, B., Jacobs, N., Gielen, J., Merville, M.-P., & Bours, V. (2003). NF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene, 22, 90-97. doi:10.1038/sj.onc.1206056
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Quivy, V., Adam, E., Collette, Y., Demonte, D., Chariot, A., Vanhulle, C., Berkhout, B., Castellano, R., de Launoit, Y., Burny, A., Piette, J., Bours, V., & Van Lint, C. (November 2002). Synergistic activation of human immunodeficiency virus type 1 promoter activity by NF-kappa B and inhibitors of deacetylases: Potential perspectives for the development of therapeutic strategies. Journal of Virology, 76 (21), 11091-11103. doi:10.1128/JVI.76.21.11091-11103.2002
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Chariot, A., Leonardi, A., Muller, J.-N., Bonif, M., Brown, K., & Siebenlist, U. (04 October 2002). Association of the adaptor TANK with the IκB kinase (IKK) regulator NEMO connects IKK complexes with IKKε and TBK1 kinases. Journal of Biological Chemistry, 277 (40), 37029-37036. doi:10.1074/jbc.M205069200
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Leonardi, A., Chariot, A., Claudio, E., Cunningham, K., & Siebenlist, U. (12 September 2000). CIKS, a connection to Ikappa B kinase and stress-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America, 97 (19), 10494-10499. doi:10.1073/pnas.190245697
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Chariot, A., Gielen, J., Merville, M.-P., & Bours, V. (December 1999). The homeodomain-containing proteins: an update on their interacting partners. Biochemical Pharmacology, 58, 1851-1857. doi:10.1016/S0006-2952(99)00234-8
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Chariot, A., Princen, F., Gielen, J., Merville, M.-P., Franzoso, G., Brown, K., Siebenlist, U., & Bours, V. (10 February 1999). Ikappab-Alpha Enhances Transactivation by the Hoxb7 Homeodomain-Containing Protein. Journal of Biological Chemistry, 274 (9), 5318-25. doi:10.1074/jbc.274.9.5318
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Chariot, A., Van Lint, C., Chapelier, M., Gielen, J., Merville, M.-P., & Bours, V. (1999). CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein. Oncogene, 18, 4007-4012. doi:10.1038/sj.onc.1202776
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Chariot, A., Senterre-Lesenfants, S., Sobel, M. E., & Castronovo, V. (01 October 1998). Molecular Cloning of a Mutated Hoxb7 Cdna Encoding a Truncated Transactivating Homeodomain-Containing Protein. Journal of Cellular Biochemistry, 71 (1), 46-54. doi:10.1002/(SICI)1097-4644(19981001)71:1<46::AID-JCB5>3.0.CO;2-1
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Chariot, A., & Gielen, J. (1998). The HOXC6 homeodomain-containing proteins. International Journal of Biochemistry and Cell Biology, 30, 651-655. doi:10.1016/S1357-2725(97)00136-2
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Chariot, A., & Castronovo, V. (11 May 1996). Detection of Hoxa1 Expression in Human Breast Cancer. Biochemical and Biophysical Research Communications, 222 (2), 292-7. doi:10.1006/bbrc.1996.0737
Peer reviewed

Chariot, A., Castronovo, V., Le, P., Gillet, C., Sobel, M. E., & Gielen, J. (1996). Cloning and expression of a new HOXC6 transcript encoding a repressing protein. Biochemical Journal, 319, 91-97. doi:10.1042/bj3190091
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Chariot, A., Moreau, L., Senterre, G., Sobel, M. E., & Castronovo, V. (13 October 1995). Retinoic Acid Induces Three Newly Cloned Hoxa1 Transcripts in Mcf7 Breast Cancer Cells. Biochemical and Biophysical Research Communications, 215 (2), 713-20. doi:10.1006/bbrc.1995.2522
Peer reviewed

Charlier, C., Chariot, A., Antoine, N., Merville, M.-P., Gielen, J., & Castronovo, V. (January 1995). Tamoxifen and its active metabolite inhibit growth of estrogen receptor-negative MDA-MB-435 cells. Biochemical Pharmacology, 49, 351-358. doi:10.1016/0006-2952(94)00492-5
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Castronovo, V., Kusaka, M., Chariot, A., Gielen, J.-L., & Sobel, M. (13 January 1994). Homeobox Genes: Potential Candidates for the Transcriptional Control of the Transformed and Invasive Phenotype. Biochemical Pharmacology, 47 (1), 137-43. doi:10.1016/0006-2952(94)90447-2
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