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GIGA Cancer - Cancer Signaling

Département de pharmacie

See author's contact details
ORCID
0000-0002-8844-9616
Main Referenced Co-authors
Chariot, Alain  (64)
Nguyen, Laurent  (32)
Rapino, Francesca  (24)
Shostak, Kateryna  (24)
Laguesse, Sophie  (16)
Main Referenced Keywords
Elongator (8); Humans (6); tRNA (5); Animals (4); Biochemistry, Genetics and Molecular Biology (all) (4);
Main Referenced Unit & Research Centers
Giga-Signal Transduction - ULiège (16)
GIGA Molecular Biology of Diseases - ULiège (4)
Giga Neurosciences - ULiège (4)
GIGA In silico medecine-Biomechanics Research Unit - ULiège (3)
GIGA‐R - Giga‐Research - ULiège (2)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (51)
Oncology (17)
Life sciences: Multidisciplinary, general & others (11)
Neurology (8)
Anatomy (cytology, histology, embryology...) & physiology (5)

Publications (total 95)

The most downloaded
860 downloads
creppe, C., malinouskaya, L., Volvert, M.-L., Close, P., Laguesse, S., Gillard, M., Chariot, A., & Nguyen, L. (2010). Elongator orchestrates cerebral cortical neurogenesis. MS. Medecine Sciences. doi:10.1051/medsci/2010262135 https://hdl.handle.net/2268/41002

The most cited

469 citations (OpenAlex)

Creppe, C., Malinouskaya, L., Volvert, M.-L., Gillard, M., Close, P., Malaise, O., Laguesse, S., Cornez, I., Rahmouni, S., Ormenese, S., Belachew, S., Malgrange, B., Chapelle, J.-P., Siebenlist, U., Moonen, G., Chariot, A., & Nguyen, L. (06 February 2009). Elongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin. Cell, 136, 551-564. doi:10.1016/j.cell.2008.11.043 https://hdl.handle.net/2268/5901

Book chapters or contributions to a collective book as author or co-author

Close, P., Debojit, B., Chariot, A., & Leidel, S. (2018). Dynamic regulation of tRNA modifications in Cancer. In Translational Epigenetics (édition revue et corrigée, pp. 163-186). Elsevier. doi:10.1016/B978-0-12-811022-5.00010-3
Peer reviewed

Articles accepted in reviewed journal

Chemla, Y.* , Itzhaki, O.* , Melamed, S.* , Weller, C.* , Sade, Y.* , Manich, P.* , Reshef, K.* , Xenidis, N.* , Maliah, A.* , Levy, G., Parikh, R., Bartok, O., Levy, O., Tal, I., Aziel, G., Nissani, A., Yunger, S., Likonen, D., Kliminsky, V., ... Levy, C. (08 January 2026). HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion. Cell, 189 (1), 233 - 251.e29. doi:10.1016/j.cell.2025.11.020
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Delhez, M.-L., Bosmans, M., Rodriguez, L. R., Gillard, A., Blacher, S., Blomme, A., Close, P., Machiels, B., Nokin, M.-J., & Cataldo, D. (January 2026). Exposure to diesel particulates induces an immunosuppressive microenvironment that promotes the progression of lung cancer. Neoplasia, 71, 101255. doi:10.1016/j.neo.2025.101255
Peer Reviewed verified by ORBi

Aajja, E., Lefort, H., Mahibullah, S., Leclercq, M., Aney, K. J., Nissim, S., Nguyen, L., Chariot, A., Henriet, P., Tyteca, D., Close, P., & Pierreux, C. E. (06 November 2025). Upregulation of ELP3 in acinar cells during acute pancreatitis is dispensable for homeostasis, inflammation, regeneration, and cancer initiation. Scientific Reports, 15 (1), 38976. doi:10.1038/s41598-025-22849-8
Peer Reviewed verified by ORBi

Dondajewska, E., Allepuz-Fuster, P., Maurizy, C., Hego, A., Ormenese, S., Lion, Q., Blomme, A., Close, P., Lavergne, A., Karim, L., Thiry, M., Nemazanyy, I., Krishnankutty, R., Marques, J., von Kriegsheim, A., Henneman, N. F., Panasyuk, G., Shostak, K., & Chariot, A. (August 2025). Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer. Advanced Science, 12 (31), 03022. doi:10.1002/advs.202503022
Peer Reviewed verified by ORBi

Quarto, G., Li Greci, A., Bizet, M., Penning, A., Primac, I., Murisier, F., Garcia-Martinez, L., Borges, R. L., Gao, Q., Cingaram, P. K. R., Calonne, E., Hassabi, B., Hubert, C., Herpoel, A., Putmans, P., Mies, F., Martin, J., Van der Linden, L., Dube, G., ... Fuks, F. (20 February 2025). Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation. Cell, 188 (4), 998 - 1018. doi:10.1016/j.cell.2024.12.009
Peer Reviewed verified by ORBi

Di Michele, M., Attina, A., Roux, P.-F., Tabet, I., Laguesse, S., Florido, J., Houdeville, M., Choquet, A., Encislai, B., Arena, G., De Blasio, C., Wendling, O., Frenois, F.-X., Papon, L., Stuani, L., Fuentes, M., Jahannault Talignani, C., Rousseau, M., Guégan, J., ... Le Cam, L. (02 January 2025). E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development. Nature Communications, 16 (1), 67. doi:10.1038/s41467-024-55444-y
Peer Reviewed verified by ORBi

Doglioni, G., Fernández-García, J., Igelmann, S., Altea-Manzano, P., Blomme, A., La Rovere, R., Liu, X.-Z., Liu, Y., Tricot, T., Nobis, M., An, N., Leclercq, M., El Kharraz, S., Karras, P., Hsieh, Y.-H., Solari, F. A., Martins Nascentes Melo, L., Allies, G., Scopelliti, A., ... Fendt, S.-M. (2025). Aspartate signalling drives lung metastasis via alternative translation. Nature. doi:10.1038/s41586-024-08335-7
Peer Reviewed verified by ORBi

Wathieu, C., Lavergne, A., Xu, X., Rolot, M., Nemazanyy, I., Shostak, K., El Hachem, N., Maurizy, C., Leemans, C., Close, P., Nguyen, L., Desmet, C., Tielens, S.* , Dewals, B. G.* , & Chariot, A.*. (2024). Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis. EMBO Journal. doi:10.1038/s44318-024-00184-4
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

El Hachem, N., Leclercq, M., Susaeta Ruiz, M., Vanleyssem, R., Shostak, K., Körner, P.-R., Capron, C., Martin Morales, L., RONCARATI, P., Lavergne, A., Blomme, A., Turchetto, S., Goffin, E., Thandapani, P., Tarassov, I., Nguyen, L., Pirotte, B., Chariot, A., Marine, J.-C., ... Close, P. (2024). Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma. Nature Cell Biology. doi:10.1038/s41556-024-01439-2
Peer Reviewed verified by ORBi

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (31 May 2024). Reversing the relative time courses of the peptide bond reaction with oligopeptides of different lengths and charged amino acid distributions in the ribosome exit tunnel. Computational and Structural Biotechnology Journal, 23, 2453-2464. doi:10.1016/j.csbj.2024.05.045
Peer Reviewed verified by ORBi

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (July 2023). A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome and its significance for the elongation cycle kinetics. Computational and Structural Biotechnology Journal, 21, 3768-3795. doi:10.1016/j.csbj.2023.07.016
Peer Reviewed verified by ORBi

Largeot, A., Klapp, V., Viry, E., Gonder, S., Fernandez Botana, I., Blomme, A., Benzarti, M., Pierson, S., Duculty, C., Marttila, P., Wierz, M., Gargiulo, E., Pagano, G., An, N., El Hachem, N., Perez Hermandez, D., Chakraborty, S., Ysebaert, L., François, J.-H., ... Moussay, E. (2023). Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL. Blood. doi:10.1182/blood.2022017839
Peer Reviewed verified by ORBi

Joiret, M., Leclercq, M., Lambrechts, G., Rapino, F., Close, P., Louppe, G., & Geris, L. (06 April 2023). Cracking the genetic code with neural networks. Frontiers in Artificial Intelligence, 6. doi:10.3389/frai.2023.1128153
Peer Reviewed verified by ORBi

Chen, D., Nemazanyy, I., Peulen, O., Shostak, K., Xu, X., Tang, S. C., Wathieu, C., Turchetto, S., Tielens, S., Nguyen, L., Close, P., Desmet, C., Klein, S., Florin, A., Büttner, R., Petrellis, G., Dewals, B. G., & Chariot, A. (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO Journal, 109353. doi:10.15252/embj.2021109353
Peer Reviewed verified by ORBi

Tang, S. C., Lion, Q., Peulen, O., Chariot, P., Lavergne, A., Mayer, A., Allepuz Fuster, P., Close, P., Klein, S., Florin, A., Büttner, R., Nemazanyy, I., Shostak, K., & Chariot, A. (29 January 2022). The E3 ligase COP1 promotes ERα signaling and suppresses EMT in breast cancer. Oncogene, 41, 173-190. doi:10.1038/s41388-021-02038-3
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Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (13 January 2022). Ribosome exit tunnel electrostatics. Physical Review. E, 105 (1), 014409-1 - 014409-43. doi:10.1103/PhysRevE.105.014409
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Blomme, A., Peter, C., Mui, E., Rodriguez Blanco, G., An, N., Mason, L. M., Jamieson, L. E., McGregor, G. H., Lilla, S., Ntala, C., Patel, R., Thiry, M., Kung, S. H. Y., Leclercq, M., Ford, C. A., Rushworth, L. K., McGarry, D. J., Mason, S., Repiscak, P., ... Leung, H. Y. (2022). THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14764. doi:10.15252/emmm.202114764
Peer Reviewed verified by ORBi

Jeschke, J., Collignon, E., Al Wardi, C., Krayem, M., Bizet, M., Jia, Y., Garaud, S., Wimana, Z., Calonne, E., Hassabi, B., Morandini, R., Deplus, R., Putmans, P., Dube, G., Singh, N. K., Koch, A., Shostak, K., Rizzotto, L., Ross, R. L., ... Fuks, F. (June 2021). Downregulation of the FTO m6A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors. Nature Cancer, 2 (6), 611-628. doi:10.1038/s43018-021-00223-7
Peer reviewed

cheli, Y., tulic, M., El Hachem, N., nottet, N., Jacquel, A., Gesson, M., Strub, T., bille, K., picard-gauci, A., montaudié, H., beranger, G., passeron, T., Close, P., Bertolotto, C., & ballotti, R. (2021). ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity. Molecular Cancer. doi:10.1186/s12943-020-01306-2
Peer Reviewed verified by ORBi

Lemaitre, P., Bai, Q., Legrand, C., Chariot, A., Close, P., Bureau, F., & Desmet, C. (2021). Loss of the Transfer RNA Wobble Uridine-Modifying Enzyme Elp3 Delays T Cell Cycle Entry and Impairs T Follicular Helper Cell Responses through Deregulation of Atf4. Journal of immunology (Baltimore, Md. : 1950). doi:10.4049/jimmunol.2000521
Peer reviewed

Rosu, A., El Hachem, N., Rapino, F., Rouault-Pierre, K., Jorssen, J., SOMJA, J., Ramery, E., Thiry, M., Nguyen, L., Jacquemyn, M., Daelemans, D., Adams, C. M., Bonnet, D., Chariot, A., Close, P., Bureau, F., & Desmet, C. (2021). Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis. Journal of Experimental Medicine, 218 (3). doi:10.1084/jem.20200662
Peer reviewed

Rapino, F.* , ZHOU, Z.* , RONCERO SANCHEZ, A. M.* , Joiret, M., Seca, C., El Hachem, N., Valenti, G., Latini, S., Shostak, K., Geris, L., Li, P., Huang, G., Mazzucchelli, G., Baiwir, D., Desmet, C., Chariot, A., Georges, M., & Close, P. (2021). Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate. Nature Communications, 12 (1), 2170. doi:10.1038/s41467-021-22254-5
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Shostak, K., Jiang, Z., CHARLOTEAUX, B., Mayer, A., Habraken, Y., Tharun, L., Klein, S., Xu, X., Duong, H. Q., Vislovukh, A., Close, P., Florin, A., Rambow, F., Marine, J.-C., Büttner, R., & Chariot, A. (09 March 2020). The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage. Nature Communications, 11 (1). doi:10.1038/s41467-020-15003-7
Peer Reviewed verified by ORBi

Lorent, J., Kusnadi, E. P., van Hoef, V., Rebello, R. J., Leibovitch, M., Ristau, J., Chen, S., Lawrence, M. G., Szkop, K. J., Samreen, B., Balanathan, P., Rapino, F., Close, P., Bukczynska, P., Scharmann, K., Takizawa, I., Risbridger, G. P., Selth, L. A., Leidel, S. A., ... Furic, L. (2019). Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression. EMBO Journal. doi:10.15252/embj.2018101323
Peer Reviewed verified by ORBi

Rapino, F., & Close, P. (2018). Wobble uridine tRNA modification: a new vulnerability of refractory melanoma. Molecular and Cellular Oncology. doi:10.1080/23723556.2018.1513725
Peer Reviewed verified by ORBi

Rapino, F., Delaunay, S., Rambow, F., Zhou, Z., Tharun, L., De Tullio, P., Sin, O., Shostak, K., Schmitz, S., Piepers, J., Guesquière, B., Karim, L., Charloteaux, B., Jamart, D., Florin, A., Lambert, C., RORIVE, A., JERUSALEM, G., Leucci, E., ... Close, P. (28 June 2018). Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature, 558, 605-609. doi:10.1038/s41586-018-0243-7
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Duong, H. Q., Nemazanyy, I., Rambow, F., Tang, S. C., Delaunay, S., Tharun, L., Florin, A., Büttner, R., VAN DAELE, D., Close, P., Marine, J.-C., Shostak, K., & Chariot, A. (2018). The endosomal protein CEMIP links Wnt signaling to MEK1-ERK1/2 activation in Selumetinib-resistant intestinal organoids. Cancer Research, 10.1158/0008-5472.CAN-17-3149. doi:10.1158/0008-5472.CAN-17-3149
Peer Reviewed verified by ORBi

Rapino, F., Zhou, Z., Delaunay, S., Chariot, A., & Close, P. (2017). tRNA modification: is cancer having a wobble? Trends in Cancer, 3, 249-252. doi:10.1016/j.trecan.2017.02.004
Peer Reviewed verified by ORBi

Laguesse, S., Close, P., Van Hees, L., Chariot, A., Malgrange, B., & Nguyen, L. (2017). Loss of Elp3 Impairs the Acetylation and Distribution of Connexin-43 in the Developing Cerebral Cortex. Frontiers in Cellular Neuroscience, 11, 122. doi:10.3389/fncel.2017.00122
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Delaunay, S., Rapino, F., Tharun, L., Zhou, Z., Heukamp, L., Termathe, M., Shostak, K., Klevernic, I., Florin, A., Desmecht, H., Desmet, C., Nguyen, L., Leiden, S. A., Willis, A. E., Buettner, R., Chariot, A., & Close, P. (October 2016). ELP3 links tRNA modification to IRES-dependent translation of LEF-1 to promote metastasis in breast cancer. Journal of Experimental Medicine, 213, 2503-2523. doi:10.1084/jem.20160397
Peer Reviewed verified by ORBi

Göktuna, S., Shostak, K., Chau, T.-L., Heukamp, L., Hennuy, B., Duong, H. Q., LADANG, A., Close, P., Klevernic, I., Olivier, F., Florin, A., Ehx, G., Baron, F., Vandereyken, M., Rahmouni, S., Vereecke, L., van Loo, G., Büttner, R., Greten, F., & Chariot, A. (2016). The Prosurvival IKK-Related Kinase IKK« Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine. Cancer Research, 76, 2587-99. doi:10.1158/0008-5472.CAN-15-1473
Peer Reviewed verified by ORBi

LADANG, A.* , Rapino, F.* , Heukamp, L., Tharun, L., Shostak, K., Hermand, D., Delaunay, S., Klevernic, I., Jiang, Z., Jacques, N., Jamart, D., Migeot, V., Florin, A., Göktuna, S., Malgrange, B., Samson, O., Nguyen, L., Buettner, R., Close, P., & Chariot, A. (16 November 2015). Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. Journal of Experimental Medicine, 212 (12), 2057-75. doi:10.1084/jem.20142288
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Laguesse, S.* , Creppe, C.* , Nedialkova, D., Prevot, P.-P., Borgs, L., Huysseune, S., Franco, B., Duysens, G., Krusy, N., Lee, G., Thelen, N., Thiry, M., Close, P., Chariot, A., Malgrange, B., Leidel, S., Godin, J., & Nguyen, L. (2015). A dynamic unfolded protein response contributes to the control of cortical neurogenesis. Developmental Cell, 35, 553-567. doi:10.1016/j.devcel.2015.11.005
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Chau, T.-L., Göktuna, S., Rammal, A., Casanova Bustos, T. R., Duong, H. Q., GATOT, J.-S., Close, P., Dejardin, E., Desmecht, D., Shostak, K., & Chariot, A. (2015). A role for APPL1 in tlr3/4-dependent TBK1 and IKKε activation in macrophages. Journal of Immunology. doi:10.4049/jimmunol.1401614
Peer Reviewed verified by ORBi

Shostak, K.* , Patrascu, F.* , Göktuna, S., Close, P., Borgs, L., Nguyen, L., Olivier, F., Rammal, A., Brinkhaus, H., Bentires-Alj, M., Marine, J.-C., & Chariot, A. (May 2014). MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation. Cell Death and Differentiation, 5 (21), 811-24. doi:10.1038/cdd.2014.2
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Volvert, M.-L., Prevot, P.-P., Close, P., Laguesse, S., Pirotte, S., Hemphill, J., Rogister, F., Krusy, N., SACHELI, R., MOONEN, G., Deiters, A., Merkenschlager, M., CHARIOT, A., Malgrange, B., Godin, J., & Nguyen, L. (May 2014). MicroRNA Targeting of CoREST controls polarization of migrating cortical neurons. Cell Reports, 7 (4), 1168-83. doi:10.1016/j.celrep.2014.03.075
Peer Reviewed verified by ORBi

Shostak, K., Zhang, X., Hubert, P., Göktuna, S., Jiang, Z., Klevernic, I., Hildebrand, J., Roncarati, P., Hennuy, B., Ladang, A., SOMJA, J., Gothot, A., Close, P., Delvenne, P., & Chariot, A. (2014). NF-kappaB-induced KIAA1199 promotes survival through EGFR signalling. Nature Communications, 5, 5232. doi:10.1038/ncomms6232
Peer Reviewed verified by ORBi

Close, P., Gillard, M., Ladang, A., Jiang, Z., Papuga, J., Hawkes, N., Nguyen, L., CHAPELLE, J.-P., Bouillenne, F., Svejstrup, J., Fillet, M., & Chariot, A. (2012). DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. Journal of Biological Chemistry. doi:10.1074/jbc.M112.402727
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Close, P., East, P., Svejstrup, B., Hartmann, H., Heron, M., Maslen, S., Chariot, A., Söding, J., Skehel, M., & Svejstrup, J. (2012). DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation. Nature. doi:10.1038/nature10925
Peer Reviewed verified by ORBi

Godin, J.* , Thomas, N.* , Laguesse, S.* , Malinouskaya, L., Close, P., MALAISE, O., Purnelle, A., Raineteau, O., Campbell, K., Fero, M., Moonen, G., Malgrange, B., Chariot, A., Metin, C., Besson, A., & Nguyen, L. (2012). p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration. Developmental Cell, 23 (4), 729-44. doi:10.1016/j.devcel.2012.08.006
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Chaballe, L., Close, P., SEMPELS, M., DELSTANCHE, S., FANIELLE, J., Moons, L., Carmeliet, P., Schoenen, J., Chariot, A., & Franzen, R. (March 2011). Involvement of placental growth factor in Wallerian degeneration. Glia, 59 (3), 379-396. doi:10.1002/glia.21108
Peer Reviewed verified by ORBi

Selth, L. A., Close, P., & Svejstrup, J. Q. (2011). Studying RNA-Protein Interactions In Vivo By RNA Immunoprecipitation. Methods in Molecular Biology, 791, 253-264. doi:10.1007/978-1-61779-316-5_19
Peer Reviewed verified by ORBi

Keutgens, A., Shostak, K., Close, P., Zhang-Shao, X., Hennuy, B., Aussems, M., Chapelle, J.-P., Viatour, P., Gothot, A., Fillet, M., & Chariot, A. (August 2010). The repressing function of the oncoprotein BCL-3 requires CtBP while its polyubiquitination and degradation involve the E3 ligase TBLR1. Molecular and Cellular Biology, 30, 4006-4021. doi:10.1128/MCB.01600-09
Peer Reviewed verified by ORBi

Close, P., Creppe, C., Gillard, M., LADANG, A., Chapelle, J.-P., Nguyen, L., & Chariot, A. (April 2010). The emerging role of lysine acetylation of non-nuclear proteins. Cellular and Molecular Life Sciences, 67 (8), 1255-1264. doi:10.1007/s00018-009-0252-7
Peer Reviewed verified by ORBi

Creppe, C., Malinouskaya, L., Volvert, M.-L., Gillard, M., Close, P., Malaise, O., Laguesse, S., Cornez, I., Rahmouni, S., Ormenese, S., Belachew, S., Malgrange, B., Chapelle, J.-P., Siebenlist, U., Moonen, G., Chariot, A., & Nguyen, L. (06 February 2009). Elongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin. Cell, 136, 551-564. doi:10.1016/j.cell.2008.11.043
Peer Reviewed verified by ORBi

Cornez, I., Creppe, C., Gillard, M., Hennuy, B., Chapelle, J.-P., Dejardin, E., Merville, M.-P., Close, P., & Chariot, A. (June 2008). Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells. Biochemical Pharmacology, 75, 2122-2134. doi:10.1016/j.bcp.2008.03.006
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Buytaert, E., Matroule, J. Y., Durinck, S., Close, P., Kocanova, S., Vandenheede, J. R., de Witte, P. A., Piette, J., & Agostinis, P. (2008). Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells. Oncogene. doi:10.1038/sj.onc.1210825
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GATOT, J.-S., Gioia, R., Chau, T.-L., Patrascu, F. A., Warnier, M., Close, P., Chapelle, J.-P., Muraille, E., Brown, K., Siebenlist, U., Piette, J., Dejardin, E., & Chariot, A. (26 October 2007). Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKK epsilon-dependent lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. Journal of Biological Chemistry, 282 (43), 31131-31146. doi:10.1074/jbc.M701690200
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Olivier, S., Close, P., Castermans, E., de Leval, L., Tabruyn, S., Chariot, A., Malaise, M., Merville, M.-P., Bours, V., & Franchimont, N. (May 2006). Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature. Molecular Pharmacology, 69 (5), 1615-1623. doi:10.1124/mol.105.020479
Peer Reviewed verified by ORBi

Close, P., Hawkes, N., Cornez, I., Creppe, C., Lambert, C. A., Rogister, B., Siebenlist, U., Merville, M.-P., Slaugenhaupt, S. A., Bours, V., Svejstrup, J. Q., & Chariot, A. (May 2006). Transcription impairment and cell migration defects in elongator-depleted cells: Implication for familial dysautonomia. Molecular Cell, 22 (4), 521-531. doi:10.1016/j.molcel.2006.04.017
Peer Reviewed verified by ORBi

Bonif, M., Meuwis, M.-A., Close, P., Benoit, V., Heyninck, K., Chapelle, J.-P., Bours, V., Merville, M.-P., Piette, J., Beyaert, R., & Chariot, A. (2006). TNFa and IKKb-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKg and NF-kB activation. Biochemical Journal, 394, 593-603. doi:10.1042/BJ20051659
Peer Reviewed verified by ORBi

Articles accepted in journal without reviewing

creppe, C., malinouskaya, L., Volvert, M.-L., Close, P., Laguesse, S., Gillard, M., Chariot, A., & Nguyen, L. (2010). Elongator orchestrates cerebral cortical neurogenesis. MS. Medecine Sciences. doi:10.1051/medsci/2010262135

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