Reference : Elongator promotes breast cancer metastasis
Scientific congresses and symposiums : Poster
Human health sciences : Oncology
Elongator promotes breast cancer metastasis
[en] Elongator promeut la formation de métastases dans le cancer du sein
Delaunay, Sylvain mailto [Université de Liège > Département de pharmacie > Chimie médicale >]
Rapino, Francesca mailto [Université de Liège > Département de pharmacie > Chimie médicale >]
Heukamp, Lukas []
LADANG, Aurélie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs Biologie clinique - Pool assistants >]
Jiang, Zheshen []
Nguyen, Laurent mailto [Université de Liège > > GIGA - Neurosciences >]
Buettner, Reinhard []
Chariot, Alain mailto [Université de Liège > Département de pharmacie > Chimie médicale >]
Close, Pierre mailto [Université de Liège > Département de pharmacie > Chimie médicale >]
EMBO meeting, Frontiers in stem cells
du 29 mars au 31 mars 2015
EMBO-EMBL organization
[en] Elongator ; Metastasis
[en] Elongator is a protein complex (Elp1-6) involved in diverse cellular processes, such as protein acetylation and tRNA modification and whose function is essential for cell migration and neuronal differentiation. Although it is well established that tumor development involves modifications of acetylation-deacetylation dynamics, as well as changes in protein translation, the role of Elongator in tumor initiation and invasion remains to be investigated in vivo. We generated a mouse model in which the Elp3 gene, encoding the catalytic subunit of the complex, is conditionally inactivated in the mammary gland epithelium by using the MMTV-CRE transgenic mouse. The role of Elp3 in tumor development and metastasis formation is then assessed in the PyMT model of invasive breast cancer.
Giga-Signal Transduction
Université de Liege
Insight into the role of Elongator in Breast Cancer

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