Caractérisation phénotypique, morphologique et fonctionnelle des éosinophiles résidents du poumon

Eosinophils have long been considered as destructive effector cells implicated in parasitic infections and allergic reactions such as asthma. This traditional restrictive view of eosinophils has now been considerably extended. Indeed, beside their pro-inflammatory functions, eosinophils are also able to finely shape local innate and adaptative immune responses. Moreover, recent studies indicate that steady-state resident eosinophils are now thought to contribute to immune homeostasis at mucosal sites such as the gut. In the normal lung, resident eosinophils (rEOS) have been little-studied so far.
Here, we report that in mice, steady-state pulmonary rEOS are parenchymal Siglec-Fint CD125int cells characterized by a ring-shaped nucleus.