Profil

Schurmans Stéphane

Département des sciences fonctionnelles (DSF) > Biochimie métabolique vétérinaire

GIGA Molecular Biology of Diseases - Functional Genetics

See author's contact details
ORCID
0000-0002-5579-3840
Main Referenced Co-authors
Lambert, P. H. (14)
Erneux, C. (13)
Merino, J. (13)
Parmentier, M. (13)
Vassart, G. (10)
Main Referenced Keywords
5-phosphatase (9); alloantigens (7); Inpp5e (7); primary cilium (7); mice (6);
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (104)
Genetics & genetic processes (73)
Human health sciences: Multidisciplinary, general & others (3)

Publications (total 109)

The most downloaded
559 downloads
Scoumanne, A., Molina Ortiz, P., Monteyne, D., Perez-Morga, D., Erneux, C., & Schurmans, S. (2016). Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice. Advances in Biological Regulation, 62, 1-10. doi:10.1016/j.jbior.2016.03.001 https://hdl.handle.net/2268/194708

The most cited

388 citations (OpenAlex)

Parmentier, M., Libert, F., Schurmans, S., Schiffmann, S., Lefort, A., Eggerickx, D., Ledent, C., Mollereau, C., Gerard, C., Perret, J., Grootegoed, A., & Vassart, G. (1992). Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature, 355, 453-455. doi:10.1038/355453a0 https://hdl.handle.net/2268/35338

Ando, K., Küçükali, F., Doeraene, E., Nagaraj, S., Antonelli, E. M., Thazin Htut, M., Yilmaz, Z., Kosa, A.-C., Lopez-Guitierrez, L., Quintanilla-Sánchez, C., Aydin, E., Ramos, A. R., Mansour, S., Turbant, S., Schurmans, S., Sleegers, K., Erneux, C., Brion, J.-P., Leroy, K., & Brain Bank NeuroCEB Neuropathology Network. (04 June 2024). Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer's disease pathology progression. Acta Neuropathologica, 147 (1), 94. doi:10.1007/s00401-024-02745-7
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Burniat, A., Noël, A., Colige, A., Vanderplasschen, A., de Kerchove d'Exaerde, A., Kupper Cardozo, A., Van Keymeulen, A., Moens, A., Bondue, A., Herpain, A., Marchant, A., Loumaye, A., Beck, B., Van den Heyden, B., Corvilain, B., Lakaye, B., Rogister, B., Malgrange, B., Michiels, C., ... Brunko, E. (2023). Cent scientifiques répliquent à SEA (Suppression des Expériences sur l’Animal vivant) et dénoncent sa désinformation. La Libre Belgique.

Fernandes, S., Srivastava, N., Pedicone, C., Sudan, R., Luke, E. A., Dungan, O. M., Pacherille, A., Meyer, S. T., Dormann, S., Schurmans, S., Jacobsen, E., Chisholm, J. D., & Kerr, W. G. (2023). Obesity control by SHIP inhibition requires pan-paralog inhibition and an intact eosinophil compartment. iScience. doi:10.1016/j.isci.2023.106071
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Moes, B., Li, H., Molina Ortiz, P., Radermecker, C., Rosu, A., Vande Catsyne, C.-A., Sayyed, S. A., Fontela Joao, Duque, M., Mostafa, A., Azzi, A., Barata Joao T., Merino Ramon, Xu, C., Desmet, C., & Schurmans, S. (2023). INPP5K controls the dynamic structure and signaling of wild type and mutated, leukemia-associated IL7 receptors. Blood, 141, 1708-1717. doi:10.1182/blood.2022017819
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Ukhavov, K., Uytingco, C., Green, W., Zhang, L., Schurmans, S., & Martens, J. R. (01 March 2022). INPP5E controls ciliary localization of phospholipids and odor response in olfactory sensory neurons. Journal of Cell Science, 135 (5). doi:10.1242/jcs.258364
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Schurmans, S., Vande Catsyne, C.-A., Desmet, C., & Moes, B. (2021). The phosphoinositide 5-phosphatase INPP5K: from gene structure to in vivo functions. Advances in Biological Regulation. doi:10.1016/j.jbior.2020.100760
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Marongiu, L., Mingozzi, F., Cigni, C., Marzi, R., Di Gioia, M., Garrè, M., Parazzoli, D., Sironi, L., Collini, M., Sakaguchi, R., Morii, T., Crosti, M., Moro, M., Schurmans, S., Catelani, T., Rotem, R., Colombo, M., Shears, S., Prosperi, D., ... Granucci, F. (2021). Inositol-triphosphate 3-kinase B promotes calcium mobilization and the inflammatory activity of dendritic cells. Science Signaling. doi:10.1126/scisignal.aaz2120
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Michael, M., McCormick, B., Anderson, K. E., Karmakar, U., Vermeren, M., Schurmans, S., Amour, A., & Vermeren, S. (2021). The 5-phosphatase SHIP2 promotes neutrophil chemotaxis and recruitment. Frontiers in Immunology. doi:10.3389/fimmu.2021.671756
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Vande Catsyne, C.-A., Sayyed, S. A., Molina Ortiz, P., Moës, B., Communi, D., Muller, J., Heusschen, R., CAERS, J., Azzi, A., Erneux, C., & Schurmans, S. (2020). Altered chondrocyte differentiation, matrix mineralization and MEK-Erk1/2 signaling in an INPPL1 catalytic knock-out mouse model of opsismodysplasia. Advances in Biological Regulation, 76, 100651. doi:10.1016/j.jbior.2019.100651
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Pal Singh, S., de Bruijn, M. J. W., Velaso Gago da Graça, C., Cornet, O. B. J., Rip, J., Stadhouders, R., Meijers, R. W. J., Schurmans, S., Kerr, W. G., ter Burg, J., Eldering, E., Langerak, A. W., Pillai, S. Y., & Hendriks, R. W. (2020). Overexpression of SH2-containing inositol phosphatase contributes to chronic lymphocytic leukemia survival. Journal of Immunology, 204, 360-374. doi:10.4049/jimmunol.1900153
Peer Reviewed verified by ORBi

Constable, S., Long, A. B., Floyd, K. A., Schurmans, S., & Caspary, T. (2020). The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling. Development. doi:10.1242/dev.183301
Peer reviewed

Chabrier, G., Hobson, S., Yuldasheva, N., Kearney, M. T., Schurmans, S., Pineda-Torra, I., & Gage, M. C. (2019). Aged insulin resistant macrophages reveal dysregulated cholesterol biosynthesis, a pro-inflammatory profile and reduced foam cell formation capacity. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/238491.

Guo, J., Otis, J. M., Suciu, S. K., Catalano, C., Xing, L., Constable, S., Wachten, D., Gupton, S., Lee, J., Lee, A., Blackley, K. H., Ptacek, T., Simon, J. M., Schurmans, S., Stuber, G. D., Caspary, T., & Anton, E. S. (2019). Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models. Developmental Cell, 51, 759-774. doi:10.1016/j.devcel.2019.11.005
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Bakker, J., Balthazart, J., Baron, F., Beguin, Y., Bettendorff, L., Blanpain, C., Bureau, F., Caers, J., Cani, P., Cataldo, D., Cornil, C., Clercx, C., Cloots, R., Colige, A., Daube, G., De Backer, O., de Kerchove d'Exaerde, A., Desmecht, D., Desmet, C., ... Wittamer, V. (2018). La souris, le patient, et le faux expert. Décryptage d'une mystification. Le Vif. L'Express.

Molina Ortiz, P.* , Orban, T.* , Martin, M., Habets, A., Dequiedt, F.* , & Schurmans, S.*. (2018). Rasa3 controls turnover of endothelial cell adhesion and vascular lumen integrity by a Rap1-dependent mechanism. PLoS Genetics. doi:10.1371/journal.pgen.1007195
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* These authors have contributed equally to this work.

Erneux, C., & Schurmans, S. (2018). SHIP2. In S. Choi, Encyclopedia of Signaling Molecules (pp. 4944-4950). Springer.
Peer reviewed

Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique.

Phua, S. C., Chiba, S., Suzuki, M., Su, E., Roberson, E. C., Pusapati, G. V., Schurmans, S., Setou, M., Rohatgi, R., Reiter, J. F., Ikegami, K., & Inoue, T. (2017). Dynamic Remodeling of membrane composition drives cell cycle through primary cilia excision. Cell, 168, 264-279. doi:10.1016/j.cell.2016.12.032
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Watt, N., Gage, M., Patel, P., Viswambharan, H., Sukumar, P., Galloway, S., Yuldasheva, N., Imrie, H., Walker, A., Griffin, K., Makava, N., Skromna, A., Bridge, K., Beech, D., Schurmans, S., Wheatcroft, S., Kearney, M., & Cubbon, R. (2017). Endothelial SHIP2 suppresses Nox2 NADPH oxidase-dependent vascular oxidative stress, endothelial dysfunction and systemic insulin resistance. Diabetes, 66 (11), 2808-2821. doi:10.2337/db17-0062
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Sayyed, S. A., JOURET, F., Vermeersch, M., Pérez-Morga, D., & Schurmans, S. (2017). The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating ERM proteins activation. Kidney International. doi:10.1016/j.kint.2017.01.008
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Sierra Potchanant, E., Cerabona, D., Sater, Z., He, Y., Sun, Z., Gehlhausen, J., Schurmans, S., Gayral, S., & Nalepa, G. (2017). INPP5E Preserves Genomic Stability through Regulation of Mitosis. Molecular and Cellular Biology, 37 (6), 500-516. doi:10.1128/MCB.00500-16
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Alphonse, M. P., Duong, T. T., Shumitzu, C., Hoang, L. T., McCrindle, B. W., Franco, A., Schurmans, S., Philpott, D. J., Hibberd, M. L., Burns, J. C., Kuijpers, T. W., & Yeung, R. S. M. (2016). Inositol-triphosphate-3-kinase C mediates inflammasome activation and treatment response in Kawasaki Disease. Journal of Immunology, 197, 3481-3489. doi:10.4049/jimmunol.1600388
Peer Reviewed verified by ORBi

Scoumanne, A., Molina Ortiz, P., Monteyne, D., Perez-Morga, D., Erneux, C., & Schurmans, S. (2016). Specific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice. Advances in Biological Regulation, 62, 1-10. doi:10.1016/j.jbior.2016.03.001
Peer Reviewed verified by ORBi

Garcia-Gonzalo, F. R., Phua, S. C., Roberson, E. C., Garcia III, G., Abedin, M., Schurmans, S., Inoue, T., & Reiter, J. F. (2015). Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling. Developmental Cell, 34, 400-409. doi:10.1016/j.devcel.2015.08.001
Peer Reviewed verified by ORBi

Magnani, D., Morlé, L., Hasenpusch-Theil, K., Paschaki, M., Jacoby, M., Schurmans, S., Durand B, B., & Theil, T. (2015). The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating patterning of prethalamus and ventral telencephalon. Human Molecular Genetics, 24, 2578-2593. doi:10.1093/hmg/ddv021
Peer Reviewed verified by ORBi

Chavez, M., Van Sande, J., de Kerchove d'Exaerde, A., Schurmans, S., & Schiffmann, S. (2015). Modulation of ciliary phosphoinositide content regulates trafficking and Sonic hedgehog signaling output. Developmental Cell, 34, 338-350. doi:10.1016/j.devcel.2015.06.016
Peer Reviewed verified by ORBi

Schurmans, S., Polizzi, S., Scoumanne, A., Sayyed, S. A., & Molina Ortiz, P. (2015). The Ras/Rap GTPase activating protein RASA3 : from gene structure to in vivo functions. Advances in Biological Regulation, 57, 153-161. doi:10.1016/j.jbior.2014.09.006
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Pirottin, D., Schurmans, S., Francois, C., Farnir, F., Closset, R., Bureau, F., & Desmet, C. (2014). Generation and validation of a mouse model for conditional inactivation of PLAGL1. In Proceedings of the 4th edition : FARAH Day 2014.

Elong Edimo, W., Schurmans, S., Roger, P., & Erneux, C. (2014). SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation. Advances in Biological Regulation, 54, 142-151. doi:10.1016/j.jbior.2013.09.002
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Molina Ortiz, P., Polizzi, S., Ramery, E., Gayral, S., Delierneux, C., Oury, C., Iwashita, S., & Schurmans, S. (2014). Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet. PLoS Genetics, 10 (6), 1004420. doi:10.1371/journal.pgen.1004420
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Stygelbout, V., Leroy, K., Pouillon, V., Ando, K., D'Amico, E., Jia, Y., Luo, H. R., Duyckaerts, C., Erneux, C., Schurmans, S.* , & Brion, J.-P.*. (2014). Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. Brain: a Journal of Neurology, 137, 537-52. doi:10.1093/brain/awt344
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* These authors have contributed equally to this work.

Pouillon, V., Maréchal, Y., Frippiat, C., Erneux, C., & Schurmans, S. (2013). Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells. Advances in Biological Regulation, 53 (1), 39-50. doi:10.1016/j.jbior.2012.08.001
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D'Amico, E., Gayral, S., Massart, C., Van Sande, J., Reiter, J. F., Dumont, J., Robaye, B., & Schurmans, S. (2013). Thyroid-specific inactivation of Kif3a alters TSH signaling pathway and leads to hypothyroidism. Journal of Molecular Endocrinology, 50, 375-387. doi:10.1530/JME-12-0219
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Dubois, E., Jacoby, M., Blockmans, M., Pernot, E., Schiffmann, S. N., Foukas, L., Henquin, J.-C., Vanhaesebroeck, B., Erneux, C., & Schurmans, S. (2012). Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse. Cellular Signalling, 24, 1971-1980. doi:10.1016/j.cellsig.2012.06.012
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D'Amico, E., Stygelbout, V., & Schurmans, S. (2012). The Spinner-IBMM mouse is a new spontaneous mutant in the Tmie gene. Genes and Genomics, 34, 107-110. doi:10.1007/s13258-011-0157-3
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Schurmans, S., Pouillon, V., & Marechal, Y. (2011). Regulation of B cell survival, development and function by inositol 1,4,5-trisphosphate 3-kinase B (Itpkb). Advances in Enzyme Regulation, 51, 66-73. doi:10.1016/j.advenzreg.2010.08.001
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Pernot, E., Terryn, S., Cheong, S. C., Markadieu, N., Janas, S., Blockmans, M., Jacoby, M., Pouillon, V., Gayral, S., Rossier, B. C., Beauwens, R., Erneux, C., Devuyst, O., & Schurmans, S. (2011). The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system. Pflügers Archiv: European Journal of Physiology, 462, 871-883. doi:10.1007/s00424-011-1028-0
Peer Reviewed verified by ORBi

Nguidjoe, E., Sokolow, S., Bigabwa, S., Pachera, N., D'Amico, E., Allagnat, F., Vanderwinden, J. M., Sener, A., Manto, M., Depreter, M., Mast, J., Joanny, G., Montanya, E., Rahier, J., Cardoso, A. K., Eizirik, D. L., Schurmans, S., & Herchuelz, A. (2011). Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass. Diabetes, 60, 2076-2085. doi:10.2337/db10-0924
Peer Reviewed verified by ORBi

Marechal, Y., Queant, S., Polizzi, S., Pouillon, V., & Schurmans, S. (2011). Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells. Immunobiology, 216, 103-109. doi:10.1016/j.imbio.2010.03.012
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Baup, D., Fraga, L., Pernot, E., Van Acker, A., Vanherck, A.-S., Breckpot, K., Thielemans, K., Schurmans, S., Moser, M., & Leo, O. (2010). Variegation and silencing in a lentiviral-based murine transgenic model. Transgenic Research, 19, 399-414. doi:10.1007/s11248-009-9318-4
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Cross, J. L., Meloni, B. P., Bakker, A. J., Sokolow, S., Herchuelz, A., Schurmans, S., & Knuckey, N. W. (2009). Neuronal injury in NCX3 knockout mice following permanent focal cerebral ischemia and in NCX3 knockout cortical neuronal cultures following oxygen-glucose deprivation and glutamate exposure. Journal of Experimental Stroke and Translational Medicine, 2 (1), 3-9.
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Jacoby, M., Cox, J. J., Gayral, S., Hampshire, D. J., Ayub, M., Blockmans, M., Pernot, E., Kisseleva, M. V., Compère, P., Schiffmann, S. N., Gergely, F., Riley, J. H., Pérez-Morga, D., Woods, C. G., & Schurmans, S. (2009). INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nature Genetics, 41, 1027-1031. doi:10.1038/ng.427
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Baup, D., Moser, M., Schurmans, S., & Leo, O. (2009). Developmental regulation of the composite CAG promoter activity in the murine T lymphocyte cell lineage. Genesis, 47, 799-804. doi:10.1002/dvg.20569
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Bielas, S. L., Silhavy, J. L., Brancati, F., Kisseleva, M. V., Al-Gazali, L., Sztriha, L., Bayoumi, R. A., Zaki, M. S., Abdel-Aleem, A., Rosti, O., Kayserili, H., Swistun, D., Scott, L. C., Bertini, E., Boltshauser, E., Fazzi, E., Travaglini, L., Field, S. J., Gayral, S., ... Gleeson, J. G. (2009). Mutations in the inositol polyphosphate-5-phosphatase E gene link phosphatidyl inositol signaling to the ciliopathies. Nature Genetics, 41, 1032-1036. doi:10.1038/ng.423
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Jeffs, G. J., Meloni, B., Sokolow, S., Herschuelz, A., Schurmans, S., & Knuckey, N. W. (2008). NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia. Experimental Neurology, 210, 268-273. doi:10.1016/j.expneurol.2007.10.013
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Jia, Y., Schurmans, S., & Luo, H. R. (2008). Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate. Cell Cycle, 7, 2803-2808. doi:10.4161/cc.7.18.6688
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Molinaro, P., Cuomo, O., Pignataro, G., Boscia, F., Sirabella, R., Pannaccione, A., Secundo, A., Scorziello, A., Adornetto, A., Gala, R., Viggiona, D., Sokolow, S., Herchuelz, A., Schurmans, S., Di Renzo, G., & Annunziato, L. (2008). Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. Journal of Neuroscience, 28, 1179-1184. doi:10.1523/JNEUROSCI.4671-07.2008
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Jia, Y., Loison, F., Erneux, C., Park, S., Gao, C., Chai, L., Silberstein, L. E., Schurmans, S., & Luo, H. R. (2008). Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proceedings of the National Academy of Sciences of the United States of America, 105, 4739-4744. doi:10.1073/pnas.0800218105
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Blero, D., Payrastre, B., Schurmans, S., & Erneux, C. (2007). Phosphoinositide phosphatases in a network of signaling reactions. Pflügers Archiv: European Journal of Physiology, 455, 31-44. doi:10.1007/s00424-007-0304-5
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Jia, Y., Subramanian, K. K., Erneux, C., Pouillon, V., Hattori, H., Jo, H., You, J., Zhu, D., Serhan, C., Schurmans, S., & Luo, H. R. (2007). Ins(1,3,4,5)P4 negatively regulates PtdIns(3,4,5)P3 signaling in neutrophils. Immunity, 27, 453-467. doi:10.1016/j.immuni.2007.07.016
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Zhang, J., Liu, Z., Rasschaert, J., Blero, D., Deneubourg, L., Schurmans, S., Erneux, C., & Pesesse, X. (2007). SHIP2 controls PtdIns(3,4,5)P3 and PKB activity in response to oxidative stress. Cellular Signalling, 19, 2194-2200. doi:10.1016/j.cellsig.2007.06.022
Peer Reviewed verified by ORBi

Maréchal, Y., Pesesse, X., Jia, Y., Pouillon, V., Pérez-Morga, D., Daniel, J., Izui, S., Cullen, P. J., Leo, O., Luo, H. R., Erneux, C., & Schurmans, S. (2007). Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells. Proceedings of the National Academy of Sciences of the United States of America, 104, 13978-13983. doi:10.1073/pnas.0704312104
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Leyman, A., Pouillon, V., Bostan, A., Schurmans, S., Erneux, C., & Pesesse, X. (2007). The absence of expression of the three isoenzymes of inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts. Cellular Signalling, 19, 1497-1504. doi:10.1016/j.cellsig.2007.01.024
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Bearzatto, B., Servais, L., Roussel, C., Gall, D., Baba-Aïssa, F., Schurmans, S., de Kerchove d’Exaerde, A., Cheron, G., & Schiffmann, S. N. (2006). Targeted calretinin expression in granule cells of calretinin-null mice restores normal cerebellar functions. FASEB Journal, 20, 380-382. doi:10.1096/fj.05-3785fje
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Blero, D., Zhang, J., Pesesse, X., Payrastre, B., Dumont, J. E., Schurmans, S., & Erneux, C. (2005). Phosphatidylinositol 3,4,5-trisphosphate modulation in Ship2-deficient mouse embryonic fibroblasts. FEBS Journal, 272, 2512-2522. doi:10.1111/j.1742-4658.2005.04672.x
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Behrends, J., Clement, S., Pajak, B., Pohl, V., Maenhaut, C., Dumont, J. E., & Schurmans, S. (2005). Normal thyroid structure and function in rhophilin 2-deficient mice. Molecular and Cellular Biology, 25, 2846-2852. doi:10.1128/MCB.25.7.2846-2852.2005
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Clément, S., Krause, U., Desmedt, F., Tanti, J. F., Behrends, J., Pesesse, X., Sasaki, T., Penninger, J., Doherty, M., Malaisse, W., Dumont, J. E., Le Marchand-Brustel, Y., Erneux, C., Hue, L., & Schurmans, S. (2004). Corrigenda: The lipid phosphatase SHIP2 controls insulin sensitivity. Nature, 431, 878. doi:10.1038/nature03003
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Sokolow, S., Manto, M., Gailly, P., Molgó, J., Vandebrouck, C., Vanderwinden, J. M., Herchuelz, A., & Schurmans, S. (2004). Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3. Journal of Clinical Investigation, 113, 265-273. doi:10.1172/JCI18688
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Wang, Y., Keogh, R. J., Hunter, M. G., Mitchell, C. A., Frey, R. S., Javaid, K., Malik, A. B., Schurmans, S., Tridandapani, S., & Marsh, C. B. (2004). SHIP2 is recruited to the cell membrane upon M-CSF stimulation and regulates M-CSF-induced signaling. Journal of Immunology, 6820-6830. doi:10.4049/jimmunol.173.11.6820
Peer Reviewed verified by ORBi

Kaisaki, P. J., Delépine, M., Woon, P. Y., Sebag-Montefiore, L., Wilder, S. P., Menzel, S., Vionnet, N., Marion, E., Riveline, J. P., Charpentier, G., Schurmans, S., Levy, J. C., Lathrop, M., Farrall, M., & Gauguier, D. (2004). Polymorphisms in Type-II SH2 domain-containing Inositol 5-Phosphatase (INPPL1, SHIP2) are Associated with Physiological Abnormalities of the Metabolic Syndrome. Diabetes, 53, 1900-1904. doi:10.2337/diabetes.53.7.1900
Peer Reviewed verified by ORBi

Hascakova-Bartova, R., Pouillon, V., Dewaste, V., Moreau, C., Jacques, C., Banting, G., Schurmans, S., & Erneux, C. (2004). Identification and subcellular distribution of endogenous Ins(1,4,5)P3 3-kinase B in mouse tissues. Biochemical and Biophysical Research Communications, 323 (3), 920-925. doi:10.1016/j.bbrc.2004.08.152
Peer reviewed

Giuriato, S., Pesesse, X., Bodin, S., Sasaki, T., Viala, C., Marion, E., Penninger, J., Schurmans, S., Erneux, C., & Payrastre, B. (2003). SH2 domain containing inositol 5-phosphatases 1 and 2 in blood platelets: interaction and respective role in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochemical Journal, 376, 199-207. doi:10.1042/BJ20030581
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Pouillon, V., Hascakova-Bartova, R., Pajak, B., Adam, E., Bex, F., Dewaste, V., Van Lint, C., Leo, O., Erneux, C., & Schurmans, S. (2003). Inositol 1,3,4,5-tetrakisphosphate is essential for normal T lymphocyte development. Nature Immunology, 4, 1136-1143. doi:10.1038/ni980
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Schurmans, S. (2003). SHIP2 et signalisation de l'insuline: quel role dans la pathogenese et le traitement du diabete de type 2? Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique, 158 (7-9), 335-9.
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Gall, D., Roussel, C., Susa, I., D’Angelo, E., Rossi, P., Bearzatto, B., Galas, M. C., Blum, D., Schurmans, S., & Schiffmann, S. N. (2003). Altered neuronal excitability in cerebellar granule cells of mice lacking calretinin. Journal of Neuroscience, 23 (28), 9320-9327. doi:10.1523/jneurosci.23-28-09320.2003
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Robaye, B., Ghanem, E., Wilkin, F., Fokan, D., Van Driessche, W., Schurmans, S., Boeynaems, J. M., & Beauwens, R. (2003). Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice. Molecular Pharmacology, 63 (4), 777-783. doi:10.1124/mol.63.4.777
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Marion, E., Kaisaki, P. J., Pouillon, V., Gueydan, C., Levy, J. C., Bodson, A., Krzentowski, G., Daubresse, J.-C., Mockel, J., Behrends, J., Servais, G., Szpirer, C., Kruys, V., Gauguier, D., & Schurmans, S. (2002). The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. Diabetes, 51, 2012-2017. doi:10.2337/diabetes.51.7.2012
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Dremier, S., Coulonval, K., Perpete, S., Vandeput, F., Fortemaison, N., Van Keymeulen, A., Deleu, S., Ledent, C., Clement, S., Schurmans, S., Dumont, J. E., Lamy, F., Roger, P. P., & Maenhaut, C. (2002). The role of cyclic AMP and its effect on protein kinase A in the mitogenic action of thyrotropin on the thyroid cell. Annals of the New York Academy of Sciences, 968, 106-121. doi:10.1111/j.1749-6632.2002.tb04330.x
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Clément, S., Refetoff, S., Robaye, B., Dumont, E., & Schurmans, S. (2001). Low TSH requirement and goiter in transgenic mice overexpressing IGF-1 and IGF-1R in the thyroid gland. Endocrinology, 142 (12), 5131-5139. doi:10.1210/endo.142.12.8534
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Clément, S., Krause, U., Desmedt, F., Tanti, J. F., Behrends, J., Pesesse, X., Sasaki, T., Penninger, J., Doherty, M., Malaisse, W., Dumont, J. E., Le Marchand-Bruste, Y., Erneux, C., Hue, L., & Schurmans, S. (2001). The lipid phosphatase SHIP2 controls insulin sensitivity. Nature, 409, 92-97. doi:10.1038/35051094
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Schurmans, S. (2001). The Insulin-Sensitive Side of SHIP2. Scientific World Journal, 1, 209-210. doi:10.1100/tsw.2001.34
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Bouilleret, V., Schwaller, B., Schurmans, S., Celio, M. R., & Fritschy, J. M. (2000). Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin. Neuroscience, 97 (1), 47-58. doi:10.1016/S0306-4522(00)00017-8
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Cheron, G., Schurmans, S., Lohof, A., d'Alcantara, P., Meyer, M., Draye, J.-P., Parmentier, M., & Schiffmann, S. N. (2000). Electrophysiological behavior of Purkinje cells and motor coordination in calretinin knock-out mice. Progress in Brain Research, 124, 299-308. doi:10.1016/s0079-6123(00)24024-7
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Cocea, L., De Smet, A., Saghatchian, M., Fillatreau, S., Ferradini, L., Schurmans, S., Weill, J. C., & Reynaud, A. (1999). A targeted deletion of a region upstream from the Jkappa cluster impairs kappa chain rearrangement in cis in mice and in the 103/bcl2 cell line. Journal of Experimental Medicine, 189, 1443-1450. doi:10.1084/jem.189.9.1443
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Schiffmann, S. N., Cheron, G., Lohoff, A., D’Alcantara, P., Meyer, M., Parmentier, M., & Schurmans, S. (1999). Impaired motor coordination and Purkinje cell excitability in mice lacking calretinin. Proceedings of the National Academy of Sciences of the United States of America, 96, 5257-5262. doi:10.1073/pnas.96.9.5257
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Pirson, I., Behrens, J., Savonet, V., Goffard, J. C., Dumont, J. E., Schurmans, S., & MaenhauT, C. (1999). Identification and characterization of mRNAs differentially expressed in thyroid cells stimulated by a mitogenic treatment. Biochimie, 81, 309-314. doi:10.1016/S0300-9084(99)80075-3
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Coppée, F., Ledent, C., Clement, S., Dessars, B., Goffart, J. C., Parma, J., Parmentier, M., Schurmans, S., & Dumont, J. E. (1999). Transgenic models of thyroid tumorigenesis: relation to Chernobyl cancers. In G. Thomas, A. Karaoglou, ... E. D. Williams (Eds.), Radiation and Thyroid Cancer. Singapore: Word Scientific Publishing.

Schurmans, S., Carrio, R., Behrens, J., Pouillon, V., Merino, J., & Clément, S. (1999). The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse. Genomics, 62, 260-271. doi:10.1006/geno.1999.5995
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Schurmans, S. (1998). Analysis of dentate gyrus long-term potentiation in calretinin mutant mice. Cell Biology International, 22 (5), 372-374.
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Gurden, H., Schiffmann, S. N., Lemaire, M., Böhme, G. A., ParmentieR, M., & Schurmans, S. (1998). Calretinin expression as a critical component in the control of dentate gyrus long-term potentiation in mice. European Journal of Neuroscience, 10, 3029-3033. doi:10.1111/j.1460-9568.1998.00373.x
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Schiffman, S. N., Schurmans, S., Gurden, H., Lemaire, M., Lipp, H. P., Pochet, R., Imperato, A., Bohme, G. A., & Parmentier, M. (1998). Impaired LTP in the dentate gyrus of calretinin deficient mice. Cell Biology International, 22 (5), 386-387.
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Halleux, P., Schurmans, S., Schiffmann, S. N., Lecocq, R., Conreur, J. L., Dumont, J. E., & Vanderhaeghen, J. J. (1998). Calcium binding protein calcyphosin in dog central astrocytes and ependymal cells and in peripheral neurons. Journal of Chemical Neuroanatomy, 15, 239-250. doi:10.1016/S0891-0618(98)00049-0
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Clément, S., Dumont, J., & Schurmans, S. (1997). Loss of calcyphosin gene expression in mouse and other rodents. Biochemical and Biophysical Research Communications, 232, 407-413. doi:10.1006/bbrc.1997.6297
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Vanderhaeghen, P., Schurmans, S., Vassart, G., & Parmentier, M. (1997). Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. Genomics, 39, 239-246. doi:10.1006/geno.1996.4490
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Vanderhaeghen, P., Schurmans, S., Vassart, G., & Parmentier, M. (1997). Molecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome. Biochemical and Biophysical Research Communications, 237, 283-287. doi:10.1006/bbrc.1997.7043
Peer reviewed

Schurmans, S., Schiffmann, S. N., Gurden, H., Lemaire, M., Lipp, H. P., Schwam, V., Pochet, R., Imperato, A., Böme, G. A., & Parmentier, M. (1997). Impaired LTP induction in dentate gyrus of calretinin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 94, 10415-10420. doi:10.1073/pnas.94.19.10415
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Gonzales, M., Schurmans, S., Ramos, A., Merino, R., Lambert, P. H., & Merino, J. (1995). CD4+ T cells determine the ability of spleen cells from F1 hybrid mice to induce neonatal tolerance to alloantigens and autoimmunity in parental mice. European Journal of Immunology, 25, 1760-1764.
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Kramar, G., Schurmans, S., Berney, M., Izui, S., del Giudice, G., & Lambert, P. H. (1995). Autoimmunity following neonatal tolerance to alloantigens: role of donor I-A and I-E molecules. Journal of Autoimmunity, 8, 177-192. doi:10.1006/jaut.1995.0014
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Schurmans, S., Gonzalez, A., Revilla, C., Ramos, A., Lambert, P. H., & Merino, J. (1994). Anti-LFA-1 (CD11a) monoclonal antibody interferes with the induction of neonatal tolerance to alloantigens. European Journal of Immunology, 24, 985-990. doi:10.1002/eji.1830240431
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Parmentier, M., Schurmans, S., Libert, F., Vanderhaegen, P., & Vassart, G. (1994). Olfactory Receptors. In S. Peroutka (Ed.), Handbook of Receptors and Channels: G Protein Coupled Receptors (pp. 237-250). CRC Press, Boca Raton.

Parmentier, M., Vanderhaeghen, P., Schurmans, S., Libert, F., & Vassart, G. (1994). Génétique moléculaire des récepteurs olfactifs. MS. Medecine Sciences, 10, 1083-1090. doi:10.4267/10608/2531
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Vanderhaeghen, P., Schurmans, S., Parmentier, M., & Vassart, G. (1994). Les spermatozoïdes ont-ils du nez ? MS. Medecine Sciences, 10, 1136-1140. doi:10.4267/10608/2537
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Kramar, G., Schurmans, S., Aguado, T., Izui, S., del Guidice, G., & Lambert, P. H. (1993). Anti-Ia treatment prevents lupus-like autoimmune syndrome in mice neonatally tolerized to alloantigens. Journal of Autoimmunity, 1, 27-37. doi:10.1006/jaut.1993.1003
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Parmentier, M., Libert, F., Perret, J., Eggerickx, D., Ledent, C., Schurmans, S., Raspe, E., Dumont, J., & Vassart, G. (1993). Cloning and characterization of G protein-coupled receptors. Advances in Second Messenger and Phosphoprotein Research, 28, 11-18.
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Schurmans, S., Muscatelli, F., Miot, F., Mattei, M. G., Vassart, G., & Parmentier, M. (1993). The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p12-17p13 region of the human genome and reveals a MspI restriction fragment lenght polymorphism. CytoGenetics and Cell Genetics, 63, 200-204. doi:10.1159/000133534
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Vanderhaeghen, P., Schurmans, S., Vassart, G., & Parmentier, M. (1993). Olfactory receptors are displayed on dog mature sperm cells. Journal of Cell Biology, 123, 1441-1452. doi:10.1083/jcb.123.6.1441
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Parmentier, M., Libert, F., Schurmans, S., Schiffmann, S., Lefort, A., Eggerickx, D., Ledent, C., Mollereau, C., Gerard, C., Perret, J., Grootegoed, A., & Vassart, G. (1992). Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Nature, 355, 453-455. doi:10.1038/355453a0
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Vassart, G., Parmentier, M., Libert, M., Eggerickx, D., Gerard, C., Maenhaut, C., Mollereau, C., Perret, J., Schurmans, S., & Van Sande, J. (1992). Identification of orphan G protein-coupled receptors. Clinical Neuropharmacology, 15, 147-148. doi:10.1097/00002826-199201001-00079
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Schurmans, S., Merino, J., Qin, H., Kramar, G., Duchosal, M., Skalli, O., Benzonana, G., Gabbiani, G., & Lambert, P. H. (1991). Autoimmune syndrome after neonatal induction of tolerance to alloantigens: analysis of the specificity and of the cellular and genetic origin of autoantibodies. Autoimmunity, 9, 283-291. doi:10.3109/08916939108997130
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Schurmans, S., Brighouse, G., Kramar, G., Wen, L., Izui, S., Merino, J., & Lambert, P. H. (1991). Transient T and B cell activation after neonatal induction of tolerance to MHC class II and Mls alloantigens. Journal of Immunology, 146, 2152-2160.
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Merino, J., Schurmans, S., Wen, L., Brighouse, G., Luzuy, S., & Lambert, P. H. (1990). Autoimmune syndrome after neonatal induction of tolerance to alloantigens: analysis of the role of donor T cells in the induction of autoimmunity. Clinical and Experimental Immunology, 79, 273-278. doi:10.1111/j.1365-2249.1990.tb05190.x
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Schurmans, S., Heusser, C., Qin, H., Merino, J., Brighouse, G., & Lambert, P. H. (1990). In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated-autoimmune syndrome. Journal of Immunology, 145, 2465-2473.
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Reininger, L., Shibata, T., Schurmans, S., Merino, R., Lacour, M., & Izui, S. (1990). Spontaneous production of anti-mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice. European Journal of Immunology, 20, 2405-2410. doi:10.1002/eji.1830201107
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Merino, J., Schurmans, S., Duchosal, M., Izui, S., & Lambert, P. H. (1989). Autoimmune syndrome after induction of neonatal tolerance to alloantigens: CD4+ T cells from the tolerant host activate autoreactive F1 B cells. Journal of Immunology, 143, 2202-2208.
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Merino, J., Qin, H., Schurmans, S., Gretener, D., Grau, G., & Lambert, P. H. (1989). Thrombocytopenia associated with the induction of neonatal tolerance to alloantigens: immunopathogenic mecanisms. European Journal of Immunology, 19, 1693-1699. doi:10.1002/eji.1830190925
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Stott, D., Merino, J., Schurmans, S., & Lambert, P. H. (1988). Expression of anti-DNA clonotypes and the role of helper T-lymphocytes during the autoimmune response in mice tolerant to alloantigens. Autoimmunity, 1 (4), 253-266. doi:10.3109/08916938809010679
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Stott, D., Merino, J., Schurmans, S., & Lambert, P. H. (1988). Analysis of the autoimmune response to DNA in tolerant mice by isoelectric focusing and reverse immunoblotting. 2: The role of Helper T cells and major histocompatibility complex antigens. Biochemical Society Transactions, 16, 148-149.
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Stott, D., Merino, J., Schurmans, S., & Lambert, P. H. (1988). Analysis of the autoimmune response to DNA in tolerant mice by isoelectric focusing and reverse immunoblotting. 1: Clonal restriction and time course. Biochemical Society Transactions, 16, 147-148. doi:10.1042/bst0160147
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Merino, J., Schurmans, S., Luzuy, S., Izui, S., Vassali, P., & Lambert, P. H. (1987). Autoimmune syndrome after induction of neonatal tolerance to alloantigens: effects of in vivo treatment with anti-T cell subset monoclonal antibodies. Journal of Immunology, 139, 1426-1431.
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