Reference : A simple calibration approach based on film-casting for confocal Raman microscopy to ...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/195263
A simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a Hot-Melt Extrusion process
English
Netchacovitch, Lauranne mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Thiry, Justine mailto [Université de Liège > Département de pharmacie > Pharmacie galénique >]
De Bleye, Charlotte mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Dumont, Elodie mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Dispas, Amandine mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Hubert, Cédric mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Krier, Fabrice [> >]
Sacre, Pierre-Yves mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Evrard, Brigitte mailto [Université de Liège > Département de pharmacie > Pharmacie galénique >]
Hubert, Philippe mailto [Université de Liège > Département de pharmacie > Chimie analytique >]
Ziemons, Eric mailto [Université de Liège > Département de pharmacie > Département de pharmacie >]
Jul-2016
Talanta
Elsevier Science
154
392-399
Yes (verified by ORBi)
International
0039-9140
1873-3573
Amsterdam
The Netherlands
[en] Hot-melt extrusion ; Film-casting technique ; Confocal Raman microscopy ; Ultra High Performance Liquid Chromatography ; Accuracy profile
[en] When developing a new formulation, the development, calibration and validation steps of analytical methods based on vibrational spectroscopy are time-consuming. For each new formulation, real samples must be produced and a “reference method” must be used in order to determine the Active Pharmaceutical Ingredient (API) content of each sample. To circumvent this issue, the paper presents a simple approach based on the film-casting technique used as a calibration tool in the framework of hot-melt extrusion process.
Confocal Raman microscopic method was successfully validated for the determination of itraconazole content in film-casting samples. Then, hot-melt extrusion was carried out to produce real samples in order to confront the results obtained with confocal Raman microscopy and Ultra High Performance Liquid Chromatography (UHPLC). The agreement between both methods was demonstrated using a comparison study based on the Bland and Altman’s plot.
Centre Interfacultaire de Recherche du Médicament - CIRM
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/195263
10.1016/j.talanta.2016.03.080

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