An in computo investigation of the Landau-Kleffner syndrome.

[en] We describe a computational model of the thalamus and the cortex able to reproduce some essential epileptiform features commonly observed in the Landau-Kleffner syndrome. Investigation with this realistic model leads us to the formulation of a cellular mechanism that could be responsible for the epileptic discharges occuring with this severe syndrome. Understanding this mechanism is of prime importance for developing new therapeutical strategies.

Disciplines :

Neurosciences & behavior
Neurology

Author, co-author :

Bonjean, Maxime ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation

Phillips, Christophe ; Université de Liège - ULiège > Centre de recherches du cyclotron - Dép. d'électric., électron. et informat. (Inst.Montefiore)

Dang Vu, Thien Thanh ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Sepulchre, Rodolphe ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation

Maquet, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

Language :

English

Title :

An in computo investigation of the Landau-Kleffner syndrome.

Publication date :

2007

Journal title :

Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society

ISSN :

1557-170X

Publisher :

IEEE Service Center, Piscataway, United States - New Jersey

Volume :

2007

Pages :

2730-4

Peer reviewed :

Peer reviewed

Available on ORBi :

since 19 April 2010

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Bibliography

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