[en] We describe a computational model of the thalamus and the cortex able to reproduce some essential epileptiform features commonly observed in the Landau-Kleffner syndrome. Investigation with this realistic model leads us to the formulation of a cellular mechanism that could be responsible for the epileptic discharges occuring with this severe syndrome. Understanding this mechanism is of prime importance for developing new therapeutical strategies.
Disciplines :
Neurosciences & behavior Neurology
Author, co-author :
Bonjean, Maxime ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Phillips, Christophe ; Université de Liège - ULiège > Centre de recherches du cyclotron - Dép. d'électric., électron. et informat. (Inst.Montefiore)
Dang Vu, Thien Thanh ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Sepulchre, Rodolphe ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Maquet, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman
Language :
English
Title :
An in computo investigation of the Landau-Kleffner syndrome.
Publication date :
2007
Journal title :
Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
ISSN :
1557-170X
Publisher :
IEEE Service Center, Piscataway, United States - New Jersey
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