Reference : Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/189898
Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy.
English
Xu, Xuewen [> >]
Ectors, Fabien mailto [Université de Liège > > GIGA-Technology platforms : Plate-forme transgénique >]
Davis, Erica E. [> >]
Pirottin, Dimitri mailto [Université de Liège > Département des sciences fonctionnelles (DSF) > Département des sciences fonctionnelles (DSF) >]
Cheng, Huijun mailto [Université de Liège - ULiège > > > Doct. sc. vété. (Bologne)]
Farnir, Frédéric mailto [Université de Liège > Département des productions animales (DPA) > Biostatistiques et bioinformatique appliquées aux sc. vétér. >]
Hadfield, Tracy [> >]
Cockett, Noelle [> >]
Charlier, Carole mailto [Université de Liège > Département des productions animales (DPA) > GIGA-R : Génomique animale >]
Georges, Michel mailto [Université de Liège > Département des productions animales (DPA) > GIGA-R : Génomique animale >]
Takeda, Haruko mailto [Université de Liège > > GIGA-Research >]
16-Oct-2015
PLoS ONE
10
10
e0140594
Yes (verified by ORBi)
International
1932-6203
United States
[en] The callipyge phenotype is an ovine muscular hypertrophy characterized by polar overdominance: only heterozygous +Mat/CLPGPat animals receiving the CLPG mutation from their father express the phenotype. +Mat/CLPGPat animals are characterized by postnatal, ectopic expression of Delta-like 1 homologue (DLK1) and Paternally expressed gene 11/Retrotransposon-like 1 (PEG11/RTL1) proteins in skeletal muscle. We showed previously in transgenic mice that ectopic expression of DLK1 alone induces a muscular hypertrophy, hence demonstrating a role for DLK1 in determining the callipyge hypertrophy. We herein describe newly generated transgenic mice that ectopically express PEG11 in skeletal muscle, and show that they also exhibit a muscular hypertrophy phenotype. Our data suggest that both DLK1 and PEG11 act together in causing the muscular hypertrophy of callipyge sheep.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/189898
10.1371/journal.pone.0140594
http://reflexions.ulg.ac.be/en/Callipyge

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