Use of the Chromosomal Class a Beta-Lactamase of Mycobacterium Fortuitum D316 to Study Potentially Poor Substrates and Inhibitory Beta-Lactam Compounds
[en] Sixteen different compounds usually considered beta-lactamase stable or representing potential beta-lactam inhibitors and inactivators were tested against the beta-lactamase produced by Mycobacterium fortuitum. The compounds exhibiting the most interesting properties were BRL42715, which was by far the best inactivator, and CGP31608 and ceftazidime, which were not recognized by the enzyme. These compounds thus exhibited adequate properties for fighting mycobacterial infections. Although cloxacillin, dicloxacillin, cefoxitin, and CP65207-2 exhibited poor inhibitory efficiency against the enzyme, they were also rather poor substrates and might be considered potential antimycobacterial agents. By contrast, CGP31523A and ceftamet were good substrates.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Galleni, Moreno ; Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques
Franceschini, N.
Quinting, B.
Fattorini, L.
Orefici, G.
Oratore, A.
Frère, Jean-Marie ; Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie
Amicosante, G.
Language :
English
Title :
Use of the Chromosomal Class a Beta-Lactamase of Mycobacterium Fortuitum D316 to Study Potentially Poor Substrates and Inhibitory Beta-Lactam Compounds
Publication date :
July 1994
Journal title :
Antimicrobial Agents and Chemotherapy
ISSN :
0066-4804
eISSN :
1098-6596
Publisher :
American Society for Microbiology, Washington, United States - District of Columbia