Inhibitors of the FEZ-1 metallo-beta-lactamase

[en] Metallo-beta-lactamases (MBLs) catalyze the hydrolysis of beta-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K-i of 6.1 +/- 0.71 mu M against the FEZ-1 MBL but does not significantly inhibit the IMP-1, Bell, CphA or L1 MBLs. (c) 2006 Elsevier Ltd. All rights reserved.

Disciplines :

Pharmacy, pharmacology & toxicology
Chemistry

Author, co-author :

Lienard, B. M. R.

Horsfall, L. E.

Galleni, Moreno ; Université de Liège - ULiège > Département des sciences de la vie > Macromolécules biologiques

Frère, Jean-Marie ; Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie

Schofield, C. J.

Language :

English

Title :

Inhibitors of the FEZ-1 metallo-beta-lactamase

Publication date :

15 February 2007

Journal title :

Bioorganic and Medicinal Chemistry Letters

ISSN :

0960-894X

eISSN :

1464-3405

Publisher :

Pergamon-Elsevier Science Ltd, Oxford, United Kingdom

Volume :

Issue :

Pages :

964-968

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 November 2015

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Bibliography

Bush K., Jacoby G.A., and Medeiros A.A. Antimicrob. Agents Chemother. 39 (1995) 1211
Phillips O.A. Expert Opin. Ther. Pat. 16 (2006) 319
Felici A., Amicosante G., Oratore A., Strom R., Ledent P., Joris B., Fanuel L., and Frère J.M. Biochem. J. 291 Pt 1 (1993) 151
Segatore B., Massidda O., Satta G., Setacci D., and Amicosante G. Antimicrob. Agents Chemother. 37 (1993) 1324
Hernandez Valladares M., Felici A., Weber G., Adolph H.W., Zeppezauer M., Rossolini G.M., Amicosante G., Frère J.M., and Galleni M. Biochemistry 36 (1997) 11534
Mollard C., Moali C., Papamicael C., Damblon C., Vessilier S., Amicosante G., Schofield C.J., Galleni M., Frère J.M., and Roberts G.C. J. Biol. Chem. 276 (2001) 45015
Heinz U., Bauer R., Wommer S., Meyer-Klaucke W., Papamichaels C., Bateson J., and Adolph H.W. J. Biol. Chem. 278 (2003) 20659
Buynak J.D., Chen H., Vogeti L., Gadhachanda V.R., Buchanan C.A., Palzkill T., Shaw R.W., Spencer J., and Walsh T.R. Bioorg. Med. Chem. Lett. 14 (2004) 1299
Sun Q., Law A., Crowder M.W., and Geysen H.M. Bioorg. Med. Chem. Lett. 16 (2006) 5169
Walter M.W., Felici A., Galleni M., Soto R.P., Adlington R.M., Baldwin J.E., Frère J.M., Gololobov M., and Schofield C.J. Bioorg. Med. Chem. Lett. 6 (1996) 2455
Walter M.W., Valladares M.H., Adlington R.M., Amicosante G., Baldwin J.E., Frère J.M., Galleni M., Rossolini G.M., and Schofield C.J. Bioorg. Chem. 27 (1999) 35
Toney J.H., Fitzgerald P.M., Grover-Sharma N., Olson S.H., May W.J., Sundelof J.G., Vanderwall D.E., Cleary K.A., Grant S.K., Wu J.K., Kozarich J.W., Pompliano D.L., and Hammond G.G. Chem. Biol. 5 (1998) 185
Siemann S., Evanoff D.P., Marrone L., Clarke A.J., Viswanatha T., and Dmitrienko G.I. Antimicrob. Agents Chemother. 46 (2002) 2450
Toney J.H., Hammond G.G., Fitzgerald P.M., Sharma N., Balkovec J.M., Rouen G.P., Olson S.H., Hammond M.L., Greenlee M.L., and Gao Y.D. J. Biol. Chem. 276 (2001) 31913
Garcia-Saez I., Mercuri P.S., Papamicael C., Kahn R., Frère J.M., Galleni M., Rossolini G.M., and Dideberg O. J. Mol. Biol. 325 (2003) 651
Kemperman G.J., Roeters T.A., and Hilberink P.W. Eur. J. Org. Chem. 9 (2003) 1681
Jones G., Willett P., Glen R.C., Leach A.R., and Taylor R. J. Mol. Biol. 267 (1997) 727
Olsen L., Pettersson I., Hemmingsen L., Adolph H.W., and Jorgensen F.S. J. Comput. Aided Mol. Des. 18 (2004) 287
Chevrier B., D'Orchymont H., Schalk C., Tarnus C., and Moras D. Eur. J. Biochem. 237 (1996) 393