[en] The human pituitary growth hormone (hGH-N) is mainly known for its effects on the staturo-ponderal growth and on the lipid and carbohydrate metabolism. It also plays a part in the immune system regulation.
According to many authors, hGH-N stimulates the proliferation of peripheral blood mononuclear cells or that of tumoral lymphoid cell lines.
With the aid of the FACS (Fluorescent-Activated Cell Sorter), we were able to detect hGH-N receptors on various tumoral cell lines : JURKAT (a acute lymphoid leukemia T cell line), DAUDI and RAJI (acute lymphoid leukemia B cell lines). These receptors were nearly absent from quiescent B or T cells prepared from human tonsils but were expressed in culture conditions after activation.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Thellin, Olivier ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie
Coumans, Bernard ; Université de Liège - ULiège > GIGA - Neurosciences
Mélot, France ; Université de Liège - ULiège > Service administratif de la Faculté (Médecine)
Melen, Laurence
Zorzi, Danièle ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Igout, Ahmed ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Heinen, Ernst ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Language :
English
Title :
Expression of growth hormone receptors by normal or pathological human lymphoid cells.
Publication date :
1995
Event name :
meeting annuel de la Belgian Immunological Society
