Reference : High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflam...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/176025
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
English
Goyette, Philippe mailto [> >]
Boucher, Gabrielle mailto [> >]
Mallon, Dermot [> >]
Ellinghaus, Eva mailto [> >]
Jostins, Luke mailto [> >]
Huang, Hailiang mailto [> >]
Ripke, Stephan mailto [> >]
Gusareva, Elena mailto [Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique >]
Annese, Vito [> >]
Hauser, Stephen L [> >]
Oksenberg, Jorge R [> >]
Thomsen, Ingo [> >]
Leslie, Stephen [> >]
Theatre, Emilie mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale > >]
Georges, Michel mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Louis, Edouard mailto [Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie >]
Daly, Mark J [> >]
Van Steen, Kristel mailto [Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique >]
Duerr, Richard H mailto [> >]
Barrett, Jeffrey C mailto [> >]
McGovern, Dermot P mailto [> >]
Schumm, L Philip mailto [> >]
Traherne, James A [> >]
Carrington, Mary N [> >]
Kosmoliaptsis, Vasilis [> >]
Karlsen, Tom H [> >]
Franke, Andre mailto [> >]
Rioux, John D mailto [> >]
5-Jan-2015
Nature Genetics
Nature Publishing Group
47
2
172-9
Yes (verified by ORBi)
International
1061-4036
1546-1718
New York
NY
[en] Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD.
Researchers ; Professionals
http://hdl.handle.net/2268/176025
10.1038/ng.3176
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3176.html

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