Article (Scientific journals)
Data processing of vibrational chemical imaging for pharmaceutical applications.
Sacre, Pierre-Yves; De Bleye, Charlotte; Chavez, Pierre-François et al.
2014In Journal of Pharmaceutical and Biomedical Analysis, 101, p. 123-140
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Keywords :
Hyperspectral imaging; Raman; Near Infrared; Infrared; Chemometrics; Pharmaceuticals
Abstract :
[en] Vibrational spectroscopy (MIR, NIR and Raman) based hyperspectral imaging is one of the most powerful tools analyze pharmaceutical preparation. Indeed, it combines the advantages of vibrational spectroscopy to imaging techniques and allows therefore the visualization of distribution of compounds, crystallization processes. However, these techniques provide a huge amount of data that must be processed to extract the relevant information. This review presents fundamental concepts of hyperspectral imaging, the basic theory of the most used chemometric tools used to pre-process, process and post-process the generated data. The last part of the present paper focuses on pharmaceutical applications of hyperspectral imaging and highlights the data processing approaches to enable the reader making the best choice among the different tools available.
Research center :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Sacre, Pierre-Yves  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
De Bleye, Charlotte  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Chavez, Pierre-François ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Netchacovitch, Lauranne ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Hubert, Philippe  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Ziemons, Eric  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Data processing of vibrational chemical imaging for pharmaceutical applications.
Publication date :
October 2014
Journal title :
Journal of Pharmaceutical and Biomedical Analysis
ISSN :
0731-7085
eISSN :
1873-264X
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
101
Pages :
123-140
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Région wallonne : Direction générale opérationnelle de l'Economie, de l'Emploi et de la Recherche (DGO 6)
Available on ORBi :
since 10 April 2014

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