Data processing of vibrational chemical imaging for pharmaceutical applications.

[en] Vibrational spectroscopy (MIR, NIR and Raman) based hyperspectral imaging is one of the most powerful tools analyze pharmaceutical preparation. Indeed, it combines the advantages of vibrational spectroscopy to imaging techniques and allows therefore the visualization of distribution of compounds, crystallization processes. However, these techniques provide a huge amount of data that must be processed to extract the relevant information. This review presents fundamental concepts of hyperspectral imaging, the basic theory of the most used chemometric tools used to pre-process, process and post-process the generated data. The last part of the present paper focuses on pharmaceutical applications of hyperspectral imaging and highlights the data processing approaches to enable the reader making the best choice among the different tools available.

Research Center/Unit :

Centre Interfacultaire de Recherche du Médicament - CIRM

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Sacre, Pierre-Yves ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

De Bleye, Charlotte ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Chavez, Pierre-François ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Netchacovitch, Lauranne ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Hubert, Philippe ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique

Ziemons, Eric ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Language :

English

Title :

Data processing of vibrational chemical imaging for pharmaceutical applications.

Publication date :

October 2014

Journal title :

Journal of Pharmaceutical and Biomedical Analysis

ISSN :

0731-7085

eISSN :

1873-264X

Publisher :

Elsevier Science, Oxford, United Kingdom

Volume :

101

Pages :

123-140

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

Région wallonne : Direction générale opérationnelle de l'Economie, de l'Emploi et de la Recherche (DGO 6)

Available on ORBi :

since 10 April 2014

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103

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