Article (Scientific journals)
Thymus Involvement in Murine Acquired Immunodeficiency (Maids)
Colombi, Sonia; Deprez, Manuel; de Leval, Laurence et al.
1994In Thymus, 23 (1), p. 27-37
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Keywords :
Immunodeficiency; Lymphoproliferation; MAIDS; Retroviral infections
Abstract :
[en] Due to self-renewal of the peripheral pool of T-cells, adult thymectomy has normally little influence on immunocompetence. However, thymus might play a more important role in the setting of viral-induced cytopathic effects on T-cells in the periphery. Therefore, thymus weight, cell numbers, and subset distribution were sequentially analysed after infection with RadLV-Rs, a viral mixture known to induce murine retrovirus induced immunodeficiency (MAIDS). Infection induced thymic atrophy (concerning organ weight as well as total cell number) which culminated seven weeks after inoculation. The atrophic process mostly reflected the depletion of double positive CD4+ CD8+ cells since their proportion sharply decreased around week 6. Single positive T-cells were less affected by the process. The proportion of B-cells progressively increased. Surprisingly, there was a strong correlation between the extent of atrophy and the frequency of B-cells in the thymus. Finally, an abnormal CD4+ T-cell subset lacking Thy-1 and previously described in the periphery also appeared in the thymus and its frequency was strongly correlated with the expansion of B-cells in this organ.
Disciplines :
Microbiology
Immunology & infectious disease
Author, co-author :
Colombi, Sonia;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie pathologique
Deprez, Manuel ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
de Leval, Laurence ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Humblet, Chantal ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Greimers, Roland ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Moutschen, Michel  ;  Université de Liège - ULiège > Département des sciences cliniques, CHU Liège, GIGA > Immunologie, Maladies Infectieuses et Médecine Interne Générale
Language :
English
Title :
Thymus Involvement in Murine Acquired Immunodeficiency (Maids)
Publication date :
1994
Journal title :
Thymus
ISSN :
0165-6090
Publisher :
Kluwer Academic Publishers, Netherlands
Volume :
23
Issue :
1
Pages :
27-37
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 November 2013

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