Article (Scientific journals)
Application of an innovative design space optimization strategy to thedevelopment of LC methods for the simultaneous screening of antibiotics to combat poor quality medicines
Mbinze Kindenge, Jérémie; Dispas, Amandine; Lebrun, Pierre et al.
2013In Journal of Pharmaceutical and Biomedical Analysis, 85, p. 83– 92
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Keywords :
Antibiotics; Poor quality medecines; Design space
Abstract :
[en] The poor quality of medicines is a crucial problem of public health. Therefore, it is important to haveanalytical tools to attend decisions of the legal authorities while combating this offense. In this context,the main objective of this study was to develop generic methods able to trace, screen and determineseveral antibiotics and common associated molecules by mean of liquid chromatographic techniques.For that purpose, an innovative Design Space optimization strategy was applied, targeting 16 antibioticsand 3 beta-lactamase inhibitors. The robustness of the developed method allowed using its use in anenvironment where operational factors such as temperature are not easy to control and eased its trans-fer to Ultra High Performance Liquid Chromatography. To demonstrate its ability to quantify the targetedmolecules, the developed and transferred method was fully validated for two active ingredients com-monly used in association, sulbactam and ceftriaxone, using the accuracy profile as decision tool. Basedon this successful step, the method was then used for the quantitative determination of these two activeingredients in three pharmaceutical brands marketed in the Democratic Republic of Congo. Two out ofthe three pharmaceutical products did not comply with the specifications
Research center :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Mbinze Kindenge, Jérémie ;  Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
Dispas, Amandine  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Lebrun, Pierre ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Mavar Tayey Mbay, Jean
Habyalimana, Védaste ;  Université de Liège - ULiège > Form. doc. sc. bioméd. & pharma.
Kalenda Tshilombo, Nicodème ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)
Rozet, Eric ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Hubert, Philippe  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Marini Djang'Eing'A, Roland ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Language :
English
Title :
Application of an innovative design space optimization strategy to thedevelopment of LC methods for the simultaneous screening of antibiotics to combat poor quality medicines
Publication date :
November 2013
Journal title :
Journal of Pharmaceutical and Biomedical Analysis
ISSN :
0731-7085
eISSN :
1873-264X
Publisher :
Elsevier Science
Volume :
85
Pages :
83– 92
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Edulink ACP-EU and CUD
Available on ORBi :
since 11 August 2013

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