Inhibition of Streptococcus pneumoniae pencillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

Zervosen, Astrid; Zapun, Andre; Frère, Jean-Marie

doi:10.1128/AAC.01593-12

Article (Scientific journals)

Inhibition of Streptococcus pneumoniae pencillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

Zervosen, Astrid; Zapun, Andre; Frère, Jean-Marie

2013 • In Antimicrobial Agents and Chemotherapy, 57 (1), p. 661-663

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/137439

DOI
10.1128/AAC.01593-12

PubMed
23147739

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Keywords :

ceftaroline; Penicillin Binding Protein

Abstract :

[en] Although the rate of acylation of a penicillin-resistant form of Streptococcus pneumoniae PBP2x by ceftaroline is 80-fold lower than that of its penicillin-sensitive counterpart, it remains sufficiently high (k(2)/K = 12600 M(-1)s(-1)) to explain the sensitivity of the penicillin-resistant strain to this new cephalosporin. Surprisingly, the Actinomadura R39 DD-peptidase is not very sensitive to ceftaroline.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
CIP - Centre d'Ingénierie des Protéines - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology
Microbiology

Author, co-author :

Zervosen, Astrid ; Université de Liège - ULiège > Centre de recherches du cyclotron

Zapun, Andre

Frère, Jean-Marie ; Université de Liège - ULiège > Centre d'ingénierie des protéines

Language :

English

Title :

Inhibition of Streptococcus pneumoniae pencillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.

Publication date :

January 2013

Journal title :

Antimicrobial Agents and Chemotherapy

ISSN :

0066-4804

eISSN :

1098-6596

Publisher :

American Society for Microbiology, Washington, United States - District of Columbia

Volume :

Issue :

Pages :

661-663

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 January 2013

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Bibliography

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