![]() ![]() | Henrottin, J., Lemaire, C., Egrise, D., Zervosen, A., Van den Eynde, B., Plenevaux, A., Franci, X., Goldman, S., & Luxen, A. (June 2016). Fully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging. Nuclear Medicine and Biology, 43 (6), 379-389. doi:10.1016/j.nucmedbio.2016.03.001 ![]() |
![]() ![]() | Simon, J., Lamborelle, N., Zervosen, A., Lemaire, C., Joris, B., & Luxen, A. (2016). Development of solid-supported methodology for the preparation of peptidoglycan fragments containing (2S,6R)-diaminopimelic acid. Tetrahedron Letters. doi:10.1016/j.tetlet.2016.02.098 ![]() |
![]() ![]() | Henrottin, J., Lemaire, C., Zervosen, A., Egrise, D., Plenevaux, A., Doumont, G., Goldman, S., & Luxen, A. (May 2015). Fully automated radiosynthesis of 1-[18F]FETrp, a potential substrate for indoleamine 2,3-dioxygenase PET imaging [Poster presentation]. The 21st International Symposium on Radiopharmaceutical Sciences (ISRS 2015), University of Missouri, Columbia, Missouri, United States. |
![]() ![]() | Henrottin, J., Lemaire, C., Zervosen, A., Egrise, D., Doumont, G., Plenevaux, A., Goldman, S., & Luxen, A. (02 April 2015). N1-(2-[18F]Fluoroethyl)-tryptophan: fully automated radiosynthesis, and study as potential substrate for indoleamine 2,3-dioxygenase PET imaging [Paper presentation]. La Journée-Rencontre des Jeunes Chimistes de la Société Royale de Chimie - 8ème édition, Namur, Belgium. |
![]() ![]() | Henrottin, J., Zervosen, A., Lemaire, C., Sapunaric, F., Laurent, S., Van den Eynde, B., Goldman, S., Plenevaux, A., & Luxen, A. (January 2015). N1-Fluoroalkyltryptophan analogues: synthesis and in vitro study as potential substrates for indoleamine 2,3-dioxygenase. ACS Medicinal Chemistry Letters, 6, 260-265. doi:10.1021/ml500385d ![]() |
![]() ![]() | Henrottin, J., Zervosen, A., Lemaire, C., Sapunaric, F., Laurent, S., Galleni, M., Van den Eynde, B., Goldman, S., Plenevaux, A., & Luxen, A. (June 2014). Synthesis of N-fluoroalkyl-tryptophan and study of their biological activity as potential substrates for indoleamine 2,3-dioxygenase [Poster presentation]. French-American Chemical society Symposium - FACS XV. |
![]() ![]() | Denoël, T., Zervosen, A., Lemaire, C., Plenevaux, A., & Luxen, A. (2014). Synthesis of protected α-alkyl lanthionine derivatives. Tetrahedron, 70 (30), 4526 - 4533. doi:10.1016/j.tet.2014.05.004 ![]() |
![]() ![]() | Denoel, T., Zervosen, A., Lemaire, C., Joris, B., Herve, M., Blanot, D., Zaragoza, G., & Luxen, A. (2014). Enantioselective synthesis of [small alpha]-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan. Organic and Biomolecular Chemistry. doi:10.1039/c4ob01476f ![]() |
![]() ![]() | Denoel, T., Zervosen, A., Gerards, T., Lemaire, C., Joris, B., Blanot, D., & Luxen, A. (2014). Stereoselective synthesis of lanthionine derivatives in aqueous solution and their incorporation into the peptidoglycan of Escherichia coli. Bioorganic and Medicinal Chemistry, 22 (17), 4621-8. doi:10.1016/j.bmc.2014.07.023 ![]() |
Simon, J., Zervosen, A., Bouillez, A., & Luxen, A. (19 June 2013). Enantioselective synthesis of thioesters as substrates for high-through put screening assays of Penicillin Binding Proteins [Poster presentation]. Biomedica 2013, Aachen, Germany. |
![]() ![]() | Henrottin, J., Zervosen, A., Lemaire, C., Galleni, M., & Luxen, A. (May 2013). Automated radiosynthesis of 1-(2-[18F]fluoroethyl)-tryptophan, a potential substrate for indoleamine 2,3-dioxygenase PET imaging [Poster presentation]. The 20th International Symposium on Radiopharmaceutical Sciences - ISRS 2013, Jéju, South Korea. |
![]() ![]() | Gahungu, M., Arguelles Arias, A., Fickers, P., Zervosen, A., Joris, B., Damblon, C., & Luxen, A. (2013). Synthesis and biological evaluation of potential threonine synthase inhibitors: Rhizocticin A and Plumbemycin A. Bioorganic and Medicinal Chemistry, 21 (17), 4958-67. doi:10.1016/j.bmc.2013.06.064 ![]() |
![]() ![]() | Zervosen, A., Zapun, A., & Frère, J.-M. (January 2013). Inhibition of Streptococcus pneumoniae pencillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline. Antimicrobial Agents and Chemotherapy, 57 (1), 661-663. doi:10.1128/AAC.01593-12 ![]() |
Zervosen, A., Sauvage, E., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Charlier, P., & Luxen, A. (18 April 2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C [Poster presentation]. Biomedica 2012, Liège, Belgium. |
![]() ![]() | Zervosen, A., Sauvage, E., Frère, J.-M., Charlier, P., & Luxen, A. (2012). Development of new drugs for an old target — the penicillin binding proteins. Molecules, 17 (11), 12478-505. doi:10.3390/molecules171112478 ![]() |
![]() ![]() | Zervosen, A., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Sauvage, E., Charlier, P., & Luxen, A. (2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C. Bioorganic and Medicinal Chemistry, 20 (12), 3915-24. doi:10.1016/j.bmc.2012.04.018 ![]() |
![]() ![]() | Sliwa, A., Dive, G., Zervosen, A., Verlaine, O., Sauvage, E., & Marchand-Brynaert, J. (2012). Unprecedented inhibition of resistant penicillin binding proteins by bis-2-oxoazetidinyl macrocycles. MedChemComm, 3, 344-351. doi:10.1039/c2md00251e ![]() |
![]() ![]() | Sosic, I., Turk, S., Sinreih, M., Trost, N., Verlaine, O., Amoroso, A. M., Zervosen, A., Luxen, A., Joris, B., & Gobec, S. (2012). Exploration of the chemical space of novel naphthalene-sulfonamide and anthranilic acid-based inhibitors of penicillin-binding Proteins. Acta Chimica Slovenica, 59 (2), 380-388. ![]() |
![]() ![]() | Zervosen, A., Herman, R., Kerff, F., Herman, A., Bouillez, A., Prati, F., Pratt, R. F., Frère, J.-M., Joris, B., Luxen, A., Charlier, P., & Sauvage, E. (2011). Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein. Journal of the American Chemical Society. doi:10.1021/ja200696y ![]() |
![]() ![]() | Turk, S., Verlaine, O., Gerards, T., Zivec, M., Humljan, J., Sosic, I., Amoroso, A. M., Zervosen, A., Luxen, A., Joris, B., & Gobec, S. (2011). New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. PLoS ONE, 6 (5), 19418. doi:10.1371/journal.pone.0019418 ![]() |
![]() ![]() | Contreras-Martel, C., Amoroso, A. M., Woon, E. C. Y., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A. M., Job, V., Luxen, A., Joris, B., Schofield, C. J., & Dessen, A. (2011). Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome beta-Lactam Resistance in Staphylococcus aureus (MRSA). ACS Chemical Biology. doi:10.1021/cb2001846 ![]() |
![]() ![]() | Woon, E. C. Y., Zervosen, A., Sauvage, E., Simmons, K. J., Zivec, M., Inglis, S. R., Fishwick, C. W. G., Gobec, S., Charlier, P., Luxen, A., & Schofield, C. J. (2011). Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors. ACS Medicinal Chemistry Letters, 2 (3), 219-223. doi:10.1021/ml100260x ![]() |
![]() ![]() | Derouaux, A., Turk, S., Olrichs, N. K., Gobec, S., Breukink, E., Amoroso, A. M., Offant, J., Bostock, J., Mariner, K., Chopra, I., Vernet, T., Zervosen, A., Joris, B., Frère, J.-M., Nguyen Van, M., & Terrak, M. (2011). Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochemical Pharmacology, 81 (9), 1098-105. doi:10.1016/j.bcp.2011.02.008 ![]() |
![]() ![]() | Kerff, F., Petrella, S., Mercier, F., Sauvage, E., Herman, R., Pennartz, A., Zervosen, A., Luxen, A., Frère, J.-M., Joris, B., & Charlier, P. (2010). Specific Structural Features of the N-Acetylmuramoyl-l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family. Journal of Molecular Biology, 397, 249-259. doi:10.1016/j.jmb.2009.12.038 ![]() |
![]() ![]() | Mercier, F., Zervosen, A., Teller, N., Frère, J.-M., Herman, R., Pennartz, A., Joris, B., & Luxen, A. (2010). 1,6-AnhMurNAc derivatives for assay development of amidase AmiD. Bioorganic and Medicinal Chemistry, 18 (21), 7422-31. doi:10.1016/j.bmc.2010.09.010 ![]() |
Derouaux, A., Turk, S., Offant, J., Amoroso, A. M., Breukink, E., Bostock, J., Chopra, I., Zervosen, A., Joris, B., Nguyen Van, M., Vernet, T., Gobec, S., & Terrak, M. (November 2009). Identification and characterization of novel peptidoglycan glycosyltransferase inhibitors with antibacterial activity [Poster presentation]. Exploration and exploitation of bacterial cell wall biosynthesis, Warwick, United Kingdom. |
![]() ![]() | Inglis, S. R., Zervosen, A., Woon, E. C. Y., Gerards, T., Teller, N., Fischer S, D., Luxen, A., & Schofield, C. J. (2009). Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids as d,d-Carboxypeptidase R39 Inhibitors. Journal of Medicinal Chemistry. doi:10.1021/jm9009718 ![]() |
Zervosen, A., Frère, J.-M., & Zapun, A. (May 2009). Enzymatic Inhibition of Streptococcus pneumoniae PBP2x transpeptidase activity by ceftaroline [Poster presentation]. 19th ECCMID, Helsinki, Finland. |
![]() ![]() | Beck, J., Gharbi, S., Herteg-Fernea, A., Vercheval, L., Bebrone, C., Lassaux, P., Zervosen, A., & Marchand-Brynaert, J. (2009). Aminophosphonic Acids and Aminobis(phosphonic acids) as Potential Inhibitors of Penicillin-Binding Proteins. European Journal of Organic Chemistry, (1), 85-97. doi:10.1002/ejoc.200800812 ![]() |
![]() ![]() | Miguet, L., Zervosen, A., Gerards, T., Pasha, F. P., Luxen, A., Nguyen-Distèche, M., & Thomas, A. (2009). Discovery of New Inhibitors of Resistant Streptococcus pneumoniae Penicillin Binding Protein (PBP) 2x by Structure-Based Virtual Screening. Journal of Medicinal Chemistry. doi:10.1021/jm900625q ![]() |
![]() ![]() | Duez, C., Zervosen, A., Teller, N., Melkonian, R., Banzubazé, E., Bouillenne, F., Luxen, A., & Frère, J.-M. (2009). Characterization of the proteins encoded by the Bacillus subtilis yoxA-dacC operon. FEMS Microbiology Letters, 300, 42-47. doi:10.1111/j.1574-6968.2009.01761.x ![]() |
![]() ![]() | Sauvage, E., Zervosen, A., Dive, G., Herman, R., Amoroso, A. M., Joris, B., Fonzé, E., Pratt, R., Luxen, A., Charlier, P., & Kerff, F. (2009). Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate. Journal of the American Chemical Society, 131 (42), 15262-15269. doi:10.1021/ja9051526 ![]() |
![]() ![]() | Zervosen, A., Saegerman, C., Antoniotti, I., Robert, B., Ruth, N., Collard, A., Schynts, F., Galleni, M., & Mercuri, P. (2008). Characterization of the cattle serum antibody responses against TEM beta-lactamase and the nonimmunogenic Escherichia coli heat-stable enterotoxin (STaI). FEMS Immunology and Medical Microbiology, 54 (3), 319-329. doi:10.1111/j.1574-695X.2008.00482.x ![]() |
![]() ![]() | Macheboeuf, P., Fischer, D. S., Brown, T. J., Zervosen, A., Luxen, A., Joris, B., Dessen, A., & Schofield, C. J. (September 2007). Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nature Chemical Biology, 3 (9), 565-569. doi:10.1038/nchembio.2007.21 ![]() |
Mercier, F., Zervosen, A., Lemaire, C., Plenevaux, A., Joris, B., & Luxen, A. (22 March 2007). Synthesis of anhydro-muramic acid derivatives as substrates for MurNAc amidase [Poster presentation]. Biomedica, Aachen, Germany. |
Mercier, F., Lemaire, C., Plenevaux, A., Nguyen-Distèche, M., Zervosen, A., Joris, B., & Luxen, A. (17 May 2006). Synthesis of anhydro-muramic acid derivatives as substrates for MurNAc amidase [Poster presentation]. Bioforum 2006. |
![]() ![]() | Fraipont, C., Sapunaric, F., Zervosen, A., Auger, G., Devreese, B., Lioux, T., Blanot, D., Mengin-Lecreulx, D., Herdewijn, P., Van Beeumen, J., Frère, J.-M., & Nguyen-Distèche, M. (28 March 2006). Glycosyl transferase activity of the Escherichia coli penicillin-binding protein 1b: Specificity profile for the substrate. Biochemistry, 45 (12), 4007-4013. doi:10.1021/bi051055m ![]() |
Mercier, F., Lemaire, C., Plenevaux, A., Nguyen, M., Zervosen, A., Joris, B., & Luxen, A. (10 October 2005). Synthesis of anhydro-muranic acid derivatives as substrates for MurNAc amidase [Poster presentation]. 9. International SFB-Symposium. Asymmetric Synthesis with Chemical and Biological Methods, Aachen, Germany. |
Teller, N., Lemaire, C., Plenevaux, A., Nguyen, M., Zervosen, A., Joris, B., & Luxen, A. (10 October 2005). Synthesis of protected meso-diaminopimelic acid [Poster presentation]. 9. International SFB-Symposium. Asymmetric Synthesis with Chemical and Biological Methods, Aachen, Germany. |
![]() ![]() | Zervosen, A., Lu, W.-P., Chen, Z., White, R. E., Demuth, T. P., & Frère, J.-M. (March 2004). Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones. Antimicrobial Agents and Chemotherapy, 48 (3), 961-969. doi:10.1128/AAC.48.3.961-969.2004 ![]() |
Zervosen, A., Elling, L., Nieder, V., Kamerling, J. P., Vliegenthart, J. F., & Gutierrez Gallego, R. (08 October 2003). Nucleotidaktivierte Di- und Oligosaccharide sowie Verfahren zu deren Herstellung. |
![]() ![]() | Zervosen, A., Valladares, M. H., Devreese, B., Prosperi, C., Adolph, H.-W., Mercuri, P., Vanhove, M., Amicosante, G., van Beeumen, J., Frère, J.-M., & Galleni, M. (July 2001). Inactivation of Aeromonas Hydrophila Metallo-Beta-Lactamase by Cephamycins and Moxalactam. European Journal of Biochemistry, 268 (13), 3840-50. doi:10.1046/j.1432-1327.2001.02298.x ![]() |
Zervosen, A., Nieder, V., Gallego, R. G., Kamerling, J. P., Vliegenthart, J. F. G., & Elling, L. (February 2001). Synthesis of nucleotide-activated oligosaccharides by beta-galactosidase from Bacillus circulans. Biological Chemistry, 382 (2), 299-311. doi:10.1515/BC.2001.037 ![]() |
Zervosen, A., Elling, L., Nieder, V., Kamerling, J. P., Vliegenthart, J. F., & Gutierrez Gallego, R. (17 January 2001). Nucleotidaktivierte Di- und Oligosaccharide sowie Verfahren zu deren Herstellung. |
Hoersch, B., Seiffert-Stoeriko, A., Marquardt, R., Zervosen, A., Elling, L., & Kula, M.-R. (05 October 1999). Method for the enzymatic galactosylation of monosaccharides and oligosaccharides. |
Marquardt, R., Hoersch, B., Seiffert-Stoeriko, A., Stein, A., Zervosen, A., Elling, L., Kula, M.-R., Verseck, S., Distler, J., & Piepersberg, W. (02 February 1999). Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexulosen. |
Zervosen, A., & Elling, L. (1999). Application of sucrose synthase in the synthesis of nucleotide sugars and saccharides. In C. Bucke (Ed.), Carbohydrate Biotechnology Protocols (pp. 235-254). Totowa, United States: Humana Press. |
![]() ![]() | Elling, L., Zervosen, A., Gallego, R. G., Nieder, V., Malissard, M., Berger, E. G., Vliegenthart, J. F. G., & Kamerling, J. P. (1999). UDP-N-Acetyl-alpha-D-glucosamine as acceptor substrate of beta-1,4-galactosyltransferase. Enzymatic synthesis of UDP-N-acetyllactosamine. Glycoconjugate Journal, 16 (7), 327-36. doi:10.1023/A:1007039825505 ![]() |
![]() ![]() | Zervosen, A., Romer, U., & Elling, L. (1998). Application of recombinant sucrose synthase large scale synthesis of ADP-glucose. Journal of Molecular Catalysis B: Enzymatic, 5 (1-4), 25-28. doi:10.1016/S1381-1177(98)00040-X ![]() |
Zervosen, A., & Elling, L. (22 September 1997). Large scale enzymatic synthesis of ADP-glucose [Poster presentation]. Biotrans'97, 3rd International Symposium on Biocatalysis and Biotransformations, La Grande Motte, France. |
![]() ![]() | Zervosen, A., Stein, A., Adrian, H., & Elling, L. (1996). Combined enzymatic synthesis of nucleotide (deoxy) sugars from sucrose and nucleoside monophosphates. Tetrahedron, 52 (7), 2395-2404. doi:10.1016/0040-4020(95)01081-5 ![]() |
![]() ![]() | Zervosen, A., & Elling, L. (1996). A novel three-enzyme reaction cycle for the synthesis of N-acetyllactosamine with in situ regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose. Journal of the American Chemical Society, 118 (8), 1836-1840. doi:10.1021/ja953495e ![]() |
![]() ![]() | Hokke, C. H., Zervosen, A., Elling, L., Joziasse, D. H., & van den Eijnden, D. H. (1996). One-pot enzymatic synthesis of the Gal alpha 1-->3Gal beta 1-->4GlcNAc sequence with in situ UDP-Gal regeneration. Glycoconjugate Journal, 13 (4), 687-92. doi:10.1007/BF00731458 ![]() |
Zervosen, A., Stein, A., & Elling, L. (July 1995). Preparative enzymatic synthesis and in situ regeneration of nucleotide sugars with sucrose synthase [Paper presentation]. Eurocarb VIII, 8th European Carbohydrate Symposium, Sevilla, Spain. |
Zervosen, A., & Elling, L. (30 May 1995). Praeparative enzymatische Synthese von Nucleotidzuckern mit Saccharose Synthase aus Reis [Poster presentation]. DECHEMA 1995, Wiesbaden, Germany. |
![]() ![]() | Elling, L., Grothus, M., Zervosen, A., & Kula, M.-R. (1995). Application of sucrose synthase from rice grains for the synthesis of carbohydrates. Annals of the New York Academy of Sciences, 750, 329-31. doi:10.1111/j.1749-6632.1995.tb19975.x ![]() |
ELLING, L., GULDENBERG, B., GROTHUS, M., Zervosen, A., PEUS, M., HELFER, A., STEIN, A., ADRIAN, H., & KULA, M.-R. (1995). ISOLATION OF SUCROSE SYNTHASE FROM RICE (ORYZA-SATIVA) GRAINS IN PILOT-SCALE FOR APPLICATION IN CARBOHYDRATE SYNTHESIS. Biotechnology and Applied Biochemistry, 21 (Part 1), 29-37. ![]() |
Zervosen, A., ELLING, L., & KULA, M.-R. (1994). CONTINUOUS ENZYMATIC-SYNTHESIS OF 2'-DEOXYTHYMIDINE-5'(ALPHA-D-GLUCOPYRANOSYL)DIPHOSPHATE. Angewandte Chemie International Edition, 33 (5), 571-572. doi:10.1002/anie.199405711 ![]() |