Tolerance to the Foeto-Placental 'Graft': Ten Ways to Support a Child for Nine Months

[en] Tolerance to the foetal 'allograft' has been extensively studied in the past few years, providing interesting new insights. In addition to a potential role for HLA-G, which has been widely discussed, there are hypotheses suggesting roles for several other molecules or cells: leukemia inhibitory factor and its receptor; indoleamine 2. 3-dioxygenase; the Th1/Th2 balance; suppressor macrophages; hormones such as progesterone or the placental growth hormone; CD95 and its ligand; and, as recently proposed, annexin II. Tolerance of the foetal allograft is probably the consequence of a wide panel of mechanisms that may or may not be pregnancy-specific, that are of major or secondary importance and that may be interconnected.

Disciplines :

Immunology & infectious disease

Author, co-author :

Thellin, Olivier ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Coumans, Bernard ; Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.

Zorzi, Willy ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Igout, Ahmed ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Heinen, Ernst ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie humaine

Language :

English

Title :

Tolerance to the Foeto-Placental 'Graft': Ten Ways to Support a Child for Nine Months

Publication date :

December 2000

Journal title :

Current Opinion in Immunology

ISSN :

0952-7915

eISSN :

1879-0372

Publisher :

elsevier, London, United Kingdom

Volume :

Issue :

Pages :

731-7

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 November 2008

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