Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies.

Katrincsakova, Beata; Takeda, Haruko; Urbankova, Helena; Michaux, Lucienne; Jarosova, Marie; Vandenberghe, Peter; Georges, Michel; Charlier, Carole; Wlodarska, Iwona

doi:10.4161/epi.4.7.9924

Article (Scientific journals)

Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies.

Katrincsakova, Beata; Takeda, Haruko; Urbankova, Helena et al.

2009 • In Epigenetics, 4 (7), p. 469-75

Peer reviewed

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https://hdl.handle.net/2268/102250

DOI
10.4161/epi.4.7.9924

PubMed
19786834

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Keywords :

Alleles; Base Sequence; Chromosomes, Human, Pair 14; Female; Genes, Immunoglobulin Heavy Chain; Humans; Intercellular Signaling Peptides and Proteins/analysis/genetics/metabolism; Leukemia, B-Cell/genetics/immunology/metabolism; Lymphoma, B-Cell/chemistry/genetics/immunology/metabolism; Male; Membrane Proteins/analysis/genetics/metabolism; Methylation; Parents; Proteins/analysis/genetics/metabolism

Abstract :

[en] Leukemias/lymphomas with IGH-involving del(14q)(1) commonly lose the DLK1-GTL2 imprinted domain that comprises several paternally and maternally expressed genes, including a cluster of microRNAs. Given that deletion of this region could lead to inactivation of a monoallelically expressed tumor suppressor gene, our study aimed at determination of the parental origin of del(14q/IGH). The designed allele-specific methylation study of the DLK1/GTL2 intergenic differentially methylated region allowed us to determine the parental origin of del(14q/IGH) in 9/20 analyzed cases. In six cases del(14q/IGH) was of the paternal origin and in three cases of the maternal origin. These findings argue against the concept that a TSG/anti-oncomir located in the imprinted region is systematically inactivated by a targeted deletion of its functional allele.

Disciplines :

Genetics & genetic processes

Author, co-author :

Katrincsakova, Beata

Takeda, Haruko ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Urbankova, Helena

Michaux, Lucienne

Jarosova, Marie

Vandenberghe, Peter

Georges, Michel ; Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale

Charlier, Carole

Wlodarska, Iwona

Language :

English

Title :

Methylation analysis of the imprinted DLK1-GTL2 domain supports the random parental origin of the IGH-involving del(14q) in B-cell malignancies.

Publication date :

2009

Journal title :

Epigenetics

ISSN :

1559-2294

eISSN :

1559-2308

Publisher :

Landes Bioscience, United States

Volume :

Issue :

Pages :

469-75

Peer reviewed :

Peer reviewed

Available on ORBi :

since 10 November 2011

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