Profil

El Hachem Najla

GIGA Stem Cells - Cancer Signaling

Département de pharmacie

See author's contact details
ORCID
0000-0002-4180-3016
Main Referenced Co-authors
Ballotti, Robert (10)
Close, Pierre  (7)
Bertolotto, Corine (3)
Chariot, Alain  (3)
Desmet, Christophe  (3)
Main Referenced Keywords
Amino Acids/chemistry/genetics/metabolism (1); Biochemistry (1); cancer (1); Cell Biology (1); Cell Line, Tumor (1);
Main Referenced Unit & Research Centers
GIGA‐R - Giga‐Research - ULiège [BE] (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (17)
Oncology (2)
Immunology & infectious disease (1)

Publications (total 19)

The most downloaded
102 downloads
cheli, Y., tulic, M., El Hachem, N., nottet, N., Jacquel, A., Gesson, M., Strub, T., bille, K., picard-gauci, A., montaudié, H., beranger, G., passeron, T., Close, P., Bertolotto, C., & ballotti, R. (2021). ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity. Molecular Cancer. doi:10.1186/s12943-020-01306-2 https://hdl.handle.net/2268/255251

The most cited

28 citations (Scopus®)

Rouaud, F., Hamouda-Tekaya, N., Cerezo, M., Abbe, P., Zangari, J., Hofman, V., Ohanna, M., Baharia, M., El Hachem, N., Benfodda, Z., Lebeau, A., Tuli, M., Hofman, P., Bertolotto, C., Passeron, T., Annicotte, J.-S., Ballotti, R., & Rocchi, S. (2018). E2F1 inhibition mediates cell death of metastatic melanoma. Cell Death and Disease. doi:10.1038/s41419-018-0566-1 https://hdl.handle.net/2268/235373

Largeot, A., Klapp, V., Viry, E., Gonder, S., Fernandez Botana, I., Blomme, A., Benzarti, M., Pierson, S., Duculty, C., Marttila, P., Wierz, M., Gargiulo, E., Pagano, G., An, N., El Hachem, N., Perez Hermandez, D., Chakraborty, S., Ysebaert, L., François, J.-H., ... Moussay, E. (2023). Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL. Blood. doi:10.1182/blood.2022017839
Peer Reviewed verified by ORBi

Wathieu, C., Tielens, S., Lavergne, A., Shostak, K., Rolot, M., El Hachem, N., Xu, X., Close, P., Nguyen, L., Desmet, C., Dewals, B. G., & CHARIOT, A. (10 May 2022). A role for the tRNA-modifying enzyme Elp3 in tuft cell differentiation and in the immune response in the intestine [Paper presentation]. Type 2 Immunity in Early Life Symposium, Liège, Belgium.

Habel, N.* , El Hachem, N.* , Soysouvanh, F.* , Hadhiri-Bzioueche, H., Giuliano, S., Nguyen, S., Horak, P., Gay, A.-S., Debayle, D., Nottet, N., Beranger, G., Bressac-de Paillerets, B., Bertolotto, C., & Ballotti, R. (2021). FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells. Cell Death and Differentiation. doi:10.1038/s41418-020-00710-x
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

cheli, Y., tulic, M., El Hachem, N., nottet, N., Jacquel, A., Gesson, M., Strub, T., bille, K., picard-gauci, A., montaudié, H., beranger, G., passeron, T., Close, P., Bertolotto, C., & ballotti, R. (2021). ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity. Molecular Cancer. doi:10.1186/s12943-020-01306-2
Peer Reviewed verified by ORBi

Rapino, F.* , ZHOU, Z.* , RONCERO SANCHEZ, A. M.* , Joiret, M., Seca, C., El Hachem, N., Valenti, G., Latini, S., Shostak, K., Geris, L., Li, P., Huang, G., Mazzucchelli, G., Baiwir, D., Desmet, C., Chariot, A., Georges, M., & Close, P. (2021). Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate. Nature Communications, 12 (1), 2170. doi:10.1038/s41467-021-22254-5
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Rosu, A., El Hachem, N., Rapino, F., Rouault-Pierre, K., Jorssen, J., SOMJA, J., Ramery, E., Thiry, M., Nguyen, L., Jacquemyn, M., Daelemans, D., Adams, C. M., Bonnet, D., Chariot, A., Close, P., Bureau, F., & Desmet, C. (2021). Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis. Journal of Experimental Medicine, 218 (3). doi:10.1084/jem.20200662
Peer reviewed

El Hachem, N., & Close, P. (September 2019). mRNA specific translation in resistant melanoma [Poster presentation]. Protein synthesis and translational control, Heidelberg, Germany.

El Hachem, N., & Close, P. (September 2019). Defining the mechanisms of selective mRNA translation regulation during resistance [Paper presentation]. A bridge between the pathology and the physiology of the melanocyte, Brussels, Belgium.

El Hachem, N., & Ballotti, R. (2018). Pro-tumoral function of HACE1. Oncoscience.
Peer Reviewed verified by ORBi

El Hachem, N., Habel, N., Naiken, T., Bzioueche, H., Cheli, Y., Beranger, G., Jaune, E., Rouaud, F., Nottet, N., Gaudel, C., Colosetti, P., Bertolotto, C., & Ballotti, R. (2018). Uncovering and deciphering the pro-invasive role of HACE1 in melanoma cells. Cell Death and Differentiation. doi:10.1038/s41418-018-0090-y
Peer Reviewed verified by ORBi

Rouaud, F., Hamouda-Tekaya, N., Cerezo, M., Abbe, P., Zangari, J., Hofman, V., Ohanna, M., Baharia, M., El Hachem, N., Benfodda, Z., Lebeau, A., Tuli, M., Hofman, P., Bertolotto, C., Passeron, T., Annicotte, J.-S., Ballotti, R., & Rocchi, S. (2018). E2F1 inhibition mediates cell death of metastatic melanoma. Cell Death and Disease. doi:10.1038/s41419-018-0566-1
Peer Reviewed verified by ORBi

El Hachem, N., & Ballotti, R. (2018). The pro-tumoral function of HACE1. Oncoscience.
Peer Reviewed verified by ORBi

El Hachem, N. (2017). Rôle pro-tumorigénique de HACE1 dans le mélanome [Doctoral thesis, Université de Nice Sophia Antipolis]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/235464

El Hachem, N., & ballotti, R. (2017). Tumorigenic role of HACE1 in Melanoma [Paper presentation]. LABEX SIGNALIFE.

El Hachem, N., & Ballotti, R. (2016). Regulation of fibronectin secretion by HACE1 [Poster presentation]. The Society for Melanoma Research (SMR).

El Hachem, N., & Ballotti, R. (2015). Role of HACE1 protein in Melanoma development [Poster presentation]. LABEX SIGNALIFE.

El Hachem, N., & Ballotti, R. (2015). Pro-tumorigenic role of HACE1 in Melanoma [Paper presentation]. Doctoral students and post-doctoral seminars.

El Hachem, N., & Ballotti, R. (2015). Pro-tumorigenic role of HACE1 in Melanoma [Poster presentation]. From basic science to clinical application.

El Hachem, N., & Ballotti, R. (2015). Role of HACE1 in Melanoma [Poster presentation]. Annual doctoral school days.

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