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Colson Thomas

Département de pharmacie > Chimie pharmaceutique

CIRM

See author's contact details
ORCID
0000-0003-4828-1289
Main Referenced Co-authors
Francotte, Pierre  (22)
Pirotte, Bernard  (20)
Lesenfants, Cindy  (17)
Goffin, Eric  (15)
Bay, Y. (7)
Main Referenced Keywords
AMPA (8); BPAM121 (8); BPAM344 (8); 1,2,4-benzothiadiazine 1,1-dioxides (6); Alzheimer (6);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège (16)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (24)
Chemistry (11)

Publications (total 24)

The most downloaded
322 downloads
Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Pickering, D., Frydenvang, K., Danober, L., Skov Kristensen, A., Sandholm Kastrup, J., & Pirotte, B. (2024). Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European Journal of Medicinal Chemistry, 264, 116036. doi:10.1016/j.ejmech.2023.116036 https://hdl.handle.net/2268/312961

The most cited

19 citations (OpenAlex)

Etse, K. S., Dorosz, J., Mc Lain Christensen, Thomas, J.-Y., Botez Pop, I., Goffin, E., Colson, T., Lestage, P., Danober, L., Pirotte, B., Sandholm Katrup, J., & Francotte, P. (09 July 2021). Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3- hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. ACS Chemical Neurosciences, 12 (14), 2679-2692. doi:10.1021/acschemneuro.1c00255 https://hdl.handle.net/2268/261395

Articles accepted in reviewed journal

Lesenfants, C., Colson, T., Goffin, E., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Danober, L., Pirotte, B., & Francotte, P. (2025). Structural Exploration around 4-Cyclopropyl-Substituted 1,2,4-Benzothiadiazine 1,1-Dioxides: Impact of the Dihalo-Substitution of the Benzene Ring on α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptor Potentiation. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5c01662
Peer Reviewed verified by ORBi

Colson, T., Lesenfants, C., Goffin, E., Fraikin, P., Schmitz, A., De Tullio, P., Danober, L., Pirotte, B., & Francotte, P. (2025). Exploration of the Isosteric Concept Applied to 1,2,4-Benzothiadiazine 1,1-Dioxides in the Discovery of Novel AMPA Receptor Positive Allosteric Modulators. ACS Omega. doi:10.1021/acsomega.5c05172
Peer Reviewed verified by ORBi

Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Pickering, D., Frydenvang, K., Danober, L., Skov Kristensen, A., Sandholm Kastrup, J., & Pirotte, B. (2024). Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European Journal of Medicinal Chemistry, 264, 116036. doi:10.1016/j.ejmech.2023.116036
Peer Reviewed verified by ORBi

Degotte, G., Frederich, M., Francotte, P., Franck, T., Colson, T., Serteyn, D., & Mouithys-Mickalad, A. (02 June 2023). Targeting Myeloperoxidase Activity and Neutrophil ROS Production to Modulate Redox Process: Effect of Ellagic Acid and Analogues. Molecules, 28 (11), 4516. doi:10.3390/molecules28114516
Peer reviewed

Etse, K. S., Dorosz, J., Mc Lain Christensen, Thomas, J.-Y., Botez Pop, I., Goffin, E., Colson, T., Lestage, P., Danober, L., Pirotte, B., Sandholm Katrup, J., & Francotte, P. (09 July 2021). Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3- hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. ACS Chemical Neurosciences, 12 (14), 2679-2692. doi:10.1021/acschemneuro.1c00255
Peer Reviewed verified by ORBi

Oral presentations in conferences with scientific selection committee

Colson, T., Lesenfants, C., Goffin, E., Counerotte, S., Pirotte, B., & Francotte, P. (30 January 2026). From Receptor Modulation To Therapeutic Innovation: AMPA And KAR Pams For Tomorrow’s Treatments [Paper presentation]. CIRMDay 2026, Liège, Belgium.
Editorial reviewed

Lesenfants, C., Labiouse, M., Soualmia, F., Goffin, E., Colson, T., Leroy, C., Schmitz, A., Garigliany, M.-M., Chavatte, P., Snoek, R., Andrei, G., Reboud-Ravaux, M., El Amri, C., Pirotte, B., & Francotte, P. (31 March 2025). FROM COUMARIN TO ANTIVIRAL INHIBITORS: TARGETING TMPRSS2 AND HAT IN THE TREATMENT OF VIRAL RESPIRATORY INFECTIONS [Paper presentation]. BSPS-La Roche en Ardennes, La Roche en Ardennes, Belgium.
Editorial reviewed

Colson, T., Pirotte, B., & Francotte, P. (29 January 2025). Design of first selective molecular glues for kainic acid receptors [Paper presentation]. CirmDay 2025, Liège, Belgium.
Editorial reviewed

Posters presentations in conferences with scientific selection committee

Lesenfants, C., Soualmia, F., Goffin, E., Colson, T., Leroy, C., Schmitz, A., Reboud-Ravaux, El Amri, C., Pirotte, B., & Francotte, P. (15 December 2025). COUMARIN DERIVATIVES AS TMPRSS2 INHIBITORS: MECHANISTIC STUDIES ON A BROAD- SPECTRUM ANTIVIRAL TARGET [Poster presentation]. MedChem 2025, Gand, Belgium.
Editorial reviewed

Colson, T., Bay, Y., Goffin, E., Lesenfants, C., Zeevaert, L., Schmitz, A., Kastrup, J. S., Pirotte, B., Kristensen, A. S., & Francotte, P. (15 December 2025). SELECTIVE MODULATION OF KAINATE RECEPTORS: DESIGN AND SYNTHESIS OF 1,2,4-BENZOTHIADIAZINE-BASED POSITIVE ALLOSTERIC MODULATORS [Poster presentation]. MedChem 2025, Gand, Belgium.
Editorial reviewed

Lesenfants, C., Soualmia, F., Chaaya, N., Goffin, E., Colson, T., Garigliany, M.-M., Chavatte, P., Snoek, R., Andrei, G., Reboud-Ravaux, M., El Amri, C., Pirotte, B., & Francotte, P. (03 September 2024). RATIONAL DESIGN OF COUMARIN DERIVATIVES AS NEW INHIBITORS OF TRANSMEMBRANE SERINE PROTEASES TO TREAT RESPIRATORY VIRAL INFECTIONS [Poster presentation]. EFMC-ISMC, Rome, Italy.
Editorial reviewed

Colson, T., Baudino, G., Bay, Y., Pickering, D. S., Kristensen, A. S., Piette, M., Tchekounang Tchonwa, I. F., Pressia, J., Pochet, L., Goffin, E., Lesenfants, C., Kastrup, J. S., & Pirotte, B. (03 September 2024). Developing selective positive allosteric modulators for kainic acid receptors using the 1,2,4-benzothiadiazine 1,1-dioxide scaffold [Poster presentation]. EFMC-ISMC, Rome, Italy.
Editorial reviewed

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Baudino, G., Tchekounang Tchonwa, I. F., Pochet, L., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (31 January 2024). Advances in Targeting Kainic Acid Receptors: Developing Selective Positive Allosteric Modulators from the 1,2,4-Benzothiadiazine 1,1-Dioxide scaffold [Poster presentation]. CIRM Day 2024, Liège, Belgium.
Editorial reviewed

Lesenfants, C., Goffin, E., Colson, T., Chaaya, N., Leroy, C., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (31 January 2024). RATIONAL DESIGN OF COUMARIN DERIVATIVES WITH A BASIC MOIETY FOR INHIBITING THE SERINE PROTEASE TMPRSS2: AN INNOVATIVE APPROACH TO COMBAT THE ENTRY OF SELECTED RESPIRATORY VIRUSES [Poster presentation]. CIRM Day, Liège, Belgium.
Editorial reviewed

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Baudino, G., Tchekounang Tchonwa, I. F., Leroy, C., Pochet, L., Goffin, E., Lesenfants, C., & Kastrup, J. S. (08 December 2023). Kainic Acid Receptors: Innovating Selective Positive Allosteric Modulators based on 1,2,4-Benzothiadiazine 1,1-Dioxides [Poster presentation]. MedChem 2023, Bruxelles, Belgium.
Editorial reviewed

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Chaaya, N., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (08 December 2023). EXPLORING COUMARIN DERIVATIVES AS NOVEL ANTIVIRAL AGENTS TARGETING TMPRSS2: A MULTIDISCIPLINARY APPROACH FOR RESPIRATORY VIRAL DISEASE TREATMENT [Poster presentation]. MedChem 2023, Bruxelles, Belgium.
Editorial reviewed

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Garigliany, M.-M., Chavatte, P., Reboud, M., Pirotte, B., El Amri, C., & Francotte, P. (19 October 2023). Design of original serine protease inhibitors to combat viral respiratory infections: a synthetic pathway for new coumarinic compounds [Poster presentation]. 2023 SRC Scientific Day, Louvain-la-Neuve, Belgium.
Editorial reviewed

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (19 October 2023). Glutamate Regulation: Synthesis of Selective Positive Allosteric Modulators of the Kainic Acid Receptors belonging to 1,2,4-Benzothiadiazine 1,1-Dioxides [Poster presentation]. SRC 2023 Scientific Day, Louvain-La-Neuve, Belgium.
Editorial reviewed

Colson, T., Valembois, S., Leroy, C., Bay, Y., Pickering, D. S., Kristensen, A. S., Pirotte, B., Kastrup, J. S., & Francotte, P. (07 September 2023). Design of potentiators targeting the allosteric pocket of the kainate subtype glutamate receptors [Poster presentation]. 10th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS), Zagreb, Croatia.
Editorial reviewed

Leka, K., Colson, T., Lesenfants, C., Zhou, D., Garigliany, M.-M., Ledoux, A., & Francotte, P. (01 July 2023). HALOGENATION OF ETHANOL EXTRACT FROM PAEONIA SUFFRUTICOSA: EXPLORING PROMISING PATHWAYS FOR ANTI-SARS-COV-2 MEDICATION DEVELOPMENT [Poster presentation]. 6e Symposium International AFERP – 17 au 19 juillet 2023 –, Orsay, France.
Peer reviewed

Schmitz, A., Colson, T., Lesenfants, C., Mankulu, J., Frederich, M., Pirotte, B., & Francotte, P. (January 2023). Towards the total synthesis of ellagic acid analogues – regioselective functionalisation of gallic acid’s phenolic functions [Poster presentation]. CIRM Day, Liège, Belgium.
Editorial reviewed

Colson, T., Bay, Y., Pickering, D. S., Møllerud, S., Frydenvang, K., Pirotte, B., Mulle, C., Kristensen, A. S., Kastrup, J. S., & Francotte, P. (02 February 2022). Design and synthesis of key intermediates giving access to potentiators for the kainate subtype glutamate receptors [Poster presentation]. CIRM Day, Liège, Belgium.
Editorial reviewed

Colson, T., Valembois, S., Bay, Y., Pickering, D. S., Møllerud, S., Frydenvang, K., Pirotte, B., Mulle, C., Kristensen, A. S., Kastrup, J. S., & Francotte, P. (19 November 2021). Design of selective ligands for the kainate subtype receptors [Poster presentation]. MedChem 2021, Liège, Belgium.
Editorial reviewed

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