Profil

Francotte Pierre

Département de pharmacie > Chimie pharmaceutique

Département de pharmacie

CIRM

See author's contact details
ORCID
0000-0001-9252-7798
Main Referenced Co-authors
Pirotte, Bernard  (101)
De Tullio, Pascal  (54)
Goffin, Eric  (38)
Frederich, Michel  (30)
Degotte, Gilles  (21)
Main Referenced Keywords
AMPA (9); Malaria (9); Plasmodium (8); malaria (7); BPAM344 (6);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (28)
Centre Interfacultaire de Recherche du Médicament - CIRM (6)
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège [BE] (3)
Center for Cellular and Molecular Neurobiology CNCM (1)
Centre Interfacultaire de Recherche du Médicament (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (112)
Chemistry (27)
Radiology, nuclear medicine & imaging (2)
Biochemistry, biophysics & molecular biology (2)
Life sciences: Multidisciplinary, general & others (2)

Publications (total 118)

The most downloaded
482 downloads
Alson, S. G., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Degotte, G., Francotte, P., & Frederich, M. (2018). In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives. Journal of Pharmacy and Pharmacology, 70 (10), 1349-1356. doi:10.1111/jphp.12982 https://hdl.handle.net/2268/227811

The most cited

68 citations (Scopus®)

Francotte, P., De Tullio, P., Goffin, E., Dintilhac, G., Graindorge, E., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2007). Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. Journal of Medicinal Chemistry, 50 (13), 3153-3157. doi:10.1021/jm070120i https://hdl.handle.net/2268/6360

The most significant

Degotte, G., Pendeville-Samain, H., Di Chio, C., Ettari, R., Pirotte, B., Frederich, M., & Francotte, P. (2023). Dimeric polyphenols to pave the way for new antimalarial drugs. RSC Medicinal Chemistry. doi:10.1039/d2md00392a
Peer reviewed

Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S. A., Francotte, P., Hanson, J., Pochet, L., Kastrup, J., & Pirotte, B. (2018). Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.8b00250
Peer Reviewed verified by ORBi

Goffin, E.* , Drapier, T.* , Probst Larsen, A., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., De Tullio, P., Olsen, L., Frydenvang, K., Pirotte, B., Hanson, J., Oswald, R. E., Sandholm Kastrup, J., & Francotte, P. (2018). 7‐Phenoxy-Substituted 3,4-Dihydro‐2H‐1,2,4-benzothiadiazine 1,1- Dioxides as Positive Allosteric Modulators of α‐Amino-3-hydroxy-5- methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. Journal of Medicinal Chemistry, 61, 251-264. doi:10.1021/acs.jmedchem.7b01323
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Larsen, A. P., Fièvre, S., Frydenvang, K., Francotte, P., Pirotte, B., Kastrup, J. S., & Mulle, C. (June 2017). Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Molecular Pharmacology, 91, 576-585. doi:10.1124/mol.116.107599
Peer Reviewed verified by ORBi

Francotte, P., Goffin, E., Fraikin, P., Lestage, P., Van Heugen, J.-C., Gillotin, F., Danober, L., Thomas, J.-Y., Chiap, P., Caignard, D.-H., Pirotte, B., & De Tullio, P. (2010). New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors. Journal of Medicinal Chemistry, 53, 1700-1711. doi:10.1021/jm901495t
Peer Reviewed verified by ORBi


Articles in scientific journals with peer reviewing

Bay, Y., Egeberg Jeppesen, M., Frydenvang, K., Francotte, P., Pirotte, B., Pickering, D. S., Kristensen, A. S., & Kastrup, J. S. (2024). The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2. FEBS Letters. doi:10.1002/1873-3468.14824
Peer Reviewed verified by ORBi

Bay, Y., Venskutonytė, R., Frantsen, S. M., Thorsen, T. S., Musgaard, M., Frydenvang, K., Francotte, P., Pirotte, B., Biggin, P. C., Kristensen, A. S., Boesen, T., Pickering, D. S., Gajhede, M., & Kastrup, J. S. (2023). Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. FEBS Journal. doi:10.1111/febs.17046
Peer Reviewed verified by ORBi

Francotte, P., Bay, Y., Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., De Tullio, P., Beaufour, C., Botez, I., Pickering, D., Frydenvang, K., Danober, L., Skov Kristensen, A., Sandholm Kastrup, J., & Pirotte, B. (09 December 2023). Exploring thienothiadiazine dioxides as isosteric analogues of benzo-and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. European Journal of Medicinal Chemistry, 264, 116036. doi:10.1016/j.ejmech.2023.116036
Peer Reviewed verified by ORBi

Degotte, G., Frederich, M., Francotte, P., Franck, T., Colson, T., Serteyn, D., & Mouithys-Mickalad, A. (02 June 2023). Targeting Myeloperoxidase Activity and Neutrophil ROS Production to Modulate Redox Process: Effect of Ellagic Acid and Analogues. Molecules, 28 (11), 4516. doi:10.3390/molecules28114516
Peer reviewed

Goffin, E., Fraikin, P., Abboud, D., De Tullio, P., Beaufour, C., Botez, I., Hanson, J., Danober, L., Francotte, P., & Pirotte, B. (15 March 2023). New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring. European Journal of Medicinal Chemistry, 250, 115221. doi:10.1016/j.ejmech.2023.115221
Peer Reviewed verified by ORBi

Bak, A., Kos, J., Degotte, G., Swietlicka, A., Strharsky, T., Pindjakova, D., Gonec, T., Smolinski, A., Francotte, P., Frederich, M., Kozik, V., & Jampilek, J. (10 February 2023). Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of Chlorinated N-arylcinnamamides. International Journal of Molecular Sciences, 24 (4), 3611. doi:10.3390/ijms24043611
Peer Reviewed verified by ORBi

Degotte, G., Pendeville-Samain, H., Di Chio, C., Ettari, R., Pirotte, B., Frederich, M., & Francotte, P. (2023). Dimeric polyphenols to pave the way for new antimalarial drugs. RSC Medicinal Chemistry. doi:10.1039/d2md00392a
Peer reviewed

Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2022). Potential of caffeic acid derivatives as antimalarial leads. Letters in Drug Design and Discovery, 19, 823-836.
Peer Reviewed verified by ORBi

Kos, J., Degotte, G., Pindjakova, D., Strharsky, T., Jankech, T., Gonec, T., Francotte, P., Frederich, M., & Jampilek, J. (2022). Insights into Antimalarial Activity of N-Phenyl- Substituted Cinnamanilides. Molecules, 27, 7799. doi:10.3390/molecules27227799
Peer Reviewed verified by ORBi

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (2021). Polyhydroxybenzoic acid derivatives as potential new antimalarial agents. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. doi:10.1002/ardp.202100190
Peer reviewed

Etse, K. S., Dorosz, J., Mc Lain Christensen, Thomas, J.-Y., Botez Pop, I., Goffin, E., Colson, T., Lestage, P., Danober, L., Pirotte, B., Sandholm Katrup, J., & Francotte, P. (09 July 2021). Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3- hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. ACS Chemical Neurosciences, 12 (14), 2679-2692. doi:10.1021/acschemneuro.1c00255
Peer Reviewed verified by ORBi

Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2021). Overview of natural antiplasmodials from the last decade to inspire medicinal chemistry. Current Medicinal Chemistry. doi:10.2174/0929867328666210329112354
Peer Reviewed verified by ORBi

Mortensen, M., Krall, J., Kongstad, K. T., Brygger, B. M., Lenzi, O., Francotte, P., Sørensen, T. E., Nielsen, B., Jensen, A. A., Smart, T. G., & Frølund, B. (20 November 2019). Developing New 4-PIOL and 4-PHP Analogues for Photoinactivation of γ-Aminobutyric Acid Type A Receptors. ACS Chemical Neuroscience, 10 (11), 4669. doi:10.1021/acschemneuro.9b00478
Peer reviewed

Manos-Turvey, A., Becker, G., Francotte, P., Serrano Navacerrada, M. E., Luxen, A., Pirotte, B., Plenevaux, A., & Lemaire, C. (11 February 2019). Fully Automated Synthesis and Evaluation of [ 18 F]BPAM121: Potential of an AMPA Receptor Positive Allosteric Modulator as PET Radiotracer. ChemMedChem, 14 (7), 788-795. doi:10.1002/cmdc.201800816
Peer Reviewed verified by ORBi

Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, K., & Kastrup, J. S. (2019). Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. ACS Medicinal Chemistry Letters, 10 (3), 243-247. doi:10.1021/acsmedchemlett.8b00369
Peer Reviewed verified by ORBi

Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S. A., Francotte, P., Hanson, J., Pochet, L., Kastrup, J., & Pirotte, B. (2018). Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds. Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.8b00250
Peer Reviewed verified by ORBi

Alson, S. G., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Degotte, G., Francotte, P., & Frederich, M. (2018). In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives. Journal of Pharmacy and Pharmacology, 70 (10), 1349-1356. doi:10.1111/jphp.12982
Peer Reviewed verified by ORBi

Goffin, E.* , Drapier, T.* , Probst Larsen, A., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., De Tullio, P., Olsen, L., Frydenvang, K., Pirotte, B., Hanson, J., Oswald, R. E., Sandholm Kastrup, J., & Francotte, P. (2018). 7‐Phenoxy-Substituted 3,4-Dihydro‐2H‐1,2,4-benzothiadiazine 1,1- Dioxides as Positive Allosteric Modulators of α‐Amino-3-hydroxy-5- methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency. Journal of Medicinal Chemistry, 61, 251-264. doi:10.1021/acs.jmedchem.7b01323
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Larsen, A. P., Fièvre, S., Frydenvang, K., Francotte, P., Pirotte, B., Kastrup, J. S., & Mulle, C. (June 2017). Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Molecular Pharmacology, 91, 576-585. doi:10.1124/mol.116.107599
Peer Reviewed verified by ORBi

Krintel, C.* , Francotte, P.* , Pickering, D. S., Juknaite, L., Pøhlsgaard, J., Olsen, L., Frydenvang, K., Goffin, E., Pirotte, B., & Kastrup, J. (07 June 2016). Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2. Biophysical Journal, 110, 2397-2406. doi:10.1016/j.bpj.2016.04.032
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Larsen, A., Francotte, P., Frydenvang, K., Tapken, D., Goffin, E., Fraikin, P., Caignard, D., Lestage, P., Danober, L., Pirotte, B., & Kastrup, J. (2016). Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors. ACS Chemical Neurosciences, 7, 378-390. doi:10.1021/acschemneuro.5b00318
Peer Reviewed verified by ORBi

Nørholm, A.-B., Francotte, P., Goffin, E., Botez-Pop, I., Danober, L., Lestage, P., Pirotte, B., Olsen, L., & Oostenbrink, C. (24 November 2014). Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces. Journal of Chemical Information and Modeling, 54 (12), 3404-3416. doi:10.1021/ci500559b
Peer Reviewed verified by ORBi

Francotte, P.* , Nørholm, A.-B.* , Deva, T., Olsen, L., Frydenvang, K., Goffin, E., Fraikin, P., De Tullio, P., Challal, S., Thomas, J.-Y., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, J. S., & Pirotte, B. (06 November 2014). Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides. Journal of Medicinal Chemistry, 57 (22), 9539-9553. doi:10.1021/jm501268r
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Noerholm, A.-B., Francotte, P., Goffin, E., Botez, L., Danober, L., Lestage, P., Pirotte, B., Kastrup, J. S., Olsen, L., & Oostenbrink, C. (2014). Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces. Journal of Chemical Information and Modeling, 54, 3404-3416.
Peer Reviewed verified by ORBi

Nørholm, A.-B., Francotte, P., Olsen, L., Krintel, C., Frydenvang, K., Goffin, E., Challal, S., Danober, L., Botez-Pop, I., Lestage, P., Pirotte, B., & Kastrup, J. S. (16 October 2013). Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold. Journal of Medicinal Chemistry, 56 (21), 8736–8745. doi:10.1021/jm4012092
Peer Reviewed verified by ORBi

Francotte, P., Goffin, E., Fraikin, P., Graindorge, E., Lestage, P., Danober, L., Challal, S., Rogez, N., Nosjean, O., Caignard, D.-H., Pirotte, B., & De Tullio, P. (03 October 2013). Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors. Journal of Medicinal Chemistry, 56 (20), 7838-7850. doi:10.1021/jm400676g
Peer Reviewed verified by ORBi

Esters, V., Karangwa, C., Tits, M., Francotte, P., Pirotte, B., Servais, A.-C., Fillet, M., Crommen, J., Robbrecht, E., MINET, A., Grisar, T., Angenot, L., & Frederich, M. (March 2013). Unusual Amino Acids and Monofluoroacetate from Dichapetalum michelsonii (Umutambasha), a Toxic Plant from Rwanda. Planta Medica, 79, 334-337. doi:10.1055/s-0032-1328283
Peer Reviewed verified by ORBi

Pirotte, B., Francotte, P., Goffin, E., & De Tullio, P. (2013). AMPA receptor positive allosteric modulators: a patent review. Expert Opinion on Therapeutic Patents, 23, 615-628. doi:10.1517/13543776.2013.770840
Peer Reviewed verified by ORBi

Krintel, C., Frydenvang, K., Olsen, L., Kristensen, M., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, M., & Kastrup, J. (2012). Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochemical Journal, 441, 173-178. doi:10.1042/BJ20111221
Peer Reviewed verified by ORBi

Pirotte, B., Francotte, P., Goffin, E., fraikin, P., Danober, L., Lesur, B., Botez, I., Caignard, D. H., Lestage, P., & De Tullio, P. (2010). Ring-fused thiadiazines as core structures for the development of potent AMPA receptor potentiators. Current Medicinal Chemistry, 17, 3575-3582. doi:10.2174/092986710792927859
Peer Reviewed verified by ORBi

Francotte, P., Goffin, E., Fraikin, P., Lestage, P., Van Heugen, J.-C., Gillotin, F., Danober, L., Thomas, J.-Y., Chiap, P., Caignard, D.-H., Pirotte, B., & De Tullio, P. (2010). New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors. Journal of Medicinal Chemistry, 53, 1700-1711. doi:10.1021/jm901495t
Peer Reviewed verified by ORBi

Gillotin, F., Chiap, P., Frederich, M., Van Heugen, J.-C., Francotte, P., Lebrun, P., Pirotte, B., & De Tullio, P. (2010). Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 (2), 232-240. doi:10.1124/dmd.109.028928
Peer Reviewed verified by ORBi

Francotte, P., De Tullio, P., Podona, T., Diouf, O., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2008). Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators. Bioorganic and Medicinal Chemistry, 16 (23), 9948-56. doi:10.1016/j.bmc.2008.10.036
Peer Reviewed verified by ORBi

Francotte, P., De Tullio, P., & Pirotte, B. (2007). Novel dipyrazoles acting as glutamate modulators. Expert Opinion on Therapeutic Patents, 17 (12), 1489-1493. doi:10.1517/13543776.17.12.1489
Peer Reviewed verified by ORBi

Francotte, P., De Tullio, P., Goffin, E., Dintilhac, G., Graindorge, E., Fraikin, P., Lestage, P., Danober, L., Thomas, J.-Y., Caignard, D.-H., & Pirotte, B. (2007). Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors. Journal of Medicinal Chemistry, 50 (13), 3153-3157. doi:10.1021/jm070120i
Peer Reviewed verified by ORBi

De Tullio, P., Dupont, L., Francotte, P., Counerotte, S., Lebrun, P., & Pirotte, B. (2006). Three-Dimentional Quantitative Structure-Activity Relationships of ATP-Sensitive Potassium (KATP) Channel Openers Belonging to the 3-Alkylamino-4H-1,2,4-benzo- and 3-Alkylamino-4H-1,2,4-pyridothiadiazine 1,1-Dioxide Families. Journal of Medicinal Chemistry, 49, 6779-6788. doi:10.1021/jm060534w
Peer Reviewed verified by ORBi

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., & Pirotte, B. (2006). In Search of Novel Ampa Potentiators. Recent Patents on CNS Drug Discovery, 1 (3), 239-46. doi:10.2174/157488906778773661
Peer reviewed

Francotte, P., De Tullio, P., Fraikin, P., & Pirotte, B. (2006). New trends in the design of drugs against Alzheimer disease. Frontiers in Medicinal Chemistry, 3, 249-284.
Peer reviewed

De Tullio, P., Lebrun, P., Florence, X., Antoine, M. H., Francotte, P., & Pirotte, B. (2006). Selective pancreatic ATP-sensitive potassium channel openers for the treatement of glucose homeostasis disorders. Drugs of the Future, 31, 991-1001. doi:10.1358/dof.2006.031.11.1036837
Peer reviewed

De Tullio, P., Boverie, S., Becker, B., Antoine, M.-H., Nguyen, Q.-A., Francotte, P., Counerotte, S., Sebille, S., Pirotte, B., & Lebrun, P. (2005). 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : effect of 6,7-distribution on potency and tissue selectivity. Journal of Medicinal Chemistry, 48, 4990-5000. doi:10.1021/jm0580050
Peer Reviewed verified by ORBi

Francotte, P., Graindorge, E., Boverie, S., De Tullio, P., & Pirotte, B. (2004). New trends in the design of drugs against Alzheimer's disease. Current Medicinal Chemistry, 11 (13), 1757-1778. doi:10.2174/0929867043364946
Peer Reviewed verified by ORBi

Graindorge, E., Francotte, P., Boverie, S., De Tullio, P., & Pirotte, B. (2004). New trends in the development of positive allosteric modulators of AMPA receptors. Current Medicinal Chemistry - Central Nervous System Agents, 4, 95-103.
Peer Reviewed verified by ORBi

Patents

Pirotte, B., Francotte, P., El Amri, C., Reboud-Ravaux, M., Chaaya, N., & Lesenfants, C. (2023). Substituted aryl esters of coumarin-3-carboxylic acid and their use as transmembrane serine protease 2 inhibitors and pharmaceutical composition.

Francotte, P., De Tullio, P., Pirotte, B., Botez, I., Danober, L., & Lestage, P. (14 July 2011). Preparation of cyclopropyl thiochroman derivatives and their use as AMPA receptor modulators.

Francotte, P., De Tullio, P., Pirotte, B., Danober, L., Lestage, P., & Caignard, D. H. (15 January 2010). Preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Francotte, P., De Tullio, P., Pirotte, B., Danober, L., Lestage, P., & Caignard, D.-H. (07 July 2009). Preparation of cycloalkylated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Francotte, P., Fraikin, P., De Tullio, P., Pirotte, B., Lestage, P., Danober, L., Caignard, D.-H., & Renard, P. (27 July 2005). Preparation of fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Francotte, P., Fraikin, P., De Tullio, P., Pirotte, B., Lestage, P., Danober, L., Caignard, D. H., & Renard, P. (27 July 2005). Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators.

Graindorge, E., Francotte, P., Boverie, S., De Tullio, P., Pirotte, B., Lestage, P., Danober, L. P., Renard, P., & Caignard, D. H. (12 November 2004). Novel thiadiazine derivatives useful as AMPA receptor modulators, preparation method, and pharmaceutical compositions containing them.

Scientific conferences in universities or research centers

Francotte, P. (25 November 2020). Design of Positive Allosteric Modulators of Glutamate receptors. An update.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2011). Development of cognitive enhancers: design of novel thienothiadiazine 1,1-dioxides acting as AMPA potentiators [Paper presentation]. Giga-day, Liège, Belgium.

Francotte, P. (24 September 2010). Development of photoreactive/fluorescent orthosteric GABAA ligands for studying localization and function of GABAA receptors [Paper presentation]. ChemMedChem Meeting, Copenhague, Denmark.

Francotte, P., De Tullio, P., & Pirotte, B. (14 December 2006). Etude de la métabolisation in vitro d’activateurs des canaux potassiques appurtenant à la classe des 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxydes: utilisation conjuguée de la LC-MS et de la LC-SPE-NMR [Paper presentation]. Forum des jeunes chercheurs du CIRM.

Scientific congresses and symposiums

Published communications

Degotte, G., Alson, S., Hans, A., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Randimbivololona, F., Francotte, P., & Frederich, M. (2019). Antiplasmodial activity of polyphenolic derivatives. Pharmaceuticals.
Peer Reviewed verified by ORBi

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D.-H., De Tullio, P., & Pirotte, B. (2004). Produgs of AMPA potentiators structurally related to IDRA21 : design, preparation, hydrolysis study and pharmacological evaluation. Fundamental and Clinical Pharmacology, 595.
Peer Reviewed verified by ORBi

Oral communications or posters

Lesenfants, C., Goffin, E., Colson, T., Chaaya, N., Leroy, C., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (31 January 2024). RATIONAL DESIGN OF COUMARIN DERIVATIVES WITH A BASIC MOIETY FOR INHIBITING THE SERINE PROTEASE TMPRSS2: AN INNOVATIVE APPROACH TO COMBAT THE ENTRY OF SELECTED RESPIRATORY VIRUSES [Poster presentation]. CIRM Day, Liège, Belgium.
Editorial reviewed

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Baudino, G., Tchekounang Tchonwa, I. F., Pochet, L., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (31 January 2024). Advances in Targeting Kainic Acid Receptors: Developing Selective Positive Allosteric Modulators from the 1,2,4-Benzothiadiazine 1,1-Dioxide scaffold [Poster presentation]. CIRM Day 2024, Liège, Belgium.
Editorial reviewed

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Chaaya, N., Garigliany, M.-M., Chavatte, P., Reboud-Ravaux, M., Pirotte, B., El Amri, C., & Francotte, P. (08 December 2023). EXPLORING COUMARIN DERIVATIVES AS NOVEL ANTIVIRAL AGENTS TARGETING TMPRSS2: A MULTIDISCIPLINARY APPROACH FOR RESPIRATORY VIRAL DISEASE TREATMENT [Poster presentation]. MedChem 2023, Bruxelles, Belgium.
Editorial reviewed

Lesenfants, C., Leroy, C., Goffin, E., Colson, T., Garigliany, M.-M., Chavatte, P., Reboud, M., Pirotte, B., El Amri, C., & Francotte, P. (19 October 2023). Design of original serine protease inhibitors to combat viral respiratory infections: a synthetic pathway for new coumarinic compounds [Poster presentation]. 2023 SRC Scientific Day, Louvain-la-Neuve, Belgium.
Editorial reviewed

Colson, T., Piette, M., Bay, Y., Pickering, D. S., Kristensen, A. S., Goffin, E., Lesenfants, C., Kastrup, J. S., Pirotte, B., & Francotte, P. (19 October 2023). Glutamate Regulation: Synthesis of Selective Positive Allosteric Modulators of the Kainic Acid Receptors belonging to 1,2,4-Benzothiadiazine 1,1-Dioxides [Poster presentation]. SRC 2023 Scientific Day, Louvain-La-Neuve, Belgium.
Editorial reviewed

Colson, T., Valembois, S., Leroy, C., Bay, Y., Pickering, D. S., Kristensen, A. S., Pirotte, B., Kastrup, J. S., & Francotte, P. (07 September 2023). Design of potentiators targeting the allosteric pocket of the kainate subtype glutamate receptors [Poster presentation]. 10th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS), Zagreb, Croatia.
Editorial reviewed

Leka, K., Colson, T., Lesenfants, C., Zhou, D., Garigliany, M.-M., Ledoux, A., & Francotte, P. (01 July 2023). HALOGENATION OF ETHANOL EXTRACT FROM PAEONIA SUFFRUTICOSA: EXPLORING PROMISING PATHWAYS FOR ANTI-SARS-COV-2 MEDICATION DEVELOPMENT [Poster presentation]. 6e Symposium International AFERP – 17 au 19 juillet 2023 –, Orsay, France.
Peer reviewed

Degotte, G., Strharsky, T., Kos, J., Francotte, P., Frederich, M., & Jampilek, J. (July 2022). Antimalarial Activity of Novel Substituted N-Arylcinnamamides [Poster presentation]. 3rd MMCS: Shaping Medicinal Chemistry for the New Decade, Roma, Italy.

Colson, T., Bay, Y., Pickering, D. S., Møllerud, S., Frydenvang, K., Pirotte, B., Mulle, C., Kristensen, A. S., Kastrup, J. S., & Francotte, P. (02 February 2022). Design and synthesis of key intermediates giving access to potentiators for the kainate subtype glutamate receptors [Poster presentation]. CIRM Day, Liège, Belgium.
Editorial reviewed

Lesenfants, C., Goffin, E., Pirotte, B., Dammicco, S., & Francotte, P. (02 February 2022). Contribution to the synthesis of positive allosteric modulators of AMPA receptors for potential use in the early diagnosis of neurodegenerative diseases [Poster presentation]. CIRM Day, Liège, Belgium.
Editorial reviewed

Degotte, G., Pirotte, B., Pendeville-Samain, H., Frederich, M., & Francotte, P. (19 November 2021). Pharmacomodulation of Ellagic Acid to Identify New Antimalarial Candidates [Poster presentation]. MedChem 2021, Liège, Belgium.

Colson, T., Valembois, S., Bay, Y., Pickering, D. S., Møllerud, S., Frydenvang, K., Pirotte, B., Mulle, C., Kristensen, A. S., Kastrup, J. S., & Francotte, P. (19 November 2021). Design of selective ligands for the kainate subtype receptors [Poster presentation]. MedChem 2021, Liège, Belgium.
Editorial reviewed

Francotte, P. (19 November 2021). Development of Positive Allosteric Modulators for Glutamate Ionotropic Receptors [Paper presentation]. MedChem 2021: Medicinal Chemistry in Belgium: Innovation and Success Stories: Annual One-Day Meeting on Medicinal Chemistry, Liège, Belgium.
Editorial reviewed

Degotte, G., Pirotte, B., Pendeville-Samain, H., Duwez, L., Frederich, M., & Francotte, P. (28 May 2021). Gallic acid dimerization to open the way for new antimalarial drugs [Paper presentation]. One-Day FNRS Med Chem Meeting, Louvain-La-Neuve, Belgium.

Degotte, G., Pirotte, B., Pendeville-Samain, H., Duwez, L., Frederich, M., & Francotte, P. (26 May 2021). Gallic acid dimerization to open the way for new antimalarial drugs [Poster presentation]. 3rd CIRMDay, Liège, Belgium.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (20 February 2020). Pharmacomodulation of natural compounds: medicinal chemistry in antimalarial purposes [Poster presentation]. ChemCys 2020, Blankenberg, Belgium.

Degotte, G., Lempereur, D., Adubofour, Y., Pirotte, B., Frederich, M., & Francotte, P. (11 December 2019). Dimerisation of gallic acid for malaria treatment [Poster presentation]. CIRMDay, Liège, Belgium.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (22 November 2019). Total synthesis approach: development of new antimalarial compounds [Poster presentation]. MedChem 2019, Bruxelles, Belgium.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (05 September 2019). Pharmacomodulation of ellagic acid: a total synthesis approach [Poster presentation]. EFMC Young Medicinal Chemist, Athènes, Greece.

Degotte, G., Halleux, A., Pirotte, B., Francotte, P., & Frederich, M. (May 2019). Design of new antimalarials inspired by ellagic acid through a total synthesis approach [Poster presentation]. Phytoday, Bruxelles, Belgium.

Degotte, G., Halleux, A., Hans, A., Jansen, O., Ledoux, A., Desdemoustier, P., Pirotte, B., Francotte, P., & Frederich, M. (December 2018). Preparation of ellagic acid derivatives through a total synthesis approach to improve bioavailability [Poster presentation]. 1st CIRM Day, Liège, Belgium.

Degotte, G., Francotte, P., Frederich, M., Halleux, A., Hans, A., Jansen, O., Ledoux, A., Desdemoustier, P., & Pirotte, B. (November 2018). Pharmacomodulation of ellagic acid, a promising antiplasmodial agent, to improve its bioavailability [Poster presentation]. 30th International Symposium on the Chemistry of Natural Products and the 10th International Conference on Biodiversity, Athens, Greece.

Degotte, G., Alson, S. G., Hans, A., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Randimbivololona, F., Francotte, P., & Frederich, M. (12 June 2018). Antiplasmodial activity of polyphenolic derivatives [Poster presentation]. 32èmes Journées Franco-Belges de Chimie Thérapeutique et 26èmes Conférences Européennes des Pharmacochimistes de l'Arc Atlantique, Asnelles sur mer, France.

Manos-Turvey, A., Lemaire, C., Becker, G., Plenevaux, A., Luxen, A., Pirotte, B., & Francotte, P. (August 2017). Design and Synthesis of [18F]BPAM121, a PET-Probe Targeting AMPA-subtype Glutamatergic Receptors [Poster presentation]. EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, Vienne, Austria.

Manos-Turvey, A., Lemaire, C., Becker, G., Plenevaux, A., Luxen, A., Francotte, P., & Pirotte, B. (July 2017). Synthesis of [18F]BPAM121: An AMPAR Modulator with Potential as a PET Probe [Poster presentation]. RICT 2017, Drug Discovery and Selection, 53rd International Conference on Medicinal Chemistry, Toulouse, France.

Manos-Turvey, A., Lemaire, C., Deverdenne, F., Luxen, A., Francotte, P., & Pirotte, B. (June 2017). [18F]BPAM121: An AMPAR Modulator with Potential as a PET Probe [Poster presentation]. Royal Society of Chemistry Medicinal Chemistry Residential School, Loughborough, United Kingdom.

Drapier, T., Geubelle, P., Bouckaert, C., Goffin, E., Dilly, S., Hanson, J., Pochet, L., Kastrup, J. S., Francotte, P., & Pirotte, B. (26 May 2016). DESIGN OF HIGH-AFFINITY LIGANDS FOR THE BENZOTHIADIAZINE ALLOSTERIC BINDING SITE OF THE AMPA RECEPTORS [Poster presentation]. JFB 2016 : 30èmes Journées Franco-Belges de Pharmacochimie 25-27 May 2016 Amboise (France), Amboise, France.

Deverdenne, F., Claes, G., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (05 June 2015). Design and synthesis of PET-probes targeting AMPA-subtype receptors [Poster presentation]. 29èmes Journées franco-belges de Pharmacochimie, Spa, Belgium.

Drapier, T., Francotte, P., Pirotte, B., Goffin, E. (Other coll.), Hanson, J. (Other coll.), Dilly, S. (Other coll.), & Kastrup, J. (Other coll.). (04 June 2015). Design, synthesis and pharmacological evaluation of dimeric ligands for the benzothiadiazine dioxide allosteric binding site of the AMPA receptors [Paper presentation]. 29ème Journées Franco-Belge de Pharmacochimie, Spa, Belgium.

Deverdenne, F., Claes, G., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (13 May 2015). Design and synthesis of PET-probes targeting AMPA subtype receptors [Poster presentation]. The Bioforum 2015 of BioLiège, Liège, Belgium.

Deverdenne, F., Goffin, E., Plenevaux, A., Pirotte, B., Luxen, A., & Francotte, P. (05 June 2014). Design and synthesis of high-affinity ligands of AMPA receptors and study of their Fluorine-18 radiolabeling [Poster presentation]. 28èmes Journées franco-belges de Pharmacochimie, Metz, France.

Drapier, T., Goffin, E., Hanson, J., Dilly, S., Francotte, P., Kastrup, J., & Pirotte, B. (June 2014). DESIGN OF HIGH-AFFINITY LIGANDS FOR THE BENZOTHIADIAZINE ALLOSTERIC BINDING SITE OF THE AMPA RECEPTORS [Poster presentation]. 28èmes Journées franco-belges de Pharmacochimie, Metz, France.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., Botez, I., Pirotte, B., & De Tullio, P. (September 2012). Design, Synthesis and Biological Evaluation of 4-Cycloalkyl-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides Acting as AMPA Potentiators [Poster presentation]. ISMC2012, Berlin, Germany.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Caignard, D.-H., Challal, S., Rogez, N., Nosjean, O., Lesur, B., De Tullio, P., & Pirotte, B. (24 May 2012). Développement d’agents cognitifs agissant par potentialisation des récepteurs AMPA : Design de nouvelles thiénothiadiazine 1,1-dioxydes [Poster presentation]. 26es Journées Franco-Belges de Pharmacochimie, Orléans, France.

Francotte, P., Nielsen, B., Krogsgaard Larsen, P., & Frølund, B. (08 May 2011). Design of Photoreactive Orthosteric GABAA Ligands Potentially Useful for Studying Localization and Function of GABAA Receptors [Poster presentation]. 25es Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D.-H., De Tullio, P., & Pirotte, B. (08 September 2010). Development of cognitive enhancers acting through AMPA potentiation: design of novel thienothiadiazine 1,1-dioxides [Poster presentation]. ISMC2010, Bruxelles, Belgium.

Francotte, P. (October 2009). Design, Synthesis and Biological Evaluation of Cognitive Enhancers Acting Through the Potentiation of the AMPA Receptors [Paper presentation]. Neme-Meeting, Copenhague, Denmark.

Francotte, P., Fraikin, P., Goffin, E., Danober, L., Lestage, P., Caignard, D. H., Lesur, B., Botez, I., Van Heugen, J.-C., Chiap, P., Pirotte, B., & De Tullio, P. (May 2009). Stabilisation métabolique par introduction d’atomes de fluor : application aux benzothiadiazine 1,1-dioxydes agissant en tant que potentialisateurs AMPA [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Francotte, P. (May 2009). Design, Synthèse et evaluation biologique de modulateurs allostériques positifs des récepteurs AMPA potentiellement intéressants en tant qu’agents procognitifs [Paper presentation]. Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Francotte, P., & Fraikin, P. (03 September 2008). Design of benzothiadiazine 1,1-dioxides acting as AMPA potentiators : New pharmacomodulations leading to an improvement of pharmacokinetic properties [Poster presentation]. ISMC2008, Vienne, Austria.

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (17 May 2008). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Liège, Belgium.

Francotte, P., De Tullio, P., Fraikin, P., Goffin, E., Dintilhac, G., Danober, L., Lestage, P., Lesur, B., Botez, I., Caignard, D. H., & Pirotte, B. (May 2008). Development of cognitive enhancers acting through AMPA potentiation: design of novel benzothiadiazine 1,1-dioxides with improved pharmacokinetic profile [Paper presentation]. 22èmes Journées Franco-Belges de Pharmacochimie, Caen, France.

Francotte, P., Gillotin, F., Van Heuguen, J. C., Frederich, M., Lebrun, P., CHIAP, P., Pirotte, B., & De Tullio, P. (October 2007). Application of LC-SPE-NMR to the structural determination of metabolites of KATP channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Paper presentation]. 13th Forum of Pharmaceutical Sciences, Spa, Belgium.

Francotte, P., Fraikin, P., De Tullio, P., Graindorge, E., Dintilhac, G., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Lesur, B., Caignard, D. H., & Pirotte, B. (May 2007). Design, synthèse et évaluation pharmacologique de 1,2,4-thiénothiadiazine 1,1-dioxydes en tant que nouveaux potentialisateurs AMPA [Poster presentation]. 21èmes Journées Franco-Belges de Pharmacochimie, Namur, Belgium.

Gillotin, F., De Tullio, P., VAN HEUGEN, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Pirotte, B., & CHIAP, P. (2007). Coupling of the LC-MS/MS and the LC-SPE-NMR for the structural identification of pancreatic KATP channel openers metabolites following in vitro biotransformation [Poster presentation]. HPLC 2007, Gent, Belgium.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (18 November 2006). In vitro metabolisation study of several 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : combined use of LC-Q-TOF MS/MS and LC-SPE-NMR [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Frederich, M., Chiap, P., Kremers, P., Francotte, P., Lebrun, P., & Pirotte, B. (17 November 2006). Application of LC-SPE-NMR to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxide derivatives [Paper presentation]. 5th YBMRS, Bruxelles, Belgium.

De Tullio, P., Gillotin, F., Francotte, P., Van Heugen, J.-C., Frederich, M., Lebrun, P., Chiap, P., & Pirotte, B. (August 2006). Combined use of LC-SPE-NMR and LC-MS for the metabolites characterization of ATP-sensitive potassium channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

Francotte, P., De Tullio, P., Fraikin, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2006). Design, synthesis and pharmacological evaluation of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

Francotte, P., Fraikin, P., De Tullio, P., Counerotte, S., Goffin, E., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (June 2006). Design, synthèse et évaluation pharmacologique de 1,2,4-pytridothiadiazine 1,1-dioxydes en tant que nouveaux potentiateurs AMPA [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (June 2006). Application de la LC-SPE-RMN et de la LC-MS à la détermination structurale des métabolites d’activateurs des canaux KATP de la classe des 3-alkylamino-4H-arylthiadiazine 1,1-dioxydes [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Gillotin, F., De Tullio, P., Van Heugen, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Chiap, P., & Pirotte, B. (17 May 2006). Application of LC-SPE-NMR and LC-Q-TOF MS/MS to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. 10th Bioforum, Liège, Belgium.

Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (May 2005). Modulateurs allostériques positifs des récepteurs AMPA de la classe des 1,2,4-benzothiadiazine 1,1-dioxydes : conception, synthèse et évaluation pharmacologique [Poster presentation]. 19èmes Journées Franco-Belges de Pharmacochimie, Liège, Belgium.

Francotte, P., Fraikin, P., De Tullio, P., Boverie, S., Danober, L., Lestage, P., Renard, P., Caignard, D. H., & Pirotte, B. (August 2004). Synthesis and biological evaluation of novel 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxides acting as AMPA potentiators [Poster presentation]. XVIIIth ISMC, Copenhague, Denmark.

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (June 2004). Prodrogues de modulateurs allostériques positifs des récepteurs AMPA apparentés à l’IDRA-21 : design, synthèse, étude de la stabilité et évaluation pharmacologique [Poster presentation]. 18èmes Journées Franco-belges de Pharmacochimie, Luxembourg, Luxembourg.

Francotte, P., Boverie, S., Fraikin, P., Lestage, P., Danober, L., Caignard, D. H., De Tullio, P., & Pirotte, B. (May 2004). Prodrugs of AMPA potentiators structurally related to IDRA-21: design, preparation, hydrolysis study and pharmacological evaluation [Paper presentation]. 12th Forum of Pharmaceutical Sciences, Blankenberge, Belgium.

Graindorge, E., Francotte, P., Boverie, S., Kempen, I., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (31 January 2003). Nouveaux composés agissant en tant que modulateurs allostériques positifs des récepteurs glutamatergiques de sous-type AMPA : les 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxydes [Poster presentation]. 10éme Journée Jeunes Chercheurs, Paris, France.

Francotte, P., Graindorge, E., Kempen, I., Boverie, S., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (31 January 2003). Préparation et évaluation pharmacologique de modulateurs allostériques positifs des récepteurs AMPA : les 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxydes [Poster presentation]. 10ème Journée Jeunes Chercheurs, Paris, France.

Francotte, P., Graindorge, E., Kempen, I., Boverie, S., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (May 2002). Synthèse et évaluation biologique de 2,3-dihydro-4H-1,2,4-pyridothiadiazine 1,1-dioxydes en tant que modulateurs allostériques positifs des récepteurs AMPA [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Graindorge, E., Francotte, P., Boverie, S., Kempen, I., De Tullio, P., Caignard, D. H., Lestage, P., & Pirotte, B. (May 2002). Les 2,3-dihydro-4H-1,2,4-benzothiadiazine 1,1-dioxydes en tant que modulateurs allostériques positifs des récepteurs glutamatergiques de sous-type AMPA [Poster presentation]. XVIemes Journées Franco-Belges de Pharmacochimie, Bagnoles de l’Orne, France.

Book chapters and contributions to collective works

Francotte, P., De Tullio, P., & Pirotte, B. (2007). AChE Inhibitors and their Clinical Assessment. In Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies (Eds: H.J. Smith, C. Simons, R.D.E. sewell, CRC Press, pp. 114-144).

Francotte, P., De Tullio, P., & Pirotte, B. (2007). Cholinergic Transmission and Acetylcholine release enhancers. In Protein Misfolding in neuro degenerative Diseases : Mechanisms and Therapeutic Strategies (Eds: H.J. Smith, C. Simons, R.D.E. sewell, CRC Press, pp. 96-103). Routledge.

Theses and dissertations

Doctoral thesis

Francotte, P. (2008). Design, synthesis and biological evaluation of cognitive enhancers acting through the potentiation of the AMPA receptors [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/125450

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