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Degotte Gilles

Main Referenced Co-authors
Frederich, Michel  (27)
Francotte, Pierre  (21)
Pirotte, Bernard  (15)
Desdemoustier, Pauline  (7)
Ledoux, Allison  (7)
Main Referenced Keywords
Malaria (18); Ellagic acid (11); Plasmodium (10); malaria (9); Pharmacomodulation (6);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège (27)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (39)

Publications (total 39)

The most downloaded
544 downloads
Alson, S. G., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Degotte, G., Francotte, P., & Frederich, M. (2018). In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives. Journal of Pharmacy and Pharmacology, 70 (10), 1349-1356. doi:10.1111/jphp.12982 https://hdl.handle.net/2268/227811

The most cited

53 citations (OpenAlex)

Alson, S. G., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Degotte, G., Francotte, P., & Frederich, M. (2018). In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives. Journal of Pharmacy and Pharmacology, 70 (10), 1349-1356. doi:10.1111/jphp.12982 https://hdl.handle.net/2268/227811

Mvondo Mbala, J.-G., Thierry Mawete, D., Makiese, A., Kwiraviwe, L., Pangu, K., Nguimi, E., Cimanga Kanyanga, R., Pieters, L., Degotte, G., Frederich, M., Matondo, A., Van Pelt, N., Caljon, G., Pirotte, B., Mbala Mavinga, B., Bambi-Nyanguile, S.-M., & Mvondo, G. (2024). Synthesis and pharmacological evaluation of fluoro/chloro-substituted acetyl and benzoyl esters of quinine as antimalarial agents. Results in Chemistry, 7, 101284. doi:10.1016/j.rechem.2023.101284
Peer Reviewed verified by ORBi

Bonnet, O., Beniddir, M. A., Champy, P., Degotte, G., Coelho Cristino Mamede, L. C., Desdemoustier, P., Ledoux, A., Tiabou Tchinda, A., Angenot, L., & Frederich, M. (2023). Are plants of the Strychnos genus still a potential source of new antiplasmodial metabolites after more than two centuries of study? Planta Medica. doi:10.1055/s-0043-1773946
Peer Reviewed verified by ORBi

Degotte, G., Frederich, M., Francotte, P., Franck, T., Colson, T., Serteyn, D., & Mouithys-Mickalad, A. (02 June 2023). Targeting Myeloperoxidase Activity and Neutrophil ROS Production to Modulate Redox Process: Effect of Ellagic Acid and Analogues. Molecules, 28 (11), 4516. doi:10.3390/molecules28114516
Peer reviewed

Bak, A., Kos, J., Degotte, G., Swietlicka, A., Strharsky, T., Pindjakova, D., Gonec, T., Smolinski, A., Francotte, P., Frederich, M., Kozik, V., & Jampilek, J. (10 February 2023). Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of Chlorinated N-arylcinnamamides. International Journal of Molecular Sciences, 24 (4), 3611. doi:10.3390/ijms24043611
Peer Reviewed verified by ORBi

Bonnet, O., Beniddir, M. A., Champy, P., Degotte, G., Coelho Cristino Mamede, L. C., Desdemoustier, P., Ledoux, A., Tiabou Tchinda, A., Angenot, L., & Frederich, M. (01 February 2023). Molecular network annotations from 43 Strychnos extracts based on their in vitro antiplasmodial activities in order to detect and target new alkaloids potentially active against malaria [Paper presentation]. 5th CIRM Day, Liège, Belgium.

Degotte, G., Pendeville-Samain, H., Di Chio, C., Ettari, R., Pirotte, B., Frederich, M., & Francotte, P. (2023). Dimeric polyphenols to pave the way for new antimalarial drugs. RSC Medicinal Chemistry, 14, 715. doi:10.1039/d2md00392a
Peer Reviewed verified by ORBi

Bonnet, O., Beniddir, M. A., Champy, P., Degotte, G., Coelho Cristino Mamede, L. C., Desdemoustier, P., Ledoux, A., Tchinda, A. T., Angenot, L., & Frederich, M. (26 September 2022). Unveiling antiplasmodial alkaloids from a cumulative collection of Strychnos extracts by multi-informative molecular networks. Frontiers in Molecular Biosciences, 9. doi:10.3389/fmolb.2022.967012
Peer Reviewed verified by ORBi

Bonnet, O., Beniddir, M. A., Champy, P., Degotte, G., Coelho Cristino Mamede, L. C., Desdemoustier, P., Ledoux, A., Tiabou Tchinda, A., Angenot, L., & Frederich, M. (13 July 2022). Identification of new alkaloids active against malaria by molecular networking based on in vitro antiplasmodial activities of 28 Strychnos species [Paper presentation]. Journées virtuelles de l'AFERP 2022 (Virtual days of AFERP 2022).

Degotte, G., Strharsky, T., Kos, J., Francotte, P., Frederich, M., & Jampilek, J. (July 2022). Antimalarial Activity of Novel Substituted N-Arylcinnamamides [Poster presentation]. 3rd MMCS: Shaping Medicinal Chemistry for the New Decade, Roma, Italy.

Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2022). Potential of caffeic acid derivatives as antimalarial leads. Letters in Drug Design and Discovery, 19, 823-836.
Peer Reviewed verified by ORBi

Kos, J., Degotte, G., Pindjakova, D., Strharsky, T., Jankech, T., Gonec, T., Francotte, P., Frederich, M., & Jampilek, J. (2022). Insights into Antimalarial Activity of N-Phenyl- Substituted Cinnamanilides. Molecules, 27, 7799. doi:10.3390/molecules27227799
Peer Reviewed verified by ORBi

Degotte, G. (2021). Design, Synthesis, and Biological Evaluation of New Antiplasmodial Compounds Related to Ellagic Acid [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/267607

Degotte, G., Pirotte, B., Pendeville-Samain, H., Frederich, M., & Francotte, P. (19 November 2021). Pharmacomodulation of Ellagic Acid to Identify New Antimalarial Candidates [Poster presentation]. MedChem 2021, Liège, Belgium.

Degotte, G. (15 October 2021). Ring-cleavage of ellagic acid scaffold to Produce new antimalarial candidates [Paper presentation]. Interview Trinity College Dublin, Dublin, Ireland.

Degotte, G. (07 October 2021). Pharmacomodulation of the ellagic acid scaffold to pave the way for new antimalarial drugs [Paper presentation]. Interview University of Dundee, Dundee, United Kingdom.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (2021). Polyhydroxybenzoic acid derivatives as potential new antimalarial agents. Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. doi:10.1002/ardp.202100190
Peer reviewed

Degotte, G., Pirotte, B., Pendeville-Samain, H., Duwez, L., Frederich, M., & Francotte, P. (28 May 2021). Gallic acid dimerization to open the way for new antimalarial drugs [Paper presentation]. One-Day FNRS Med Chem Meeting, Louvain-La-Neuve, Belgium.

Degotte, G., Pirotte, B., Pendeville-Samain, H., Duwez, L., Frederich, M., & Francotte, P. (26 May 2021). Gallic acid dimerization to open the way for new antimalarial drugs [Poster presentation]. 3rd CIRMDay, Liège, Belgium.

Degotte, G. (2021). Le parasite, le moustique et la grenade, fable ou traitement? [Paper presentation]. Ma thèse en 180 secondes, Liège, Belgium.

Degotte, G., Pirotte, B., Francotte, P., & Frederich, M. (2021). Overview of natural antiplasmodials from the last decade to inspire medicinal chemistry. Current Medicinal Chemistry. doi:10.2174/0929867328666210329112354
Peer Reviewed verified by ORBi

Degotte, G. (15 December 2020). Design & development of ellagic acid derivatives as new pharmacological entities [Paper presentation]. GIGA doctoral school, Liège, Belgium.

Degotte, G. (09 October 2020). Development of new antimalarial agents inspired by a common polyphenol, ellagic acid [Paper presentation]. PSE econgress.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (20 February 2020). Pharmacomodulation of natural compounds: medicinal chemistry in antimalarial purposes [Poster presentation]. ChemCys 2020, Blankenberg, Belgium.

Degotte, G., Lempereur, D., Adubofour, Y., Pirotte, B., Frederich, M., & Francotte, P. (11 December 2019). Dimerisation of gallic acid for malaria treatment [Poster presentation]. CIRMDay, Liège, Belgium.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (22 November 2019). Total synthesis approach: development of new antimalarial compounds [Poster presentation]. MedChem 2019, Bruxelles, Belgium.

Degotte, G., Pirotte, B., Frederich, M., & Francotte, P. (05 September 2019). Pharmacomodulation of ellagic acid: a total synthesis approach [Poster presentation]. EFMC Young Medicinal Chemist, Athènes, Greece.

Degotte, G. (29 July 2019). Total synthesis approach of new entities inspired by ellagic acid [Paper presentation]. Natural Products in Drug Discovery and Human Health, Lisbon, Portugal.

Bastin, Y., & Degotte, G. (2019). Il met au point une molécule antimalaria. La Meuse Verviers.

Servais, A.-C., Degotte, G., & Koch, N. (19 June 2019). Update on the progresses and development of the Biopharmaceutics/Biopharmaceuticals Unifying Thematic [Paper presentation]. CIRM Seminar.

Degotte, G., Alson, S., Hans, A., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Randimbivololona, F., Francotte, P., & Frederich, M. (2019). Antiplasmodial activity of polyphenolic derivatives. Pharmaceuticals.
Peer Reviewed verified by ORBi

Degotte, G. (May 2019). Total synthesis approach of new antimalarials inspired by ellagic acid [Paper presentation]. BSPS 2019 Forum of Pharmaceutical Sciences, Bruxelles, Belgium.

Degotte, G., Halleux, A., Pirotte, B., Francotte, P., & Frederich, M. (May 2019). Design of new antimalarials inspired by ellagic acid through a total synthesis approach [Poster presentation]. Phytoday, Bruxelles, Belgium.

Degotte, G. (2019). Paludisme : Un nouveau candidat au traitement. FNRS NEWS.

Degotte, G., Halleux, A., Hans, A., Jansen, O., Ledoux, A., Desdemoustier, P., Pirotte, B., Francotte, P., & Frederich, M. (December 2018). Preparation of ellagic acid derivatives through a total synthesis approach to improve bioavailability [Poster presentation]. 1st CIRM Day, Liège, Belgium.

Degotte, G., Francotte, P., Frederich, M., Halleux, A., Hans, A., Jansen, O., Ledoux, A., Desdemoustier, P., & Pirotte, B. (November 2018). Pharmacomodulation of ellagic acid, a promising antiplasmodial agent, to improve its bioavailability [Poster presentation]. 30th International Symposium on the Chemistry of Natural Products and the 10th International Conference on Biodiversity, Athens, Greece.

Coelho Cristino Mamede, L. C., Degotte, G., Ledoux, A., Jansen, O., Desdemoustier, P., & Frederich, M. (November 2018). Antiplasmodial activity and interaction between cannabidiol and artemisinin [Poster presentation]. 30th International Symposium on the Chemistry of Natural Products and the 10th International Conference on Biodiversity, Athens, Greece.

Degotte, G., Alson, S. G., Hans, A., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Randimbivololona, F., Francotte, P., & Frederich, M. (12 June 2018). Antiplasmodial activity of polyphenolic derivatives [Poster presentation]. 32èmes Journées Franco-Belges de Chimie Thérapeutique et 26èmes Conférences Européennes des Pharmacochimistes de l'Arc Atlantique, Asnelles sur mer, France.

Alson, S. G., Jansen, O., Cieckiewicz, E., Rakotoarimanana, H., Rafatro, H., Degotte, G., Francotte, P., & Frederich, M. (2018). In-vitro and in-vivo antimalarial activity of caffeic acid and some of its derivatives. Journal of Pharmacy and Pharmacology, 70 (10), 1349-1356. doi:10.1111/jphp.12982
Peer Reviewed verified by ORBi

Degotte, G. (2018). Use and cleaning of BioChem-VacuuCenter and VHCpro (Vacuubrand).

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