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Van Heugen Jean-Claude

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Main Referenced Co-authors
Chiap, Patrice  (12)
De Tullio, Pascal  (10)
Pirotte, Bernard  (9)
Francotte, Pierre  (8)
Frederich, Michel  (8)
Main Referenced Keywords
Acyl Coenzyme A/isolation & purification/metabolism (1); Alzheimer's disease (1); AMPA potentiator (1); Antarctic Regions (1); antisickling activity (1);
Main Referenced Unit & Research Centers
CRBB - Centre Interfacultaire de Recherches Bioanalytiques et Biopharmaceutiques - ULiège [BE] (1)
Centre Interfacultaire de Recherche du Médicament - CIRM (1)
Main Referenced Disciplines
Pharmacy, pharmacology & toxicology (15)
Biochemistry, biophysics & molecular biology (1)
Microbiology (1)
Phytobiology (plant sciences, forestry, mycology...) (1)
Veterinary medicine & animal health (1)

Publications (total 17)

The most downloaded
964 downloads
Fillet, M., Van Heugen, J.-C., Servais, A.-C., De Graeve, J., & Crommen, J. (2002). Separation, identification and quantitation of ceramides in human cancer cells by liquid chromatography–electrospray ionization tandem mass spectrometry. Journal of Chromatography. A, 949, 225-233. doi:10.1016/S0021-9673(01)01422-4 https://hdl.handle.net/2268/13395

The most cited

77 citations (Scopus®)

Rocks, N., Bekaert, S., Coia, I., Paulissen, G., Guéders, M., Evrard, B., VAN HEUGEN, J.-C., CHIAP, P., Foidart, J.-M., Noël, A., & Cataldo, D. (2012). Curcumin-cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer. British Journal of Cancer, 107 (7), 1083-92. doi:10.1038/bjc.2012.379 https://hdl.handle.net/2268/131389

Denooz, R., VAN HEUGEN, J.-C., Frederich, M., De Tullio, P.* , & Charlier, C.*. (March 2013). Identification and structure elucidation of four cannabimimetic compounds in seized products. Journal of Analytical Toxicology, 37 (2), 56-63. doi:10.1093/jat/bks095
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Constant-Urban, C., Charif, M., Goffin, E., VAN HEUGEN, J.-C., Elmoualij, B., CHIAP, P., Mouithys-Mickalad, A., Serteyn, D., Lebrun, P., Pirotte, B., & De Tullio, P. (2013). Triphenylphosphonium salts of 1,2,4-benzothiadiazine 1,1-dioxides related to diazoxide targeting mitochondrial ATP-sensitive potassium channels. Bioorganic and Medicinal Chemistry Letters, 23, 5878-5881. doi:10.1016/j.bmcl.2013.08.091
Peer Reviewed verified by ORBi

Rocks, N., Bekaert, S., Coia, I., Paulissen, G., Guéders, M., Evrard, B., VAN HEUGEN, J.-C., CHIAP, P., Foidart, J.-M., Noël, A., & Cataldo, D. (2012). Curcumin-cyclodextrin complexes potentiate gemcitabine effects in an orthotopic mouse model of lung cancer. British Journal of Cancer, 107 (7), 1083-92. doi:10.1038/bjc.2012.379
Peer Reviewed verified by ORBi

Francotte, P., Goffin, E., Fraikin, P., Lestage, P., Van Heugen, J.-C., Gillotin, F., Danober, L., Thomas, J.-Y., Chiap, P., Caignard, D.-H., Pirotte, B., & De Tullio, P. (2010). New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors. Journal of Medicinal Chemistry, 53, 1700-1711. doi:10.1021/jm901495t
Peer Reviewed verified by ORBi

Gillotin, F., Chiap, P., Frederich, M., Van Heugen, J.-C., Francotte, P., Lebrun, P., Pirotte, B., & De Tullio, P. (2010). Coupling of Liquid Chromatography/Tandem Mass Spectrometry and Liquid Chromatography/Solid-Phase Extraction/NMR Techniques for the Structural Identification of Metabolites following In Vitro Biotransformation of SUR1-Selective ATP-Sensitive Potassium Channel Openers. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 (2), 232-240. doi:10.1124/dmd.109.028928
Peer Reviewed verified by ORBi

Francotte, P., Fraikin, P., Goffin, E., Danober, L., Lestage, P., Caignard, D. H., Lesur, B., Botez, I., Van Heugen, J.-C., Chiap, P., Pirotte, B., & De Tullio, P. (May 2009). Stabilisation métabolique par introduction d’atomes de fluor : application aux benzothiadiazine 1,1-dioxydes agissant en tant que potentialisateurs AMPA [Poster presentation]. 23èmes Journées Franco-Belges de Pharmacochimie, Mons, Belgium.

Bimazubute, M. A., Rozet, E., Dizier, I., Van Heugen, J.-C., Arancio, E., Gustin, P., Crommen, J., & Chiap, P. (2009). Pre-study and in-study validation of an ultra-high pressure LC method coupled to tandem mass spectrometry for off-line determination of oxytetracycline in nasal secretions of healthy pigs. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (23), 2349-57. doi:10.1016/j.jchromb.2009.01.033
Peer Reviewed verified by ORBi

Bimazubute, M., Rozet, E., Van Heugen, J.-C., Hubert, P., Gustin, P., & Chiap, P. (2009). Dosage d'oxytétracycline dans les secrétions nasales de porcs par chromatographie liquide : comparaison d'associations de méthodes de préparations d'échantillons et de modes de détection [Poster presentation]. 8e cognrès francophone de l'AFSEP sur les sciences séparatives et couplages, Marseille, France.

Gillotin, F., De Tullio, P., VAN HEUGEN, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Pirotte, B., & CHIAP, P. (2007). Coupling of the LC-MS/MS and the LC-SPE-NMR for the structural identification of pancreatic KATP channel openers metabolites following in vitro biotransformation [Poster presentation]. HPLC 2007, Gent, Belgium.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (18 November 2006). In vitro metabolisation study of several 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers : combined use of LC-Q-TOF MS/MS and LC-SPE-NMR [Poster presentation]. Réunion de la Société Belge de Physiologie et de Pharmacologie Fondamentales et Cliniques, Bruxelles, Belgium.

De Tullio, P., Gillotin, F., Francotte, P., Van Heugen, J.-C., Frederich, M., Lebrun, P., Chiap, P., & Pirotte, B. (August 2006). Combined use of LC-SPE-NMR and LC-MS for the metabolites characterization of ATP-sensitive potassium channel openers belonging to 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. XIXth International Symposium on Medicinal Chemistry, Istanbul, Turkey.

De Tullio, P., Chiap, P., Francotte, P., Van Heugen, J.-C., Florence, X., Frederich, M., Gillotin, F., Kremers, P., Lebrun, P., & Pirotte, B. (June 2006). Application de la LC-SPE-RMN et de la LC-MS à la détermination structurale des métabolites d’activateurs des canaux KATP de la classe des 3-alkylamino-4H-arylthiadiazine 1,1-dioxydes [Poster presentation]. 20èmes Journées Franco-Belges de Pharmacochimie, Lille, France.

Gillotin, F., De Tullio, P., Van Heugen, J.-C., Francotte, P., Frederich, M., Lebrun, P., Kremers, P., Chiap, P., & Pirotte, B. (17 May 2006). Application of LC-SPE-NMR and LC-Q-TOF MS/MS to the structural determination of KATP channel openers metabolites belonging to the 3-alkylamino-4H-1,2,4-arylthiadiazine 1,1-dioxides [Poster presentation]. 10th Bioforum, Liège, Belgium.

Ouattara, B., Angenot, L., Guissou, P., Fondu, P., Dubois, J., Frederich, M., Jansen, O., Van Heugen, J.-C., Wauters, J.-N., & Tits, M. (April 2004). LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry, 65 (8), 1145-1151. doi:10.1016/j.phytochem.2004.02.025
Peer Reviewed verified by ORBi

Fillet, M., Van Heugen, J.-C., Servais, A.-C., De Graeve, J., & Crommen, J. (2002). Separation, identification and quantitation of ceramides in human cancer cells by liquid chromatography–electrospray ionization tandem mass spectrometry. Journal of Chromatography. A, 949, 225-233. doi:10.1016/S0021-9673(01)01422-4
Peer Reviewed verified by ORBi

Fillet, M., Servais, A.-C., Van Heugen, J.-C., De Graeve, J., & Crommen, J. (2002). Identification and quantification of endogenous ceramides in human cancer cells by LC-ESI-MS-MS [Poster presentation]. 7th International Symposium on Drug Analysis, Bruges, Belgium.

Sabri, A., Bare, G., Jacques, P., Jabrane, A., Ongena, M., Van Heugen, J.-C., Devreese, B., & Thonart, P. (2001). Influence of moderate temperatures on myristoyl-CoA metabolism and acyl-CoA thioesterase activity in the psychrophilic antarctic yeast Rhodotorula aurantiaca. Journal of Biological Chemistry, 276 (16), 12691-6. doi:10.1074/jbc.M100155200
Peer Reviewed verified by ORBi

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