Article (Scientific journals)
Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium
Goffin, Frédéric; Munaut, Carine; Frankenne, Francis et al.
2003In Biology of Reproduction, 69 (3), p. 976-984
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Keywords :
female reproductive tract; gene regulation; menstrual cycle
Abstract :
[en] The cyclic growth, differentiation, and cell death of endometrium represents the most dynamic example of steroid-driven tissue turnover in human adults. Key effectors in these processes-matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs)-are regulated by ovarian steroids and, locally, by cytokines. We used reverse transcription-polymerase chain reaction to evaluate the expression of both transcriptionally regulated molecules such as estrogen receptor-alpha, progesterone receptor, and prolactin and a large array of MMPs and TIMPs (MMP-1, -2, -3, -7, -8, -9, -11, -12, -19, -26, MT1-MMP, MT2-MMP, MT3-MMP, TIMP-1, -2, -3). Altogether, three distinct patterns of MMP and two patterns of TIMP expression were detected in cycling endometrium: 1). MMPs restricted to the menstrual period (MMPs-1, -3, -8, -9, -12); 2). MMPs and TIMPs expressed throughout the cycle (MMP-2, MT1-MMP, MT2-MMP, MMP-19, TIMP-1, and TIMP-2); 3). MMPs predominantly expressed during the proliferative phase (MMP-7, MMP-11, MMP-26, and MT3-MMP); and 4). TIMP-3, which, contrary to the other TIMPs, shows significant modulations, with maximum expression during the late secretory and menstrual phases. These specific patterns of MMP expression associated with each phase of the cycle may point to specific roles in the processes of menstruation, housekeeping activities, angiogenesis, tissue growth, and extracellular matrix remodeling.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Goffin, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Munaut, Carine  ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Frankenne, Francis
PERRIER d'HAUTERIVE, Sophie ;  Université de Liège - ULiège > Gynécologie-Obstétrique CHR
Beliard, Aude ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Fridman, Viviana ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Nervo, Patricia ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Colige, Alain ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Protéines et glycoprot. de matr.extracell. et membran.basal.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
English
Title :
Expression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium
Publication date :
September 2003
Journal title :
Biology of Reproduction
ISSN :
0006-3363
eISSN :
1529-7268
Publisher :
Society for the Study of Reproduction, Madison, United States - Wisconsin
Volume :
69
Issue :
3
Pages :
976-984
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 March 2009

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