Reference : Massive Ketonuria During Sedation with Propofol in a 12 Year Old Girl with Severe Hea...
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/9621
Massive Ketonuria During Sedation with Propofol in a 12 Year Old Girl with Severe Head Trauma
English
Canivet, Jean-Luc mailto [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Gustad, K. [> > > >]
Leclercq, P. [ > > ]
Damas, Pierre mailto [Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation]
Lamy, Maurice mailto [Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation]
1994
Acta Anaesthesiologica Belgica
Acta Medica Belgica
45
1
19-22
Yes (verified by ORBi)
International
0001-5164
Bruxelles
Belgique
[en] Propofol ; Ketonuria ; Head trauma
[en] Severe ketonuria developed during sedation with propofol in a 12 year old girl with brain injury. Deep sedation with propofol (5.1 mg/kg/h) was required because of agitation and severe intracranial hypertension; as a part of our management protocol, glucose intake was restricted to 5 Kcal/h. After 18 hours of propofol infusion there was intense ketonuria (8+ by Ketostix) without any evidence of metabolic acidosis (pH, HCO3- and anion gap were within normal values). At this time, indirect calorimetry (Deltatrac) confirmed that energy expenditure was principally based on fat consumption (70% of energy expenditure). Lowering the propofol infusion rate and increasing glucose intake reduced fat consumption to 39% within 8 hours: at this time, Ketostix was negative for ketone bodies. This case illustrates a potential risk of ketonuria during prolonged sedation with propofol (a 10% solution of intralipid), particularly if glucose intake is restricted. Monitoring urinary ketone bodies is recommended under these circumstances.
http://hdl.handle.net/2268/9621

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
241.pdfPublisher postprint279.77 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.