[en] The inhibitory effect of adrenochrome on glutamic decarboxylase from brain homogenates in vitro, does not occur with mescaline and LSD 25. Certain stable derivatives of adrenochrome such as MSCA and AHA, in which the quinonic function is blocked, have an opposite effect, and behave like activators of brain glutamic decarboxylase. This activation seems to be indirect; MSCA and AHA do not constitute new coenzymes.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Deltour, G. H.; Laboratoire LABAZ > Service de Recherche
Ghuysen, Jean-Marie ; Université de Liège - ULiège > Laboratoire de Micriobiologie Générale et Médicale
Claus, A.; Laboratoire LABAZ > Service de Recherche
Language :
French
Title :
Effet de la mescaline, du lsd 25 et de dérivés de l'adrenochrome sur la décarboxlyase glutamique du cerveau
