Reference : The frequency of cutaneous vasculitis is not increased in patients with rheumatoid ar...
Scientific journals : Article
Human health sciences : Rheumatology
http://hdl.handle.net/2268/94591
The frequency of cutaneous vasculitis is not increased in patients with rheumatoid arthritis treated with methotrexate
English
Kaye, O. [> >]
BECKERS, Catherine mailto [> >]
Paquet, P. [> >]
Arrese Estrada, Jorge [Université de Liège - ULiège > > Dermatopathologie >]
Pierard, Gérald mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Malaise, Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie >]
1996
Journal of Rheumatology
Journal of Rheumatology Publishing Company
23
2
253-257
Yes (verified by ORBi)
International
0315-162X
Toronto
Canada
[en] Methotrexate ; Rheumatoid arthritis
[en] OBJECTIVE: To analyse the frequency, type, and immunohistological features of
clinical cutaneous vasculitis developing in patients with rheumatoid arthritis
(RA) treated or not with methotrexate as well as their demographic, clinical and
biological characteristics. METHODS: Ninety-one patients with RA receiving 9.5
mg/wk of methotrexate (MTX) were compared for an average observation time of 18
months to 130 matched patients with RA treated with various drugs excluding MTX.
RESULTS: Whether receiving MTX or not, 5.4% of patients with RA developed a
clinical cutaneous vasculitis. There were significant differences between both
groups for 2 variables only: a higher percentage of polyneuropathies and a higher
level of immune complex-plasma levels in non-MTX patients. The immunohistological
analysis did not differentiate both groups. CONCLUSION: The percentage of
cutaneous vasculitis that developed under MTX therapy was not different from that
occurring as a natural complication of longstanding severe RA.
Researchers ; Professionals
http://hdl.handle.net/2268/94591

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