Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not

[en] OBJECTIVE: To study the levels of matrix metalloproteinase-3 (MMP-3) in the knee synovial fluid (SF) of inflammatory arthropathies (rheumatoid arthritis whether erosive or not, reactive arthritis, acute crystal arthritis) and degenerative arthropathies [chronic crystal disease, osteoarthritis and (control) meniscus pathology] and to correlate them with the degree of joint destruction, local inflammatory and immune parameters and systemic markers of inflammation. METHODS: SF levels of MMP-3 (precursor, active and tissue inhibitor of MMP-bound forms), tumour necrosis factor (TNF) alpha, soluble TNF receptors I and II, interleukin (IL)-6 and soluble IL-6 receptor were measured by ELISA in 107 inflammatory and 53 degenerative arthropathies. RESULTS: MMP-3 levels in SF were (i) significantly higher in inflammatory than in degenerative arthropathies; (ii) not related to the degree of joint destruction; (iii) significantly correlated with the levels of all SF markers tested and with erythrocyte sedimentation rate and serum levels of C-reactive protein and fibrinogen. CONCLUSION: Increased MMP-3 levels in SF are found in inflammatory arthropathies and are not specific for erosive joint diseases. MMP-3 in SF is therefore a potential candidate for the assessment of the inflammatory process in joints. However, the exclusive determination of the active form could indicate the degree of joint destruction.

Disciplines :

Rheumatology

Author, co-author :

Ribbens, Clio ; Université de Liège - ULiège > Rhumatologie

Andre, Béatrice ; Université de Liège - ULiège > Rhumatologie - Néphrologie

Kaye, O.

Kaiser, M. J.

Bonnet, V.

Jaspar, J. M.

de Groote, D.

Franchimont, N.

Malaise, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie

Language :

English

Title :

Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not

Publication date :

2000

Journal title :

Rheumatology

ISSN :

1462-0324

eISSN :

1462-0332

Publisher :

Oxford University Press, Oxford, United Kingdom

Volume :

Issue :

Pages :

1357-1365

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 June 2011

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