Reference : Matrix metalloproteinase-3 serum levels are correlated with disease activity and pred...
Scientific journals : Article
Human health sciences : Rheumatology
Matrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis
Ribbens, Clio mailto [Université de Liège - ULg > > Rhumatologie >]
Andre, Béatrice mailto [Université de Liège - ULg > > Rhumatologie - Néphrologie >]
Jaspar, J. M. [ > > ]
Kaye, O. [ > > ]
Kaiser, Marie-Joëlle mailto [Université de Liège - ULg > > Rhumatologie >]
De Groote, D. [ > > ]
Malaise, Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Rhumatologie >]
Journal of Rheumatology
Journal of Rheumatology Publishing Company
Yes (verified by ORBi)
[en] Non-Steroidal Anti-Inflammatory Agents ; Antirheumatic Agents ; Indoles ; Interleukin-6 ; Matrix Metalloproteinase 3 ; C-Reactive Protein
[en] OBJECTIVE: To demonstrate that serum matrix metalloproteinase-3 (MMP-3) is a
variable associated with disease activity and with the response to treatment in
rheumatoid arthritis (RA). METHODS: Serum MMP-3 levels were measured and compared
to biological and clinical disease activity variables in 20 patients with active
RA assessed serially during a one year prospective open label trial with
methotrexate or tenidap. RESULTS: MMP-3 levels were significantly correlated with
C-reactive protein (CRP) and interleukin 6 serum levels as well as with the
disease activity score (DAS), not only at start in untreated patients but also
during the 12 month followup period in both treated groups. Early changes (after
0.5, 1, 2, or 3 months) in MMP-3 levels were significantly associated with change
in DAS observed 4 to 6 months later. CONCLUSION: In addition to CRP, a systemic
marker of inflammation, serum MMP-3 may serve as a consistent synovial derived
marker of RA disease activity, early changes of which predict disease outcome.
Researchers ; Professionals

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