Article (Scientific journals)
Hyperammonemia after high-dose chemotherapy and stem cell transplantation.
Frere, Pascale; Canivet, Jean-Luc; Gennigens, Christine et al.
2000In Bone Marrow Transplantation, 26 (3), p. 343-5
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Keywords :
Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse effects/therapeutic use; Cyclophosphamide/administration & dosage/adverse effects; Dexamethasone/administration & dosage/adverse effects; Doxorubicin/administration & dosage/adverse effects; Female; Hematopoietic Stem Cell Transplantation/adverse effects; Humans; Hyperammonemia/etiology; Melphalan/administration & dosage/adverse effects; Middle Aged; Multiple Myeloma/blood/drug therapy/therapy; Prednisolone/administration & dosage/adverse effects; Vincristine/administration & dosage/adverse effects
Abstract :
[en] We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the possibility of this diagnosis in patients developing confusion and neurological degradation with respiratory alkalosis after intensive chemotherapy, could allow earlier treatment and perhaps improved survival. Possible mechanisms and potential therapies are discussed. With rapid recognition and treatment of the syndrome, the patient fully recovered. One and a half years later, she is still alive and well, on interferon for persisting myeloma.
Disciplines :
Hematology
Author, co-author :
Frere, Pascale ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Canivet, Jean-Luc ;  Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
Gennigens, Christine  ;  Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale
Rebeix, J. P.
Fillet, Georges ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Beguin, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Language :
English
Title :
Hyperammonemia after high-dose chemotherapy and stem cell transplantation.
Publication date :
2000
Journal title :
Bone Marrow Transplantation
ISSN :
0268-3369
eISSN :
1476-5365
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
26
Issue :
3
Pages :
343-5
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 March 2009

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