Reference : Transgenic engineering of male-specific muscular hypertrophy.
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Life sciences : Genetics & genetic processes
Transgenic engineering of male-specific muscular hypertrophy.
Pirottin, Dimitri mailto [Université de Liège - ULiège > Département de productions animales > Génétique factorielle et moléculaire > >]
Grobet, Luc mailto [Université de Liège - ULiège > Département de morphologie et pathologie > Embryologie >]
Adamantidis, Antoine [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Farnir, Frédéric mailto [Université de Liège - ULiège > Département de productions animales > Biostatistique, économie, sélection animale >]
Herens, Christian mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Daa Schroder, Henrik [Odense Universiteitshospital - OUH > Institute of Pathology > > >]
Georges, Michel mailto [Université de Liège - ULiège > Département de productions animales > Génétique factorielle et moléculaire > >]
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
Yes (verified by ORBi)
[en] Animals ; Body Weights and Measures ; Breeding/methods ; DNA-Binding Proteins/genetics ; Gene Targeting/methods ; Genetic Engineering/methods ; Genetic Vectors/genetics ; Male ; Mice ; Mice, Transgenic ; Muscle Development/genetics ; Muscle, Skeletal/growth & development ; Myosin Light Chains/genetics ; Myostatin ; Nuclear Proteins/genetics ; Promoter Regions, Genetic/genetics ; Sex-Determining Region Y Protein ; Totipotent Stem Cells/metabolism ; Transcription Factors/genetics ; Transforming Growth Factor beta/genetics/metabolism ; Y Chromosome/genetics
[en] Using a two-step procedure involving insertional gene targeting and recombinase-mediated cassette exchange in ES cells, we have produced two lines of transgenic mice expressing a dominant-negative latency-associated myostatin propeptide under control of the myosin light chain 1F promoter and 1/3 enhancer from the TSPY locus on the Y chromosome. Males of the corresponding lines are characterized by a 5-20% increase in skeletal muscle mass. This experiment demonstrates the feasibility of a more efficient cattle production system combining superior beef production abilities for bulls and dairy abilities for cows.
Researchers ; Professionals

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