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The Streptomyces DD-carboxypeptidase-transpeptidase system as a model for the study of penicillin action
Ghuysen, Jean-Marie; Leyh-Bouille, Mélina; Frère, Jean-Marie et al.
1972In Pratesi, P. (Ed.) Medicinal Chemistry : Special contributions - Milan 1972
 

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Keywords :
penicillin
Abstract :
[en] A new model for the transpeptidation reaction involved in the biosynthesis of the bacterial wall peptidoglycan and for its inhibition by penicillin is proposed. This model is in open conflict with the hypotheses previously postulated. It rests upon the demonstration that 1) carboxypeptidase and transpep-tidase activities are performed by the same enzyme, 2) inhibition of both activities by penicillin is carried out in the absence of irreversible acylation of the protein, 3) the enzyme contains multiple sites some of which are involved in regulation, 4) penicillin does not act as a structural analogue of the donor peptide involved in transpeptidation but may act at the level of regulatory site(s).
Research center :
CIP - Centre d'Ingénierie des Protéines - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Microbiology
Author, co-author :
Ghuysen, Jean-Marie ;  Université de Liège - ULiège > Institut de Botanique > Service de Microbiologie
Leyh-Bouille, Mélina;  Université de Liège - ULiège > Institut de Botanique > Service de Microbiologie
Frère, Jean-Marie ;  Université de Liège - ULiège
Dusart, Jean;  Université de Liège - ULiège > Institut de Botanique > Service de Microbiologie
Perkins, Harold R.;  National Institute for Medical Research - London
Nieto, Manuel;  National Institute for Medical Research - London
Language :
English
Title :
The Streptomyces DD-carboxypeptidase-transpeptidase system as a model for the study of penicillin action
Publication date :
1972
Event name :
3rd International Symposium on Medicinal Chemistry
Event place :
Milan, Italy
Event date :
1972
Audience :
International
Main work title :
Medicinal Chemistry : Special contributions - Milan 1972
Editor :
Pratesi, P.
Publisher :
Butterworths, London, United Kingdom
Pages :
1-11
Available on ORBi :
since 26 May 2011

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