[en] Isosungucine (1) is a quasi-symmetric bisindolomonoterpenoid alkaloid isolated from the roots of Strychnos icaja. The in vivo antimalarial activity against the P. vinckei petteri murine strain was determined. In the Peters 4-day suppressive test, 1 suppressed the parasitemia by almost 50 percent on day 4 at the dose of 30 mg/kg by intraperitoneal route.
Neuwinger HD. Alkaloids in arrow poisons. In: Roberts MC, Wink M, editors. Alkaloids: biochemistry, ecology and medicinal applications New York: Plenum Press; 1998: 45-84.
Iwu M. Handbook of African medicinal plants. Boca Raton: CRC Press; 1993:244-5.
Wright CW, Bray DH, O'Neill MJ, Warhurst DC, Phillipson JD, Quetin-Leclercq J et al. Antiamoebic and antiplasmodial activities of alkaloids isolated from Strychnos usambarensis. Planta Med 1991; 57: 337-40.
Wright CW, Allen D, Cai Y, Chen ZP, Phillipson JD, Kirby GC et al. Selective antiprotozoal activity of some Strychnos alkaloids. Phytother Res 1994; 8: 149-52.
Frederich M, Hayette MP, Tits M, De Mol P, Angenot L. In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum. Antimicrob Agents Chemother 1999; 43: 2328-31.
Frederich M, Tits M, Coffin E, Philippe G, Grellier P, De Mol P et al. In vitro and in vivo antimalarial properties of isostrychnopentamine, an indolomonoterpenic alkaloid from Strychnos usambarensis. Planta Med 2004; 70: 520-5.
Frederich M, De Pauw M, Prosperi C, Tits M, Brandt V, Penelle J et al. Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja. J Nat Prod 2001; 64: 12-6.
Philippe G, Nguyen L, Angenot L, Frederich M, Moonen G, Tits M et al. Study of the interaction of antiplasmodial strychnine derivatives with the glycine receptor. Eur J Pharmacol 2006; 530: 15-22.
Frederich M, Depauw-Gillet MC, Llabres G, Tits M, Hayette MP, Brandt V et al. New antimalarial and cytotoxic sungucine derivatives from Strychnos icaja roots. Planta Med 2000; 66: 262-9.
Peters W, Robinson BL. The chemotherapy of rodent malaria. XLV1. Reversal of mefloquine resistance in rodent Plasmodium. Ann Trop Med Hyg 1991; 85: 5-10.
Pink R, Hudson A, Mouries MA, Bendig M. Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov 2005; 4: 727-40.
Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov 2004; 3: 509-20.
Frederich M, Jacquier MJ, Thepenier P, De Mol P, Tits M, Philippe G et al. Antiplasmodial activity of alkaloids from various Strychnos species. J Nat Prod 2002; 65: 1381-6.
