Article (Scientific journals)
Downregulation of CD94/NKG2A inhibitory receptors on CD8+ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts.
Zeddou, Mustapha; Rahmouni, Souad; Vandamme, Arnaud et al.
2007In Retrovirology, 4, p. 72
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Keywords :
CD8-Positive T-Lymphocytes/metabolism; Chronic Disease; Down-Regulation; HIV Infections/immunology/virology; HIV-1; Humans; Killer Cells, Natural/metabolism; NK Cell Lectin-Like Receptor Subfamily C; NK Cell Lectin-Like Receptor Subfamily D/metabolism; Receptors, Immunologic/metabolism; Receptors, Natural Killer Cell; Viral Load
Abstract :
[en] The CD94/NKG2A heterodimer is a natural killer receptor (NKR), which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small fraction of activated CD8+ T lymphocytes. Abnormal upregulation of the CD94/NKG2A inhibitory NKR on cytotoxic T cells (CTLs) could be responsible for a failure of immunosurveillance in cancer or HIV infection. In this study, CD94/NKG2A receptor expression on CD8+ T lymphocytes and NK cells was assessed in 46 HIV-1-infected patients (24 viraemic, 22 aviraemic) and 10 healthy volunteers. The percentage of CD8+ T lymphocytes expressing the CD94/NKG2A inhibitory heterodimer was very significantly decreased in HIV-1-infected patients in comparison with non-infected controls. Within the HIV infected patients, the proportion of CD8+ T lymphocytes and NK cells expressing CD94/NKG2A was higher in subjects with undetectable viral loads in comparison with their viraemic counterparts. No significant difference was detected in the proportion of CD8+ T lymphocytes expressing the activatory CD94/NKG2C heterodimer between the HIV-1 infected patients and the healthy donors, nor between the vireamic and avireamic HIV-1 infected patients. In conclusion, chronic stimulation with HIV antigens in viraemic patients leads to a decreased rather than increased CD94/NKG2A expression on CD8+ T lymphocytes and NK cells.
Disciplines :
Immunology & infectious disease
Hematology
Author, co-author :
Zeddou, Mustapha ;  Université de Liège - ULiège > Département des sciences cliniques > GIGA-R : Hématologie
Rahmouni, Souad  ;  Université de Liège - ULiège > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén.
Vandamme, Arnaud ;  Université de Liège - ULiège > Département des sciences cliniques > Immunopathologie - Transplantation
Jacobs, Nathalie  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Frippiat, Frédéric  ;  Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale - Direction médicale
Leonard, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
SCHAAF-LAFONTAINE, Nicole ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Vaira, Dolorès ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie
Boniver, Jacques ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Moutschen, Michel  ;  Centre Hospitalier Universitaire de Liège - CHU > Maladies infectieuses et médecine interne générale
Language :
English
Title :
Downregulation of CD94/NKG2A inhibitory receptors on CD8+ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts.
Publication date :
2007
Journal title :
Retrovirology
eISSN :
1742-4690
Publisher :
BioMed Central, London, United Kingdom
Volume :
4
Pages :
72
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 March 2009

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