Article (Scientific journals)
Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.
Peixoto, Paul; Zeghida, Walid; Carrez, Daniele et al.
2009In European Journal of Medicinal Chemistry, 44 (11), p. 4758-63
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Keywords :
Acridines/pharmacokinetics/pharmacology; Antineoplastic Agents/pharmacokinetics/pharmacology; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation/drug effects; Humans; Lysosomes/metabolism; Microscopy, Fluorescence; Spectrometry, Mass, Secondary Ion
Abstract :
[en] Aminoacridine derivatives display interesting chemical and biological properties in the field of antitumor agents. The synthesis of 4-hydroxymethyl-3-aminoacridine and its iodo labelled analogue allows the study of cell distribution using two innovative, complementary and powerful techniques, real time fluorescence microscopy and dynamic secondary ion mass spectrometry (SIMS). All the data point to lysosomal localization of the active molecule.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Peixoto, Paul 
Zeghida, Walid
Carrez, Daniele
Wu, Ting*-Di
Wattez, Nicole
Croisy, Alain
Demeunynck, Martine
Guerquin-Kern, Jean*-Luc
Lansiaux, Amelie
Language :
English
Title :
Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine.
Publication date :
2009
Journal title :
European Journal of Medicinal Chemistry
ISSN :
0223-5234
eISSN :
1768-3254
Publisher :
Elsevier, Netherlands
Volume :
44
Issue :
11
Pages :
4758-63
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 March 2011

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