Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness.
Adolescent; Adult; Conscious Sedation/methods; Consciousness/drug effects/physiology; Deep Sedation/methods; Female; Humans; Magnetic Resonance Imaging/methods; Male; Nerve Net/drug effects/physiology; Propofol/pharmacology; Rest/physiology; Unconsciousness/chemically induced/physiopathology; Young Adult
Abstract :
[en] BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness. METHODS: Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers during wakefulness, mild sedation, deep sedation with clinical unconsciousness, and subsequent recovery of consciousness. RESULTS: Propofol-induced decrease in consciousness linearly correlates with decreased corticocortical and thalamocortical connectivity in frontoparietal networks (i.e., default- and executive-control networks). Furthermore, during propofol-induced unconsciousness, a negative correlation was identified between thalamic and cortical activity in these networks. Finally, negative correlations between default network and lateral frontoparietal cortices activity, present during wakefulness, decreased proportionally to propofol-induced loss of consciousness. In contrast, connectivity was globally preserved in low-level sensory cortices, (i.e., in auditory and visual networks across sedation stages). This was paired with preserved thalamocortical connectivity in these networks. Rather, waning of consciousness was associated with a loss of cross-modal interactions between visual and auditory networks. CONCLUSIONS: Our results shed light on the functional significance of spontaneous brain activity fluctuations observed in functional magnetic resonance imaging. They suggest that propofol-induced unconsciousness could be linked to a breakdown of cerebral temporal architecture that modifies both within- and between-network connectivity and thus prevents communication between low-level sensory and higher-order frontoparietal cortices, thought to be necessary for perception of external stimuli. They emphasize the importance of thalamocortical connectivity in higher-order cognitive brain networks in the genesis of conscious perception.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Boveroux, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Vanhaudenhuyse, Audrey ; Université de Liège - ULiège > Centre de recherches du cyclotron > Coma Science Group
Bruno, Marie-Aurélie ; Université de Liège - ULiège > Centre de recherches du cyclotron > Coma Science Group
Noirhomme, Quentin ; Université de Liège - ULiège > Centre de recherches du cyclotron
Lauwick, Séverine ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Luxen, André ; Université de Liège - ULiège > Centre de recherches du cyclotron Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron
Schnakers, Caroline ; Université de Liège - ULiège > Centre de recherches du cyclotron
Phillips, Christophe ; Université de Liège - ULiège > Centre de recherches du cyclotron
Brichant, Jean-François ; Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Bonhomme, Vincent ; Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Maquet, Pierre ; Université de Liège - ULiège > Centre de reherches du cyclotron > Neurologie Sart Tilman
Greicius, Michael D
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron - Département des sciences cliniques
Boly, Mélanie ; Université de Liège - ULiège > Centre de recherches du cyclotron - Coma group Département des sciences cliniques > Neurologie
Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness.
Publication date :
2010
Journal title :
Anesthesiology
ISSN :
0003-3022
eISSN :
1528-1175
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Volume :
113
Issue :
5
Pages :
1038-53
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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