[en] Kinetics and optical studies of Streptomyces DD-carboxypeptidases-transpeptidases led to the conclusion that the donor, acceptor, and penicillin sites on these enzymes are different but not independent and that penicillin acts as a modifier of the conformation of the protein. In the presence of penicillin, the penicillin-sensitive enzymes would be frozen in a conformation that prevents catalytic activity.
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Ghuysen J.‐M., Leyh‐Bouille M., Frère J.M., Dusart J., Marquet A., Perkins H.R., Nieto M., Unpublished observations.; .
Flanagan M.T., Nieto M., Unpublished observations.; .
